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Search results 301 to 400 out of 1278 for Nfkb1

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Type Details Score
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ghosh S
Year: 1990
Journal: Cell
Title: Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.
Volume: 62
Issue: 5
Pages: 1019-29
Publication
First Author: Huo L
Year: 1994
Journal: Gene
Title: C-terminal sequence of the NF-kappa B p50 precursor from primary murine B-lymphocytes.
Volume: 139
Issue: 2
Pages: 287-9
Publication
First Author: Conner JR
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: IRAK1BP1 inhibits inflammation by promoting nuclear translocation of NF-kappaB p50.
Volume: 107
Issue: 25
Pages: 11477-82
Publication
First Author: Hilliard B
Year: 1999
Journal: J Immunol
Title: Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells.
Volume: 163
Issue: 5
Pages: 2937-43
Publication
First Author: Ishikawa H
Year: 1998
Journal: J Exp Med
Title: Chronic inflammation and susceptibility to bacterial infections in mice lacking the polypeptide (p)105 precursor (NF-kappaB1) but expressing p50.
Volume: 187
Issue: 7
Pages: 985-96
Publication
First Author: Prell T
Year: 2014
Journal: J Neuroimmunol
Title: Endoplasmic reticulum stress is accompanied by activation of NF-κB in amyotrophic lateral sclerosis.
Volume: 270
Issue: 1-2
Pages: 29-36
Publication      
First Author: Wang KW
Year: 2014
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Finlay. Updated on December 19, 2014
Publication      
First Author: Zhong X
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for kookaburra
Publication      
First Author: Choi JH
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Roomba
Publication
First Author: Corn RA
Year: 2003
Journal: J Immunol
Title: T cell-intrinsic requirement for NF-kappa B induction in postdifferentiation IFN-gamma production and clonal expansion in a Th1 response.
Volume: 171
Issue: 4
Pages: 1816-24
Publication
First Author: Zhang X
Year: 2009
Journal: Neuroscience
Title: Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice.
Volume: 161
Issue: 1
Pages: 53-8
Publication
First Author: Tang Y
Year: 2010
Journal: Am J Pathol
Title: Epithelial NF-kappaB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation.
Volume: 176
Issue: 1
Pages: 158-67
Publication
First Author: Inoue T
Year: 2010
Journal: J Am Soc Nephrol
Title: Fibroblast expression of an IκB dominant-negative transgene attenuates renal fibrosis.
Volume: 21
Issue: 12
Pages: 2047-52
Publication
First Author: Jin R
Year: 2014
Journal: Cancer Res
Title: NF-κB gene signature predicts prostate cancer progression.
Volume: 74
Issue: 10
Pages: 2763-72
Publication  
First Author: Poulos MG
Year: 2016
Journal: Nat Commun
Title: Endothelial-specific inhibition of NF-κB enhances functional haematopoiesis.
Volume: 7
Pages: 13829
Publication
First Author: Young D
Year: 2008
Journal: J Mol Biol
Title: Blockade of NF-kappaB using IkappaB alpha dominant-negative mice ameliorates cardiac hypertrophy in myotrophin-overexpressed transgenic mice.
Volume: 381
Issue: 3
Pages: 559-68
Publication
First Author: Methot L
Year: 2018
Journal: Glia
Title: Nuclear factor-kappaB regulates multiple steps of gliogenesis in the developing murine cerebral cortex.
Volume: 66
Issue: 12
Pages: 2659-2672
Publication
First Author: Gushchina S
Year: 2009
Journal: Mol Cell Neurosci
Title: Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury.
Volume: 40
Issue: 2
Pages: 207-16
Publication      
First Author: Choi JH
Year: 2018
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Murgatroyd.
Publication      
First Author: SoRelle J
Year: 2019
Journal: MGI Direct Data Submission
Title: Mutagenetix entry for Wheelo.
Publication
First Author: Yamauchi S
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: IkappaBeta, a nuclear IkappaB protein, positively regulates the NF-kappaB-mediated expression of proinflammatory cytokines.
Volume: 107
Issue: 26
Pages: 11924-9
Publication
First Author: Tak PP
Year: 2001
Journal: J Clin Invest
Title: NF-kappaB: a key role in inflammatory diseases.
Volume: 107
Issue: 1
Pages: 7-11
Publication
First Author: Hatada EN
Year: 2000
Journal: Curr Opin Immunol
Title: NF-kappaB and the innate immune response.
Volume: 12
Issue: 1
Pages: 52-8
Publication
First Author: Ivanov V
Year: 1994
Journal: J Immunol
Title: Regulation of nuclear factor-kappa B and activator protein-1 activities after stimulation of T cells via glycosylphosphatidylinositol-anchored Ly-6A/E.
Volume: 153
Issue: 6
Pages: 2394-406
Publication
First Author: Schulze-Osthoff K
Year: 1995
Journal: Biochem Pharmacol
Title: Redox signalling by transcription factors NF-kappa B and AP-1 in lymphocytes.
Volume: 50
Issue: 6
Pages: 735-41
Publication
First Author: Casolaro V
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: Inhibition of NF-AT-dependent transcription by NF-kappa B: implications for differential gene expression in T helper cell subsets.
Volume: 92
Issue: 25
Pages: 11623-7
Publication
First Author: Khaled AR
Year: 1997
Journal: Clin Immunol Immunopathol
Title: Inhibition of the p50 (NKkappaB1) subunit of NF-kappaB by phosphorothioate-modified antisense oligodeoxynucleotides reduces NF-kappaB expression and immunoglobulin synthesis in murine B cells.
Volume: 83
Issue: 3
Pages: 254-63
Publication
First Author: Bellas RE
Year: 1997
Journal: Am J Pathol
Title: Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes.
Volume: 151
Issue: 4
Pages: 891-6
Publication
First Author: Seitz CS
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.
Volume: 95
Issue: 5
Pages: 2307-12
Publication
First Author: Kistler B
Year: 1998
Journal: J Immunol
Title: Induction of nuclear factor-kappa B during primary B cell differentiation.
Volume: 160
Issue: 5
Pages: 2308-17
Publication
First Author: Han Z
Year: 1998
Journal: Autoimmunity
Title: AP-1 and NF-kappaB regulation in rheumatoid arthritis and murine collagen-induced arthritis.
Volume: 28
Issue: 4
Pages: 197-208
Publication
First Author: Ladner KJ
Year: 2003
Journal: J Biol Chem
Title: Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products.
Volume: 278
Issue: 4
Pages: 2294-303
Publication
First Author: Kassed CA
Year: 2003
Journal: Brain Res Mol Brain Res
Title: Mice expressing human mutant presenilin-1 exhibit decreased activation of NF-kappaB p50 in hippocampal neurons after injury.
Volume: 110
Issue: 1
Pages: 152-7
Publication
First Author: Jimi E
Year: 2005
Journal: Int Immunol
Title: Activation of NF-kappaB promotes the transition of large, CD43+ pre-B cells to small, CD43- pre-B cells.
Volume: 17
Issue: 6
Pages: 815-25
Publication
First Author: Covert MW
Year: 2005
Journal: Science
Title: Achieving stability of lipopolysaccharide-induced NF-kappaB activation.
Volume: 309
Issue: 5742
Pages: 1854-7
Publication
First Author: Freudenthal R
Year: 2005
Journal: Eur J Neurosci
Title: NF-kappaB transcription factor is required for inhibitory avoidance long-term memory in mice.
Volume: 21
Issue: 10
Pages: 2845-52
Publication
First Author: Alexander G
Year: 2006
Journal: Exp Eye Res
Title: Corneal NF-kappaB activity is necessary for the retention of transparency in the cornea of UV-B-exposed transgenic reporter mice.
Volume: 82
Issue: 4
Pages: 700-9
Publication
First Author: Greenberg H
Year: 2006
Journal: Biochem Biophys Res Commun
Title: Chronic intermittent hypoxia activates nuclear factor-kappaB in cardiovascular tissues in vivo.
Volume: 343
Issue: 2
Pages: 591-6
Publication
First Author: Wullaert A
Year: 2006
Journal: Biochem Pharmacol
Title: Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
Volume: 72
Issue: 9
Pages: 1090-101
Publication
First Author: Cronstein BN
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB.
Volume: 96
Issue: 11
Pages: 6377-81
Publication
First Author: Pasparakis M
Year: 2006
Journal: Cell Death Differ
Title: Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.
Volume: 13
Issue: 5
Pages: 861-72
Publication
First Author: Jüttler E
Year: 2007
Journal: J Neuroimmunol
Title: Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model.
Volume: 189
Issue: 1-2
Pages: 41-9
Publication
First Author: Frantz S
Year: 2006
Journal: FASEB J
Title: Absence of NF-kappaB subunit p50 improves heart failure after myocardial infarction.
Volume: 20
Issue: 11
Pages: 1918-20
Publication
First Author: Bracchi-Ricard V
Year: 2008
Journal: J Neurochem
Title: Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice.
Volume: 104
Issue: 3
Pages: 611-23
Publication
First Author: Sadikot RT
Year: 2006
Journal: J Immunol
Title: Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosa.
Volume: 176
Issue: 8
Pages: 4923-30
Publication
First Author: Robles MS
Year: 2002
Journal: J Immunol
Title: Inhibitor of apoptosis protein from Orgyia pseudotsugata nuclear polyhedrosis virus provides a costimulatory signal required for optimal proliferation of developing thymocytes.
Volume: 168
Issue: 4
Pages: 1770-9
Publication  
First Author: Zeng HY
Year: 2008
Journal: Mol Vis
Title: Activation of nuclear factor-kappaB during retinal degeneration in rd mice.
Volume: 14
Pages: 1075-80
Publication
First Author: Droebner K
Year: 2008
Journal: J Virol
Title: Role of hypercytokinemia in NF-kappaB p50-deficient mice after H5N1 influenza A virus infection.
Volume: 82
Issue: 22
Pages: 11461-6
Publication
First Author: Wang D
Year: 2009
Journal: J Immunol
Title: NF-kappa B p50 regulates C/EBP alpha expression and inflammatory cytokine-induced neutrophil production.
Volume: 182
Issue: 9
Pages: 5757-62
Publication
First Author: Jayakumar AR
Year: 2011
Journal: Neurobiol Dis
Title: NF-κB in the mechanism of brain edema in acute liver failure: studies in transgenic mice.
Volume: 41
Issue: 2
Pages: 498-507
Publication
First Author: Ather JL
Year: 2010
Journal: Am J Respir Cell Mol Biol
Title: Distinct functions of airway epithelial nuclear factor-kappaB activity regulate nitrogen dioxide-induced acute lung injury.
Volume: 43
Issue: 4
Pages: 443-51
Publication
First Author: Martinez Calejman C
Year: 2011
Journal: Mol Cell Endocrinol
Title: Lipopolysaccharide stimulates adrenal steroidogenesis in rodent cells by a NFκB-dependent mechanism involving COX-2 activation.
Volume: 337
Issue: 1-2
Pages: 1-6
Publication
First Author: Gilboa-Geffen A
Year: 2011
Journal: PLoS One
Title: Activation of the alternative NFκB pathway improves disease symptoms in a model of Sjogren's syndrome.
Volume: 6
Issue: 12
Pages: e28727
Publication
First Author: Haegens A
Year: 2012
Journal: Am J Physiol Lung Cell Mol Physiol
Title: NF-κB activation and polyubiquitin conjugation are required for pulmonary inflammation-induced diaphragm atrophy.
Volume: 302
Issue: 1
Pages: L103-10
Publication
First Author: Qi J
Year: 2012
Journal: FEBS Lett
Title: microRNA-210 negatively regulates LPS-induced production of proinflammatory cytokines by targeting NF-κB1 in murine macrophages.
Volume: 586
Issue: 8
Pages: 1201-7
Publication
First Author: Zaynagetdinov R
Year: 2012
Journal: Oncogene
Title: Epithelial nuclear factor-κB signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes.
Volume: 31
Issue: 26
Pages: 3164-76
Publication
First Author: Dou X
Year: 2012
Journal: Am J Pathol
Title: Inhibition of NF-κB activation by 4-hydroxynonenal contributes to liver injury in a mouse model of alcoholic liver disease.
Volume: 181
Issue: 5
Pages: 1702-10
Publication
First Author: Crawley CD
Year: 2013
Journal: Nucleic Acids Res
Title: DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site.
Volume: 41
Issue: 2
Pages: 764-74
Publication
First Author: Sehnert B
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases.
Volume: 110
Issue: 41
Pages: 16556-61
Publication
First Author: King AJ
Year: 2013
Journal: PLoS One
Title: Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes.
Volume: 8
Issue: 10
Pages: e77452
Publication
First Author: Tirziu D
Year: 2012
Journal: Circulation
Title: Endothelial nuclear factor-κB-dependent regulation of arteriogenesis and branching.
Volume: 126
Issue: 22
Pages: 2589-600
Publication
First Author: Zhu F
Year: 2014
Journal: Exp Cell Res
Title: The nuclear factor kappa B (NF-κB) activation is required for phagocytosis of staphylococcus aureus by RAW 264.7 cells.
Volume: 327
Issue: 2
Pages: 256-63
Publication
First Author: Taetzsch T
Year: 2015
Journal: Glia
Title: Redox regulation of NF-κB p50 and M1 polarization in microglia.
Volume: 63
Issue: 3
Pages: 423-40
Publication
First Author: Di Pilato M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: NFκB activation by modified vaccinia virus as a novel strategy to enhance neutrophil migration and HIV-specific T-cell responses.
Volume: 112
Issue: 11
Pages: E1333-42
Publication
First Author: Zhang ZX
Year: 2015
Journal: Biochem Biophys Res Commun
Title: BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-κB1.
Volume: 465
Issue: 2
Pages: 225-31
Publication
First Author: Zhang N
Year: 2017
Journal: Aging Cell
Title: Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.
Volume: 16
Issue: 4
Pages: 847-858
Publication  
First Author: Dong HY
Year: 2017
Journal: Arch Biochem Biophys
Title: Automatic regulation of NF-κB by pHSP70/IκBαm to prevent acute lung injury in mice.
Volume: 634
Pages: 47-56
Publication
First Author: Castellanos-Rubio A
Year: 2017
Journal: J Immunol
Title: Cytoplasmic Form of Carlr lncRNA Facilitates Inflammatory Gene Expression upon NF-κB Activation.
Volume: 199
Issue: 2
Pages: 581-588
Publication
First Author: DeDiego ML
Year: 2014
Journal: J Virol
Title: Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival.
Volume: 88
Issue: 2
Pages: 913-24
Publication
First Author: Wang P
Year: 2019
Journal: Gut
Title: Diverse tumour susceptibility in Collaborative Cross mice: identification of a new mouse model for human gastric tumourigenesis.
Volume: 68
Issue: 11
Pages: 1942-1952
Publication
First Author: Porta C
Year: 2018
Journal: Cancer Immunol Res
Title: Protumor Steering of Cancer Inflammation by p50 NF-κB Enhances Colorectal Cancer Progression.
Volume: 6
Issue: 5
Pages: 578-593
Publication  
First Author: Jo DH
Year: 2020
Journal: Neurobiol Aging
Title: Intracellular amyloid-β disrupts tight junctions of the retinal pigment epithelium via NF-κB activation.
Volume: 95
Pages: 115-122
Publication
First Author: Zhao J
Year: 2020
Journal: J Biol Chem
Title: Transcription factor NF-κB promotes acute lung injury via microRNA-99b-mediated PRDM1 down-regulation.
Volume: 295
Issue: 52
Pages: 18638-18648
Publication
First Author: Yang YR
Year: 2015
Journal: Oncotarget
Title: Elevated O-GlcNAcylation promotes colonic inflammation and tumorigenesis by modulating NF-κB signaling.
Volume: 6
Issue: 14
Pages: 12529-42
Publication
First Author: Kim SR
Year: 2013
Journal: J Allergy Clin Immunol
Title: Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation.
Volume: 132
Issue: 6
Pages: 1397-408
Publication
First Author: Xie C
Year: 2014
Journal: Int Immunopharmacol
Title: Protective effect of SKLB010 against D-galactosamine/lipopolysaccharide-induced acute liver failure via nuclear factor-κB signaling pathway in macrophages.
Volume: 21
Issue: 2
Pages: 261-8
Publication
First Author: Yang RM
Year: 2023
Journal: Nat Commun
Title: Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB.
Volume: 14
Issue: 1
Pages: 8082
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3185716
Stage: TS16
Assay Id: MGI:2662472
Age: embryonic day 10.0
Specimen Label: Whole body 10
Specimen Num: 1
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3185718
Stage: TS18
Assay Id: MGI:2662472
Age: embryonic day 11.0
Specimen Label: Whole body 11
Specimen Num: 2
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3185820
Stage: TS20
Assay Id: MGI:2662472
Age: embryonic day 12.0
Specimen Label: Head 12
Specimen Num: 3
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:3185821
Stage: TS21
Assay Id: MGI:2662472
Age: embryonic day 13.0
Specimen Label: Head 13
Specimen Num: 4
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689423
Stage: TS23
Assay Id: MGI:2662472
Age: embryonic day 15.0
Specimen Label: Brain 15
Specimen Num: 5
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689425
Stage: TS25
Assay Id: MGI:2662472
Age: embryonic day 17.0
Specimen Label: Brain 17
Specimen Num: 6
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689427
Stage: TS27
Assay Id: MGI:2662472
Age: postnatal newborn
Specimen Label: Brain N0
Specimen Num: 7
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662472
Age: postnatal day 7
Specimen Label: Brain N7
Specimen Num: 8
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1689428
Stage: TS28
Assay Id: MGI:2662472
Age: postnatal week 13
Specimen Label: Brain A
Specimen Num: 9
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684620
Stage: TS20
Assay Id: MGI:2662472
Age: embryonic day 12.0
Specimen Label: Liver 12
Specimen Num: 14
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684621
Stage: TS21
Assay Id: MGI:2662472
Age: embryonic day 13.0
Specimen Label: Liver 13
Specimen Num: 15
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684623
Stage: TS23
Assay Id: MGI:2662472
Age: embryonic day 15.0
Specimen Label: Liver 15
Specimen Num: 16
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684625
Stage: TS25
Assay Id: MGI:2662472
Age: embryonic day 17.0
Specimen Label: Liver 17
Specimen Num: 17
GXD Expression        
Probe: MGI:2662451
Assay Type: RT-PCR
Annotation Date: 2003-06-11
Strength: Not Specified
Sex: Not Specified
Emaps: EMAPS:1684627
Stage: TS27
Assay Id: MGI:2662472
Age: postnatal newborn
Specimen Label: Liver N0
Specimen Num: 18