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Search results 301 to 381 out of 381 for Pax4

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Tg(Pax4-cre,-GFP)1Pgr | MGI:4365811
Name: transgene insertion 1, Peter Gruss
Allele Type: Transgenic
Attribute String: Recombinase
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Strain
MGI:4365822 | 129-Tg(Pax4-cre,-GFP)1Pgr/Mmnc
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tg(Pax4-lacZ)2Pgr | MGI:3057320
Name: transgene insertion 2, Peter Gruss
Allele Type: Transgenic
Attribute String: Reporter
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Publication
9675102 | J:48560
First Author: Tokuyama Y
Year: 1998
Journal: Biochem Biophys Res Commun
Title: Molecular cloning of rat Pax4: identification of four isoforms in rat insulinoma cells.
Volume: 248
Issue: 1
Pages: 153-6
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Strain
MGI:3040177 | FVB-Tg(Pax4-lacZ)1Pgr/PgrIeg
Attribute String: mutant strain, transgenic
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Strain
MGI:3057321 | FVB-Tg(Pax4-lacZ)2Pgr/Ieg
Attribute String: mutant strain, transgenic, coisogenic
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Publication
16443760 | J:106430
First Author: Artner I
Year: 2006
Journal: Diabetes
Title: MafB: an activator of the glucagon gene expressed in developing islet alpha- and beta-cells.
Volume: 55
Issue: 2
Pages: 297-304
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Publication
30352876 | J:272988
First Author: Lee G
Year: 2019
Journal: Diabetes
Title: SREBP1c-PAX4 Axis Mediates Pancreatic β-Cell Compensatory Responses Upon Metabolic Stress.
Volume: 68
Issue: 1
Pages: 81-94
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Publication
26711255 | J:236207
First Author: Ripoche D
Year: 2015
Journal: Mol Cell Biol
Title: ActivinB Is Induced in Insulinoma To Promote Tumor Plasticity through a β-Cell-Induced Dedifferentiation.
Volume: 36
Issue: 5
Pages: 756-64
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Publication
16511571 | J:106988
First Author: Mellitzer G
Year: 2006
Journal: EMBO J
Title: IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.
Volume: 25
Issue: 6
Pages: 1344-52
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Publication
20040487 | J:155929
First Author: Soyer J
Year: 2010
Journal: Development
Title: Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development.
Volume: 137
Issue: 2
Pages: 203-12
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Publication
23610061 | J:208967
First Author: Mazur MA
Year: 2013
Journal: Diabetes
Title: Microphthalmia transcription factor regulates pancreatic β-cell function.
Volume: 62
Issue: 8
Pages: 2834-42
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Publication
24204325 | J:205133
First Author: Courtney M
Year: 2013
Journal: PLoS Genet
Title: The inactivation of Arx in pancreatic α-cells triggers their neogenesis and conversion into functional β-like cells.
Volume: 9
Issue: 10
Pages: e1003934
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Publication
17003335 | J:116578
First Author: Maedler K
Year: 2006
Journal: Diabetes
Title: Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets.
Volume: 55
Issue: 10
Pages: 2713-22
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Publication
7557441 | J:28816
First Author: Chalepakis G
Year: 1995
Journal: Gene
Title: Identification of DNA recognition sequences for the Pax3 paired domain.
Volume: 162
Issue: 2
Pages: 267-70
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Publication
14576336 | J:201714
First Author: Smith SB
Year: 2004
Journal: Mol Endocrinol
Title: Neurogenin3 activates the islet differentiation program while repressing its own expression.
Volume: 18
Issue: 1
Pages: 142-9
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Protein Domain
IPR001523 | Paired_dom
Type: Domain
Description: The paired domain is an approximately 126 amino acid DNA-binding domain, which is found in eukaryotic transcription regulatory proteins involved in embryogenesis. The domain was originally described as the 'paired box' in the Drosophila protein paired (prd) [, ]. The paired domain is generally located in the N-terminal part. An octapeptide []and/or a homeodomain can occur C-terminal to the paired domain, as well as a Pro-Ser-Thr-rich C terminus.Paired domain proteins can function as transcription repressors or activators. The paired domain contains three subdomains, which show functional differences in DNA-binding. The crystal structures of prd and Pax proteins show that the DNA-bound paired domain is bipartite, consisting of an N-terminal subdomain (PAI or NTD) and a C-terminal subdomain (RED or CTD), connected by a linker. PAI and RED each form a three-helical fold, with the most C-terminal helices comprising a helix-turn-helix (HTH) motif that binds the DNA major groove. In addition, the PAI subdomain encompasses an N-terminal β-turn andβ-hairpin, also named 'wing', participating in DNA-binding. The linker canbind into the DNA minor groove. Different Pax proteins and their alternativelyspliced isoforms use different (sub)domains for DNA-binding to mediate thespecificity of sequence recognition [, ].Some proteins known to contain a paired domain:Drosophila paired (prd), a segmentation pair-rule class protein.Drosophila gooseberry proximal (gsb-p) and gooseberry distal (gsb-d),segmentation polarity class proteins.Drosophila Pox-meso and Pox-neuro proteins.The Pax proteins:Mammalian protein Pax1, which may play a role in the formation of segmented structures in the embryo. In mouse, mutations in Pax1 produce the undulated phenotype, characterised by vertebral malformations along the entire rostro-caudal axis.Mammalian protein Pax2, a probable transcription factor that may have arole in kidney cell differentiation.Mammalian protein Pax3. Pax3 is expressed during early neurogenesis. In humans, defects in Pax3 are the cause of Waardenburg's syndrome (WS), anautosomal dominant combination of deafness and pigmentary disturbance.Mammalian protein Pax4 pays an important role in the differentiation and development of pancreatic islet beta cells. It binds to a common element in the glucagon, insulin and somatostatin promoters. In humans, it has been related to the rare, familial, clinically and genetically heterogeneous form of diabetes MODY (maturity-onset diabetes of the young).Mammalian protein Pax5, also known as B-cell specific transcription factor(BSAP). Pax5 is involved in the regulation of the CD19 gene. It plays animportant role in B-cell differentiation as well as neural development andspermatogenesis.Mammalian protein Pax6 (oculorhombin). Pax6 is a transcription factor withimportant functions in eye and nasal development. In Man, defects in Pax6are the cause of aniridia type II (AN2), an autosomal dominant disordercharacterised by complete or partial absence of the iris.Mammalian protein Pax7 is involved in the regulation of muscle stem cells proliferation, playing a role in myogenesis and muscle regeneration.Mammalian protein Pax8, required in thyroid development.Mammalian protein Pax9, required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. In man, defects in Pax9 cause oligodontia.Zebrafish protein Paired box protein Pax-2a, involved in the development of the midbrain/hindbrain boundary organizer and specification of neuronal cell fates.Xenopus laevis protein Paired box protein Pax-3-A, which promotes both hatching gland and neural crest cell fates, two of the cell populations that arise from the neural plate border.
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Publication
10811620 | -
First Author: Eberhard D
Year: 2000
Journal: EMBO J
Title: Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family.
Volume: 19
Issue: 10
Pages: 2292-303
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Protein
Q8VDB6
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
A2A409
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: true
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Protein
G3UY80
Organism: Mus musculus/domesticus
Length: 273  
Fragment?: true
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Protein
Q8VHH9
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: false
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Protein
Q8VBY9
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: false
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Protein
G3UYK4
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: true
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Protein
Q8VDB4
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
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Protein
Q8VBZ1
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
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Publication
2877747 | -
First Author: Bopp D
Year: 1986
Journal: Cell
Title: Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila.
Volume: 47
Issue: 6
Pages: 1033-40
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Publication
3123319 | -
First Author: Baumgartner S
Year: 1987
Journal: Genes Dev
Title: Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.
Volume: 1
Issue: 10
Pages: 1247-67
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Publication
11103953 | -
First Author: Underhill DA
Year: 2000
Journal: Biochem Cell Biol
Title: Genetic and biochemical diversity in the Pax gene family.
Volume: 78
Issue: 5
Pages: 629-38
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Publication
15148315 | -
First Author: Apuzzo S
Year: 2004
Journal: J Biol Chem
Title: Cross-talk between the paired domain and the homeodomain of Pax3: DNA binding by each domain causes a structural change in the other domain, supporting interdependence for DNA Binding.
Volume: 279
Issue: 32
Pages: 33601-12
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Protein
P09084
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: false
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Protein
Q02650
Organism: Mus musculus/domesticus
Length: 391  
Fragment?: false
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Protein
P32114
Organism: Mus musculus/domesticus
Length: 414  
Fragment?: false
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Protein
Q00288
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
P47242
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
G3UZ86
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
Q548R5
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
Q8K4Q1
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
A2AIU8
Organism: Mus musculus/domesticus
Length: 169  
Fragment?: true
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Protein
Q8BS81
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
G3X8Q7
Organism: Mus musculus/domesticus
Length: 416  
Fragment?: false
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Protein
G3UXF6
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
Q8K4Q2
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
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Protein
A2AIU7
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: true
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Protein
G3UW65
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
G3UZ49
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
Q8CIP2
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: true
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Protein
A2AKM6
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: false
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Protein
A0A087WST9
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: true
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Protein
G3UX39
Organism: Mus musculus/domesticus
Length: 319  
Fragment?: false
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Protein
A2ALK0
Organism: Mus musculus/domesticus
Length: 384  
Fragment?: true
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Protein
A2AKM7
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
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Protein
A2AIU6
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
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Protein
Q8VHP0
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: true
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Protein
G3UZ20
Organism: Mus musculus/domesticus
Length: 303  
Fragment?: true
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Protein
G3UZ71
Organism: Mus musculus/domesticus
Length: 288  
Fragment?: false
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Protein
Q3UZ60
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
I6YXB9
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
A2AKM5
Organism: Mus musculus/domesticus
Length: 357  
Fragment?: false
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Protein
A2AKM8
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
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Protein
V9GXS5
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
G3V008
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
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Protein
Q8VDB7
Organism: Mus musculus/domesticus
Length: 292  
Fragment?: false
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Protein
A0A0R4J267
Organism: Mus musculus/domesticus
Length: 394  
Fragment?: false
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Protein
Q3V1K1
Organism: Mus musculus/domesticus
Length: 342  
Fragment?: false
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Protein
P47239
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
P32115
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
P24610
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
P63015
Organism: Mus musculus/domesticus
Length: 422  
Fragment?: false
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Protein
Q8VDB3
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9CZK7
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q3UGH9
Organism: Mus musculus/domesticus
Length: 479  
Fragment?: false
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Protein
Q8VHL9
Organism: Mus musculus/domesticus
Length: 352  
Fragment?: true
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Protein
G3UX36
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: false
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Protein
G3UZE8
Organism: Mus musculus/domesticus
Length: 307  
Fragment?: false
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Protein
A2RRY5
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q3TZM4
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Protein
Q8BRF1
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: false
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Publication
- | J:94077
     
First Author: Mutant Mouse Regional Resource Centers
Year: 2004
Journal: Unpublished
Title: Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC)
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom