Type |
Details |
Score |
DO Term |
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GO Term |
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Allele |
Name: |
transgene insertion LJ85, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
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Strain |
Attribute String: |
mutant stock, transgenic |
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Publication |
First Author: |
Zeng A |
Year: |
2013 |
Journal: |
J Cell Biol |
Title: |
Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. |
Volume: |
201 |
Issue: |
3 |
Pages: |
409-25 |
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Publication |
First Author: |
Seroussi E |
Year: |
1999 |
Journal: |
Genomics |
Title: |
TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM. |
Volume: |
57 |
Issue: |
3 |
Pages: |
380-8 |
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Publication |
First Author: |
Hsu I |
Year: |
2014 |
Journal: |
Carcinogenesis |
Title: |
Suppression of ERβ signaling via ERβ knockout or antagonist protects against bladder cancer development. |
Volume: |
35 |
Issue: |
3 |
Pages: |
651-61 |
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Publication |
First Author: |
Laresgoiti U |
Year: |
2013 |
Journal: |
Nucleic Acids Res |
Title: |
E2F2 and CREB cooperatively regulate transcriptional activity of cell cycle genes. |
Volume: |
41 |
Issue: |
22 |
Pages: |
10185-98 |
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Publication |
First Author: |
Chuang CH |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells. |
Volume: |
40 |
Issue: |
11 |
Pages: |
4914-24 |
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Publication |
First Author: |
Kukimoto-Niino M |
Year: |
2008 |
Journal: |
Structure |
Title: |
Structural basis for the exclusive specificity of Slac2-a/melanophilin for the Rab27 GTPases. |
Volume: |
16 |
Issue: |
10 |
Pages: |
1478-90 |
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Publication |
First Author: |
Nagashima K |
Year: |
2002 |
Journal: |
FEBS Lett |
Title: |
Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. |
Volume: |
517 |
Issue: |
1-3 |
Pages: |
233-8 |
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Publication |
First Author: |
Oberhofer A |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro. |
Volume: |
114 |
Issue: |
24 |
Pages: |
E4714-E4723 |
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Protein Domain |
Type: |
Domain |
Description: |
Melanophilin, also termed SlaC2-a, or exophilin-3, is a GTP-bound form of Rab27A-, myosin Va-, and actin-binding protein present on melanosomes. It is involved in the control of transferring of melanosomes from microtubules to actin filaments. It also functions as a melanocyte type myosin Va (McM5) binding partner and directly activates the actin-activated ATPase activity of McM5 through forming a tripartite protein complex with Rab27A and an actin-based motor myosin Va [,]. SlaC2-a belongs to the Slp homologue lacking C2 domains (Slac2) family. It contains an N-terminal Slp homology domain (SHD), but lacks tandem C2 domains. The SHD consists of two conserved regions, designated SHD1 (Slp homology domain 1) and SHD2, which may function as protein interaction sites []. The SHD1 and SHD2 of SlaC2-a are separated by a putative FYVE zinc finger, which resembles a FYVE-related domain that is structurally similar to the canonical FYVE domains but lacks the three signature sequences: an N-terminal WxxD motif (x for any residue), the central basic R(R/K)HHCRxCG patch, and a C-terminal RVC motif. Moreover, Slac2-a has a middle myosin-binding domain and a C-terminal actin-binding domain []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
590
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
590
 |
Fragment?: |
false |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
120
 |
Fragment?: |
true |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
590
 |
Fragment?: |
false |
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Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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Publication |
First Author: |
Carninci P |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. |
Volume: |
10 |
Issue: |
10 |
Pages: |
1617-30 |
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Publication |
First Author: |
Carninci P |
Year: |
1999 |
Journal: |
Methods Enzymol |
Title: |
High-efficiency full-length cDNA cloning. |
Volume: |
303 |
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Pages: |
19-44 |
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Publication |
First Author: |
Shibata K |
Year: |
2000 |
Journal: |
Genome Res |
Title: |
RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. |
Volume: |
10 |
Issue: |
11 |
Pages: |
1757-71 |
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Publication |
First Author: |
Katayama S |
Year: |
2005 |
Journal: |
Science |
Title: |
Antisense transcription in the mammalian transcriptome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1564-6 |
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Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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Publication |
First Author: |
Huttlin EL |
Year: |
2010 |
Journal: |
Cell |
Title: |
A tissue-specific atlas of mouse protein phosphorylation and expression. |
Volume: |
143 |
Issue: |
7 |
Pages: |
1174-89 |
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Publication |
First Author: |
Church DM |
Year: |
2009 |
Journal: |
PLoS Biol |
Title: |
Lineage-specific biology revealed by a finished genome assembly of the mouse. |
Volume: |
7 |
Issue: |
5 |
Pages: |
e1000112 |
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