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Search results 301 to 344 out of 344 for Mthfr

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Type Details Score
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Tg(Nppa-EGFP)BAC337Vmc | MGI:7380642
Name: transgene insertion BAC337, Vincent M Christoffels
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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GO Term
GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity
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Publication
10201405 | -
First Author: Guenther BD
Year: 1999
Journal: Nat Struct Biol
Title: The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia.
Volume: 6
Issue: 4
Pages: 359-65
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Publication
19610625 | -
First Author: Lee MN
Year: 2009
Journal: Biochemistry
Title: Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli.
Volume: 48
Issue: 32
Pages: 7673-85
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Protein Domain
IPR003171 | Mehydrof_redctse-like
Type: Family
Description: This represents the catalytic domain of 5,10-methylenetetrahydrofolate reductase from prokaryotes and methylenetetrahydrofolate reductase (MTHFR) from eukaryotes (). Both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate.Mammalian and yeast MTHFRs are homodimers in which each subunit contains an N-terminal catalytic domain, and a C-terminal regulatory domain to which the allosteric inhibitor adenosylmethionine binds []. NADPH is the preferred reductant. In humans, there are several clinically significant mutations in MTHFR that result in hyperhomocysteinemia, which is a risk factor for the development of cardiovascular disease [].The bacterial enzyme is a homotetramer. MTHFRs of enteric bacteria comprise shorter chains around 300 residues in length. Their sequences can be aligned with the N-terminal catalytic domains of the eukaryotic MTHFRs []. Escherichia coli MTHFR, along with plant MTHFRs, prefer NADHs as the source of reducing equivalents []. The structure of E. coli MTHFR is known to be a TIM barrel [].
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HT Experiment
E-GEOD-34010 | Expression data from mouse intestine: C57Bl/6 MTHFR+/- vs BALB/c MTHFR+/-
Series Id: GSE34010
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
Q8CJA5
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
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Protein
Q8CJA7
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: true
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Protein
A2A7F9
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Protein
Q9WU20
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
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Protein
Q3UDB2
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
A2A7F7
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
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Protein
F6Z4F8
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: true
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Publication
12208134 | J:101647
First Author: Tran P
Year: 2002
Journal: Mol Genet Metab
Title: The curly-tail (ct) mouse, an animal model of neural tube defects, displays altered homocysteine metabolism without folate responsiveness or a defect in Mthfr.
Volume: 76
Issue: 4
Pages: 297-304
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Publication
23525608 | J:290484
First Author: Narayanan N
Year: 2013
Journal: Int J Physiol Pathophysiol Pharmacol
Title: Hyperhomocysteinemia during aortic aneurysm, a plausible role of epigenetics.
Volume: 5
Issue: 1
Pages: 32-42
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Publication
20836991 | J:165848
First Author: Mishra PK
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Attenuation of beta2-adrenergic receptors and homocysteine metabolic enzymes cause diabetic cardiomyopathy.
Volume: 401
Issue: 2
Pages: 175-81
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Publication
17111379 | J:134595
First Author: Anthony TE
Year: 2007
Journal: J Comp Neurol
Title: The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects.
Volume: 500
Issue: 2
Pages: 368-83
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Publication
26199398 | J:227291
First Author: Koczor CA
Year: 2015
Journal: Physiol Genomics
Title: AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress.
Volume: 47
Issue: 10
Pages: 447-54
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Publication
19808787 | J:153207
First Author: Greene ND
Year: 2009
Journal: Hum Mol Genet
Title: Genetics of human neural tube defects.
Volume: 18
Issue: R2
Pages: R113-29
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Publication
- | J:317078
     
First Author: Reagan AM
Year: 2021
Journal: bioRxiv
Title: The 677C>T variant in methylenetetrahydrofolate reductase causes morphological and functional cerebrovascular deficits in mice
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Publication
23001810 | J:356522
First Author: Leclerc D
Year: 2013
Journal: Mol Nutr Food Res
Title: Differential gene expression and methylation in the retinoid/PPARA pathway and of tumor suppressors may modify intestinal tumorigenesis induced by low folate in mice.
Volume: 57
Issue: 4
Pages: 686-97
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Publication
18276916 | J:278530
First Author: Horsthuis T
Year: 2008
Journal: Circ Res
Title: Distinct regulation of developmental and heart disease-induced atrial natriuretic factor expression by two separate distal sequences.
Volume: 102
Issue: 7
Pages: 849-59
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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