Type |
Details |
Score |
Publication |
First Author: |
Dorsett D |
Year: |
2009 |
Journal: |
Chromosome Res |
Title: |
Cohesin, gene expression and development: lessons from Drosophila. |
Volume: |
17 |
Issue: |
2 |
Pages: |
185-200 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE60932 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Sox17/Sox17<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
H2az2/H2az2<+> Nipbl/Nipbl<+> |
Background: |
involves: 129P2/OlaHsd * C57BL/6J * CBA/J * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Sox17/Sox17<+> |
Background: |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Foxa2/Foxa2<+> |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mau2/Mau2 Nipbl/Nipbl H2az2/H2az2<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Wapl/Wapl<+> |
Background: |
involves: 129 * C57BL/6J * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nipbl/Nipbl<+> Wapl/Wapl |
Background: |
involves: 129 * C57BL/6J * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lachner M |
Year: |
2001 |
Journal: |
Nature |
Title: |
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins. |
Volume: |
410 |
Issue: |
6824 |
Pages: |
116-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duong HA |
Year: |
2014 |
Journal: |
Nat Struct Mol Biol |
Title: |
Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes. |
Volume: |
21 |
Issue: |
2 |
Pages: |
126-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Obuse C |
Year: |
2004 |
Journal: |
Nat Cell Biol |
Title: |
A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1. |
Volume: |
6 |
Issue: |
11 |
Pages: |
1135-41 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Chromobox protein homologue 3 (CBX3, also known as HP1 gamma) is a component of heterochromatin that binds histone H3 tails methylated at 'Lys-9' which leads to epigenetic repression []. By interacting with MIS12 complex, it is involved in the formation of a functional kinetochore []. It recruits NIPBL to sites of DNA damage at double-strand breaks []. It is a component of the E2F6.com-1 []and PER []complexes. The PER complex controls the circadian clock []. |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Mau2/Mau2 Nipbl/Nipbl<+> H2az2/H2az2<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA/J * SJL |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H2az2/? Nipbl/Nipbl<+> |
Background: |
involves: 129S/Sv * C57BL/6J * C57BL/6NCrl * CBA/J * CD-1 |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernard P |
Year: |
2006 |
Journal: |
Curr Biol |
Title: |
A screen for cohesion mutants uncovers Ssl3, the fission yeast counterpart of the cohesin loading factor Scc4. |
Volume: |
16 |
Issue: |
9 |
Pages: |
875-81 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ciosk R |
Year: |
2000 |
Journal: |
Mol Cell |
Title: |
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins. |
Volume: |
5 |
Issue: |
2 |
Pages: |
243-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Seitan VC |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance. |
Volume: |
4 |
Issue: |
8 |
Pages: |
e242 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watrin E |
Year: |
2006 |
Journal: |
Curr Biol |
Title: |
Human Scc4 is required for cohesin binding to chromatin, sister-chromatid cohesion, and mitotic progression. |
Volume: |
16 |
Issue: |
9 |
Pages: |
863-74 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents the chromatid cohesion factor Mau2 and its homologues, including Scc4 from budding yeasts and Ssl3 from fission yeasts. Scc4 is a subunit of the cohesin loading factor complex (Scc2-Scc4), which is required for the loading of cohesin complexes onto chromosomes []. Ssl3 is in complex with Mis4 (Scc2 homologue) and is required in G1 for cohesin binding to chromosomes []. Animal Mau2 interacts with Nipbl (Scc2 orthologue), and both proteins are involved in sister chromatid cohesion and segregation [, , ]. |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2798
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
416
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2022 |
Journal: |
Nat Immunol |
Title: |
TCF-1 promotes chromatin interactions across topologically associating domains in T cell progenitors. |
Volume: |
23 |
Issue: |
7 |
Pages: |
1052-1062 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang Y |
Year: |
2020 |
Journal: |
Nat Commun |
Title: |
JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. |
Volume: |
11 |
Issue: |
1 |
Pages: |
5061 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
619
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
619
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
650
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Ogawa H |
Year: |
2002 |
Journal: |
Science |
Title: |
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. |
Volume: |
296 |
Issue: |
5570 |
Pages: |
1132-6 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
183
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
183
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
183
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
183
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
110
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
|
•
•
•
•
•
|