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Search results 301 to 386 out of 386 for Mcm7

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Type Details Score
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 2
Description: DNA replication licensing factor MCM7
Type: chain
End: 719
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Publication
20388916 | J:185413
First Author: Poliseno L
Year: 2010
Journal: Sci Signal
Title: Identification of the miR-106b~25 microRNA cluster as a proto-oncogenic PTEN-targeting intron that cooperates with its host gene MCM7 in transformation.
Volume: 3
Issue: 117
Pages: ra29
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Protein
D3Z335
Organism: Mus musculus/domesticus
Length: 50  
Fragment?: true
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Allele
Mcm7<tm1Smoc> | MGI:7290999
Name: minichromosome maintenance complex component 7; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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GO Term
GO:0097373 | MCM core complex
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Allele
Mirc3<tm1Tyj> | MGI:3795503
Name: microRNA cluster 3, including Mir25 through Mir106b; targeted mutation 1, Tyler Jacks
Allele Type: Targeted
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Mirc3/Mirc3
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
17254966 | J:120363
First Author: Grimmler M
Year: 2007
Journal: Cell
Title: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Volume: 128
Issue: 2
Pages: 269-80
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Publication
18354415 | -
First Author: Chu IM
Year: 2008
Journal: Nat Rev Cancer
Title: The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy.
Volume: 8
Issue: 4
Pages: 253-67
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Publication
18267085 | -
First Author: Besson A
Year: 2008
Journal: Dev Cell
Title: CDK inhibitors: cell cycle regulators and beyond.
Volume: 14
Issue: 2
Pages: 159-69
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Publication
15652749 | J:96084
First Author: Baldassarre G
Year: 2005
Journal: Cancer Cell
Title: p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion.
Volume: 7
Issue: 1
Pages: 51-63
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Protein Domain
IPR029843 | CDKN1B
Type: Family
Description: Cyclin-dependent kinase inhibitor 1B (CDKN1B, also known as p27Kip1) controls cell proliferation by binding to and regulating the activity of cyclin-dependent kinases (Cdks) []. It is also involved in cell migration through binding and regulation of RhoA or stathmin [, , ]. It also inhibits DNA replication by binding to the DNA replication licensing factor MCM7 [].
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Publication
35535434 | J:329536
First Author: Dommann N
Year: 2022
Journal: FEBS Lett
Title: LIM protein Ajuba promotes liver cell proliferation through its involvement in DNA replication and DNA damage control.
Volume: 596
Issue: 14
Pages: 1746-1764
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Protein
P46414
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Protein
Q4FJM2
Organism: Mus musculus/domesticus
Length: 197  
Fragment?: false
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Publication
20501654 | J:165835
First Author: Long J
Year: 2010
Journal: J Biol Chem
Title: Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.
Volume: 285
Issue: 30
Pages: 23457-65
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Publication
17018593 | J:113382
First Author: Balsitis S
Year: 2006
Journal: Cancer Res
Title: Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis.
Volume: 66
Issue: 19
Pages: 9393-400
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Publication
17556357 | J:124806
First Author: Srinivasan SV
Year: 2007
Journal: J Biol Chem
Title: RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors.
Volume: 282
Issue: 33
Pages: 23867-77
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Publication
17308103 | J:118649
First Author: Shai A
Year: 2007
Journal: Cancer Res
Title: The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities.
Volume: 67
Issue: 4
Pages: 1626-35
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Publication
12614612 | J:82383
First Author: Kneissl M
Year: 2003
Journal: J Mol Biol
Title: Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
Volume: 327
Issue: 1
Pages: 111-28
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Publication
38182577 | J:344190
First Author: Akkawi R
Year: 2024
Journal: Cell Death Dis
Title: WWOX promotes osteosarcoma development via upregulation of Myc.
Volume: 15
Issue: 1
Pages: 13
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Publication
9305914 | -
First Author: Ishimi Y
Year: 1997
Journal: J Biol Chem
Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
Volume: 272
Issue: 39
Pages: 24508-13
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Publication
9366552 | -
First Author: Adachi Y
Year: 1997
Journal: Genes Cells
Title: A globular complex formation by Nda1 and the other five members of the MCM protein family in fission yeast.
Volume: 2
Issue: 7
Pages: 467-79
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Publication
9658174 | -
First Author: Sherman DA
Year: 1998
Journal: Mol Biol Cell
Title: Multiple domains of fission yeast Cdc19p (MCM2) are required for its association with the core MCM complex.
Volume: 9
Issue: 7
Pages: 1833-45
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Publication
10588642 | -
First Author: Pasion SG
Year: 1999
Journal: Mol Biol Cell
Title: Nuclear localization of Schizosaccharomyces pombe Mcm2/Cdc19p requires MCM complex assembly.
Volume: 10
Issue: 12
Pages: 4043-57
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Protein
A0A0A0MQF4
Organism: Mus musculus/domesticus
Length: 358  
Fragment?: false
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Publication
9383050 | -
First Author: Forsburg SL
Year: 1997
Journal: Genetics
Title: Mutational analysis of Cdc19p, a Schizosaccharomyces pombe MCM protein.
Volume: 147
Issue: 3
Pages: 1025-41
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Protein Domain
IPR018525 | MCM_CS
Type: Conserved_site
Description: MCM proteins are DNA-dependent ATPases required for the initiation ofeukaryotic DNA replication [, , ]. In eukaryotes there is a family of six proteins, MCM2 to MCM7. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins [].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.The "MCM motif"contains Walker-A and Walker-B type nucleotide binding motifs. The diagnostic sequence defining the MCMs is IDEFDKM. Only Mcm2 (aka Cdc19 or Nda1) has been subjected to mutational analysis in this region, and most mutations abolish its activity []. The presence of a putative ATP-binding domain implies that these proteins may be involved in an ATP-consuming step in the initiation of DNA replication in eukaryotes.The MCM proteins bind together in a large complex [].Within this complex, individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. This core complex in human MCMs has been associated with helicase activity in vitro[], leading to the suggestion that the MCM proteins are the eukaryotic replicative helicase.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].The signature pattern used in this entry represents a perfectly conserved region that is a special version of the B motif found in ATP-binding proteins.
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Protein Domain
IPR031327 | MCM
Type: Family
Description: MCM proteins are DNA-dependent ATPases required for the initiation of eukaryotic DNA replication [, , ]. In eukaryotes there is a family of eight proteins, MCM2 to MCM9. They were first identified in yeast where most of them have adirect role in the initiation of chromosomal DNA replication by interacting directly with autonomously replicating sequences (ARS). They were thus called minichromosome maintenance proteins, MCM proteins []. These proteins are evolutionarily related and belong to the AAA+ superfamily. They contain the Mcm family domain, which includes motifs that are required for ATP hydrolysis (such as the Walker A and B, and R-finger motifs). Mcm2-7 forms a hexameric complex []in which individual subunits associate with different affinities, and there is a tightly associated core of Mcm4 (Cdc21), Mcm6 (Mis5) and Mcm7 []. Mcm2-7 complex is the replicative helicase involved in replication initiation and elongation [], whereas Mcm8 and Mcm9 from and separate one, conserved among many eukaryotes except yeast and C. elegans. Mcm8/9 complex play a role during replication elongation or recombination, being involved in the repair of double-stranded DNA breaks and DNA interstrand cross-links by homologous recombination. Drosophila is the only organism that has MCM8 without MCM9, involved in meiotic recombination [, ].This family is also present in the archebacteria in 1 to 4 copies. Methanocaldococcus jannaschii (Methanococcus jannaschii) has four members, MJ0363, MJ0961, MJ1489 and MJECL13.Schizosaccharomyces pombe (Fission yeast) MCMs, like those in metazoans, are found in the nucleus throughout the cell cycle. This is in contrast to the Saccharomyces cerevisiae (Baker's yeast) in which MCM proteins move in and out of the nucleus during each cell cycle. The assembly of the MCM complex in S. pombe is required for MCM localisation, ensuring that only intact MCM complexes remain in the nucleus [].
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Protein
E9Q956
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
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Protein
H9KV11
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
H7BXC1
Organism: Mus musculus/domesticus
Length: 692  
Fragment?: false
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Publication
22771115 | -
First Author: Nishimura K
Year: 2012
Journal: Mol Cell
Title: Mcm8 and Mcm9 form a complex that functions in homologous recombination repair induced by DNA interstrand crosslinks.
Volume: 47
Issue: 4
Pages: 511-22
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Publication
30743181 | -
 
First Author: Griffin WC
Year: 2019
Journal: DNA Repair (Amst)
Title: The MCM8/9 complex: A recent recruit to the roster of helicases involved in genome maintenance.
Volume: 76
Pages: 1-10
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Protein
Q8C2I9
Organism: Mus musculus/domesticus
Length: 393  
Fragment?: true
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Protein
Q8C5L1
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: true
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Publication
1454522 | -
First Author: Coxon A
Year: 1992
Journal: Nucleic Acids Res
Title: Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication.
Volume: 20
Issue: 21
Pages: 5571-7
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Publication
8332451 | -
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication.
Volume: 21
Issue: 11
Pages: 2541-7
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Publication
8265339 | -
First Author: Hu B
Year: 1993
Journal: Nucleic Acids Res
Title: The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins.
Volume: 21
Issue: 23
Pages: 5289-93
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Publication
14731643 | -
First Author: Tye BK
Year: 1994
Journal: Trends Cell Biol
Title: The MCM2-3-5 proteins: are they replication licensing factors?
Volume: 4
Issue: 5
Pages: 160-6
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Protein
P97311
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
P97310
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
P49718
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
P49717
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
P25206
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q542I2
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q921D5
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UJN1
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q3UA65
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UK39
Organism: Mus musculus/domesticus
Length: 904  
Fragment?: false
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Protein
Q3UC10
Organism: Mus musculus/domesticus
Length: 821  
Fragment?: false
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Protein
Q8BQ03
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
Q3UZH2
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q9D077
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3ULD6
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q5DTS8
Organism: Mus musculus/domesticus
Length: 677  
Fragment?: true
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Protein
Q542F4
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Protein
Q3UI57
Organism: Mus musculus/domesticus
Length: 812  
Fragment?: false
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Protein
Q3ULG5
Organism: Mus musculus/domesticus
Length: 794  
Fragment?: false
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Protein
A0A1W2P804
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q3UXG9
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
A0A2R8VHP7
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Protein
A0A2R8VKJ4
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
A0A1W2P801
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: true
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Protein
Q9CWV1
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
Q2KHI9
Organism: Mus musculus/domesticus
Length: 1134  
Fragment?: false
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Protein
Q8C1Z0
Organism: Mus musculus/domesticus
Length: 862  
Fragment?: false
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom