Type |
Details |
Score |
GXD Expression |
Probe: |
MGI:7380625 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616415 |
Pattern: |
Widespread |
Stage: |
TS15 |
Assay Id: |
MGI:7380671 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression throughout neural tube. |
Specimen Label: |
S2A Pax6 bromi |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7380625 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-09 |
Strength: |
Absent |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616415 |
|
Stage: |
TS15 |
Assay Id: |
MGI:7380671 |
Age: |
embryonic day 9.5 |
|
|
Specimen Label: |
S2A Pax6 Prch1 |
Detected: |
false |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7380625 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-11-09 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616415 |
Pattern: |
Widespread |
Stage: |
TS15 |
Assay Id: |
MGI:7380671 |
Age: |
embryonic day 9.5 |
|
Note: |
Expression throughout neural tube. Dorsal border of expression expanded dorsally compared to wild type. |
Specimen Label: |
S2A Pax6 bromi,Ptch1 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2157328 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-02-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616417 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7579286 |
Age: |
embryonic day 10.5 |
|
Note: |
Expression used as dorsal marker. |
Specimen Label: |
2B Pax6 WT |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:2157328 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-02-02 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1616417 |
Pattern: |
Regionally restricted |
Stage: |
TS17 |
Assay Id: |
MGI:7579286 |
Age: |
embryonic day 10.5 |
|
Note: |
Authors report normal pattern of expression compared to wild type. |
Specimen Label: |
2B Pax6 Rab34-/- |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1928078 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754722 |
Pattern: |
Not Specified |
Stage: |
TS22 |
Assay Id: |
MGI:7520521 |
Age: |
embryonic day 14.5 |
|
|
Specimen Label: |
S2G Pax6 Control |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1928078 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754721 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:7520521 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
S2H Pax6 Control |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:1928078 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2023-08-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1754721 |
Pattern: |
Regionally restricted |
Stage: |
TS21 |
Assay Id: |
MGI:7520521 |
Age: |
embryonic day 13.5 |
|
Note: |
Neocortical layers not completely disrupted - largely preserved at E13.5 |
Specimen Label: |
S2H Pax6 DKO |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
van Raamsdonk CD |
Year: |
2000 |
Journal: |
Development |
Title: |
Dosage requirement and allelic expression of PAX6 during lens placode formation. |
Volume: |
127 |
Issue: |
24 |
Pages: |
5439-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Makarenkova HP |
Year: |
2000 |
Journal: |
Development |
Title: |
FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. |
Volume: |
127 |
Issue: |
12 |
Pages: |
2563-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ericson J |
Year: |
1997 |
Journal: |
Cell |
Title: |
Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling. |
Volume: |
90 |
Issue: |
1 |
Pages: |
169-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Talamillo A |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
Pax6 regulates regional development and neuronal migration in the cerebral cortex. |
Volume: |
255 |
Issue: |
1 |
Pages: |
151-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piñon MC |
Year: |
2008 |
Journal: |
J Neurosci |
Title: |
Altered molecular regionalization and normal thalamocortical connections in cortex-specific Pax6 knock-out mice. |
Volume: |
28 |
Issue: |
35 |
Pages: |
8724-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu T |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e46934 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carney RS |
Year: |
2009 |
Journal: |
Cereb Cortex |
Title: |
Differential regulation of telencephalic pallial-subpallial boundary patterning by Pax6 and Gsh2. |
Volume: |
19 |
Issue: |
4 |
Pages: |
745-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ninkovic J |
Year: |
2010 |
Journal: |
Neuron |
Title: |
The transcription factor Pax6 regulates survival of dopaminergic olfactory bulb neurons via crystallin αA. |
Volume: |
68 |
Issue: |
4 |
Pages: |
682-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yamashita W |
Year: |
2018 |
Journal: |
Development |
Title: |
Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain. |
Volume: |
145 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ahmad Z |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Pax6 Inactivation in the Adult Pancreas Reveals Ghrelin as Endocrine Cell Maturation Marker. |
Volume: |
10 |
Issue: |
12 |
Pages: |
e0144597 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim CH |
Year: |
2012 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Transcriptional activity of paired homeobox Pax6 is enhanced by histone acetyltransferase Tip60 during mouse retina development. |
Volume: |
424 |
Issue: |
3 |
Pages: |
427-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goudreau G |
Year: |
2002 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype. |
Volume: |
99 |
Issue: |
13 |
Pages: |
8719-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dorà NJ |
Year: |
2016 |
Journal: |
Transgenic Res |
Title: |
Analysis of compound heterozygotes reveals that the mouse floxed Pax6 (tm1Ued) allele produces abnormal eye phenotypes. |
Volume: |
25 |
Issue: |
5 |
Pages: |
679-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gosmain Y |
Year: |
2010 |
Journal: |
J Biol Chem |
Title: |
Pax6 controls the expression of critical genes involved in pancreatic {alpha} cell differentiation and function. |
Volume: |
285 |
Issue: |
43 |
Pages: |
33381-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ranaei Pirmardan E |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina. |
Volume: |
8 |
Issue: |
1 |
Pages: |
17700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fang J |
Year: |
2014 |
Journal: |
Stem Cells Dev |
Title: |
PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation. |
Volume: |
23 |
Issue: |
19 |
Pages: |
2297-310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pinson J |
Year: |
2005 |
Journal: |
BMC Dev Biol |
Title: |
Regulation of the Pax6 : Pax6(5a) mRNA ratio in the developing mammalian brain. |
Volume: |
5 |
|
Pages: |
13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suzuki J |
Year: |
2015 |
Journal: |
Stem Cells Dev |
Title: |
Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury. |
Volume: |
24 |
Issue: |
16 |
Pages: |
1923-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yun K |
Year: |
2001 |
Journal: |
Development |
Title: |
Gsh2 and Pax6 play complementary roles in dorsoventral patterning of the mammalian telencephalon. |
Volume: |
128 |
Issue: |
2 |
Pages: |
193-205 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dimanlig PV |
Year: |
2001 |
Journal: |
Development |
Title: |
The upstream ectoderm enhancer in Pax6 has an important role in lens induction. |
Volume: |
128 |
Issue: |
22 |
Pages: |
4415-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuoc TC |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice. |
Volume: |
29 |
Issue: |
26 |
Pages: |
8335-49 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kinare V |
Year: |
2018 |
Journal: |
J Biosci |
Title: |
PAX6 can substitute for LHX2 and override NFIA-induced astrogliogenesis in developing hippocampus in vivo. |
Volume: |
43 |
Issue: |
1 |
Pages: |
75-83 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
64
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
McBride DJ |
Year: |
2011 |
Journal: |
PLoS One |
Title: |
DNaseI hypersensitivity and ultraconservation reveal novel, interdependent long-range enhancers at the complex Pax6 cis-regulatory region. |
Volume: |
6 |
Issue: |
12 |
Pages: |
e28616 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yoshizaki K |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders. |
Volume: |
11 |
Issue: |
11 |
Pages: |
e0166665 |
|
•
•
•
•
•
|
Publication |
First Author: |
Boretius S |
Year: |
2009 |
Journal: |
Cereb Cortex |
Title: |
In vivo MRI of altered brain anatomy and fiber connectivity in adult pax6 deficient mice. |
Volume: |
19 |
Issue: |
12 |
Pages: |
2838-47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chauhan BK |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Identification of genes downstream of Pax6 in the mouse lens using cDNA microarrays. |
Volume: |
277 |
Issue: |
13 |
Pages: |
11539-48 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huettl RE |
Year: |
2016 |
Journal: |
Dev Biol |
Title: |
Functional dissection of the Pax6 paired domain: Roles in neural tube patterning and peripheral nervous system development. |
Volume: |
413 |
Issue: |
1 |
Pages: |
86-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang P |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Kruppel-Like Factor 4 Regulates Granule Cell Pax6 Expression and Cell Proliferation in Early Cerebellar Development. |
Volume: |
10 |
Issue: |
7 |
Pages: |
e0134390 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swisa A |
Year: |
2017 |
Journal: |
J Clin Invest |
Title: |
PAX6 maintains β cell identity by repressing genes of alternative islet cell types. |
Volume: |
127 |
Issue: |
1 |
Pages: |
230-243 |
|
•
•
•
•
•
|
Publication |
First Author: |
Swanson DJ |
Year: |
2005 |
Journal: |
Brain Res Dev Brain Res |
Title: |
Disruption of cerebellar granule cell development in the Pax6 mutant, Sey mouse. |
Volume: |
160 |
Issue: |
2 |
Pages: |
176-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nural HF |
Year: |
2004 |
Journal: |
J Comp Neurol |
Title: |
Pax6 guides a relay of pioneer longitudinal axons in the embryonic mouse forebrain. |
Volume: |
479 |
Issue: |
4 |
Pages: |
399-409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Favor J |
Year: |
2008 |
Journal: |
Genetics |
Title: |
Relationship of Pax6 activity levels to the extent of eye development in the mouse, Mus musculus. |
Volume: |
179 |
Issue: |
3 |
Pages: |
1345-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lalitha S |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis. |
Volume: |
10 |
Issue: |
1 |
Pages: |
16075 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dorà NJ |
Year: |
2018 |
Journal: |
BMC Res Notes |
Title: |
A conditional Pax6 depletion study with no morphological effect on the adult mouse corneal epithelium. |
Volume: |
11 |
Issue: |
1 |
Pages: |
705 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li S |
Year: |
2007 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras. |
Volume: |
48 |
Issue: |
7 |
Pages: |
3292-300 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nolte C |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis. |
Volume: |
299 |
Issue: |
2 |
Pages: |
582-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chanas SA |
Year: |
2009 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Effects of elevated Pax6 expression and genetic background on mouse eye development. |
Volume: |
50 |
Issue: |
9 |
Pages: |
4045-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Favor J |
Year: |
2009 |
Journal: |
Genetics |
Title: |
Analysis of Pax6 contiguous gene deletions in the mouse, Mus musculus, identifies regions distinct from Pax6 responsible for extreme small-eye and belly-spotting phenotypes. |
Volume: |
182 |
Issue: |
4 |
Pages: |
1077-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tétreault N |
Year: |
2009 |
Journal: |
Dev Biol |
Title: |
The LIM homeobox transcription factor Lhx2 is required to specify the retina field and synergistically cooperates with Pax6 for Six6 trans-activation. |
Volume: |
327 |
Issue: |
2 |
Pages: |
541-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Collinson JM |
Year: |
2003 |
Journal: |
Dev Biol |
Title: |
The roles of Pax6 in the cornea, retina, and olfactory epithelium of the developing mouse embryo. |
Volume: |
255 |
Issue: |
2 |
Pages: |
303-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim J |
Year: |
2008 |
Journal: |
Dev Biol |
Title: |
Overexpression of pairedless Pax6 in the retina disrupts corneal development and affects lens cell survival. |
Volume: |
313 |
Issue: |
1 |
Pages: |
434-54 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chapouton P |
Year: |
1999 |
Journal: |
Development |
Title: |
The role of Pax6 in restricting cell migration between developing cortex and basal ganglia. |
Volume: |
126 |
Issue: |
24 |
Pages: |
5569-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Packard AI |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Sox2 and Pax6 Play Counteracting Roles in Regulating Neurogenesis within the Murine Olfactory Epithelium. |
Volume: |
11 |
Issue: |
5 |
Pages: |
e0155167 |
|
•
•
•
•
•
|
Publication |
First Author: |
Genethliou N |
Year: |
2009 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Spatially distinct functions of PAX6 and NKX2.2 during gliogenesis in the ventral spinal cord. |
Volume: |
382 |
Issue: |
1 |
Pages: |
69-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holm PC |
Year: |
2007 |
Journal: |
Mol Cell Neurosci |
Title: |
Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon. |
Volume: |
34 |
Issue: |
1 |
Pages: |
99-119 |
|
•
•
•
•
•
|
Publication |
First Author: |
Raviv S |
Year: |
2014 |
Journal: |
PLoS Genet |
Title: |
PAX6 regulates melanogenesis in the retinal pigmented epithelium through feed-forward regulatory interactions with MITF. |
Volume: |
10 |
Issue: |
5 |
Pages: |
e1004360 |
|
•
•
•
•
•
|
Publication |
First Author: |
Philips GT |
Year: |
2005 |
Journal: |
Dev Biol |
Title: |
Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type. |
Volume: |
279 |
Issue: |
2 |
Pages: |
308-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Huang YT |
Year: |
2017 |
Journal: |
BMC Neurosci |
Title: |
Lateral cortical Cdca7 expression levels are regulated by Pax6 and influence the production of intermediate progenitors. |
Volume: |
18 |
Issue: |
1 |
Pages: |
47 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quintana-Urzainqui I |
Year: |
2018 |
Journal: |
iScience |
Title: |
Tissue-Specific Actions of Pax6 on Proliferation and Differentiation Balance in Developing Forebrain Are Foxg1 Dependent. |
Volume: |
10 |
|
Pages: |
171-191 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sheng J |
Year: |
2021 |
Journal: |
Theranostics |
Title: |
Smad3 deficiency promotes beta cell proliferation and function in db/db mice via restoring Pax6 expression. |
Volume: |
11 |
Issue: |
6 |
Pages: |
2845-2859 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tomas-Roca L |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model. |
Volume: |
13 |
Issue: |
1 |
Pages: |
6836 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jordan T |
Year: |
1992 |
Journal: |
Nat Genet |
Title: |
The human PAX6 gene is mutated in two patients with aniridia. |
Volume: |
1 |
Issue: |
5 |
Pages: |
328-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stoykova A |
Year: |
2003 |
Journal: |
Cereb Cortex |
Title: |
Increase in reelin-positive cells in the marginal zone of Pax6 mutant mouse cortex. |
Volume: |
13 |
Issue: |
6 |
Pages: |
560-71 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7367225 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-10-26 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:7367247 |
Age: |
embryonic day 15.5 |
Image: |
4L Pax6 Het |
Note: |
Number of expressing beta cells reduced by 22% compared to wild type. |
Specimen Label: |
4L Pax6 Het |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7367225 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-10-26 |
Strength: |
Weak |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:7367279 |
Age: |
embryonic day 15.5 |
Image: |
4L Pax6 Het |
Note: |
Number of expressing beta cells reduced by 22% compared to wild type. |
Specimen Label: |
4L Pax6 Het |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7367225 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:7367279 |
Age: |
embryonic day 15.5 |
Image: |
4L Pax6 WT |
|
Specimen Label: |
4L Pax6 WT |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7367225 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2022-10-26 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1750323 |
Pattern: |
Not Specified |
Stage: |
TS23 |
Assay Id: |
MGI:7367247 |
Age: |
embryonic day 15.5 |
Image: |
4L Pax6 WT |
|
Specimen Label: |
4L Pax6 WT |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7764088 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-10-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3791727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7764106 |
Age: |
postnatal day 0 |
Image: |
2F +/+ Pax6 |
|
Specimen Label: |
2F +/+ Pax6 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:7764088 |
Assay Type: |
Immunohistochemistry |
Annotation Date: |
2024-10-29 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:3791727 |
Pattern: |
Not Specified |
Stage: |
TS27 |
Assay Id: |
MGI:7764106 |
Age: |
postnatal day 0 |
Image: |
2F -/- Pax6 |
Note: |
Neuronal populations were visibly reduced. |
Specimen Label: |
2F -/- Pax6 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blizzard LE |
Year: |
2021 |
Journal: |
J Dev Biol |
Title: |
A Novel Mutation in Cse1l Disrupts Brain and Eye Development with Specific Effects on Pax6 Expression. |
Volume: |
9 |
Issue: |
3 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Muzio L |
Year: |
2003 |
Journal: |
Cereb Cortex |
Title: |
Emx1, emx2 and pax6 in specification, regionalization and arealization of the cerebral cortex. |
Volume: |
13 |
Issue: |
6 |
Pages: |
641-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen YT |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease. |
Volume: |
8 |
Issue: |
10 |
Pages: |
e77286 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun J |
Year: |
2015 |
Journal: |
Nucleic Acids Res |
Title: |
Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during forebrain and lens development. |
Volume: |
43 |
Issue: |
14 |
Pages: |
6827-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heller RS |
Year: |
2004 |
Journal: |
Dev Biol |
Title: |
The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. |
Volume: |
268 |
Issue: |
1 |
Pages: |
123-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Toresson H |
Year: |
2000 |
Journal: |
Development |
Title: |
Genetic control of dorsal-ventral identity in the telencephalon: opposing roles for Pax6 and Gsh2. |
Volume: |
127 |
Issue: |
20 |
Pages: |
4361-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fujimura N |
Year: |
2015 |
Journal: |
Dev Genes Evol |
Title: |
Genetic interaction between Pax6 and β-catenin in the developing retinal pigment epithelium. |
Volume: |
225 |
Issue: |
2 |
Pages: |
121-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Duan D |
Year: |
2013 |
Journal: |
Brain Struct Funct |
Title: |
Spatiotemporal expression patterns of Pax6 in the brain of embryonic, newborn, and adult mice. |
Volume: |
218 |
Issue: |
2 |
Pages: |
353-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stenman J |
Year: |
2003 |
Journal: |
Development |
Title: |
Tlx and Pax6 co-operate genetically to establish the pallio-subpallial boundary in the embryonic mouse telencephalon. |
Volume: |
130 |
Issue: |
6 |
Pages: |
1113-22 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fuccillo M |
Year: |
2006 |
Journal: |
Cereb Cortex |
Title: |
Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice. |
Volume: |
16 Suppl 1 |
|
Pages: |
i96-102 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gan Q |
Year: |
2014 |
Journal: |
Stem Cells |
Title: |
Pax6 mediates ß-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. |
Volume: |
32 |
Issue: |
1 |
Pages: |
45-58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gómez-López S |
Year: |
2011 |
Journal: |
Glia |
Title: |
Sox2 and Pax6 maintain the proliferative and developmental potential of gliogenic neural stem cells In vitro. |
Volume: |
59 |
Issue: |
11 |
Pages: |
1588-99 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kanakubo S |
Year: |
2006 |
Journal: |
Genes Cells |
Title: |
Abnormal migration and distribution of neural crest cells in Pax6 heterozygous mutant eye, a model for human eye diseases. |
Volume: |
11 |
Issue: |
8 |
Pages: |
919-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Remez LA |
Year: |
2017 |
Journal: |
Dev Biol |
Title: |
Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis. |
Volume: |
432 |
Issue: |
1 |
Pages: |
140-150 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davis J |
Year: |
2011 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Overexpression of Pax6 in mouse cornea directly alters corneal epithelial cells: changes in immune function, vascularization, and differentiation. |
Volume: |
52 |
Issue: |
7 |
Pages: |
4158-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Azuma N |
Year: |
2005 |
Journal: |
Hum Mol Genet |
Title: |
Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. |
Volume: |
14 |
Issue: |
8 |
Pages: |
1059-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Parish EV |
Year: |
2016 |
Journal: |
BMC Neurosci |
Title: |
Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo. |
Volume: |
17 |
Issue: |
1 |
Pages: |
76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aryal S |
Year: |
2020 |
Journal: |
Hum Genet |
Title: |
The cataract-linked RNA-binding protein Celf1 post-transcriptionally controls the spatiotemporal expression of the key homeodomain transcription factors Pax6 and Prox1 in lens development. |
Volume: |
139 |
Issue: |
12 |
Pages: |
1541-1554 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manuel M |
Year: |
2022 |
Journal: |
PLoS Biol |
Title: |
Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. |
Volume: |
20 |
Issue: |
9 |
Pages: |
e3001563 |
|
•
•
•
•
•
|
Publication |
First Author: |
Compagnucci C |
Year: |
2011 |
Journal: |
Genesis |
Title: |
Pax6 regulates craniofacial form through its control of an essential cephalic ectodermal patterning center. |
Volume: |
49 |
Issue: |
4 |
Pages: |
307-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shi F |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
The expression of Pax6 variants is subject to posttranscriptional regulation in the developing mouse eyelid. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e53919 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xie Q |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Pax6 interactions with chromatin and identification of its novel direct target genes in lens and forebrain. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e54507 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pratt T |
Year: |
2000 |
Journal: |
Development |
Title: |
A role for Pax6 in the normal development of dorsal thalamus and its cortical connections. |
Volume: |
127 |
Issue: |
23 |
Pages: |
5167-78 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim J |
Year: |
2006 |
Journal: |
Dev Biol |
Title: |
Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. |
Volume: |
292 |
Issue: |
2 |
Pages: |
486-505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kucerova R |
Year: |
2012 |
Journal: |
Mol Vis |
Title: |
Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium. |
Volume: |
18 |
|
Pages: |
139-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cohen-Tayar Y |
Year: |
2018 |
Journal: |
Development |
Title: |
Pax6 regulation of Sox9 in the mouse retinal pigmented epithelium controls its timely differentiation and choroid vasculature development. |
Volume: |
145 |
Issue: |
15 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Collinson JM |
Year: |
2000 |
Journal: |
Development |
Title: |
Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye. |
Volume: |
127 |
Issue: |
5 |
Pages: |
945-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kroeber M |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
Reduced expression of Pax6 in lens and cornea of mutant mice leads to failure of chamber angle development and juvenile glaucoma. |
Volume: |
19 |
Issue: |
17 |
Pages: |
3332-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burrill JD |
Year: |
1997 |
Journal: |
Development |
Title: |
PAX2 is expressed in multiple spinal cord interneurons, including a population of EN1+ interneurons that require PAX6 for their development. |
Volume: |
124 |
Issue: |
22 |
Pages: |
4493-503 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sander M |
Year: |
1997 |
Journal: |
Genes Dev |
Title: |
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. |
Volume: |
11 |
Issue: |
13 |
Pages: |
1662-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dames P |
Year: |
2010 |
Journal: |
BMC Dev Biol |
Title: |
Relative roles of the different Pax6 domains for pancreatic alpha cell development. |
Volume: |
10 |
|
Pages: |
39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mirasierra M |
Year: |
2016 |
Journal: |
Diabetologia |
Title: |
Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells. |
Volume: |
59 |
Issue: |
4 |
Pages: |
766-75 |
|
•
•
•
•
•
|