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Search results 301 to 400 out of 518 for Nod2

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Type Details Score
Publication
19652017 | J:152182
First Author: McWhirter SM
Year: 2009
Journal: J Exp Med
Title: A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.
Volume: 206
Issue: 9
Pages: 1899-911
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Publication
23148704 | J:296298
First Author: Oosting M
Year: 2012
Journal: Arthritis Res Ther
Title: Murine Borrelia arthritis is highly dependent on ASC and caspase-1, but independent of NLRP3.
Volume: 14
Issue: 6
Pages: R247
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Publication
17433728 | J:123579
First Author: Kanneganti TD
Year: 2007
Journal: Immunity
Title: Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling.
Volume: 26
Issue: 4
Pages: 433-43
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Publication
22323544 | J:181854
First Author: Lacroix-Lamandé S
Year: 2012
Journal: J Immunol
Title: Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome.
Volume: 188
Issue: 6
Pages: 2805-14
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Publication
33412104 | J:320744
First Author: Koren N
Year: 2021
Journal: Cell Host Microbe
Title: Maturation of the neonatal oral mucosa involves unique epithelium-microbiota interactions.
Volume: 29
Issue: 2
Pages: 197-209.e5
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Publication
24453255 | J:209447
First Author: Gurung P
Year: 2014
Journal: J Immunol
Title: FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes.
Volume: 192
Issue: 4
Pages: 1835-46
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Publication
23630357 | J:204774
First Author: Shenderov K
Year: 2013
Journal: J Immunol
Title: Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome.
Volume: 190
Issue: 11
Pages: 5722-30
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19006696 | J:142395
First Author: Kang SJ
Year: 2008
Journal: Immunity
Title: Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells.
Volume: 29
Issue: 5
Pages: 819-33
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Publication
34526512 | J:354631
First Author: Yang C
Year: 2021
Journal: Nat Commun
Title: Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.
Volume: 12
Issue: 1
Pages: 5454
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Publication
38409108 | J:361094
First Author: Han JH
Year: 2024
Journal: Nat Commun
Title: NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress.
Volume: 15
Issue: 1
Pages: 1739
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28410990 | J:254534
First Author: Gurung P
Year: 2017
Journal: Immunity
Title: Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease.
Volume: 46
Issue: 4
Pages: 635-648
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Publication
12819136 | J:84168
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:147112
     
First Author: Taconic
Year: 2006
Journal: MGI Direct Data Submission
Title: Information obtained from Taconic website.
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- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
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- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
24960071 | J:213863
First Author: Parkhouse R
Year: 2014
Journal: FEBS Lett
Title: Interaction between NOD2 and CARD9 involves the NOD2 NACHT and the linker region between the NOD2 CARDs and NACHT domain.
Volume: 588
Issue: 17
Pages: 2830-6
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Publication
31649195 | J:287065
First Author: Lu Y
Year: 2019
Journal: Science
Title: Palmitoylation of NOD1 and NOD2 is required for bacterial sensing.
Volume: 366
Issue: 6464
Pages: 460-467
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Publication
21887730 | J:205032
First Author: Zhao Y
Year: 2012
Journal: Inflamm Bowel Dis
Title: Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
Volume: 18
Issue: 4
Pages: 603-12
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Publication
36821686 | J:340956
First Author: Schwarzer M
Year: 2023
Journal: Science
Title: Microbe-mediated intestinal NOD2 stimulation improves linear growth of undernourished infant mice.
Volume: 379
Issue: 6634
Pages: 826-833
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Publication
16552041 | J:107425
First Author: Pan Q
Year: 2006
Journal: Infect Immun
Title: NF-kappa B-inducing kinase regulates selected gene expression in the Nod2 signaling pathway.
Volume: 74
Issue: 4
Pages: 2121-7
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Publication
19592251 | J:152552
First Author: Tao M
Year: 2009
Journal: Curr Biol
Title: ITCH K63-ubiquitinates the NOD2 binding protein, RIP2, to influence inflammatory signaling pathways.
Volume: 19
Issue: 15
Pages: 1255-63
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Publication
30378174 | J:267367
First Author: Singh K
Year: 2018
Journal: Glia
Title: Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation.
Volume: 66
Issue: 11
Pages: 2427-2437
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GO Term
GO:0070431 | nucleotide-binding oligomerization domain containing 2 signaling pathway
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Publication
19570976 | J:292537
First Author: Lee J
Year: 2009
Journal: J Biol Chem
Title: pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling.
Volume: 284
Issue: 35
Pages: 23818-29
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Publication
23322906 | J:259506
First Author: Warner N
Year: 2013
Journal: Sci Signal
Title: A genome-wide siRNA screen reveals positive and negative regulators of the NOD2 and NF-κB signaling pathways.
Volume: 6
Issue: 258
Pages: rs3
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Publication
17919942 | J:126102
First Author: van Beelen AJ
Year: 2007
Journal: Immunity
Title: Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells.
Volume: 27
Issue: 4
Pages: 660-9
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Publication
27283905 | -
 
First Author: Maekawa S
Year: 2016
Journal: Nat Commun
Title: Crystal structure of NOD2 and its implications in human disease.
Volume: 7
Pages: 11813
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Publication
24238340 | J:208987
First Author: Sorbara MT
Year: 2013
Journal: Immunity
Title: The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner.
Volume: 39
Issue: 5
Pages: 858-73
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Allele
Nod2<tm1Mka> | MGI:3530578
Name: nucleotide-binding oligomerization domain containing 2; targeted mutation 1, Michael Karin
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Slc22a4<tm1Atsu> | MGI:5554255
Name: solute carrier family 22 (organic cation transporter), member 4; targeted mutation 1, Akira Tsuji
Allele Type: Targeted
Attribute String: Null/knockout
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Publication
27050483 | J:236900
 
First Author: Canton J
Year: 2016
Journal: Nat Commun
Title: Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Volume: 7
Pages: 11284
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Interaction Experiment
Yang Y (2007)
Description: NOD2 pathway activation by MDP or Mycobacterium tuberculosis infection involves the stable polyubiquitination of Rip2.
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Interaction Experiment
Lee KH (2012)
Description: Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.
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Interaction Experiment
Watanabe T (2014)
Description: NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.
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Publication
21469090 | J:175412
First Author: Magalhaes JG
Year: 2011
Journal: Eur J Immunol
Title: Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands.
Volume: 41
Issue: 5
Pages: 1445-55
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Publication
16260731 | J:103431
First Author: Netea MG
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism.
Volume: 102
Issue: 45
Pages: 16309-14
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Publication
32094205 | J:287542
First Author: Buteyn NJ
Year: 2020
Journal: J Immunol
Title: Activation of the Intracellular Pattern Recognition Receptor NOD2 Promotes Acute Myeloid Leukemia (AML) Cell Apoptosis and Provides a Survival Advantage in an Animal Model of AML.
Volume: 204
Issue: 7
Pages: 1988-1997
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GO Term
GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
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GO Term
GO:0070433 | negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
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GO Term
GO:0070432 | regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
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Allele
Nod2<em1Smoc> | MGI:7291345
Name: nucleotide-binding oligomerization domain containing 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6355069 | C57BL/6JSmoc-Nod2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Nod2/Nod2
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0110892 | inflammatory bowel disease 1
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Genotype
Genotype
 
Background: SAMP1
Zygosity: ot
Has Mutant Allele: false
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Allele
Nod2<em1Cya> | MGI:7657303
Name: nucleotide-binding oligomerization domain containing 2; endonuclease-mediated mutation 1, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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DO Term
DOID:0050678 | Blau syndrome
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Publication
22829933 | -
First Author: Zurek B
Year: 2012
Journal: PLoS One
Title: TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.
Volume: 7
Issue: 7
Pages: e41255
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Strain
MGI:7657561 | C57BL/6N-Nod2<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
23019338 | -
First Author: Lee KH
Year: 2012
Journal: J Biol Chem
Title: Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.
Volume: 287
Issue: 47
Pages: 39800-11
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Publication
25367361 | -
First Author: Sales-Marques C
Year: 2014
Journal: Hum Genet
Title: NOD2 and CCDC122-LACC1 genes are associated with leprosy susceptibility in Brazilians.
Volume: 133
Issue: 12
Pages: 1525-32
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Publication
24670424 | -
First Author: Watanabe T
Year: 2014
Journal: Mucosal Immunol
Title: NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.
Volume: 7
Issue: 6
Pages: 1312-25
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Protein Domain
IPR041075 | NOD2_WH
Type: Domain
Description: This winged helix domain is found in the NOD2 protein []. Its molecular function is not known.
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Publication
26632377 | -
First Author: Kim YK
Year: 2016
Journal: Yonsei Med J
Title: NOD-Like Receptors in Infection, Immunity, and Diseases.
Volume: 57
Issue: 1
Pages: 5-14
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Publication
30571723 | -
First Author: Maharana J
Year: 2018
Journal: PLoS One
Title: Deciphering the ATP-binding mechanism(s) in NLRP-NACHT 3D models using structural bioinformatics approaches.
Volume: 13
Issue: 12
Pages: e0209420
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Protein Domain
IPR041267 | NLRP_HD2
Type: Domain
Description: This entry represents the second of two helical domains (HD2) found in the NLRC proteins [], the NOD2 protein []and NACHT, LRR and PYD domains-containing proteins [, ].
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Publication
19706687 | -
First Author: Stenzel N
Year: 2009
Journal: J Cell Sci
Title: PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells.
Volume: 122
Issue: Pt 18
Pages: 3374-84
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Protein Domain
IPR029906 | FRMPD2
Type: Family
Description: FERM and PDZ domain-containing protein 2 (FRMPD2) may play a role in the regulation of tight junction formation []. It interacts with NOD2 (nucleotide-binding oligomerisation domain-2) via leucine-rich repeats, and acts as a membrane-scaffolding complex that provides a spatial control mechanism for NOD2-mediated immune responses [].
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Publication
23765277 | J:245334
First Author: Hu Z
Year: 2013
Journal: Science
Title: Crystal structure of NLRC4 reveals its autoinhibition mechanism.
Volume: 341
Issue: 6142
Pages: 172-5
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Publication
12633874 | J:82173
First Author: Albrecht M
Year: 2003
Journal: FEBS Lett
Title: Identification of mammalian orthologs associates PYPAF5 with distinct functional roles.
Volume: 538
Issue: 1-3
Pages: 173-7
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Protein Domain
IPR042149 | CARD_RIP2
Type: Domain
Description: This entry represents the CARD domain found in Receptor Interacting Protein 2 (RIP2). RIP2 harbours a C-terminal CARD domain and functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR)-family, NOD1 and NOD2, which recognizes bacterial peptidoglycans released upon infection. This cascade is implicated in inflammatory immune responses and the clearance of intracellular pathogens. RIP2 associates with NOD1 and NOD2 via CARD-CARDinteractions [].In general, CARDs are death domains (DDs) found associated with caspases []. They are known to be important in the signaling pathways for apoptosis, inflammation, and host-defense mechanisms []. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes [].
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Publication
16083881 | J:200305
First Author: Hahn JS
Year: 2005
Journal: FEBS Lett
Title: Regulation of Nod1 by Hsp90 chaperone complex.
Volume: 579
Issue: 20
Pages: 4513-9
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Publication
18342009 | J:132994
First Author: Hitotsumatsu O
Year: 2008
Journal: Immunity
Title: The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.
Volume: 28
Issue: 3
Pages: 381-90
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Publication
33893298 | J:306089
First Author: Garo LP
Year: 2021
Journal: Nat Commun
Title: MicroRNA-146a limits tumorigenic inflammation in colorectal cancer.
Volume: 12
Issue: 1
Pages: 2419
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Publication
18079694 | J:130530
First Author: Hasegawa M
Year: 2008
Journal: EMBO J
Title: A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
Volume: 27
Issue: 2
Pages: 373-83
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Publication
18769721 | J:162718
First Author: Bauler LD
Year: 2008
Journal: PLoS Pathog
Title: XIAP regulates cytosol-specific innate immunity to Listeria infection.
Volume: 4
Issue: 8
Pages: e1000142
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Publication
29425505 | J:271097
First Author: Stafford CA
Year: 2018
Journal: Cell Rep
Title: IAPs Regulate Distinct Innate Immune Pathways to Co-ordinate the Response to Bacterial Peptidoglycans.
Volume: 22
Issue: 6
Pages: 1496-1508
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Publication
19464198 | J:149992
First Author: Bertrand MJ
Year: 2009
Journal: Immunity
Title: Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.
Volume: 30
Issue: 6
Pages: 789-801
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Publication
25891078 | J:347306
First Author: Chauhan S
Year: 2015
Journal: Mol Cell
Title: IRGM governs the core autophagy machinery to conduct antimicrobial defense.
Volume: 58
Issue: 3
Pages: 507-21
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Publication
32954645 | J:301385
First Author: Heim VJ
Year: 2020
Journal: EMBO Rep
Title: A regulatory region on RIPK2 is required for XIAP binding and NOD signaling activity.
Volume: 21
Issue: 11
Pages: e50400
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Protein
A0A1G5SJM7
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Publication
17983803 | J:130258
First Author: Renner M
Year: 2007
Journal: Gastroenterology
Title: DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.
Volume: 133
Issue: 5
Pages: 1499-509
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Publication
37373041 | J:337464
 
First Author: Riquelme-Neira R
Year: 2023
Journal: Int J Mol Sci
Title: IL-10 Modulates the Expression and Activation of Pattern Recognition Receptors in Mast Cells.
Volume: 24
Issue: 12
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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