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Search results 301 to 354 out of 354 for Opa1

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0.033s

Type

Details

Score

Publication

32379273 | -

First Author:	Yu C
Year:	2020
Journal:	J Cell Biol
Title:	Structural insights into G domain dimerization and pathogenic mutation of OPA1.
Volume:	219
Issue:	7

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Publication

16778770 | -

First Author:	Ishihara N
Year:	2006
Journal:	EMBO J
Title:	Regulation of mitochondrial morphology through proteolytic cleavage of OPA1.
Volume:	25
Issue:	13
Pages:	2966-77

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Protein Domain

IPR045817 | OPA1_C

Type:

Domain

Description:

This entry represents the C-terminal domain of Dynamin-like GTPase OPA1. This protein is involved in mitochondrial fusion and inner membrane remodelling, essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission [, , ]. Mutations in human OPA1 cause optic atrophy []. This domain includes the helix bundle (HB) domains HB1 (at the extreme C-terminal) and HB2 (equivalent to bundle signaling element (BSE) and to the stalk domain of dynamin-1, respectively) that associate with the N-terminal G domain and the lipid-interacting stalk (LIS, equivalent to the PH domain of dynamin-1) [].

•

Strain

MGI:5002660 | C3.B6-Opa1<lilr3>/Mmucd

Attribute String:

congenic, mutant strain, chemically induced mutation

•

Genotype

Symbol:	Opa1/Opa1
Background:	involves: C3HeB/FeJ * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Genotype

Symbol:	Opa1/Opa1
Background:	involves: C3H/HeJ * C57BL/6J
Zygosity:	hm
Has Mutant Allele:	true

•

Gene

7466 | WFS1

Type:	gene
Organism:	human

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Publication

24719224 | J:289068

First Author:	Zhang K
Year:	2014
Journal:	EMBO Rep
Title:	Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.
Volume:	15
Issue:	5
Pages:	576-85

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Publication

25651174 | J:219782

First Author:	Song M
Year:	2015
Journal:	Cell Metab
Title:	Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart.
Volume:	21
Issue:	2
Pages:	195-205

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Publication

33592173 | J:303734

First Author:	Latorre-Muro P
Year:	2021
Journal:	Cell Metab
Title:	A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation.
Volume:	33
Issue:	3
Pages:	598-614.e7

•

Publication

35081358 | J:322572

First Author:	Zhao H
Year:	2022
Journal:	Cell Rep
Title:	Opioid receptor signaling suppresses leukemia through both catalytic and non-catalytic functions of TET2.
Volume:	38
Issue:	4
Pages:	110253

•

Publication

28228254 | J:254403

First Author:	Faccenda D
Year:	2017
Journal:	Cell Rep
Title:	Control of Mitochondrial Remodeling by the ATPase Inhibitory Factor 1 Unveils a Pro-survival Relay via OPA1.
Volume:	18
Issue:	8
Pages:	1869-1883

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Publication

24970086 | J:212078

First Author:	Boissan M
Year:	2014
Journal:	Science
Title:	Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.
Volume:	344
Issue:	6191
Pages:	1510-5

•

Publication

29545505 | J:261668

First Author:	Consolato F
Year:	2018
Journal:	J Cell Sci
Title:	m-AAA and i-AAA complexes coordinate to regulate OMA1, the stress-activated supervisor of mitochondrial dynamics.
Volume:	131
Issue:	7

•

Publication

32778760 | J:301131

First Author:	Zhou H
Year:	2020
Journal:	Nat Immunol
Title:	IL-1 induces mitochondrial translocation of IRAK2 to suppress oxidative metabolism in adipocytes.
Volume:	21
Issue:	10
Pages:	1219-1231

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Publication

32373606 | J:311088

First Author:	Yang L
Year:	2020
Journal:	Front Cell Dev Biol
Title:	OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion.
Volume:	8

Pages:	180

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Publication

21364629 | J:203398

First Author:	McKeller MR
Year:	2010
Journal:	Cell Death Dis
Title:	Vital function of PRELI and essential requirement of its LEA motif.
Volume:	1

Pages:	e21

•

Publication

26908605 | J:233022

First Author:	Yin X
Year:	2016
Journal:	Hum Mol Genet
Title:	Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Volume:	25
Issue:	9
Pages:	1739-53

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Publication

30301784 | J:267465

First Author:	Loro E
Year:	2018
Journal:	J Cell Sci
Title:	Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA.
Volume:	131
Issue:	21

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Publication

18281461 | J:131699

First Author:	Merkwirth C
Year:	2008
Journal:	Genes Dev
Title:	Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria.
Volume:	22
Issue:	4
Pages:	476-88

•

Publication

33200421 | J:347149

First Author:	Murata D
Year:	2020
Journal:	EMBO J
Title:	Mitochondrial Safeguard: a stress response that offsets extreme fusion and protects respiratory function via flickering-induced Oma1 activation.
Volume:	39
Issue:	24
Pages:	e105074

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Publication

34272364 | J:343915

First Author:	He J
Year:	2021
Journal:	Nat Commun
Title:	Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Volume:	12
Issue:	1
Pages:	4371

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Publication

32239723 | J:307491

First Author:	Cassina L
Year:	2020
Journal:	FASEB J
Title:	Increased mitochondrial fragmentation in polycystic kidney disease acts as a modifier of disease progression.
Volume:	34
Issue:	5
Pages:	6493-6507

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Publication

33631794 | J:307383

First Author:	Sato S
Year:	2021
Journal:	Hum Mol Genet
Title:	Homeostatic p62 levels and inclusion body formation in CHCHD2 knockout mice.
Volume:	30
Issue:	6
Pages:	443-453

•

Publication

20335458 | J:159219

First Author:	Misko A
Year:	2010
Journal:	J Neurosci
Title:	Mitofusin 2 is necessary for transport of axonal mitochondria and interacts with the Miro/Milton complex.
Volume:	30
Issue:	12
Pages:	4232-40

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Publication

31908024 | J:297017

First Author:	Yoo SM
Year:	2020
Journal:	FASEB J
Title:	FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions.
Volume:	34
Issue:	2
Pages:	2944-2957

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Publication

22678058 | J:185979

First Author:	Maltecca F
Year:	2012
Journal:	Hum Mol Genet
Title:	Respiratory dysfunction by AFG3L2 deficiency causes decreased mitochondrial calcium uptake via organellar network fragmentation.
Volume:	21
Issue:	17
Pages:	3858-70

•

Publication

24681487 | J:210967

First Author:	Kondadi AK
Year:	2014
Journal:	EMBO J
Title:	Loss of the m-AAA protease subunit AFG₃L₂ causes mitochondrial transport defects and tau hyperphosphorylation.
Volume:	33
Issue:	9
Pages:	1011-26

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Publication

37024121 | J:334918

First Author:	Miallot R
Year:	2023
Journal:	Life Sci Alliance
Title:	An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity.
Volume:	6
Issue:	6

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Publication

31392754 | J:283985

First Author:	Chandra R
Year:	2019
Journal:	J Neurosci Res
Title:	Differential mitochondrial morphology in ventral striatal projection neuron subtypes.
Volume:	97
Issue:	12
Pages:	1579-1589

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Publication

26177961 | J:326169

First Author:	Greene NP
Year:	2015
Journal:	Physiol Rep
Title:	Mitochondrial quality control, promoted by PGC-1α, is dysregulated by Western diet-induced obesity and partially restored by moderate physical activity in mice.
Volume:	3
Issue:	7

•

Publication

33765018 | J:304396

First Author:	Bouche L
Year:	2021
Journal:	PLoS One
Title:	DRP1 haploinsufficiency attenuates cardiac ischemia/reperfusion injuries.
Volume:	16
Issue:	3
Pages:	e0248554

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Publication

24282027 | J:204661

First Author:	Stafa K
Year:	2014
Journal:	Hum Mol Genet
Title:	Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily.
Volume:	23
Issue:	8
Pages:	2055-77

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Publication

34625584 | J:359938

First Author:	Federico M
Year:	2021
Journal:	Sci Rep
Title:	CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling.
Volume:	11
Issue:	1
Pages:	20025

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Publication

30389403 | J:277510

First Author:	Mancini C
Year:	2019
Journal:	Neurobiol Dis
Title:	Mice harbouring a SCA28 patient mutation in AFG3L2 develop late-onset ataxia associated with enhanced mitochondrial proteotoxicity.
Volume:	124

Pages:	14-28

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Publication

32338760 | J:295994

First Author:	Liu YT
Year:	2020
Journal:	Hum Mol Genet
Title:	Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.
Volume:	29
Issue:	9
Pages:	1547-1567

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Publication

16713954 | J:292519

First Author:	McQuibban GA
Year:	2006
Journal:	Curr Biol
Title:	Normal mitochondrial dynamics requires rhomboid-7 and affects Drosophila lifespan and neuronal function.
Volume:	16
Issue:	10
Pages:	982-9

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Publication

18056990 | J:131589

First Author:	Zhang D
Year:	2008
Journal:	J Biol Chem
Title:	The mitochondrial permeability transition regulates cytochrome c release for apoptosis during endoplasmic reticulum stress by remodeling the cristae junction.
Volume:	283
Issue:	6
Pages:	3476-86

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Publication

19445933 | J:150438

First Author:	Uo T
Year:	2009
Journal:	Exp Neurol
Title:	Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.
Volume:	218
Issue:	2
Pages:	274-85

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Publication

24595304 | J:212280

First Author:	Hahn WS
Year:	2014
Journal:	Am J Physiol Endocrinol Metab
Title:	Proinflammatory cytokines differentially regulate adipocyte mitochondrial metabolism, oxidative stress, and dynamics.
Volume:	306
Issue:	9
Pages:	E1033-45

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Publication

31281589 | J:291743

First Author:	Xu M
Year:	2019
Journal:	Oxid Med Cell Longev
Title:	TRPV1 and TRPA1 in Lung Inflammation and Airway Hyperresponsiveness Induced by Fine Particulate Matter (PM_2.5).
Volume:	2019

Pages:	7450151

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Publication

31150651 | J:282147

First Author:	Xu YJ
Year:	2019
Journal:	Brain Res
Title:	Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction.
Volume:	1719

Pages:	113-123

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Publication

36012573 | J:327819

First Author:	Zhang Z
Year:	2022
Journal:	Int J Mol Sci
Title:	Chrono-Aerobic Exercise Optimizes Metabolic State in DB/DB Mice through CLOCK-Mitophagy-Apoptosis.
Volume:	23
Issue:	16

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Publication

37995600 | J:343225

First Author:	Tang X
Year:	2023
Journal:	Atherosclerosis
Title:	Macrophage-specific deletion of MIC26 (APOO) mitigates advanced atherosclerosis by increasing efferocytosis.
Volume:	386

Pages:	117374

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Publication

21459773 | J:174031

First Author:	Manczak M
Year:	2011
Journal:	Hum Mol Genet
Title:	Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Volume:	20
Issue:	13
Pages:	2495-509

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Publication

36830601 | J:335694

First Author:	Fihurka O
Year:	2023
Journal:	Biomolecules
Title:	Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Volume:	13
Issue:	2

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Publication

28173111 | J:241780

First Author:	Kandimalla R
Year:	2016
Journal:	Hum Mol Genet
Title:	Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume:	25
Issue:	22
Pages:	4881-4897

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Publication

29040533 | J:256287

First Author:	Kandimalla R
Year:	2018
Journal:	Hum Mol Genet
Title:	Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Volume:	27
Issue:	1
Pages:	30-40

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Publication

23144624 | J:194110

First Author:	Merkwirth C
Year:	2012
Journal:	PLoS Genet
Title:	Loss of prohibitin membrane scaffolds impairs mitochondrial architecture and leads to tau hyperphosphorylation and neurodegeneration.
Volume:	8
Issue:	11
Pages:	e1003021

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Publication

27597528 | J:260529

First Author:	Sen NE
Year:	2016
Journal:	Neurobiol Dis
Title:	Search for SCA2 blood RNA biomarkers highlights Ataxin-2 as strong modifier of the mitochondrial factor PINK1 levels.
Volume:	96

Pages:	115-126

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Publication

30537740 | J:318535

First Author:	Feng J
Year:	2018
Journal:	Cell Physiol Biochem
Title:	Mammalian STE20-Like Kinase 1 Deletion Alleviates Renal Ischaemia-Reperfusion Injury via Modulating Mitophagy and the AMPK-YAP Signalling Pathway.
Volume:	51
Issue:	5
Pages:	2359-2376

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Publication

27677309 | J:239247

First Author:	Manczak M
Year:	2016
Journal:	Hum Mol Genet
Title:	Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume:	25
Issue:	23
Pages:	5148-5166

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Publication

33218272 | J:313636

First Author:	Choong CJ
Year:	2021
Journal:	Autophagy
Title:	Alternative mitochondrial quality control mediated by extracellular release.
Volume:	17
Issue:	10
Pages:	2962-2974

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Publication

30283778 | J:303406

First Author:	Diot A
Year:	2018
Journal:	Front Cell Dev Biol
Title:	Validating the RedMIT/GFP-LC3 Mouse Model by Studying Mitophagy in Autosomal Dominant Optic Atrophy Due to the OPA1Q285STOP Mutation.
Volume:	6

Pages:	103

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