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Search results 301 to 400 out of 408 for Pcp2

0.03s
Type Details Score
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Pcp2-cre)3555Jdhu/?
Background: involves: 129S4/SvJaeSor * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Klement IA
Year: 1998
Journal: Cell
Title: Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice.
Volume: 95
Issue: 1
Pages: 41-53
Publication  
First Author: Raike RS
Year: 2013
Journal: Neurobiol Dis
Title: Limited regional cerebellar dysfunction induces focal dystonia in mice.
Volume: 49
Pages: 200-10
Publication
First Author: Serra HG
Year: 2006
Journal: Cell
Title: RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
Volume: 127
Issue: 4
Pages: 697-708
Publication
First Author: Chung C
Year: 2016
Journal: PLoS Genet
Title: Heat Shock Protein Beta-1 Modifies Anterior to Posterior Purkinje Cell Vulnerability in a Mouse Model of Niemann-Pick Type C Disease.
Volume: 12
Issue: 5
Pages: e1006042
Publication
First Author: Marino S
Year: 2003
Journal: Development
Title: Rb and p107 are required for normal cerebellar development and granule cell survival but not for Purkinje cell persistence.
Volume: 130
Issue: 15
Pages: 3359-68
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: transgenic, targeted mutation, mutant stock
Publication
First Author: Urbanus BHA
Year: 2020
Journal: Sci Rep
Title: Region-specific Foxp2 deletions in cortex, striatum or cerebellum cannot explain vocalization deficits observed in spontaneous global knockouts.
Volume: 10
Issue: 1
Pages: 21631
Publication
First Author: Ferro A
Year: 2018
Journal: PLoS One
Title: Inhibition of NF-κB signaling in IKKβF/F;LysM Cre mice causes motor deficits but does not alter pathogenesis of Spinocerebellar ataxia type 1.
Volume: 13
Issue: 7
Pages: e0200013
Publication  
First Author: Peperstraete K
Year: 2023
Journal: Exp Eye Res
Title: Unexpected failure of rod bipolar cell targeting using L7Cre-2 mice.
Volume: 228
Pages: 109406
Publication
First Author: Wulff P
Year: 2007
Journal: Nat Neurosci
Title: From synapse to behavior: rapid modulation of defined neuronal types with engineered GABAA receptors.
Volume: 10
Issue: 7
Pages: 923-9
Publication    
First Author: Wu B
Year: 2019
Journal: Elife
Title: TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells.
Volume: 8
Publication  
First Author: Jaarsma D
Year: 2024
Journal: Neurobiol Dis
Title: Different Purkinje cell pathologies cause specific patterns of progressive gait ataxia in mice.
Volume: 192
Pages: 106422
Publication  
First Author: Wu B
Year: 2024
Journal: J Neurosci
Title: PP2B-Dependent Cerebellar Plasticity Sets the Amplitude of the Vestibulo-ocular Reflex during Juvenile Development.
Volume: 44
Issue: 17
Publication  
First Author: Hayashi Y
Year: 2014
Journal: Mol Brain
Title: Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus.
Volume: 7
Pages: 44
Publication
First Author: Vig PJ
Year: 2014
Journal: Cerebellum
Title: Knockdown of acid-sensing ion channel 1a (ASIC1a) suppresses disease phenotype in SCA1 mouse model.
Volume: 13
Issue: 4
Pages: 479-90
Publication
First Author: Wozniak EAL
Year: 2021
Journal: Cell Rep
Title: Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice.
Volume: 37
Issue: 2
Pages: 109831
Publication
First Author: Brown AS
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.
Volume: 115
Issue: 52
Pages: E12407-E12416
Publication
First Author: Skinner PJ
Year: 1997
Journal: Nature
Title: Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures.
Volume: 389
Issue: 6654
Pages: 971-4
Publication
First Author: Orr HT
Year: 2000
Journal: Neurobiol Dis
Title: The ins and outs of a polyglutamine neurodegenerative disease: spinocerebellar ataxia type 1 (SCA1).
Volume: 7
Issue: 3
Pages: 129-34
Publication
First Author: Barnes JA
Year: 2011
Journal: J Neurosci
Title: Abnormalities in the climbing fiber-Purkinje cell circuitry contribute to neuronal dysfunction in ATXN1[82Q] mice.
Volume: 31
Issue: 36
Pages: 12778-89
Publication
First Author: Sánchez I
Year: 2013
Journal: Hum Mol Genet
Title: A novel function of Ataxin-1 in the modulation of PP2A activity is dysregulated in the spinocerebellar ataxia type 1.
Volume: 22
Issue: 17
Pages: 3425-37
Publication
First Author: Edamakanti CR
Year: 2018
Journal: J Clin Invest
Title: Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1.
Volume: 128
Issue: 6
Pages: 2252-2265
Publication
First Author: Bosch MK
Year: 2014
Journal: PLoS One
Title: Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo.
Volume: 9
Issue: 8
Pages: e104062
Publication  
First Author: Friedrich B
Year: 2012
Journal: Brain Res
Title: Comparative analyses of Purkinje cell gene expression profiles reveal shared molecular abnormalities in models of different polyglutamine diseases.
Volume: 1481
Pages: 37-48
Publication
First Author: Cvetanovic M
Year: 2011
Journal: Nat Med
Title: Vascular endothelial growth factor ameliorates the ataxic phenotype in a mouse model of spinocerebellar ataxia type 1.
Volume: 17
Issue: 11
Pages: 1445-7
Publication    
First Author: Driessen TM
Year: 2018
Journal: Elife
Title: Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1.
Volume: 7
Publication
First Author: Tejwani L
Year: 2024
Journal: Neuron
Title: Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1.
Volume: 112
Issue: 3
Pages: 362-383.e15
Publication
First Author: Morrison LM
Year: 2024
Journal: Hum Mol Genet
Title: Increased intrinsic membrane excitability is associated with olivary hypertrophy in spinocerebellar ataxia type 1.
Volume: 33
Issue: 24
Pages: 2159-2176
Publication
First Author: Kim JH
Year: 2018
Journal: Glia
Title: Astroglia contribute to the pathogenesis of spinocerebellar ataxia Type 1 (SCA1) in a biphasic, stage-of-disease specific manner.
Volume: 66
Issue: 9
Pages: 1972-1987
Publication
First Author: Burright EN
Year: 1995
Journal: Cell
Title: SCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.
Volume: 82
Issue: 6
Pages: 937-48
Publication
First Author: Tsirigotis M
Year: 2006
Journal: Neuropathol Appl Neurobiol
Title: Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin.
Volume: 32
Issue: 1
Pages: 26-39
Publication
First Author: Dell'Orco JM
Year: 2015
Journal: J Neurosci
Title: Neuronal Atrophy Early in Degenerative Ataxia Is a Compensatory Mechanism to Regulate Membrane Excitability.
Volume: 35
Issue: 32
Pages: 11292-307
Publication
First Author: Clark HB
Year: 1997
Journal: J Neurosci
Title: Purkinje cell expression of a mutant allele of SCA1 in transgenic mice leads to disparate effects on motor behaviors, followed by a progressive cerebellar dysfunction and histological alterations.
Volume: 17
Issue: 19
Pages: 7385-95
Publication
First Author: Oz G
Year: 2010
Journal: J Neurosci
Title: Noninvasive detection of presymptomatic and progressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
Volume: 30
Issue: 10
Pages: 3831-8
Publication
First Author: Hourez R
Year: 2011
Journal: J Neurosci
Title: Aminopyridines correct early dysfunction and delay neurodegeneration in a mouse model of spinocerebellar ataxia type 1.
Volume: 31
Issue: 33
Pages: 11795-807
Publication
First Author: Chopra R
Year: 2018
Journal: Hum Mol Genet
Title: Protein kinase C activity is a protective modifier of Purkinje neuron degeneration in cerebellar ataxia.
Volume: 27
Issue: 8
Pages: 1396-1410
Publication
First Author: Zhang S
Year: 2020
Journal: Nat Commun
Title: The ataxin-1 interactome reveals direct connection with multiple disrupted nuclear transport pathways.
Volume: 11
Issue: 1
Pages: 3343
Publication
First Author: French CA
Year: 2019
Journal: Mol Psychiatry
Title: Differential effects of Foxp2 disruption in distinct motor circuits.
Volume: 24
Issue: 3
Pages: 447-462
Publication    
First Author: Gaffield MA
Year: 2022
Journal: Elife
Title: Cerebellum encodes and influences the initiation, performance, and termination of discontinuous movements in mice.
Volume: 11
Publication
First Author: Han KS
Year: 2020
Journal: Nat Neurosci
Title: Climbing fiber synapses rapidly and transiently inhibit neighboring Purkinje cells via ephaptic coupling.
Volume: 23
Issue: 11
Pages: 1399-1409
Publication
First Author: Tsutsumi S
Year: 2020
Journal: Cell Rep
Title: Purkinje Cell Activity Determines the Timing of Sensory-Evoked Motor Initiation.
Volume: 33
Issue: 12
Pages: 108537
Publication
First Author: Bonnan A
Year: 2021
Journal: Nat Commun
Title: Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.
Volume: 12
Issue: 1
Pages: 2153
Publication
First Author: Fanning AS
Year: 2021
Journal: J Neurophysiol
Title: Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by nonvisual input.
Volume: 126
Issue: 4
Pages: 1391-1402
Publication
First Author: van der Heijden ME
Year: 2022
Journal: iScience
Title: Influence of data sampling methods on the representation of neural spiking activity in vivo.
Volume: 25
Issue: 11
Pages: 105429
Publication    
First Author: Payne HL
Year: 2019
Journal: Elife
Title: Cerebellar Purkinje cells control eye movements with a rapid rate code that is invariant to spike irregularity.
Volume: 8
Publication
First Author: Deverett B
Year: 2019
Journal: Nat Commun
Title: Cerebellar disruption impairs working memory during evidence accumulation.
Volume: 10
Issue: 1
Pages: 3128
Publication
First Author: Han KS
Year: 2018
Journal: Neuron
Title: Ephaptic Coupling Promotes Synchronous Firing of Cerebellar Purkinje Cells.
Volume: 100
Issue: 3
Pages: 564-578.e3
Publication    
First Author: de Groot A
Year: 2020
Journal: Elife
Title: NINscope, a versatile miniscope for multi-region circuit investigations.
Volume: 9
Publication
First Author: Chen WV
Year: 2017
Journal: Science
Title: Pcdhαc2 is required for axonal tiling and assembly of serotonergic circuitries in mice.
Volume: 356
Issue: 6336
Pages: 406-411
Publication  
First Author: Tang FS
Year: 2022
Journal: eNeuro
Title: Glutamate Transporters EAAT2 and EAAT5 Differentially Shape Synaptic Transmission from Rod Bipolar Cell Terminals.
Volume: 9
Issue: 3
Publication
First Author: Zeidler Z
Year: 2020
Journal: J Neurosci
Title: HippoBellum: Acute Cerebellar Modulation Alters Hippocampal Dynamics and Function.
Volume: 40
Issue: 36
Pages: 6910-6926
Publication
First Author: Smeyne RJ
Year: 1995
Journal: Mol Cell Neurosci
Title: Local control of granule cell generation by cerebellar Purkinje cells.
Volume: 6
Issue: 3
Pages: 230-51
Publication    
First Author: Beekhof GC
Year: 2021
Journal: Elife
Title: Differential spatiotemporal development of Purkinje cell populations and cerebellum-dependent sensorimotor behaviors.
Volume: 10
Genotype
Symbol: Gabrg2/Gabrg2 Tg(Pcp2-cre)2Mpin/? Tg(Pcp2-EGFP/Gabrg2)1Wul/?
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pdss2/Pdss2 Tg(Pcp2-cre)3555Jdhu/?
Background: involves: 129 * C3H/HeNCr MMTV<-> * C57BL/6N * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Yamazaki M
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior.
Volume: 112
Issue: 4
Pages: E371-9
Publication
First Author: Marino S
Year: 2002
Journal: Development
Title: PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.
Volume: 129
Issue: 14
Pages: 3513-22
Publication    
First Author: Halverson HE
Year: 2022
Journal: Elife
Title: Feedback inhibition underlies new computational functions of cerebellar interneurons.
Volume: 11
Publication  
First Author: Birkisdóttir MB
Year: 2022
Journal: Front Aging Neurosci
Title: Purkinje-cell-specific DNA repair-deficient mice reveal that dietary restriction protects neurons by cell-intrinsic preservation of genomic health.
Volume: 14
Pages: 1095801
Publication
First Author: Jorgensen ND
Year: 2009
Journal: J Neurochem
Title: Phosphorylation of ATXN1 at Ser776 in the cerebellum.
Volume: 110
Issue: 2
Pages: 675-86
Publication
First Author: von Schimmelmann M
Year: 2016
Journal: Nat Neurosci
Title: Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.
Volume: 19
Issue: 10
Pages: 1321-30
Publication
First Author: Park J
Year: 2013
Journal: Nature
Title: RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.
Volume: 498
Issue: 7454
Pages: 325-331
Publication  
First Author: Cvetanovic M
Year: 2015
Journal: Neuroscience
Title: Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.
Volume: 289
Pages: 289-99
Publication
First Author: Gatchel JR
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: The insulin-like growth factor pathway is altered in spinocerebellar ataxia type 1 and type 7.
Volume: 105
Issue: 4
Pages: 1291-6
Publication
First Author: Ebner BA
Year: 2013
Journal: J Neurosci
Title: Purkinje cell ataxin-1 modulates climbing fiber synaptic input in developing and adult mouse cerebellum.
Volume: 33
Issue: 13
Pages: 5806-20
Publication
First Author: Duvick L
Year: 2010
Journal: Neuron
Title: SCA1-like disease in mice expressing wild-type ataxin-1 with a serine to aspartic acid replacement at residue 776.
Volume: 67
Issue: 6
Pages: 929-35
Publication
First Author: Lee JH
Year: 2023
Journal: Cell Rep
Title: Cerebellar granule cell signaling is indispensable for normal motor performance.
Volume: 42
Issue: 5
Pages: 112429
Publication
First Author: Ing-Esteves S
Year: 2018
Journal: J Neurosci
Title: Combinatorial Effects of Alpha- and Gamma-Protocadherins on Neuronal Survival and Dendritic Self-Avoidance.
Volume: 38
Issue: 11
Pages: 2713-2729
Publication    
First Author: Deverett B
Year: 2018
Journal: Elife
Title: Cerebellar involvement in an evidence-accumulation decision-making task.
Volume: 7
Publication    
First Author: Heffley W
Year: 2019
Journal: Elife
Title: Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum.
Volume: 8
Publication
First Author: Roy S
Year: 2023
Journal: Cell Rep Methods
Title: Large-scale interrogation of retinal cell functions by 1-photon light-sheet microscopy.
Volume: 3
Issue: 4
Pages: 100453
Publication    
First Author: Guo C
Year: 2021
Journal: Elife
Title: Purkinje cell outputs selectively inhibit a subset of unipolar brush cells in the input layer of the cerebellar cortex.
Volume: 10
Publication
First Author: Lu S
Year: 2012
Journal: Neurobiol Dis
Title: Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood.
Volume: 45
Issue: 1
Pages: 219-33
Publication
First Author: Quintana A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.
Volume: 107
Issue: 24
Pages: 10996-1001
Publication
First Author: Luttik K
Year: 2022
Journal: Proc Natl Acad Sci U S A
Title: Differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in spinocerebellar ataxia type 1.
Volume: 119
Issue: 34
Pages: e2208513119
Publication  
First Author: Leppä E
Year: 2016
Journal: Front Pharmacol
Title: Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABAA Receptor γ2 Subunit in the Cerebellum.
Volume: 7
Pages: 403
Publication
First Author: Johnson RE
Year: 2017
Journal: Nat Commun
Title: Homeostatic plasticity shapes the visual system's first synapse.
Volume: 8
Issue: 1
Pages: 1220
Publication
First Author: Zhou Q
Year: 2021
Journal: iScience
Title: Celsr3 is required for Purkinje cell maturation and regulates cerebellar postsynaptic plasticity.
Volume: 24
Issue: 7
Pages: 102812
Publication
First Author: Schwarz JR
Year: 2024
Journal: Sci Adv
Title: Purkinje cell hyperexcitability and depressive-like behavior in mice lacking erg3 (ether-à-go-go-related gene) K(+) channel subunits.
Volume: 10
Issue: 40
Pages: eadn6836
Publication  
First Author: Liang CQ
Year: 2021
Journal: eNeuro
Title: Calmodulin Bidirectionally Regulates Evoked and Spontaneous Neurotransmitter Release at Retinal Ribbon Synapses.
Volume: 8
Issue: 1
Publication  
First Author: Liu Y
Year: 2022
Journal: Mol Cell Neurosci
Title: Hyperactivity of Purkinje cell and motor deficits in C9orf72 knockout mice.
Volume: 121
Pages: 103756
Publication
First Author: Oberdick J
Year: 1990
Journal: Science
Title: A promoter that drives transgene expression in cerebellar Purkinje and retinal bipolar neurons.
Volume: 248
Issue: 4952
Pages: 223-6
Publication  
First Author: Lalonde R
Year: 2007
Journal: Brain Res
Title: Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry.
Volume: 1140
Pages: 51-74
Publication
First Author: Joo W
Year: 2014
Journal: Science
Title: Neurodevelopment. Dendrite morphogenesis depends on relative levels of NT-3/TrkC signaling.
Volume: 346
Issue: 6209
Pages: 626-9
Publication
First Author: Flechsig E
Year: 2003
Journal: EMBO J
Title: Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.
Volume: 22
Issue: 12
Pages: 3095-101
Publication  
First Author: Krook-Magnuson E
Year: 2014
Journal: eNeuro
Title: Cerebellar Directed Optogenetic Intervention Inhibits Spontaneous Hippocampal Seizures in a Mouse Model of Temporal Lobe Epilepsy.
Volume: 1
Issue: 1
Publication
First Author: Jin S
Year: 2021
Journal: Nat Metab
Title: Brain ethanol metabolism by astrocytic ALDH2 drives the behavioural effects of ethanol intoxication.
Volume: 3
Issue: 3
Pages: 337-351
Publication  
First Author: Jahncke JN
Year: 2024
Journal: eNeuro
Title: Tools for Cre-Mediated Conditional Deletion of Floxed Alleles from Developing Cerebellar Purkinje Cells.
Volume: 11
Issue: 6
Publication
First Author: Blot FGC
Year: 2023
Journal: Nat Commun
Title: Purkinje cell microzones mediate distinct kinematics of a single movement.
Volume: 14
Issue: 1
Pages: 4358
Publication
First Author: Rousseaux MWC
Year: 2018
Journal: Neuron
Title: ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism.
Volume: 97
Issue: 6
Pages: 1235-1243.e5
Publication    
First Author: Bowie E
Year: 2020
Journal: Elife
Title: TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons.
Volume: 9
Publication
First Author: Ye L
Year: 2020
Journal: Nat Commun
Title: Ethanol abolishes vigilance-dependent astroglia network activation in mice by inhibiting norepinephrine release.
Volume: 11
Issue: 1
Pages: 6157
Publication    
First Author: Jackman SL
Year: 2020
Journal: Elife
Title: Cerebellar Purkinje cell activity modulates aggressive behavior.
Volume: 9
Publication
First Author: Chen CH
Year: 2023
Journal: Nat Neurosci
Title: A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain.
Volume: 26
Issue: 11
Pages: 1929-1941
Publication    
First Author: Vaaga CE
Year: 2020
Journal: Elife
Title: Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray.
Volume: 9
Publication      
First Author: Shuster SA
Year: 2022
Journal: Neuron
Title: In situ cell-type-specific cell-surface proteomic profiling in mice.
Publication    
First Author: Willett RT
Year: 2019
Journal: Elife
Title: Cerebellar nuclei excitatory neurons regulate developmental scaling of presynaptic Purkinje cell number and organ growth.
Volume: 8
Publication
First Author: Cazzaro S
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.
Volume: 120
Issue: 30
Pages: e2217128120