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Search results 301 to 362 out of 362 for Mcu

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0.032s

Type

Details

Score

Publication

30454562 | J:269007

First Author:	Paillard M
Year:	2018
Journal:	Mol Cell
Title:	MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca²⁺ Flux and Sensitivity to Ru360.
Volume:	72
Issue:	4
Pages:	778-785.e3

•

Protein

Q9CXD6

Organism:	Mus musculus/domesticus
Length:	340
Fragment?:	false

•

Allele

Mcu<em2Smoc> | MGI:7291007

Name:	mitochondrial calcium uniporter; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Null/knockout

•

Protein

Q9CXD6-2

Organism:	Mus musculus/domesticus
Length:	286
Fragment?:	false

•

Protein

Q9CXD6-3

Organism:	Mus musculus/domesticus
Length:	160
Fragment?:	false

•

Strain

MGI:6770935 | C57BL/6JSmoc-Mcu<em2Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

Allele

Mcu<em1Smoc> | MGI:7291006

Name:	mitochondrial calcium uniporter; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type:	Endonuclease-mediated
Attribute String:	Conditional ready, No functional change

•

Publication

26387864 | -

First Author:	Petrungaro C
Year:	2015
Journal:	Cell Metab
Title:	The Ca(2+)-Dependent Release of the Mia40-Induced MICU1-MICU2 Dimer from MCU Regulates Mitochondrial Ca(2+) Uptake.
Volume:	22
Issue:	4
Pages:	721-33

•

Strain

MGI:6475764 | C57BL/6JSmoc-Mcu<em1Smoc>/Smoc

Attribute String:

coisogenic, endonuclease-mediated mutation, mutant strain

•

GO Term

GO:1990246 | uniplex complex

•

Publication

23178883 | -

First Author:	Mallilankaraman K
Year:	2012
Journal:	Nat Cell Biol
Title:	MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism.
Volume:	14
Issue:	12
Pages:	1336-43

•

Publication

26445506 | -

First Author:	Vais H
Year:	2015
Journal:	Cell Metab
Title:	MCUR1, CCDC90A, Is a Regulator of the Mitochondrial Calcium Uniporter.
Volume:	22
Issue:	4
Pages:	533-5

•

Publication

26976564 | -

First Author:	Chaudhuri D
Year:	2016
Journal:	Proc Natl Acad Sci U S A
Title:	Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.
Volume:	113
Issue:	13
Pages:	E1872-80

•

Protein

Q8C3X2

Organism:	Mus musculus/domesticus
Length:	256
Fragment?:	false

•

Publication

25565209 | -

First Author:	Paupe V
Year:	2015
Journal:	Cell Metab
Title:	CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.
Volume:	21
Issue:	1
Pages:	109-16

•

Protein Domain

IPR024461 | CCDC90-like

Type:

Family

Description:

This entry includes coiled-coil domain-containing proteins 90 (CCDC90) and related proteins. CCDC90A is a key regulator of the mitochondrial calcium uniporter (MCU) and hence was renamed MCUR1 [, , ]. A study in mammals and in yeast homologue fmp32 has reported that MCUR1 is a cytochrome c oxidase assembly factor and that it has an indirect role as a regulator of MCU [], however, subsequent publications confirmed the function of MCUR1 as a regulator of MCU [, ]. The role of CCDC90B proteins is still not known.

•

Protein

V9GXX9

Organism:	Mus musculus/domesticus
Length:	87
Fragment?:	false

•

Publication

26903221 | -

First Author:	Matesanz-Isabel J
Year:	2016
Journal:	Biochim Biophys Acta
Title:	Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake.
Volume:	1858
Issue:	6
Pages:	1110-7

•

Publication

29725115 | -

First Author:	Patron M
Year:	2018
Journal:	Cell Death Differ
Title:	MICU3 is a tissue-specific enhancer of mitochondrial calcium uptake.

•

Publication

28194521 | -

First Author:	Mishra J
Year:	2017
Journal:	Handb Exp Pharmacol
Title:	The Mitochondrial Ca²⁺ Uniporter: Structure, Function, and Pharmacology.
Volume:	240

Pages:	129-156

•

Protein Domain

IPR006769 | MCU_C

Type:	Domain
Description:	This entry represents the C-terminal domain of MCU, which is a mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria [, , ]. This domain can also be found in MCUb, which negatively regulates the activity of MCU [].

•

Protein Domain

IPR012439 | MCUR1

Type:	Family
Description:	Mitochondrial calcium uniporter regulator 1 (MCUR1), also known as CCDC90A, is a key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. It plays a direct role in uniporter-mediated calcium uptake, possibly via a direct interaction with MCU [, , ].

•

Protein Domain

IPR039800 | MICU1/2/3

Type:	Family
Description:	This entry represents a group of calcium uptake proteins, including MICU1/2/3 from humans. They contain the conserved EF-hand Ca2+-binding domains. MICU1 and MICU2 are the main regulators of the mitochondrial Ca(2+)-uniporter (MCU) []. MICU2 forms a heterodimer with MICU1 to modulate MCU channel activity []. MICU3 a tissue-specific enhancer of mitochondrial calcium uptake [].

•

Publication

38599304 | J:350505

First Author:	Ponnusamy T
Year:	2024
Journal:	Mitochondrion
Title:	Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability.
Volume:	76

Pages:	101877

•

Protein Coding Gene

MGI:1925756 | Micu3

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

26956930 | J:236567

First Author:	Antony AN
Year:	2016
Journal:	Nat Commun
Title:	MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.
Volume:	7

Pages:	10955

•

Publication

34936875 | J:321451

First Author:	Serrat R
Year:	2021
Journal:	Cell Rep
Title:	Astroglial ER-mitochondria calcium transfer mediates endocannabinoid-dependent synaptic integration.
Volume:	37
Issue:	12
Pages:	110133

•

Publication

30597405 | J:276157

First Author:	Tadić V
Year:	2019
Journal:	Neurobiol Aging
Title:	Investigation of mitochondrial calcium uniporter role in embryonic and adult motor neurons from G93A^hSOD1 mice.
Volume:	75

Pages:	209-222

•

Publication

27818145 | J:248720

First Author:	Vecellio Reane D
Year:	2016
Journal:	Mol Cell
Title:	A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca²⁺ Uptake Machinery of Skeletal Muscle.
Volume:	64
Issue:	4
Pages:	760-773

•

Publication

23747253 | J:203491

First Author:	Csordás G
Year:	2013
Journal:	Cell Metab
Title:	MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca²⁺ uniporter.
Volume:	17
Issue:	6
Pages:	976-87

•

Publication

26968367 | J:253906

First Author:	Mammucari C
Year:	2016
Journal:	Biochim Biophys Acta
Title:	Molecular structure and pathophysiological roles of the Mitochondrial Calcium Uniporter.
Volume:	1863
Issue:	10
Pages:	2457-64

•

Publication

28740830 | J:267438

First Author:	Mammucari C
Year:	2017
Journal:	Front Oncol
Title:	Structure, Activity Regulation, and Role of the Mitochondrial Calcium Uniporter in Health and Disease.
Volume:	7

Pages:	139

•

Publication

34161774 | J:306632

First Author:	De Mario A
Year:	2021
Journal:	Cell Rep
Title:	Identification and functional validation of FDA-approved positive and negative modulators of the mitochondrial calcium uniporter.
Volume:	35
Issue:	12
Pages:	109275

•

Protein Coding Gene

MGI:1915764 | Micu2

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:1916279 | Smdt1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:2384909 | Micu1

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:1914065 | Mcub

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Publication

32047033 | J:320008

First Author:	Ham SJ
Year:	2020
Journal:	Proc Natl Acad Sci U S A
Title:	Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.
Volume:	117
Issue:	8
Pages:	4281-4291

•

Publication

26849136 | J:248891

First Author:	Motloch LJ
Year:	2016
Journal:	PLoS One
Title:	By Regulating Mitochondrial Ca2+-Uptake UCP2 Modulates Intracellular Ca2+.
Volume:	11
Issue:	2
Pages:	e0148359

•

Publication

35269658 | J:329149

First Author:	Vecellio Reane D
Year:	2022
Journal:	Int J Mol Sci
Title:	The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
Volume:	23
Issue:	5

•

Publication

31607937 | J:314279

First Author:	Canato M
Year:	2019
Journal:	Front Physiol
Title:	Excessive Accumulation of Ca^{2 +} in Mitochondria of Y522S-RYR1 Knock-in Mice: A Link Between Leak From the Sarcoplasmic Reticulum and Altered Redox State.
Volume:	10

Pages:	1142

•

Publication

24492610 | J:210676

First Author:	Miller BA
Year:	2014
Journal:	J Biol Chem
Title:	TRPM2 channels protect against cardiac ischemia-reperfusion injury: role of mitochondria.
Volume:	289
Issue:	11
Pages:	7615-29

•

Publication

23051746 | J:189223

First Author:	Joiner ML
Year:	2012
Journal:	Nature
Title:	CaMKII determines mitochondrial stress responses in heart.
Volume:	491
Issue:	7423
Pages:	269-73

•

Publication

29073097 | J:252915

First Author:	Zaglia T
Year:	2017
Journal:	Proc Natl Acad Sci U S A
Title:	Content of mitochondrial calcium uniporter (MCU) in cardiomyocytes is regulated by microRNA-1 in physiologic and pathologic hypertrophy.
Volume:	114
Issue:	43
Pages:	E9006-E9015

•

Publication

25896525 | J:254138

First Author:	De Stefani D
Year:	2015
Journal:	Biochim Biophys Acta
Title:	Structure and function of the mitochondrial calcium uniporter complex.
Volume:	1853
Issue:	9
Pages:	2006-11

•

Publication

30228190 | J:272899

First Author:	Basso E
Year:	2018
Journal:	J Biol Chem
Title:	Slow activation of fast mitochondrial Ca²⁺ uptake by cytosolic Ca².
Volume:	293
Issue:	44
Pages:	17081-17094

•

Publication

32801213 | J:295968

First Author:	Vais H
Year:	2020
Journal:	Proc Natl Acad Sci U S A
Title:	Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca²⁺ uptake.
Volume:	117
Issue:	35
Pages:	21731-21739

•

Publication

30670946 | J:313114

First Author:	Wang X
Year:	2018
Journal:	Front Mol Neurosci
Title:	Mitochondrial Calcium Transporters Mediate Sensitivity to Noise-Induced Losses of Hair Cells and Cochlear Synapses.
Volume:	11

Pages:	469

•

Publication

31377553 | J:326309

First Author:	Niemann J
Year:	2019
Journal:	Cell Calcium
Title:	Cytosolic and mitochondrial Ca²⁺ concentrations in primary hepatocytes change with ageing and in consequence of an mtDNA mutation.
Volume:	82

Pages:	102055

•

Publication

33625952 | J:330413

First Author:	Huang HR
Year:	2021
Journal:	Am J Respir Cell Mol Biol
Title:	RIPK3 Activates MLKL-mediated Necroptosis and Inflammasome Signaling during Streptococcus Infection.
Volume:	64
Issue:	5
Pages:	579-591

•

Protein

Q8CD10

Organism:	Mus musculus/domesticus
Length:	432
Fragment?:	false

•

Publication

31533452 | J:298046

First Author:	Lambert JP
Year:	2019
Journal:	Circulation
Title:	MCUB Regulates the Molecular Composition of the Mitochondrial Calcium Uniporter Channel to Limit Mitochondrial Calcium Overload During Stress.
Volume:	140
Issue:	21
Pages:	1720-1733

•

Publication

35387872 | J:352469

First Author:	Pérez-Liébana I
Year:	2022
Journal:	J Neurosci
Title:	A Ca(2+)-Dependent Mechanism Boosting Glycolysis and OXPHOS by Activating Aralar-Malate-Aspartate Shuttle, upon Neuronal Stimulation.
Volume:	42
Issue:	19
Pages:	3879-3895

•

Publication

29038245 | J:251390

First Author:	Verma M
Year:	2017
Journal:	J Neurosci
Title:	Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.
Volume:	37
Issue:	46
Pages:	11151-11165

•

Protein

Q8VCX5

Organism:	Mus musculus/domesticus
Length:	477
Fragment?:	false

•

Protein

Q9CTY5

Organism:	Mus musculus/domesticus
Length:	523
Fragment?:	false

•

Protein

F6WMX7

Organism:	Mus musculus/domesticus
Length:	262
Fragment?:	true

•

Protein

E9Q9E0

Organism:	Mus musculus/domesticus
Length:	234
Fragment?:	true

•

Protein

B7ZND1

Organism:	Mus musculus/domesticus
Length:	374
Fragment?:	true

•

Protein

A0JLX6

Organism:	Mus musculus/domesticus
Length:	387
Fragment?:	true

•

Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

•

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Search results 301 to 362 out of 362 for Mcu

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