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Search results 301 to 400 out of 447 for Mmp8

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Type Details Score
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1796228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691272
Age: postnatal adult
Image: JAX_1798709
Specimen Label: JAX_1798709
Detected: true
Specimen Num: 3
GXD Expression  
Probe: MGI:1703746
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826413
Age: embryonic day 14.5
Image: euxassay_001201_15
Specimen Label: euxassay_001201_15
Detected: true
Specimen Num: 15
GXD Expression  
Probe: MGI:1703746
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4826413
Age: embryonic day 14.5
Image: euxassay_001201_16
Specimen Label: euxassay_001201_16
Detected: true
Specimen Num: 16
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1881228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691272
Age: postnatal adult
Image: JAX_1798711
Specimen Label: JAX_1798711
Detected: true
Specimen Num: 5
Publication
First Author: Quintero PA
Year: 2010
Journal: J Immunol
Title: Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice.
Volume: 184
Issue: 3
Pages: 1575-88
Publication
First Author: Aström P
Year: 2014
Journal: Exp Cell Res
Title: Matrix metalloproteinase-8 regulates transforming growth factor-β1 levels in mouse tongue wounds and fibroblasts in vitro.
Volume: 328
Issue: 1
Pages: 217-27
Publication
First Author: Gutiérrez-Fernández A
Year: 2007
Journal: FASEB J
Title: Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8).
Volume: 21
Issue: 10
Pages: 2580-91
Publication
First Author: Cheung C
Year: 2008
Journal: Circulation
Title: Ablation of matrix metalloproteinase-9 increases severity of viral myocarditis in mice.
Volume: 117
Issue: 12
Pages: 1574-82
Publication  
First Author: Decock J
Year: 2015
Journal: Breast Cancer Res
Title: Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice.
Volume: 17
Pages: 38
Publication
First Author: Quillard T
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Matrix metalloproteinase-13 predominates over matrix metalloproteinase-8 as the functional interstitial collagenase in mouse atheromata.
Volume: 34
Issue: 6
Pages: 1179-86
Publication
First Author: Craig VJ
Year: 2013
Journal: J Immunol
Title: Profibrotic activities for matrix metalloproteinase-8 during bleomycin-mediated lung injury.
Volume: 190
Issue: 8
Pages: 4283-96
Publication
First Author: Rowe RG
Year: 2011
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Pulmonary fibroblasts mobilize the membrane-tethered matrix metalloprotease, MT1-MMP, to destructively remodel and invade interstitial type I collagen barriers.
Volume: 301
Issue: 5
Pages: L683-92
Publication
First Author: González-López A
Year: 2012
Journal: PLoS One
Title: MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia.
Volume: 7
Issue: 6
Pages: e39940
Publication
First Author: Lee EJ
Year: 2014
Journal: J Immunol
Title: Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.
Volume: 193
Issue: 5
Pages: 2384-93
Publication
First Author: Lin M
Year: 2008
Journal: Am J Pathol
Title: Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro.
Volume: 173
Issue: 1
Pages: 144-53
Publication  
First Author: Kokash J
Year: 2019
Journal: Brain Res
Title: Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response.
Volume: 1719
Pages: 24-29
Publication
First Author: Cua RC
Year: 2013
Journal: Glia
Title: Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.
Volume: 61
Issue: 6
Pages: 972-84
Publication
First Author: Balbín M
Year: 2001
Journal: J Biol Chem
Title: Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantation.
Volume: 276
Issue: 13
Pages: 10253-62
Publication
First Author: Sounni NE
Year: 2010
Journal: Dis Model Mech
Title: Stromal regulation of vessel stability by MMP14 and TGFbeta.
Volume: 3
Issue: 5-6
Pages: 317-32
Publication  
First Author: Rohani MG
Year: 2015
Journal: Matrix Biol
Title: Matrix remodeling by MMPs during wound repair.
Volume: 44-46
Pages: 113-21
Publication
First Author: Vanden Berghe T
Year: 2015
Journal: Immunity
Title: Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.
Volume: 43
Issue: 1
Pages: 200-9
Publication
First Author: Sabeh F
Year: 2009
Journal: J Biol Chem
Title: Secreted versus membrane-anchored collagenases: relative roles in fibroblast-dependent collagenolysis and invasion.
Volume: 284
Issue: 34
Pages: 23001-11
Publication
First Author: Koenig GC
Year: 2012
Journal: Am J Pathol
Title: MT1-MMP-dependent remodeling of cardiac extracellular matrix structure and function following myocardial infarction.
Volume: 180
Issue: 5
Pages: 1863-78
Publication
First Author: Chen L
Year: 2007
Journal: Reproduction
Title: Expression of extracellular matrix metalloproteinase inducer and matrix metalloproteinases during mouse embryonic development.
Volume: 133
Issue: 2
Pages: 405-14
Publication
First Author: Nagase H
Year: 1999
Journal: J Biol Chem
Title: Matrix metalloproteinases.
Volume: 274
Issue: 31
Pages: 21491-4
Publication
First Author: Inada M
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification.
Volume: 101
Issue: 49
Pages: 17192-7
Publication
First Author: Johansson N
Year: 2000
Journal: Cell Mol Life Sci
Title: Matrix metalloproteinases in tumor invasion.
Volume: 57
Issue: 1
Pages: 5-15
Publication
First Author: Hirahashi J
Year: 2006
Journal: Immunity
Title: Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy.
Volume: 25
Issue: 2
Pages: 271-83
Publication  
First Author: Flood HM
Year: 2019
Journal: Biol Open
Title: The Forkhead box F1 transcription factor inhibits collagen deposition and accumulation of myofibroblasts during liver fibrosis.
Volume: 8
Issue: 2
Publication  
First Author: Newby AC
Year: 2015
Journal: Matrix Biol
Title: Metalloproteinases promote plaque rupture and myocardial infarction: A persuasive concept waiting for clinical translation.
Volume: 44-46
Pages: 157-66
Publication
First Author: Simón-Carrasco L
Year: 2017
Journal: Genes Dev
Title: Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma.
Volume: 31
Issue: 14
Pages: 1456-1468
Publication
First Author: Córdoba-Jover B
Year: 2023
Journal: Liver Int
Title: Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans.
Volume: 43
Issue: 8
Pages: 1822-1836
Publication  
First Author: Wu Z
Year: 2014
Journal: Matrix Biol
Title: Biglycan and decorin differentially regulate signaling in the fetal membranes.
Volume: 35
Pages: 266-75
Publication
First Author: Lee Y
Year: 2011
Journal: Dev Cell
Title: ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization.
Volume: 21
Issue: 4
Pages: 746-57
Publication  
First Author: Varadinkova S
Year: 2023
Journal: Front Cell Dev Biol
Title: Expression dynamics of metalloproteinases during mandibular bone formation: association with Myb transcription factor.
Volume: 11
Pages: 1168866
Publication
First Author: Wang X
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice.
Volume: 102
Issue: 44
Pages: 15791-6
Publication  
First Author: Liu G
Year: 2016
Journal: JCI Insight
Title: Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases.
Volume: 1
Issue: 9
Publication
First Author: Nuttall RK
Year: 2004
Journal: FEBS Lett
Title: Expression analysis of the entire MMP and TIMP gene families during mouse tissue development.
Volume: 563
Issue: 1-3
Pages: 129-34
Publication
First Author: Tocchi A
Year: 2013
Journal: FEBS J
Title: Functional interactions between matrix metalloproteinases and glycosaminoglycans.
Volume: 280
Issue: 10
Pages: 2332-41
Publication
First Author: Gordon EJ
Year: 2010
Journal: Development
Title: Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation.
Volume: 137
Issue: 22
Pages: 3899-910
Publication
First Author: Iwama A
Year: 1998
Journal: Nucleic Acids Res
Title: Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.
Volume: 26
Issue: 12
Pages: 3034-43
Publication
First Author: Perez SE
Year: 2005
Journal: Diabetes
Title: Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo.
Volume: 54
Issue: 3
Pages: 694-701
Publication
First Author: Cai X
Year: 2013
Journal: Development
Title: Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.
Volume: 140
Issue: 15
Pages: 3176-87
Publication  
First Author: Rauch F
Year: 2018
Journal: Bone
Title: Crispr-Cas9 engineered osteogenesis imperfecta type V leads to severe skeletal deformities and perinatal lethality in mice.
Volume: 107
Pages: 131-142
Publication
First Author: Nagarajan P
Year: 2010
Journal: J Cell Sci
Title: Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.
Volume: 123
Issue: Pt 20
Pages: 3566-75
Publication  
First Author: Yonebayashi S
Year: 2021
Journal: Front Immunol
Title: Generation of Transgenic Mice that Conditionally Overexpress Tenascin-C.
Volume: 12
Pages: 620541
Publication  
First Author: Sah RK
Year: 2020
Journal: Int J Mol Sci
Title: Targeted Disruption of Mouse Dip2B Leads to Abnormal Lung Development and Prenatal Lethality.
Volume: 21
Issue: 21
Publication  
First Author: Lei Z
Year: 2022
Journal: Front Immunol
Title: EpCAM Is Essential to Maintaining the Immune Homeostasis of Intestines via Keeping the Expression of pIgR in the Intestinal Epithelium of Mice.
Volume: 13
Pages: 843378
Publication
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
Publication      
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
Publication
First Author: Abonnenc M
Year: 2013
Journal: Circ Res
Title: Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c.
Volume: 113
Issue: 10
Pages: 1138-47
Publication      
First Author: NIH Mouse Knockout Inventory
Year: 2004
Journal: MGI Direct Data Submission
Title: Information obtained from the NIH Mouse Knockout Inventory
Publication
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
Publication        
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
Publication      
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
Publication
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
Publication      
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
Publication      
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
Publication
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Allele
Name: matrix metallopeptidase 8; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Publication
First Author: d'Ortho MP
Year: 1997
Journal: Eur J Biochem
Title: Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases.
Volume: 250
Issue: 3
Pages: 751-7
Publication
First Author: Takino T
Year: 1995
Journal: J Biol Chem
Title: Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP family.
Volume: 270
Issue: 39
Pages: 23013-20
Publication
First Author: Bodnar M
Year: 2013
Journal: J Oral Pathol Med
Title: Differentiated expression of membrane type metalloproteinases (MMP-14, MMP-15) and pro-MMP2 in laryngeal squamous cell carcinoma. A novel mechanism.
Volume: 42
Issue: 3
Pages: 267-74
Protein Domain
Type: Family
Description: Matrix metalloproteinases (MMPs) are zinc-dependent and calcium-dependent proteases that cleave within a polypeptide (endopeptidases). They degrade most components of the extracellular matrix (such as growth factors, their binding proteins, and other bioactive molecules, as well as binding sites for cell-surface molecules) and some non-extracellular-matrix molecules []. Two categories of MMPs can be recognised based on their cellular localisation: soluble vs. membrane-bound. The soluble MMPs are divided into the collagenases (MMP1, MMP8 and MMP13), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP12) and those yet to be classified. The membrane-bound MMPs include MT1, 2, 3, 4, 5 and their hallmark is the presence of plasma membrane anchoring domains []. MMPs are highly expressed in various cancers, both by tumour cells and in surrounding stromal cells such as macrophages []. Matrix metalloproteinase-15 (MMP15; MEROPS identifier M10.015) or membrane-type matrix metalloproteinase 2 degrades various components of the extracellular matrix [, ]. The increase expression of MMP15 has been linked to cancer progression [].
HT Experiment  
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: GEO
Publication
First Author: Yao X
Year: 2024
Journal: J Immunol
Title: Neutrophil Heterogeneity Is Modified during Acute Lung Inflammation in Apoa1-/- Mice.
Volume: 213
Issue: 4
Pages: 456-468
Publication
First Author: Hartenstein B
Year: 2006
Journal: J Invest Dermatol
Title: Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice.
Volume: 126
Issue: 2
Pages: 486-96
Publication
First Author: Mancini M
Year: 2019
Journal: J Immunol
Title: Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis.
Volume: 202
Issue: 5
Pages: 1479-1493
Publication
First Author: Kim J
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Differences in genetic signaling, and not mechanical properties of the wall, are linked to ascending aortic aneurysms in fibulin-4 knockout mice.
Volume: 309
Issue: 1
Pages: H103-13
Publication
First Author: Saijou E
Year: 2018
Journal: Hepatol Commun
Title: Neutrophils alleviate fibrosis in the CCl4-induced mouse chronic liver injury model.
Volume: 2
Issue: 6
Pages: 703-717
Publication
First Author: Mota R
Year: 2018
Journal: Am J Pathol
Title: Increasing Cardiomyocyte Atrogin-1 Reduces Aging-Associated Fibrosis and Regulates Remodeling in Vivo.
Volume: 188
Issue: 7
Pages: 1676-1692
Publication
First Author: Flannelly J
Year: 2002
Journal: Osteoarthritis Cartilage
Title: Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis.
Volume: 10
Issue: 9
Pages: 722-33
Publication
First Author: Hernandez-Barrantes S
Year: 2002
Journal: Semin Cancer Biol
Title: Regulation of membrane type-matrix metalloproteinases.
Volume: 12
Issue: 2
Pages: 131-8
Publication
First Author: Somerville RP
Year: 2003
Journal: Genome Biol
Title: Matrix metalloproteinases: old dogs with new tricks.
Volume: 4
Issue: 6
Pages: 216
Publication
First Author: English WR
Year: 2000
Journal: J Biol Chem
Title: Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.
Volume: 275
Issue: 19
Pages: 14046-55
Publication
First Author: Pei D
Year: 1999
Journal: J Biol Chem
Title: Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP.
Volume: 274
Issue: 13
Pages: 8925-32