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Search results 301 to 388 out of 388 for Mfn2

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Type Details Score
Interaction Experiment
Chen H (2003)
Description: Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.
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Interaction Experiment
McLelland GL (2018)
Description: Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
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HT Experiment
GSE194377 | RNA-seq from MFN2;Stra8-Cre cKO vs WT spermatocytes in mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q80U63
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Allele
Tg(Eno2-MFN2*R94Q)L51Ugfm | MGI:4440895
Name: transgene insertion L51, University of Geneva Faculty of Medicine
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Transgene
MGI:4440921 | Tg(Eno2-MFN2*R94Q)L51Ugfm
Type: transgene
Organism: mouse, laboratory
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Transgene
MGI:5476532 | Tg(Eno2-MFN2*R94Q)L87Ugfm
Type: transgene
Organism: mouse, laboratory
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Allele
Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc | MGI:6198713
Name: transgene insertion 1, David C Chan
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Transgene
MGI:6198712 | Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Type: transgene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Tg(Eno2-MFN2*R94Q)L51Ugfm/?
Background: involves: C57BL/6 * C57BL/6J * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Eno2-MFN2*R94Q)L51Ugfm/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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DO Term
DOID:0110155 | Charcot-Marie-Tooth disease type 2A2A
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Genotype
Genotype
Symbol: Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc/Tg(Mnx1-Mfn2*T105M,-EGFP)1Dcc
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
29676259 | -
   
First Author: McLelland GL
Year: 2018
Journal: Elife
Title: Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.
Volume: 7
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HT Experiment
GSE214984 | mRNA Sequencing of pups heart Knock-in Mfn2R400Q
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Protein
Q80U63-2
Organism: Mus musculus/domesticus
Length: 605  
Fragment?: false
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Publication
12598526 | -
First Author: Bach D
Year: 2003
Journal: J Biol Chem
Title: Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity.
Volume: 278
Issue: 19
Pages: 17190-7
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Publication
15322553 | -
First Author: Chen KH
Year: 2004
Journal: Nat Cell Biol
Title: Dysregulation of HSG triggers vascular proliferative disorders.
Volume: 6
Issue: 9
Pages: 872-83
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Publication
17901359 | -
First Author: Guo X
Year: 2007
Journal: Circ Res
Title: Mitofusin 2 triggers vascular smooth muscle cell apoptosis via mitochondrial death pathway.
Volume: 101
Issue: 11
Pages: 1113-22
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Publication
15549395 | -
First Author: Kijima K
Year: 2005
Journal: Hum Genet
Title: Mitochondrial GTPase mitofusin 2 mutation in Charcot-Marie-Tooth neuropathy type 2A.
Volume: 116
Issue: 1-2
Pages: 23-7
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Publication
22206013 | -
First Author: Lin KP
Year: 2011
Journal: PLoS One
Title: The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan.
Volume: 6
Issue: 12
Pages: e29393
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Protein Domain
IPR027089 | Mitofusin-2
Type: Family
Description: Mitofusin-2 (MFN2) is an essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton [, , ]. MFN2 plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes [, ]. It plays an important role in the regulation of vascular smooth muscle cell proliferation []. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). CMT2A2 is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system [, , ].
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HT Experiment
E-GEOD-71501 | Mitofusin 2 expression in muscle decreases during aging and generates a gene signature characteristic of aged muscle
Series Id: GSE71501
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Allele
Tg(Mfn2-EGFP)HR116Gsat | MGI:4847232
Name: transgene insertion HR116, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5629290 | C57BL/6-Gt(ROSA)26Sor<tm1(CAG-MFN2*T105M)Dple>/J
Attribute String: mutant strain, targeted mutation, coisogenic
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Allele
Tg(Nppa-EGFP)BAC336Vmc | MGI:7380641
Name: transgene insertion BAC336, Vincent M Christoffels
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:5003753 | STOCK Tg(Mfn2-EGFP)HR116Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Allele
Tg(Eno2-MFN2)L916Ugfm | MGI:5476630
Name: transgene insertion L916, University of Geneva Faculty of Medicine
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
11950885 | -
First Author: Rojo M
Year: 2002
Journal: J Cell Sci
Title: Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.
Volume: 115
Issue: Pt 8
Pages: 1663-74
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Protein
A2A7Y8
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: true
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Publication
11181170 | -
First Author: Santel A
Year: 2001
Journal: J Cell Sci
Title: Control of mitochondrial morphology by a human mitofusin.
Volume: 114
Issue: Pt 5
Pages: 867-74
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Strain
MGI:5476632 | B6;D2-Tg(Eno2-MFN2)L916Ugfm/Orl
Attribute String: mutant stock, transgenic
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Genotype
Genotype
Symbol: Tg(Eno2-MFN2)L916Ugfm/Tg(Eno2-MFN2)L916Ugfm
Background: involves: C57BL/6 * DBA/2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:5476626 | B6;D2-Tg(Eno2-MFN2*R94Q)L87Ugfm/Orl
Attribute String: mutant stock, transgenic
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Publication
19498200 | J:164751
First Author: Horsthuis T
Year: 2009
Journal: Circ Res
Title: Gene expression profiling of the forming atrioventricular node using a novel tbx3-based node-specific transgenic reporter.
Volume: 105
Issue: 1
Pages: 61-9
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Publication
30887444 | J:359266
First Author: Li T
Year: 2019
Journal: Protein Cell
Title: PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation.
Volume: 10
Issue: 8
Pages: 583-594
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Publication
28746876 | J:254859
First Author: Huang G
Year: 2017
Journal: Cell Rep
Title: WBSCR16 Is a Guanine Nucleotide Exchange Factor Important for Mitochondrial Fusion.
Volume: 20
Issue: 4
Pages: 923-934
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Publication
26717518 | J:245987
First Author: Yu CY
Year: 2015
Journal: PLoS Pathog
Title: Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins.
Volume: 11
Issue: 12
Pages: e1005350
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Publication
26321632 | J:264396
First Author: Tang FL
Year: 2015
Journal: Cell Rep
Title: VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function.
Volume: 12
Issue: 10
Pages: 1631-43
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Publication
39528719 | J:358599
First Author: Zhang L
Year: 2024
Journal: Nat Cardiovasc Res
Title: Klf9 is essential for cardiac mitochondrial homeostasis.
Volume: 3
Issue: 11
Pages: 1318-1336
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Publication
30659145 | J:271119
First Author: Bernard-Marissal N
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Altered interplay between endoplasmic reticulum and mitochondria in Charcot-Marie-Tooth type 2A neuropathy.
Volume: 116
Issue: 6
Pages: 2328-2337
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Publication
36936780 | J:340971
First Author: Shahin S
Year: 2023
Journal: iScience
Title: MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model.
Volume: 26
Issue: 3
Pages: 106270
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Publication
21296869 | J:170498
First Author: Chan NC
Year: 2011
Journal: Hum Mol Genet
Title: Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy.
Volume: 20
Issue: 9
Pages: 1726-37
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Publication
31409786 | J:281088
First Author: Puri R
Year: 2019
Journal: Nat Commun
Title: Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts.
Volume: 10
Issue: 1
Pages: 3645
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Publication
33972668 | J:308379
First Author: Silwal P
Year: 2021
Journal: Commun Biol
Title: Mitofusin-2 boosts innate immunity through the maintenance of aerobic glycolysis and activation of xenophagy in mice.
Volume: 4
Issue: 1
Pages: 548
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Publication
37738362 | J:350207
First Author: Yang JF
Year: 2023
Journal: Sci Immunol
Title: Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8(+) T cell metabolic fitness and function in tumors.
Volume: 8
Issue: 87
Pages: eabq2424
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Protein
A8Y5E5
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
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Publication
20418531 | J:173431
First Author: Cartoni R
Year: 2010
Journal: Brain
Title: Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A.
Volume: 133
Issue: Pt 5
Pages: 1460-9
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Protein
Q3TEX7
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Protein
Q3UGM1
Organism: Mus musculus/domesticus
Length: 757  
Fragment?: false
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Publication
28973648 | J:249487
First Author: Lemos V
Year: 2017
Journal: Hum Mol Genet
Title: The NAD+-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes.
Volume: 26
Issue: 21
Pages: 4105-4117
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Publication
26908605 | J:233022
First Author: Yin X
Year: 2016
Journal: Hum Mol Genet
Title: Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Volume: 25
Issue: 9
Pages: 1739-53
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Publication
30606759 | J:272886
First Author: Ishikawa K
Year: 2019
Journal: J Neurosci
Title: Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior.
Volume: 39
Issue: 9
Pages: 1588-1604
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Publication
23465714 | J:211749
First Author: Williams PA
Year: 2013
Journal: Neurobiol Aging
Title: Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease.
Volume: 34
Issue: 7
Pages: 1799-806
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Publication
29408999 | J:260501
First Author: Manczak M
Year: 2018
Journal: Hum Mol Genet
Title: Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Volume: 27
Issue: 8
Pages: 1332-1342
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Publication
30756520 | J:294484
First Author: Kitaoka Y
Year: 2019
Journal: Physiol Rep
Title: Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle.
Volume: 7
Issue: 3
Pages: e13998
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Publication
24009260 | J:208920
First Author: Parra V
Year: 2014
Journal: Diabetes
Title: Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway.
Volume: 63
Issue: 1
Pages: 75-88
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Publication
35646911 | J:325067
 
First Author: Li J
Year: 2022
Journal: Front Cell Dev Biol
Title: Reciprocal Regulation of Mitofusin 2-Mediated Mitophagy and Mitochondrial Fusion by Different PINK1 Phosphorylation Events.
Volume: 10
Pages: 868465
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Publication
35046471 | J:321290
First Author: Rajab BS
Year: 2022
Journal: Sci Rep
Title: Differential remodelling of mitochondrial subpopulations and mitochondrial dysfunction are a feature of early stage diabetes.
Volume: 12
Issue: 1
Pages: 978
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Publication
23983249 | J:218729
First Author: Paillard M
Year: 2013
Journal: Circulation
Title: Depressing mitochondria-reticulum interactions protects cardiomyocytes from lethal hypoxia-reoxygenation injury.
Volume: 128
Issue: 14
Pages: 1555-65
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Publication
32003595 | J:294121
First Author: Yan Y
Year: 2020
Journal: Am J Physiol Renal Physiol
Title: miR-214 represses mitofusin-2 to promote renal tubular apoptosis in ischemic acute kidney injury.
Volume: 318
Issue: 4
Pages: F878-F887
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Publication
32147437 | J:299195
 
First Author: Picci C
Year: 2020
Journal: Exp Neurol
Title: HDAC6 inhibition promotes α-tubulin acetylation and ameliorates CMT2A peripheral neuropathy in mice.
Volume: 328
Pages: 113281
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Publication
37415667 | J:338482
 
First Author: Alka K
Year: 2023
Journal: Front Endocrinol (Lausanne)
Title: Impaired mitochondrial dynamics and removal of the damaged mitochondria in diabetic retinopathy.
Volume: 14
Pages: 1160155
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Publication
17959936 | J:132035
First Author: Detmer SA
Year: 2008
Journal: Hum Mol Genet
Title: Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A.
Volume: 17
Issue: 3
Pages: 367-75
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Publication
29969932 | J:308567
First Author: Li G
Year: 2018
Journal: Autophagy
Title: PTENα regulates mitophagy and maintains mitochondrial quality control.
Volume: 14
Issue: 10
Pages: 1742-1760
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Publication
24381286 | J:205588
First Author: Guardia-Laguarta C
Year: 2014
Journal: J Neurosci
Title: α-Synuclein is localized to mitochondria-associated ER membranes.
Volume: 34
Issue: 1
Pages: 249-59
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Publication
28053050 | J:241427
First Author: Zheng L
Year: 2017
Journal: Hum Mol Genet
Title: Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.
Volume: 26
Issue: 3
Pages: 582-598
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Publication
31281589 | J:291743
 
First Author: Xu M
Year: 2019
Journal: Oxid Med Cell Longev
Title: TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM2.5).
Volume: 2019
Pages: 7450151
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Publication
31150651 | J:282147
 
First Author: Xu YJ
Year: 2019
Journal: Brain Res
Title: Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction.
Volume: 1719
Pages: 113-123
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Publication
25855408 | J:310274
First Author: Zawada I
Year: 2015
Journal: Aging (Albany NY)
Title: Gene expression of key regulators of mitochondrial biogenesis is sex dependent in mice with growth hormone receptor deletion in liver.
Volume: 7
Issue: 3
Pages: 195-204
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Publication
36640668 | J:333082
 
First Author: Qi C
Year: 2023
Journal: Biochem Biophys Res Commun
Title: Linc279227 contributes to mitochondrial dysfunction in high glucose-treated mouse renal tubular epithelial cells.
Volume: 644
Pages: 95-104
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Publication
26827898 | J:251086
 
First Author: Veeranki S
Year: 2016
Journal: J Mol Cell Cardiol
Title: Moderate intensity exercise prevents diabetic cardiomyopathy associated contractile dysfunction through restoration of mitochondrial function and connexin 43 levels in db/db mice.
Volume: 92
Pages: 163-173
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Publication
21148472 | J:169040
First Author: White JP
Year: 2011
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Muscle oxidative capacity during IL-6-dependent cancer cachexia.
Volume: 300
Issue: 2
Pages: R201-11
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Publication
21459773 | J:174031
First Author: Manczak M
Year: 2011
Journal: Hum Mol Genet
Title: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Volume: 20
Issue: 13
Pages: 2495-509
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Publication
36830601 | J:335694
 
First Author: Fihurka O
Year: 2023
Journal: Biomolecules
Title: Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Volume: 13
Issue: 2
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Publication
28173111 | J:241780
First Author: Kandimalla R
Year: 2016
Journal: Hum Mol Genet
Title: Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 22
Pages: 4881-4897
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Publication
29040533 | J:256287
First Author: Kandimalla R
Year: 2018
Journal: Hum Mol Genet
Title: Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Volume: 27
Issue: 1
Pages: 30-40
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Publication
27565029 | J:256846
 
First Author: Guan X
Year: 2016
Journal: J Mol Cell Cardiol
Title: miR-106a promotes cardiac hypertrophy by targeting mitofusin 2.
Volume: 99
Pages: 207-217
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Publication
29715546 | J:265750
 
First Author: Davis SA
Year: 2018
Journal: Neurosci Lett
Title: TDP-43 interacts with mitochondrial proteins critical for mitophagy and mitochondrial dynamics.
Volume: 678
Pages: 8-15
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Publication
37890359 | J:342396
 
First Author: Zhang Y
Year: 2023
Journal: Redox Biol
Title: Nogo-B mediates endothelial oxidative stress and inflammation to promote coronary atherosclerosis in pressure-overloaded mouse hearts.
Volume: 68
Pages: 102944
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Publication
27677309 | J:239247
First Author: Manczak M
Year: 2016
Journal: Hum Mol Genet
Title: Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 23
Pages: 5148-5166
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Publication
29682760 | J:321151
First Author: Gouspillou G
Year: 2018
Journal: J Physiol
Title: Protective role of Parkin in skeletal muscle contractile and mitochondrial function.
Volume: 596
Issue: 13
Pages: 2565-2579
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Publication
37904222 | J:342232
First Author: Mazaki Y
Year: 2023
Journal: Cell Commun Signal
Title: LRRK2 is involved in the chemotaxis of neutrophils and differentiated HL-60 cells, and the inhibition of LRRK2 kinase activity increases fMLP-induced chemotactic activity.
Volume: 21
Issue: 1
Pages: 300
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Publication
18276916 | J:278530
First Author: Horsthuis T
Year: 2008
Journal: Circ Res
Title: Distinct regulation of developmental and heart disease-induced atrial natriuretic factor expression by two separate distal sequences.
Volume: 102
Issue: 7
Pages: 849-59
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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