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Search results 301 to 330 out of 330 for Mib1

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0.024s

Type

Details

Score

Genotype

Symbol:	Mir133a-1/Mir133a-1
Background:	involves: 129S/SvEv * C57BL/6 * SJL
Zygosity:	hm
Has Mutant Allele:	true

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Genotype

Symbol:	Mir133a-1/Mir133a-1 Mir133a-2/Mir133a-2
Background:	involves: 129S/SvEv * C57BL/6
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

15760269 | -

First Author:	Le Borgne R
Year:	2005
Journal:	PLoS Biol
Title:	Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.
Volume:	3
Issue:	4
Pages:	e96

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Publication

24121310 | -

First Author:	Villumsen BH
Year:	2013
Journal:	EMBO J
Title:	A new cellular stress response that triggers centriolar satellite reorganization and ciliogenesis.
Volume:	32
Issue:	23
Pages:	3029-40

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Protein Domain

IPR042056 | MIB1/2_ZZ

Type:

Domain

Description:

This entry represents the Zinc finger found in the mammalian MIB1/2 protein and Drosophila Mind bomb (D-mib) protein. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. MIB1 and MIB2 are E3 ubiquitin-protein ligases []. Mind bomb is an E3 ubiqitin ligase that has been shown to regulate signaling by the Notch ligand Delta in Drosophila melanogaster [, , , ].

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Publication

21737882 | J:176171

First Author:	Liu N
Year:	2011
Journal:	J Clin Invest
Title:	Mice lacking microRNA 133a develop dynamin 2–dependent centronuclear myopathy.
Volume:	121
Issue:	8
Pages:	3258-68

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Publication

27458245 | J:239691

First Author:	Nie Y
Year:	2016
Journal:	FASEB J
Title:	Impaired exercise tolerance, mitochondrial biogenesis, and muscle fiber maintenance in miR-133a-deficient mice.
Volume:	30
Issue:	11
Pages:	3745-3758

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Genotype

Symbol:	Mir133a-1/Mir133a-1 Mir133a-2/Mir133a-2
Background:	involves: 129S/SvEv * C57BL/6 * SJL
Zygosity:	cx
Has Mutant Allele:	true

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Myh6-cre)2182Mds/?
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Myh6-cre)2182Mds/?
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

•

Publication

25747658 | -

First Author:	McMillan BJ
Year:	2015
Journal:	Mol Cell
Title:	A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.
Volume:	57
Issue:	5
Pages:	912-924

•

Protein Domain

IPR040847 | SH3_15

Type:

Domain

Description:

The REP domain of Mind bomb which serves as the substrate recognition domain for a second, membrane-distal epitope of the Notch ligand (C-box). Although the first Mib repeat of REP may play a dominant role in ligand binding, the two repeats appear to cooperate in the engagement of the Jag1 tail. Mind bomb (Mib) proteins are large, multi-domain E3 ligases that promote ubiquitination of the cytoplasmic tails of Notch ligands. The structure and functional analysis, show that Mib1 contains two independent substrate recognition domains that engage two distinct epitopes from the cytoplasmic tail of the ligand Jagged1, one in the intracellular membrane proximal region and the other near the C terminus. REP domains have a five-stranded anti-parallel twisted beta sheet topology similar to that of SH3 domains [].

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HT Experiment

E-MTAB-6890 | RNA-seq of Pdx1-GFP+ sorted E10.5, wildtype and Hes1-/-. Neurog3-dependent Pancreas Dysgenesis Causes Ectopic Pancreas in Hes1 Mutants


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

27146717 | J:233833

First Author:	Wang L
Year:	2016
Journal:	Elife
Title:	Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis.
Volume:	5

•

Publication

28117277 | J:268989

First Author:	Wang C
Year:	2017
Journal:	EBioMedicine
Title:	Loss of MyoD Promotes Fate Transdifferentiation of Myoblasts Into Brown Adipocytes.
Volume:	16

Pages:	212-223

•

Publication

23874225 | J:199296

First Author:	Liu W
Year:	2013
Journal:	PLoS Genet
Title:	miR-133a regulates adipocyte browning in vivo.
Volume:	9
Issue:	7
Pages:	e1003626

•

Publication

24904084 | J:316110

First Author:	Guo Q
Year:	2015
Journal:	J Am Soc Nephrol
Title:	Adam10 mediates the choice between principal cells and intercalated cells in the kidney.
Volume:	26
Issue:	1
Pages:	149-59

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Publication

39057643 | J:360825

First Author:	Piñeiro-Sabarís R
Year:	2024
Journal:	J Cardiovasc Dev Dis
Title:	Intricate MIB1-NOTCH-GATA6 Interactions in Cardiac Valvular and Septal Development.
Volume:	11
Issue:	7

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Protein

A2A9P8

Organism:	Mus musculus/domesticus
Length:	375
Fragment?:	true

•

Protein

Q3UTL6

Organism:	Mus musculus/domesticus
Length:	368
Fragment?:	true

•

Protein

Q8R516

Organism:	Mus musculus/domesticus
Length:	973
Fragment?:	false

•

Protein

A2RRJ6

Organism:	Mus musculus/domesticus
Length:	1006
Fragment?:	false

•

Protein

B2RUG2

Organism:	Mus musculus/domesticus
Length:	946
Fragment?:	false

•

Protein

F6ZBL2

Organism:	Mus musculus/domesticus
Length:	641
Fragment?:	true

•

Publication

15476823 | -

First Author:	Legge GB
Year:	2004
Journal:	J Mol Biol
Title:	ZZ domain of CBP: an unusual zinc finger fold in a protein interaction module.
Volume:	343
Issue:	4
Pages:	1081-93

•

Publication

8848831 | -

First Author:	Ponting CP
Year:	1996
Journal:	Trends Biochem Sci
Title:	ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins.
Volume:	21
Issue:	1
Pages:	11-13

•

Publication

14621295 | J:86686

First Author:	Okazaki N
Year:	2003
Journal:	DNA Res
Title:	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume:	10
Issue:	4
Pages:	167-80

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

•

Publication

21183079 | J:292518

First Author:	Huttlin EL
Year:	2010
Journal:	Cell
Title:	A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume:	143
Issue:	7
Pages:	1174-89

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Publication

19468303 | -

First Author:	Church DM
Year:	2009
Journal:	PLoS Biol
Title:	Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume:	7
Issue:	5
Pages:	e1000112

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