Type |
Details |
Score |
Publication |
First Author: |
Maiuri AR |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Mismatch Repair Proteins Initiate Epigenetic Alterations during Inflammation-Driven Tumorigenesis. |
Volume: |
77 |
Issue: |
13 |
Pages: |
3467-3478 |
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•
•
•
•
•
|
Publication |
First Author: |
Alsøe L |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. |
Volume: |
7 |
Issue: |
1 |
Pages: |
7199 |
|
•
•
•
•
•
|
Publication |
First Author: |
So CC |
Year: |
2019 |
Journal: |
PLoS Genet |
Title: |
DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells. |
Volume: |
15 |
Issue: |
4 |
Pages: |
e1008101 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xue K |
Year: |
2006 |
Journal: |
J Exp Med |
Title: |
The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice. |
Volume: |
203 |
Issue: |
9 |
Pages: |
2085-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kemmerich K |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice. |
Volume: |
40 |
Issue: |
13 |
Pages: |
6016-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zan H |
Year: |
2012 |
Journal: |
Cell Rep |
Title: |
Rev1 recruits ung to switch regions and enhances du glycosylation for immunoglobulin class switch DNA recombination. |
Volume: |
2 |
Issue: |
5 |
Pages: |
1220-32 |
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•
•
•
•
•
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Publication |
First Author: |
Tosti E |
Year: |
2022 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Loss of MMR and TGFBR2 Increases the Susceptibility to Microbiota-Dependent Inflammation-Associated Colon Cancer. |
Volume: |
14 |
Issue: |
3 |
Pages: |
693-717 |
|
•
•
•
•
•
|
Publication |
First Author: |
McDonald DA |
Year: |
2011 |
Journal: |
Hum Mol Genet |
Title: |
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. |
Volume: |
20 |
Issue: |
2 |
Pages: |
211-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Enoiu M |
Year: |
2012 |
Journal: |
Nucleic Acids Res |
Title: |
Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis. |
Volume: |
40 |
Issue: |
18 |
Pages: |
8953-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Campbell MR |
Year: |
2005 |
Journal: |
Cancer Res |
Title: |
A lack of DNA mismatch repair on an athymic murine background predisposes to hematologic malignancy. |
Volume: |
65 |
Issue: |
7 |
Pages: |
2626-35 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belcheva A |
Year: |
2014 |
Journal: |
Cell |
Title: |
Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells. |
Volume: |
158 |
Issue: |
2 |
Pages: |
288-299 |
|
•
•
•
•
•
|
Publication |
First Author: |
Belcheva A |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Elevated incidence of polyp formation in APC(Min/⁺)Msh2⁻/⁻ mice is independent of nitric oxide-induced DNA mutations. |
Volume: |
8 |
Issue: |
5 |
Pages: |
e65204 |
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•
•
•
•
•
|
Publication |
First Author: |
Bacher JW |
Year: |
2005 |
Journal: |
Mol Carcinog |
Title: |
Use of mononucleotide repeat markers for detection of microsatellite instability in mouse tumors. |
Volume: |
44 |
Issue: |
4 |
Pages: |
285-92 |
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•
•
•
•
•
|
Publication |
First Author: |
Sansom OJ |
Year: |
2001 |
Journal: |
Cancer Res |
Title: |
Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice. |
Volume: |
61 |
Issue: |
19 |
Pages: |
7060-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Oers JM |
Year: |
2014 |
Journal: |
Oncogene |
Title: |
The MutSβ complex is a modulator of p53-driven tumorigenesis through its functions in both DNA double-strand break repair and mismatch repair. |
Volume: |
33 |
Issue: |
30 |
Pages: |
3939-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shenkar R |
Year: |
2015 |
Journal: |
Genet Med |
Title: |
Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. |
Volume: |
17 |
Issue: |
3 |
Pages: |
188-196 |
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•
•
•
•
•
|
Publication |
First Author: |
Jinnah HA |
Year: |
1993 |
Journal: |
J Neurochem |
Title: |
Brain purines in a genetic mouse model of Lesch-Nyhan disease. |
Volume: |
60 |
Issue: |
6 |
Pages: |
2036-45 |
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•
•
•
•
•
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Publication |
First Author: |
Martinez-Usatorre A |
Year: |
2021 |
Journal: |
Sci Transl Med |
Title: |
Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models. |
Volume: |
13 |
Issue: |
606 |
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•
•
•
•
•
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Publication |
First Author: |
Zhao XN |
Year: |
2015 |
Journal: |
Hum Mutat |
Title: |
The transcription-coupled repair protein ERCC6/CSB also protects against repeat expansion in a mouse model of the fragile X premutation. |
Volume: |
36 |
Issue: |
4 |
Pages: |
482-7 |
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•
•
•
•
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Publication |
First Author: |
Boulianne B |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
AID and caspase 8 shape the germinal center response through apoptosis. |
Volume: |
191 |
Issue: |
12 |
Pages: |
5840-7 |
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•
•
•
•
•
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Publication |
First Author: |
Schrader CE |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Reduced isotype switching in splenic B cells from mice deficient in mismatch repair enzymes. |
Volume: |
190 |
Issue: |
3 |
Pages: |
323-30 |
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•
•
•
•
•
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Publication |
First Author: |
Kucherlapati MH |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Loss of Rb1 in the gastrointestinal tract of Apc1638N mice promotes tumors of the cecum and proximal colon. |
Volume: |
105 |
Issue: |
40 |
Pages: |
15493-8 |
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•
•
•
•
•
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Publication |
First Author: |
Albertson TM |
Year: |
2009 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
DNA polymerase epsilon and delta proofreading suppress discrete mutator and cancer phenotypes in mice. |
Volume: |
106 |
Issue: |
40 |
Pages: |
17101-4 |
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•
•
•
•
•
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Publication |
First Author: |
Westcott PMK |
Year: |
2023 |
Journal: |
Nat Genet |
Title: |
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity. |
Volume: |
55 |
Issue: |
10 |
Pages: |
1686-1695 |
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•
•
•
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Publication |
First Author: |
Owens JA |
Year: |
2021 |
Journal: |
Cell Mol Gastroenterol Hepatol |
Title: |
Lactobacillus rhamnosus GG Orchestrates an Antitumor Immune Response. |
Volume: |
12 |
Issue: |
4 |
Pages: |
1311-1327 |
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Publication |
First Author: |
Irrazabal T |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer. |
Volume: |
11 |
Issue: |
1 |
Pages: |
1802 |
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Publication |
First Author: |
Hance KW |
Year: |
2005 |
Journal: |
Mutat Res |
Title: |
Mouse models expressing human carcinoembryonic antigen (CEA) as a transgene: evaluation of CEA-based cancer vaccines. |
Volume: |
576 |
Issue: |
1-2 |
Pages: |
132-54 |
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Publication |
First Author: |
Boivin GP |
Year: |
2003 |
Journal: |
Gastroenterology |
Title: |
Pathology of mouse models of intestinal cancer: consensus report and recommendations. |
Volume: |
124 |
Issue: |
3 |
Pages: |
762-77 |
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Publication |
First Author: |
Vuong BQ |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination. |
Volume: |
14 |
Issue: |
11 |
Pages: |
1183-1189 |
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Publication |
First Author: |
Schrader CE |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Activation-induced cytidine deaminase-dependent DNA breaks in class switch recombination occur during G1 phase of the cell cycle and depend upon mismatch repair. |
Volume: |
179 |
Issue: |
9 |
Pages: |
6064-71 |
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Publication |
First Author: |
Pastille E |
Year: |
2019 |
Journal: |
Mucosal Immunol |
Title: |
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer. |
Volume: |
12 |
Issue: |
4 |
Pages: |
990-1003 |
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Publication |
First Author: |
McGrail DJ |
Year: |
2020 |
Journal: |
Cancer Cell |
Title: |
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. |
Volume: |
37 |
Issue: |
3 |
Pages: |
371-386.e12 |
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Publication |
First Author: |
Ghodgaonkar MM |
Year: |
2013 |
Journal: |
Mol Cell |
Title: |
Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair. |
Volume: |
50 |
Issue: |
3 |
Pages: |
323-32 |
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Publication |
First Author: |
Yoshioka K |
Year: |
2006 |
Journal: |
Mol Cell |
Title: |
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. |
Volume: |
22 |
Issue: |
4 |
Pages: |
501-10 |
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Year: |
2001 |
Journal: |
Mutat Res |
Title: |
DNA mismatch repair and cancer. |
Volume: |
488 |
Issue: |
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Pages: |
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Year: |
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Cancer Res |
Title: |
Refined chromosomal localization of the mismatch repair and hereditary nonpolyposis colorectal cancer genes hMSH2 and hMSH6. |
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Oliver G |
Year: |
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Journal: |
Development |
Title: |
Six3, a murine homologue of the sine oculis gene, demarcates the most anterior border of the developing neural plate and is expressed during eye development. |
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Year: |
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Journal: |
J Immunol |
Title: |
Trp53 deficiency protects against acute intestinal inflammation. |
Volume: |
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Year: |
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Immunity |
Title: |
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages. |
Volume: |
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J Exp Med |
Title: |
Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice. |
Volume: |
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First Author: |
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Year: |
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J Cell Biol |
Title: |
Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. |
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Genes Dev |
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MutS homolog 4 localization to meiotic chromosomes is required for chromosome pairing during meiosis in male and female mice. |
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Gene Expr Patterns |
Title: |
Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract. |
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Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. |
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First Author: |
Shanghai Model Organisms Center |
Year: |
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Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
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Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom |
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Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity |
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BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
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MGI Direct Data Submission |
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Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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Wellcome Trust Sanger Institute |
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MGI Direct Data Submission |
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UniProt-GOA |
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Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
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Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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UniProt Feature |
Begin: |
2 |
Description: |
DNA mismatch repair protein Msh2 |
Type: |
chain |
End: |
935 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
68
 |
Fragment?: |
true |
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Publication |
First Author: |
Houlleberghs H |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Oligonucleotide-directed mutagenesis screen to identify pathogenic Lynch syndrome-associated MSH2 DNA mismatch repair gene variants. |
Volume: |
113 |
Issue: |
15 |
Pages: |
4128-33 |
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Publication |
First Author: |
Vani RG |
Year: |
1997 |
Journal: |
Gene |
Title: |
Cloning of the cDNA encoding rat homologue of the mismatch repair gene MSH2 and its expression during spermatogenesis. |
Volume: |
185 |
Issue: |
1 |
Pages: |
19-26 |
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Publication |
First Author: |
Hirayama Y |
Year: |
1999 |
Journal: |
Exp Anim |
Title: |
Linkage mapping of the rat Msh2 DNA mismatch repair gene on chromosome 6. |
Volume: |
48 |
Issue: |
1 |
Pages: |
63-4 |
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DO Term |
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Publication |
First Author: |
Bhandari A |
Year: |
2013 |
Journal: |
Oncogene |
Title: |
The Grainyhead transcription factor Grhl3/Get1 suppresses miR-21 expression and tumorigenesis in skin: modulation of the miR-21 target MSH2 by RNA-binding protein DND1. |
Volume: |
32 |
Issue: |
12 |
Pages: |
1497-507 |
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Allele |
Name: |
mutS homolog 2; targeted mutation 2, Hein Te Riele |
Allele Type: |
Targeted |
Attribute String: |
Not Specified |
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DO Term |
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Gene |
Type: |
gene |
Organism: |
human |
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Allele |
Name: |
mutS homolog 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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HT Experiment |
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Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
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GO Term |
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GO Term |
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Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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Protein Domain |
Type: |
Family |
Description: |
Mismatch repair (MMR) is one of five major DNA repair pathways, the others being homologous recombination repair, non-homologous end joining, nucleotide excision repair, and base excision repair. The mismatch repair system recognises and repairs mispaired or unpaired nucleotides that result from errors in DNA replication. The most extensively studied general MMR system is the MutHLS pathway of the bacterium Escherichia coli. In the first step of the MutHLS pathway, the MutS protein (in the form of a dimer) binds to the site of a mismatch in double-stranded DNA. Through a complex interaction between MutS, MutL and MutH, a section of the newly replicated DNA strand (and thus the strand with the replication error) at the location of the mismatch bound by MutS is targeted for removal []. Homologues of MutS have been found in many species including eukaryotes, Archaea and other bacteria, and together these proteins have been grouped into the MutS family.This entry represents a subset of the MutS family members, including Msh2. Msh2 (MutS homologue 2) has a dual role in DNA repair and apoptosis. Msh2 acts as a heterodimer with Msh6, which together function to recruit the Mlh (MutL homologue) - Pms (post-meiotic segregation) heterodimer, and to replace the mispaired base []. |
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Publication |
First Author: |
Baker SM |
Year: |
1996 |
Journal: |
Nat Genet |
Title: |
Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. |
Volume: |
13 |
Issue: |
3 |
Pages: |
336-42 |
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Publication |
First Author: |
Drotschmann K |
Year: |
2002 |
Journal: |
Biol Chem |
Title: |
DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. |
Volume: |
383 |
Issue: |
6 |
Pages: |
969-75 |
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