Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:5309250 |
Assay Type: |
RNA in situ |
Annotation Date: |
2012-06-12 |
Strength: |
Moderate |
Sex: |
Not Specified |
Emaps: |
EMAPS:2672022 |
Pattern: |
Regionally restricted |
Stage: |
TS22 |
Assay Id: |
MGI:5422810 |
Age: |
embryonic day 14.5 |
Image: |
MH191; Specimen C940 |
Note: |
Expression was detected in whisker follicle. |
Specimen Label: |
MH191; Specimen C940 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:5636480 |
Assay Type: |
RNA in situ |
Annotation Date: |
2015-05-19 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:3561128 |
|
Stage: |
TS28 |
Assay Id: |
MGI:5636481 |
Age: |
postnatal day 6 |
Image: |
4C |
|
Specimen Label: |
4C |
Detected: |
false |
Specimen Num: |
2 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozeki Y |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. |
Volume: |
100 |
Issue: |
1 |
Pages: |
289-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamaguchi N |
Year: |
2004 |
Journal: |
FEBS Lett |
Title: |
Expression of NUDEL in manchette and its implication in spermatogenesis. |
Volume: |
566 |
Issue: |
1-3 |
Pages: |
71-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sweeney KJ |
Year: |
2001 |
Journal: |
Mech Dev |
Title: |
NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins. |
Volume: |
101 |
Issue: |
1-2 |
Pages: |
21-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moon HM |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex. |
Volume: |
23 |
Issue: |
2 |
Pages: |
449-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Niethammer M |
Year: |
2000 |
Journal: |
Neuron |
Title: |
NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein. |
Volume: |
28 |
Issue: |
3 |
Pages: |
697-711 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wilkinson B |
Year: |
2019 |
Journal: |
Biol Psychiatry |
Title: |
Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders. |
Volume: |
85 |
Issue: |
4 |
Pages: |
305-316 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toyo-oka K |
Year: |
2003 |
Journal: |
Nat Genet |
Title: |
14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. |
Volume: |
34 |
Issue: |
3 |
Pages: |
274-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cahana A |
Year: |
2003 |
Journal: |
Mol Reprod Dev |
Title: |
A study of the nature of embryonic lethality in LIS1-/- mice. |
Volume: |
66 |
Issue: |
2 |
Pages: |
134-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen MD |
Year: |
2004 |
Journal: |
Nat Cell Biol |
Title: |
A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons. |
Volume: |
6 |
Issue: |
7 |
Pages: |
595-608 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gao FJ |
Year: |
2017 |
Journal: |
Mol Biol Cell |
Title: |
Insulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein. |
Volume: |
28 |
Issue: |
5 |
Pages: |
587-599 |
|
•
•
•
•
•
|
Publication |
First Author: |
Amberg N |
Year: |
2021 |
Journal: |
STAR Protoc |
Title: |
Genetic mosaic dissection of candidate genes in mice using mosaic analysis with double markers. |
Volume: |
2 |
Issue: |
4 |
Pages: |
100939 |
|
•
•
•
•
•
|
Publication |
First Author: |
Singh KK |
Year: |
2010 |
Journal: |
Neuron |
Title: |
Dixdc1 is a critical regulator of DISC1 and embryonic cortical development. |
Volume: |
67 |
Issue: |
1 |
Pages: |
33-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ko J |
Year: |
2001 |
Journal: |
J Neurosci |
Title: |
p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment. |
Volume: |
21 |
Issue: |
17 |
Pages: |
6758-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Feng Y |
Year: |
2004 |
Journal: |
Neuron |
Title: |
Mitotic spindle regulation by Nde1 controls cerebral cortical size. |
Volume: |
44 |
Issue: |
2 |
Pages: |
279-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sumigray KD |
Year: |
2011 |
Journal: |
J Cell Biol |
Title: |
Lis1 is essential for cortical microtubule organization and desmosome stability in the epidermis. |
Volume: |
194 |
Issue: |
4 |
Pages: |
631-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taconic |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from Taconic website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Tamplin OJ |
Year: |
2008 |
Journal: |
BMC Genomics |
Title: |
Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. |
Volume: |
9 |
|
Pages: |
511 |
|
•
•
•
•
•
|
Publication |
First Author: |
Willnow T |
Year: |
2005 |
Journal: |
Organogenesis |
Title: |
The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. |
Volume: |
2 |
Issue: |
2 |
Pages: |
42-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen J |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. |
Volume: |
100 |
Issue: |
17 |
Pages: |
9918-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory |
Year: |
2012 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by The Jackson Laboratory |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stryke D |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. |
Volume: |
31 |
Issue: |
1 |
Pages: |
278-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GUDMAP Consortium |
Year: |
2004 |
Journal: |
www.gudmap.org |
Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Hansen GM |
Year: |
2008 |
Journal: |
Genome Res |
Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
Volume: |
18 |
Issue: |
10 |
Pages: |
1670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2014 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
|
Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Toyo-oka K |
Year: |
2008 |
Journal: |
J Cell Biol |
Title: |
Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. |
Volume: |
180 |
Issue: |
6 |
Pages: |
1133-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Inaba H |
Year: |
2016 |
Journal: |
J Cell Biol |
Title: |
Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway. |
Volume: |
212 |
Issue: |
4 |
Pages: |
409-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Soares DC |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers, and polymers with a folded back structure in solution. |
Volume: |
287 |
Issue: |
39 |
Pages: |
32381-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shu T |
Year: |
2004 |
Journal: |
Neuron |
Title: |
Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning. |
Volume: |
44 |
Issue: |
2 |
Pages: |
263-77 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion HK143, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
88
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Efimov VP |
Year: |
2003 |
Journal: |
Mol Biol Cell |
Title: |
Roles of NUDE and NUDF proteins of Aspergillus nidulans: insights from intracellular localization and overexpression effects. |
Volume: |
14 |
Issue: |
3 |
Pages: |
871-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Efimov VP |
Year: |
2006 |
Journal: |
Mol Biol Cell |
Title: |
CLIP-170 homologue and NUDE play overlapping roles in NUDF localization in Aspergillus nidulans. |
Volume: |
17 |
Issue: |
4 |
Pages: |
2021-34 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry includes nuclear distribution element 1 (NDE1) and NDE-like 1 (NDEL1). Human NDE1 and NDEL1 are believed to be evolved from a common ancestral gene, such as the NudE gene of Aspergillus nidulans. They share protein sequence and structure similarities and have overlapping functions in the cell and developing brain. They are essential for mitosis and neurodevelopment []. They both interact with LIS1 through their N-terminal domain, and this interaction stimulates the movement of dynein. However, their expression and post-translational modification within the cell are different []. This entry also includes Emericella nidulans NUDE, which is required for nuclear migration within hyphae during vegetative growth [, ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
344
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
175
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Tarricone C |
Year: |
2004 |
Journal: |
Neuron |
Title: |
Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. |
Volume: |
44 |
Issue: |
5 |
Pages: |
809-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yingling J |
Year: |
2008 |
Journal: |
Cell |
Title: |
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. |
Volume: |
132 |
Issue: |
3 |
Pages: |
474-86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Klinman E |
Year: |
2015 |
Journal: |
Cell Rep |
Title: |
Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein. |
Volume: |
12 |
Issue: |
3 |
Pages: |
462-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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