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Search results 301 to 372 out of 372 for Npm1

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Type Details Score
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23435463 | J:196690
First Author: Sportoletti P
Year: 2013
Journal: Blood
Title: The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model.
Volume: 121
Issue: 17
Pages: 3447-58
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Publication
39690184 | J:361611
First Author: Falini B
Year: 2025
Journal: Leukemia
Title: Functions of the native NPM1 protein and its leukemic mutant.
Volume: 39
Issue: 2
Pages: 276-290
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DO Term
DOID:0081089 | acute myeloid leukemia with mutated NPM1
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Publication
30755706 | J:278202
First Author: Sportoletti P
Year: 2019
Journal: Leukemia
Title: GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations.
Volume: 33
Issue: 7
Pages: 1827-1832
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Allele
Npm1<em1Smoc> | MGI:7291369
Name: nucleophosmin 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
24991885 | -
First Author: Lührig S
Year: 2014
Journal: Stem Cells Dev
Title: Lrrc34, a novel nucleolar protein, interacts with npm1 and ncl and has an impact on pluripotent stem cells.
Volume: 23
Issue: 23
Pages: 2862-74
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GXD Expression
GXD Expression
 
Probe: MGI:5295858
Assay Type: Immunohistochemistry
Annotation Date: 2011-11-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1616417
Pattern: Not Specified
Stage: TS17
Assay Id: MGI:5295632
Age: embryonic day 10.5
Note: Expression was largely in the cytoplasm of cells in the trunk neural tube. A very small portion of staining was present in the nucleus and some of it colocalizes with the nucleolar marker Npm1 (B23).
Specimen Label: 6J p53 L24 Bst/+
Detected: true
Specimen Num: 4
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Allele
Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno> | MGI:5502770
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Genoway
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Allele
Npm1<tm1Trow> | MGI:6285874
Name: nucleophosmin 1; targeted mutation 1, Jennifer Trowbridge
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence
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Strain
MGI:7853689 | B6.Cg-Gt(ROSA)26Sor<tm1(CAG-NPM1*)Geno>/Cnrm
Attribute String: targeted mutation, mutant strain
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Strain
MGI:6285878 | C57BL/6-Npm1<tm1Trow>/J
Attribute String: coisogenic, mutant strain, targeted mutation
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Publication
25772360 | -
     
First Author: Onikubo T
Year: 2015
Journal: Cell Rep
Title: Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition.
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Protein Domain
IPR004301 | Nucleoplasmin
Type: Family
Description: The nucleoplasmin family includes nucleophosmin, nucleoplasmin and nucleoplasmin-like proteins. Nucleophosmin (also known as NPM1/B23) is a multifunctional protein that is involved in a number of cellular activities, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli []. Nucleoplasmin (NPM2) is a histone chaperone for histones H2A-H2B and is highly expressed in the oocyte and through the early stages of embryogenesis [].Mutations of the NPM1 gene has been linked to acute myeloid leukemia [].
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Strain
MGI:6286133 | B6.Cg-Gt(ROSA)26Sor<tm3(CAG-flpo/ERT2)Alj> Npm1<tm1Trow>
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npm1/Npm1<+>
Background: B6.Cg-Gt(ROSA)26Sor Npm1
Zygosity: cn
Has Mutant Allele: true
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Publication
16041368 | -
First Author: Wang W
Year: 2005
Journal: Nat Cell Biol
Title: Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.
Volume: 7
Issue: 8
Pages: 823-30
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Publication
24952945 | -
First Author: Arcovito A
Year: 2014
Journal: J Biol Chem
Title: Synergic role of nucleophosmin three-helix bundle and a flanking unstructured tail in the interaction with G-quadruplex DNA.
Volume: 289
Issue: 31
Pages: 21230-41
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Protein Domain
IPR032569 | NPM1_C
Type: Domain
Description: This domain, approximately 50 residues in length, is mainly found in C-terminal region of nucleophosmin from animals []. Nucleophosmin (also known as NPM1/B23) is a multifunctional protein that is involved in a number of cellular activities, such as ribosome maturatation and export, centrosome duplication, and response to stress stimuli []. Although it shuttles rapidly between the nucleus and the cytoplasm, a large fraction of NPM1/B23 resides in the nucleoli []. Mutations of the NPM1 gene has been linked to acute myeloid leukemia []. This domain has a three-helix bundle which binds the G-quadruplex DNA at the interface between helices H1 and H2 through electrostatic interactions with the G-quadruplex phosphate backbone [, ].
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Publication
22707729 | -
First Author: Gallo A
Year: 2012
Journal: J Biol Chem
Title: Structure of nucleophosmin DNA-binding domain and analysis of its complex with a G-quadruplex sequence from the c-MYC promoter.
Volume: 287
Issue: 32
Pages: 26539-48
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Publication
16794633 | -
First Author: Grisendi S
Year: 2006
Journal: Nat Rev Cancer
Title: Nucleophosmin and cancer.
Volume: 6
Issue: 7
Pages: 493-505
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Publication
31767858 | J:285814
First Author: Papaioannou D
Year: 2019
Journal: Nat Commun
Title: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia.
Volume: 10
Issue: 1
Pages: 5351
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Publication
37615668 | J:345635
 
First Author: Zhou L
Year: 2023
Journal: J Cell Biol
Title: T cell proliferation requires ribosomal maturation in nucleolar condensates dependent on DCAF13.
Volume: 222
Issue: 10
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Publication
28017614 | J:238414
First Author: Li Z
Year: 2017
Journal: Cancer Cell
Title: FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Volume: 31
Issue: 1
Pages: 127-141
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Publication
19666870 | J:160805
First Author: Cheng K
Year: 2010
Journal: Blood
Title: The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model.
Volume: 115
Issue: 16
Pages: 3341-5
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Publication
22614325 | J:193069
First Author: Mano H
Year: 2012
Journal: Cancer Discov
Title: ALKoma: a cancer subtype with a shared target.
Volume: 2
Issue: 6
Pages: 495-502
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Publication
26836305 | J:230716
   
First Author: Mitrea DM
Year: 2016
Journal: Elife
Title: Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA.
Volume: 5
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Publication
33523834 | J:327672
 
First Author: Gueiderikh A
Year: 2021
Journal: Sci Adv
Title: Fanconi anemia A protein participates in nucleolar homeostasis maintenance and ribosome biogenesis.
Volume: 7
Issue: 1
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Publication
39103576 | J:361543
First Author: Zhao R
Year: 2024
Journal: Nat Immunol
Title: Nucleophosmin 1 promotes mucosal immunity by supporting mitochondrial oxidative phosphorylation and ILC3 activity.
Volume: 25
Issue: 9
Pages: 1565-1579
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Protein
Q61937
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q5SQB0
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
Q5U438
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q3U536
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
Q5SQB7
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Strain
MGI:6286135 | B6.Cg-Gt(ROSA)26Sor<tm3(CAG-flpo/ERT2)Alj> Npm1<tm1Trow> Dnmt3a<tm1Trow> Tg(Mx1-cre)1Cgn
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Dnmt3a/Dnmt3a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Npm1/Npm1<+> Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Gt(ROSA)26Sor Npm1 Dnmt3a Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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Protein
Q80W85
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q9CPP0
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q3UDA7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
Q3TAH3
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q8BSZ3
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: true
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Protein
Q3UTE3
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
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Protein
Q5SQB5
Organism: Mus musculus/domesticus
Length: 285  
Fragment?: false
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Protein
A0A2I3BR42
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
Q3SXW7
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q9DAY9
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: false
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Publication
34880223 | J:318006
First Author: Sönmez A
Year: 2021
Journal: Cell Death Dis
Title: Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.
Volume: 12
Issue: 12
Pages: 1139
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Publication
35563782 | J:338852
 
First Author: Ko CF
Year: 2022
Journal: Cells
Title: The Puf-A Protein Is Required for Primordial Germ Cell Development.
Volume: 11
Issue: 9
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Publication
23327922 | J:195868
First Author: Diffner E
Year: 2013
Journal: Blood
Title: Activity of a heptad of transcription factors is associated with stem cell programs and clinical outcome in acute myeloid leukemia.
Volume: 121
Issue: 12
Pages: 2289-300
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Publication
16984370 | J:115913
First Author: Naoe T
Year: 2006
Journal: Cancer Sci
Title: Nucleophosmin: a versatile molecule associated with hematological malignancies.
Volume: 97
Issue: 10
Pages: 963-9
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Publication
16189272 | J:126614
First Author: Piva R
Year: 2006
Journal: Blood
Title: Ablation of oncogenic ALK is a viable therapeutic approach for anaplastic large-cell lymphomas.
Volume: 107
Issue: 2
Pages: 689-97
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Publication
28481984 | J:243430
First Author: Farg MA
Year: 2017
Journal: Hum Mol Genet
Title: The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.
Volume: 26
Issue: 15
Pages: 2882-2896
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Publication
28536276 | J:243198
First Author: Tripodo C
Year: 2017
Journal: Cancer Res
Title: Persistent Immune Stimulation Exacerbates Genetically Driven Myeloproliferative Disorders via Stromal Remodeling.
Volume: 77
Issue: 13
Pages: 3685-3699
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Publication
28916722 | J:248993
First Author: Shinde MY
Year: 2017
Journal: J Biol Chem
Title: Phosphoproteomics reveals that glycogen synthase kinase-3 phosphorylates multiple splicing factors and is associated with alternative splicing.
Volume: 292
Issue: 44
Pages: 18240-18255
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Publication
33782403 | J:304846
First Author: Zhu G
Year: 2021
Journal: Nat Commun
Title: HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia.
Volume: 12
Issue: 1
Pages: 1956
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Publication
34999733 | J:321220
First Author: Cho HC
Year: 2022
Journal: Oncogene
Title: Puf-A promotes cancer progression by interacting with nucleophosmin in nucleolus.
Volume: 41
Issue: 8
Pages: 1155-1165
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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