| Type |
Details |
Score |
| Allele |
| Name: |
NOP2 nucleolar protein; gene trap IST14008F3, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NOP2 nucleolar protein; gene trap IST14073H9, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Allele |
| Name: |
NOP2 nucleolar protein; gene trap IST14209E5, Texas A&M Institute for Genomic Medicine |
| Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Nop2/Nop2 |
| Background: |
Not Specified |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
793
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
794
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tscherne JS |
| Year: |
1999 |
| Journal: |
Biochemistry |
| Title: |
Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli. |
| Volume: |
38 |
| Issue: |
6 |
| Pages: |
1884-92 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reid R |
| Year: |
1999 |
| Journal: |
Nucleic Acids Res |
| Title: |
Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences. |
| Volume: |
27 |
| Issue: |
15 |
| Pages: |
3138-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
King MY |
| Year: |
2002 |
| Journal: |
Biochemistry |
| Title: |
RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. |
| Volume: |
41 |
| Issue: |
37 |
| Pages: |
11218-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Pavlopoulou A |
| Year: |
2009 |
| Journal: |
Genomics |
| Title: |
Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases. |
| Volume: |
93 |
| Issue: |
4 |
| Pages: |
350-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Motorin Y |
| Year: |
2010 |
| Journal: |
Nucleic Acids Res |
| Title: |
5-methylcytosine in RNA: detection, enzymatic formation and biological functions. |
| Volume: |
38 |
| Issue: |
5 |
| Pages: |
1415-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gu XR |
| Year: |
1999 |
| Journal: |
Biochemistry |
| Title: |
Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. |
| Volume: |
38 |
| Issue: |
13 |
| Pages: |
4053-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bujnicki JM |
| Year: |
2004 |
| Journal: |
Nucleic Acids Res |
| Title: |
Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases. |
| Volume: |
32 |
| Issue: |
8 |
| Pages: |
2453-63 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Repeat |
| Description: |
This characteristic repeat of proliferating cell nuclear antigen P120 is found in three copies []. This repeat can be found in the human NOP2 protein, a probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hikida Y |
| Year: |
2010 |
| Journal: |
Acta Crystallogr D Biol Crystallogr |
| Title: |
Structure of an archaeal homologue of the bacterial Fmu/RsmB/RrmB rRNA cytosine 5-methyltransferase. |
| Volume: |
66 |
| Issue: |
Pt 12 |
| Pages: |
1301-7 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
The C-terminal catalytic domain of ribosomal RNA cysteine methyltransferases is highly conserved in archaeal, bacterial and eukaryotic proteins [], such as ribosomal RNA methyltransferase B (RsmB, Sun, Fmu) and Nop2. Escherichia coli RsmB methylates cytosine C967 in 16S rRNA []. Nop2 methylates cytosine C2870 in the 25S rRNA of S. cerevisiae []and is critical for 60S biogenesis []. |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE57824 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
Baseline |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schubert HL |
| Year: |
2003 |
| Journal: |
Trends Biochem Sci |
| Title: |
Many paths to methyltransfer: a chronicle of convergence. |
| Volume: |
28 |
| Issue: |
6 |
| Pages: |
329-35 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang F |
| Year: |
2014 |
| Journal: |
Hepatology |
| Title: |
Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2. |
| Volume: |
60 |
| Issue: |
4 |
| Pages: |
1278-90 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
724
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
705
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
700
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hong B |
| Year: |
1997 |
| Journal: |
Mol Cell Biol |
| Title: |
Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. |
| Volume: |
17 |
| Issue: |
1 |
| Pages: |
378-88 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
465
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
381
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
348
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
476
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
757
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
425
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
782
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
722
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Staub E |
| Year: |
2004 |
| Journal: |
Bioessays |
| Title: |
Insights into the evolution of the nucleolus by an analysis of its protein domain repertoire. |
| Volume: |
26 |
| Issue: |
5 |
| Pages: |
567-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerhard DS |
| Year: |
2004 |
| Journal: |
Genome Res |
| Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
| Volume: |
14 |
| Issue: |
10B |
| Pages: |
2121-7 |
|
•
•
•
•
•
|