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Search results 301 to 400 out of 425 for Pcsk1

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Type Details Score
GXD Expression
GXD Expression
     
Probe: MGI:6460430
Assay Type: RNA in situ
Annotation Date: 2020-11-05
Strength: Ambiguous
Sex: Female
Emaps: EMAPS:3814928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6470808
Age: postnatal adult
Specimen Label: 2D D4 Ampulla
Specimen Num: 4
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Publication
2017186 | J:11129
First Author: Seidah NG
Year: 1991
Journal: Mol Endocrinol
Title: Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2.
Volume: 5
Issue: 1
Pages: 111-22
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Publication
2169760 | J:10744
First Author: Seidah NG
Year: 1990
Journal: DNA Cell Biol
Title: cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases.
Volume: 9
Issue: 6
Pages: 415-24
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Publication
15956344 | J:112500
First Author: Hardiman A
Year: 2005
Journal: J Mol Endocrinol
Title: Endocrinomic profile of neurointermediate lobe pituitary prohormone processing in PC1/3- and PC2-Null mice using SELDI-TOF mass spectrometry.
Volume: 34
Issue: 3
Pages: 739-51
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Publication
12145326 | J:78369
First Author: Zhu X
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Volume: 99
Issue: 16
Pages: 10293-8
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Publication
20412386 | J:161820
First Author: Wardman JH
Year: 2010
Journal: J Neurochem
Title: Analysis of peptides in prohormone convertase 1/3 null mouse brain using quantitative peptidomics.
Volume: 114
Issue: 1
Pages: 215-25
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Publication
8262946 | J:131459
First Author: Breslin MB
Year: 1993
Journal: J Biol Chem
Title: Differential processing of proenkephalin by prohormone convertases 1(3) and 2 and furin.
Volume: 268
Issue: 36
Pages: 27084-93
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Publication
8397508 | J:135486
 
First Author: Benjannet S
Year: 1993
Journal: Biochem J
Title: Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2.
Volume: 294 ( Pt 3)
Pages: 735-43
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Publication
1988934 | J:33623
First Author: Smeekens SP
Year: 1991
Journal: Proc Natl Acad Sci U S A
Title: Identification of a cDNA encoding a second putative prohormone convertase related to PC2 in AtT20 cells and islets of Langerhans.
Volume: 88
Issue: 2
Pages: 340-4
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Publication
8003017 | J:18659
First Author: Goodman LJ
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Autoproteolytic activation of the mouse prohormone convertase mPC1.
Volume: 201
Issue: 2
Pages: 795-804
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Publication
7925129 | J:20976
First Author: Marcinkiewicz M
Year: 1994
Journal: Endocrinology
Title: Developmental expression of the prohormone convertases PC1 and PC2 in mouse pancreatic islets.
Volume: 135
Issue: 4
Pages: 1651-60
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Publication
8891276 | J:35361
First Author: Meyer A
Year: 1996
Journal: Brain Res
Title: Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus.
Volume: 732
Issue: 1-2
Pages: 121-32
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Publication
25153248 | J:220410
 
First Author: Miyamoto A
Year: 2014
Journal: Matrix Biol
Title: Binding of MAGP2 to microfibrils is regulated by proprotein convertase cleavage.
Volume: 40
Pages: 27-33
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Publication
12358783 | J:78623
First Author: Villeneuve P
Year: 2002
Journal: J Neurochem
Title: Altered processing of the neurotensin/neuromedin N precursor in PC2 knock down mice: a biochemical and immunohistochemical study.
Volume: 82
Issue: 4
Pages: 783-93
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Publication
22396549 | J:184882
First Author: Refaie S
Year: 2012
Journal: J Biol Chem
Title: Disruption of proprotein convertase 1/3 (PC1/3) expression in mice causes innate immune defects and uncontrolled cytokine secretion.
Volume: 287
Issue: 18
Pages: 14703-17
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Publication
21888904 | J:176425
First Author: Tamura Y
Year: 2011
Journal: FEBS Lett
Title: NO donor induces Nec-1-inhibitable, but RIP1-independent, necrotic cell death in pancreatic β-cells.
Volume: 585
Issue: 19
Pages: 3058-64
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Publication
22579794 | J:192432
 
First Author: Chavez-Valdez R
Year: 2012
Journal: Neuroscience
Title: Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia.
Volume: 219
Pages: 192-203
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Publication
7730317 | J:34511
First Author: Rothenberg ME
Year: 1995
Journal: J Biol Chem
Title: Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro.
Volume: 270
Issue: 17
Pages: 10136-46
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Publication
15018810 | J:75717
First Author: Feng Y
Year: 2002
Journal: Brain Res Gene Expr Patterns
Title: ProSAAS and prohormone convertase 1 are broadly expressed during mouse development.
Volume: 1
Issue: 2
Pages: 135-40
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Publication
16476726 | J:112681
First Author: Ugleholdt R
Year: 2006
Journal: J Biol Chem
Title: Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor.
Volume: 281
Issue: 16
Pages: 11050-7
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Publication
39435302 | J:360142
First Author: Moeller J
Year: 2024
Journal: J Endocr Soc
Title: Ablation of PC1/3 in POMC-Expressing Tissues but Not in Immune Cells Induces Sepsis Hypersensitivity.
Volume: 8
Issue: 11
Pages: bvae171
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Publication
18554181 | J:140372
First Author: Rehfeld JF
Year: 2008
Journal: Biochem J
Title: Prohormone convertases 1/3 and 2 together orchestrate the site-specific cleavages of progastrin to release gastrin-34 and gastrin-17.
Volume: 415
Issue: 1
Pages: 35-43
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Publication
9242664 | J:139345
First Author: Schaner P
Year: 1997
Journal: J Biol Chem
Title: Processing of prothyrotropin-releasing hormone by the family of prohormone convertases.
Volume: 272
Issue: 32
Pages: 19958-68
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Publication
8940009 | J:137491
First Author: Decroly E
Year: 1996
Journal: J Biol Chem
Title: Identification of the paired basic convertases implicated in HIV gp160 processing based on in vitro assays and expression in CD4(+) cell lines.
Volume: 271
Issue: 48
Pages: 30442-50
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Publication
1765368 | J:419
First Author: Seidah NG
Year: 1991
Journal: Genomics
Title: Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region).
Volume: 11
Issue: 1
Pages: 103-7
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Publication
14693708 | J:87252
First Author: Marzban L
Year: 2004
Journal: Diabetes
Title: Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
Volume: 53
Issue: 1
Pages: 141-8
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Publication
14684599 | J:88698
First Author: Dey A
Year: 2004
Journal: Endocrinology
Title: Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone.
Volume: 145
Issue: 4
Pages: 1961-71
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Publication
18356286 | J:136071
First Author: Fox DL
Year: 2008
Journal: Mol Endocrinol
Title: Nescient helix-loop-helix 2 interacts with signal transducer and activator of transcription 3 to regulate transcription of prohormone convertase 1/3.
Volume: 22
Issue: 6
Pages: 1438-48
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Publication
10701998 | J:59052
First Author: Seidah NG
Year: 1999
Journal: Brain Res
Title: Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides.
Volume: 848
Issue: 1-2
Pages: 45-62
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Publication
17050541 | J:117652
First Author: Zhu X
Year: 2006
Journal: J Biol Chem
Title: On the processing of proghrelin to ghrelin.
Volume: 281
Issue: 50
Pages: 38867-70
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Publication
19837164 | J:158324
First Author: Minokadeh A
Year: 2010
Journal: Mol Cell Neurosci
Title: Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression.
Volume: 43
Issue: 1
Pages: 98-107
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Publication
18410501 | J:137265
First Author: Funkelstein L
Year: 2008
Journal: J Neurochem
Title: Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression.
Volume: 106
Issue: 1
Pages: 384-91
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Publication
35963866 | J:328782
First Author: Meier DT
Year: 2022
Journal: Nat Commun
Title: Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing.
Volume: 13
Issue: 1
Pages: 4761
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Publication
24101515 | J:201970
First Author: Wetsel WC
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice.
Volume: 110
Issue: 43
Pages: 17362-7
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Publication
23056534 | J:192100
First Author: Liu T
Year: 2012
Journal: PLoS One
Title: Pax6 directly down-regulates Pcsk1n expression thereby regulating PC1/3 dependent proinsulin processing.
Volume: 7
Issue: 10
Pages: e46934
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Publication
8198617 | J:23179
First Author: Behan DP
Year: 1993
Journal: Genomics
Title: Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP)
Volume: 16
Issue: 1
Pages: 63-8
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Publication
1429684 | J:52522
First Author: Steiner DF
Year: 1992
Journal: J Biol Chem
Title: The new enzymology of precursor processing endoproteases.
Volume: 267
Issue: 33
Pages: 23435-8
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Publication
8389457 | J:35634
First Author: Marcinkiewicz M
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: Ontogeny of the prohormone convertases PC1 and PC2 in the mouse hypophysis and their colocalization with corticotropin and alpha-melanotropin.
Volume: 90
Issue: 11
Pages: 4922-6
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Publication
9291583 | J:42730
First Author: Rancourt SL
Year: 1997
Journal: Dev Genet
Title: Murine subtilisin-like proteinase SPC6 is expressed during embryonic implantation, somitogenesis, and skeletal formation.
Volume: 21
Issue: 1
Pages: 75-81
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Publication
23027401 | J:191140
First Author: Grigoryan M
Year: 2012
Journal: Dev Dyn
Title: Phenotype of entero-endocrine L cells becomes restricted during development.
Volume: 241
Issue: 12
Pages: 1986-92
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Publication
10894496 | J:62933
First Author: Kayo T
Year: 2000
Journal: Comp Med
Title: Identification of two chromosomal loci determining glucose intolerance in a C57BL/6 mouse strain.
Volume: 50
Issue: 3
Pages: 296-302
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Publication
7819324 | J:23191
First Author: Seidah NG
Year: 1994
Journal: Biochimie
Title: The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions.
Volume: 76
Issue: 3-4
Pages: 197-209
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Publication
9885250 | J:52417
First Author: Constam DB
Year: 1999
Journal: J Cell Biol
Title: Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.
Volume: 144
Issue: 1
Pages: 139-49
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Publication
8698813 | J:34068
First Author: Constam DB
Year: 1996
Journal: J Cell Biol
Title: SPC4, SPC6, and the novel protease SPC7 are coexpressed with bone morphogenetic proteins at distinct sites during embryogenesis.
Volume: 134
Issue: 1
Pages: 181-91
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Publication
16627579 | J:129652
First Author: Vuguin PM
Year: 2006
Journal: Endocrinology
Title: Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation.
Volume: 147
Issue: 9
Pages: 3995-4006
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Publication
24855103 | J:213203
First Author: Chen Y
Year: 2014
Journal: Biol Reprod
Title: Preimplantation mouse embryo is a target for opioid ligand-receptor signaling.
Volume: 91
Issue: 1
Pages: 4
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Publication
12049785 | J:77320
First Author: Wilson ME
Year: 2002
Journal: Mech Dev
Title: Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
Volume: 115
Issue: 1-2
Pages: 171-6
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Publication
16163737 | J:104961
First Author: St Germain C
Year: 2005
Journal: Mol Reprod Dev
Title: Expression and transient nuclear translocation of proprotein convertase 1 (PC1) during mouse preimplantation embryonic development.
Volume: 72
Issue: 4
Pages: 483-93
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Publication
8223273 | J:12612
First Author: Tessarollo L
Year: 1993
Journal: Development
Title: trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.
Volume: 118
Issue: 2
Pages: 463-75
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Publication
12933680 | J:85590
First Author: Vincent M
Year: 2003
Journal: Endocrinology
Title: Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.
Volume: 144
Issue: 9
Pages: 4061-9
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Publication
17938243 | J:125691
First Author: Masui T
Year: 2007
Journal: Genes Dev
Title: Early pancreatic development requires the vertebrate Suppressor of Hairless (RBPJ) in the PTF1 bHLH complex.
Volume: 21
Issue: 20
Pages: 2629-43
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Publication
15587270 | J:94589
First Author: Lamotte L
Year: 2004
Journal: Transgenic Res
Title: Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain.
Volume: 13
Issue: 5
Pages: 463-73
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Publication
20138042 | J:236958
First Author: Lu J
Year: 2010
Journal: Gastroenterology
Title: Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.
Volume: 138
Issue: 5
Pages: 1954-65
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Publication
1354647 | J:1676
First Author: Copeland NG
Year: 1992
Journal: Genomics
Title: Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.
Volume: 13
Issue: 4
Pages: 1356-8
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Publication
8824815 | J:31188
First Author: Pathak BG
Year: 1996
Journal: Genomics
Title: Mouse chromosomal location of four Na/H exchanger isoform genes.
Volume: 31
Issue: 2
Pages: 261-3
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Publication
8114702 | J:16903
First Author: Martin JF
Year: 1994
Journal: Mol Cell Biol
Title: A Mef2 gene that generates a muscle-specific isoform via alternative mRNA splicing.
Volume: 14
Issue: 3
Pages: 1647-56
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Publication
11076772 | J:65594
First Author: Sander M
Year: 2000
Journal: Development
Title: Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
Volume: 127
Issue: 24
Pages: 5533-40
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Publication
20876279 | J:165252
First Author: Mesnard D
Year: 2010
Journal: J Cell Biol
Title: Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst.
Volume: 191
Issue: 1
Pages: 129-39
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Publication
9584121 | J:48576
First Author: Sussel L
Year: 1998
Journal: Development
Title: Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells.
Volume: 125
Issue: 12
Pages: 2213-21
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Publication
21880149 | J:176201
 
First Author: Kordowich S
Year: 2011
Journal: BMC Dev Biol
Title: Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage.
Volume: 11
Pages: 52
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Publication
18723011 | J:141017
First Author: Seymour PA
Year: 2008
Journal: Dev Biol
Title: A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation.
Volume: 323
Issue: 1
Pages: 19-30
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Publication
17537793 | J:122518
First Author: Nelson SB
Year: 2007
Journal: Development
Title: The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells.
Volume: 134
Issue: 13
Pages: 2491-500
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Publication
32694784 | J:310126
First Author: Quarta C
Year: 2019
Journal: Nat Metab
Title: Functional identity of hypothalamic melanocortin neurons depends on Tbx3.
Volume: 1
Issue: 2
Pages: 222-235
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Publication
24258027 | J:321229
First Author: Murakami-Kawaguchi S
Year: 2014
Journal: Cell Tissue Res
Title: Expression of Ins1 and Ins2 genes in mouse fetal liver.
Volume: 355
Issue: 2
Pages: 303-14
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Publication
16951258 | J:112173
First Author: Gierl MS
Year: 2006
Journal: Genes Dev
Title: The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.
Volume: 20
Issue: 17
Pages: 2465-78
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Publication
22980982 | J:187963
First Author: Talchai C
Year: 2012
Journal: Cell
Title: Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure.
Volume: 150
Issue: 6
Pages: 1223-34
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Publication
25784544 | J:246477
First Author: Talchai SC
Year: 2015
Journal: Diabetes
Title: Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.
Volume: 64
Issue: 8
Pages: 2868-79
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Publication
25186293 | J:218695
First Author: Soggia A
Year: 2014
Journal: Diabetologia
Title: von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation.
Volume: 57
Issue: 11
Pages: 2348-56
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Publication
17339028 | J:129765
First Author: Goulley J
Year: 2007
Journal: Cell Metab
Title: BMP4-BMPR1A signaling in beta cells is required for and augments glucose-stimulated insulin secretion.
Volume: 5
Issue: 3
Pages: 207-19
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Publication
20413507 | J:169647
First Author: Ait-Lounis A
Year: 2010
Journal: Diabetes
Title: The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression.
Volume: 59
Issue: 7
Pages: 1674-85
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Publication
37168577 | J:335566
First Author: Lu C
Year: 2023
Journal: iScience
Title: Casein kinase 1α is required to maintain murine hypothalamic pro-opiomelanocortin expression.
Volume: 26
Issue: 5
Pages: 106670
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Publication
24227653 | J:206319
First Author: Welcker JE
Year: 2013
Journal: Development
Title: Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.
Volume: 140
Issue: 24
Pages: 4947-58
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Publication
28576773 | J:242899
First Author: Sinagoga KL
Year: 2017
Journal: Development
Title: Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Volume: 144
Issue: 13
Pages: 2402-2414
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Publication
26901059 | J:248945
First Author: Abdellatif AM
Year: 2016
Journal: PLoS One
Title: β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Volume: 11
Issue: 2
Pages: e0150010
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Publication
27534441 | J:234901
 
First Author: Potter PK
Year: 2016
Journal: Nat Commun
Title: Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.
Volume: 7
Pages: 12444
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Publication
8662221 | J:33558
First Author: Marine JC
Year: 1996
Journal: Mamm Genome
Title: Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.
Volume: 7
Issue: 6
Pages: 413-6
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Publication
16987237 | J:119559
First Author: Bouwman J
Year: 2006
Journal: J Neurochem
Title: Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.
Volume: 99
Issue: 1
Pages: 84-96
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Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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First Author: MGD Nomenclature Committee
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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