Type |
Details |
Score |
Publication |
First Author: |
Shi Y |
Year: |
2021 |
Journal: |
Biol Reprod |
Title: |
Functional roles of the chromatin remodeler SMARCA5 in mouse and bovine preimplantation embryos†. |
Volume: |
105 |
Issue: |
2 |
Pages: |
359-370 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yuan J |
Year: |
2015 |
Journal: |
Autophagy |
Title: |
MYBL2 guides autophagy suppressor VDAC2 in the developing ovary to inhibit autophagy through a complex of VDAC2-BECN1-BCL2L1 in mammals. |
Volume: |
11 |
Issue: |
7 |
Pages: |
1081-98 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
190
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Takahashi I |
Year: |
1998 |
Journal: |
Gene |
Title: |
Existence of a bovine LINE repetitive insert that appears in the cDNA of bovine protein BCNT in ruminant, but not in human, genomes. |
Volume: |
211 |
Issue: |
2 |
Pages: |
387-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bell DR |
Year: |
1993 |
Journal: |
Biochem J |
Title: |
Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. |
Volume: |
294 ( Pt 1) |
|
Pages: |
173-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guarini G |
Year: |
2012 |
Journal: |
Am J Physiol Heart Circ Physiol |
Title: |
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels. |
Volume: |
303 |
Issue: |
2 |
Pages: |
H216-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Holvoet P |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
Low Cytochrome Oxidase 1 Links Mitochondrial Dysfunction to Atherosclerosis in Mice and Pigs. |
Volume: |
12 |
Issue: |
1 |
Pages: |
e0170307 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kärst S |
Year: |
2013 |
Journal: |
BMC Genomics |
Title: |
Effect of the myostatin locus on muscle mass and intramuscular fat content in a cross between mouse lines selected for hypermuscularity. |
Volume: |
14 |
|
Pages: |
16 |
|
•
•
•
•
•
|
Publication |
First Author: |
Safar JG |
Year: |
2011 |
Journal: |
Lab Invest |
Title: |
Conserved properties of human and bovine prion strains on transmission to guinea pigs. |
Volume: |
91 |
Issue: |
9 |
Pages: |
1326-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watts JC |
Year: |
2016 |
Journal: |
J Virol |
Title: |
Guinea Pig Prion Protein Supports Rapid Propagation of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease Prions. |
Volume: |
90 |
Issue: |
21 |
Pages: |
9558-9569 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2010 |
Journal: |
PLoS One |
Title: |
Community dynamics in the mouse gut microbiota: a possible role for IRF9-regulated genes in community homeostasis. |
Volume: |
5 |
Issue: |
4 |
Pages: |
e10335 |
|
•
•
•
•
•
|
Publication |
First Author: |
Torres JM |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
Elements modulating the prion species barrier and its passage consequences. |
Volume: |
9 |
Issue: |
3 |
Pages: |
e89722 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun X |
Year: |
1999 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Role of decay-accelerating factor in regulating complement activation on the erythrocyte surface as revealed by gene targeting. |
Volume: |
96 |
Issue: |
2 |
Pages: |
628-33 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kim AJ |
Year: |
2020 |
Journal: |
Circulation |
Title: |
Deficiency of Circulating Monocytes Ameliorates the Progression of Myxomatous Valve Degeneration in Marfan Syndrome. |
Volume: |
141 |
Issue: |
2 |
Pages: |
132-146 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qiu J |
Year: |
2018 |
Journal: |
Endocrinology |
Title: |
Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance. |
Volume: |
159 |
Issue: |
2 |
Pages: |
647-664 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balmer TS |
Year: |
2021 |
Journal: |
Front Neurosci |
Title: |
Trigeminal Contributions to the Dorsal Cochlear Nucleus in Mouse. |
Volume: |
15 |
|
Pages: |
715954 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stohn JP |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Cthrc1, a novel circulating hormone regulating metabolism. |
Volume: |
7 |
Issue: |
10 |
Pages: |
e47142 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shinkel TA |
Year: |
1997 |
Journal: |
Transplantation |
Title: |
Changes in cell surface glycosylation in alpha1,3-galactosyltransferase knockout and alpha1,2-fucosyltransferase transgenic mice. |
Volume: |
64 |
Issue: |
2 |
Pages: |
197-204 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen CG |
Year: |
1998 |
Journal: |
Transplantation |
Title: |
Transgenic expression of human alpha1,2-fucosyltransferase (H-transferase) prolongs mouse heart survival in an ex vivo model of xenograft rejection. |
Volume: |
65 |
Issue: |
6 |
Pages: |
832-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lahbib-Mansais Y |
Year: |
2000 |
Journal: |
Mamm Genome |
Title: |
Comparative mapping between humans and pigs: localization of 58 anchorage markers (TOASTs) by use of porcine somatic cell and radiation hybrid panels. |
Volume: |
11 |
Issue: |
12 |
Pages: |
1098-106 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gross SR |
Year: |
1975 |
Journal: |
Biochem Genet |
Title: |
The phosphorylase kinase deficiency (Phk) locus in the mouse: evidence that the mutant allele codes for an enzyme with an abnormal structure. |
Volume: |
13 |
Issue: |
9-10 |
Pages: |
567-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
MacLennan DH |
Year: |
1990 |
Journal: |
Nature |
Title: |
Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia. |
Volume: |
343 |
Issue: |
6258 |
Pages: |
559-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cullen RT |
Year: |
1992 |
Journal: |
Thorax |
Title: |
Immune responses to colophony, an agent causing occupational asthma. |
Volume: |
47 |
Issue: |
12 |
Pages: |
1050-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rothenberg ME |
Year: |
1995 |
Journal: |
J Exp Med |
Title: |
Constitutive and allergen-induced expression of eotaxin mRNA in the guinea pig lung. |
Volume: |
181 |
Issue: |
3 |
Pages: |
1211-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meijerink E |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Two alpha(1,2) fucosyltransferase genes on porcine chromosome 6q11 are closely linked to the blood group inhibitor (S) and Escherichia coli F18 receptor (ECF18R) loci. |
Volume: |
8 |
Issue: |
10 |
Pages: |
736-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mori T |
Year: |
1997 |
Journal: |
Arch Biochem Biophys |
Title: |
Regulation of CYP1A and CYP3A mRNAs by ascorbic acid in guinea pigs. |
Volume: |
348 |
Issue: |
2 |
Pages: |
268-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Grunwald KA |
Year: |
1999 |
Journal: |
J Lipid Res |
Title: |
Identification of a novel Arg-->Cys mutation in the LDL receptor that contributes to spontaneous hypercholesterolemia in pigs. |
Volume: |
40 |
Issue: |
3 |
Pages: |
475-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang G |
Year: |
1999 |
Journal: |
J Biol Chem |
Title: |
Cloning and characterization of the gene for a new epithelial beta-defensin. Genomic structure, chromosomal localization, and evidence for its constitutive expression. |
Volume: |
274 |
Issue: |
34 |
Pages: |
24031-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jeevan A |
Year: |
2003 |
Journal: |
Infect Immun |
Title: |
Differential expression of gamma interferon mRNA induced by attenuated and virulent Mycobacterium tuberculosis in guinea pig cells after Mycobacterium bovis BCG vaccination. |
Volume: |
71 |
Issue: |
1 |
Pages: |
354-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen TV |
Year: |
2006 |
Journal: |
Clin Vaccine Immunol |
Title: |
High titers of circulating maternal antibodies suppress effector and memory B-cell responses induced by an attenuated rotavirus priming and rotavirus-like particle-immunostimulating complex boosting vaccine regimen. |
Volume: |
13 |
Issue: |
4 |
Pages: |
475-85 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen F |
Year: |
2011 |
Journal: |
Infect Immun |
Title: |
Proinflammatory caspase-2-mediated macrophage cell death induced by a rough attenuated Brucella suis strain. |
Volume: |
79 |
Issue: |
6 |
Pages: |
2460-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu YM |
Year: |
2018 |
Journal: |
J Transl Med |
Title: |
Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice. |
Volume: |
16 |
Issue: |
1 |
Pages: |
141 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramírez-Carvajal L |
Year: |
2016 |
Journal: |
J Virol |
Title: |
Constitutively Active IRF7/IRF3 Fusion Protein Completely Protects Swine against Foot-and-Mouth Disease. |
Volume: |
90 |
Issue: |
19 |
Pages: |
8809-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hoyle CH |
Year: |
1999 |
Journal: |
Brain Res |
Title: |
Neuropeptide families and their receptors: evolutionary perspectives. |
Volume: |
848 |
Issue: |
1-2 |
Pages: |
1-25 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ward JM |
Year: |
1994 |
Journal: |
J Natl Cancer Inst |
Title: |
Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. |
Volume: |
86 |
Issue: |
16 |
Pages: |
1222-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Moore SJ |
Year: |
2017 |
Journal: |
J Virol |
Title: |
Experimental Transmission of the Chronic Wasting Disease Agent to Swine after Oral or Intracranial Inoculation. |
Volume: |
91 |
Issue: |
19 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Huang C |
Year: |
2019 |
Journal: |
Front Immunol |
Title: |
Porcine Beta-Defensin 2 Provides Protection Against Bacterial Infection by a Direct Bactericidal Activity and Alleviates Inflammation via Interference With the TLR4/NF-κB Pathway. |
Volume: |
10 |
|
Pages: |
1673 |
|
•
•
•
•
•
|
Publication |
First Author: |
Abdoli A |
Year: |
2022 |
Journal: |
bioRxiv |
Title: |
Omicron-based vaccine candidate elicits potent neutralizing antibodies in the animal model. |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
955
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
232
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
395
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
969
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
977
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
642
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gillberg M |
Year: |
2006 |
Journal: |
Basic Clin Pharmacol Toxicol |
Title: |
Regulation of gender-dependent CYP2A expression in pigs: involvement of androgens and CAR. |
Volume: |
98 |
Issue: |
5 |
Pages: |
480-7 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Cytochrome P450 enzymes are a superfamily of haem-containing mono-oxygenases that are found in all kingdoms of life, and which show extraordinary diversity in their reaction chemistry. In mammals, these proteins are found primarily in microsomes of hepatocytes and other cell types, where they oxidise steroids, fatty acids and xenobiotics, and are important for the detoxification and clearance of various compounds, as well as for hormone synthesis and breakdown, cholesterol synthesis and vitamin D metabolism. In plants, these proteins are important for the biosynthesis of several compounds such as hormones, defensive compounds and fatty acids. In bacteria, they are important for several metabolic processes, such as the biosynthesis of antibiotic erythromycin in Saccharopolyspora erythraea (Streptomyces erythraeus).Cytochrome P450 enzymes use haem to oxidise their substrates, using protons derived from NADH or NADPH to split the oxygen so a single atom can be added to a substrate. They also require electrons, which they receive from a variety of redox partners. In certain cases, cytochrome P450 can be fused to its redox partner to produce a bi-functional protein, such as with P450BM-3 from Bacillus megaterium [], which has haem and flavin domains.Organisms produce many different cytochrome P450 enzymes (at least 58 in humans), which together with alternative splicing can provide a wide array of enzymes with different substrate and tissue specificities. Individual cytochrome P450 proteins follow the nomenclature: CYP, followed by a number (family), then a letter (subfamily), and another number (protein); e.g. CYP3A4 is the fourth protein in family 3, subfamily A. In general, family members should share >40% identity, while subfamily members should share >55% identity.Cytochrome P450 proteins can also be grouped by two different schemes. One scheme was based on a taxonomic split: class I (prokaryotic/mitochondrial) and class II (eukaryotic microsomes). The other scheme was based on the number of components in the system: class B (3-components) and class E (2-components). These classes merge to a certain degree. Most prokaryotes and mitochondria (and fungal CYP55) have 3-component systems (class I/class B) - a FAD-containing flavoprotein (NAD(P)H-dependent reductase), an iron-sulphur protein and P450. Most eukaryotic microsomes have 2-component systems (class II/class E) - NADPH:P450 reductase (FAD and FMN-containing flavoprotein) and P450. There are exceptions to this scheme, such as 1-component systems that resemble class E enzymes [, , ]. The class E enzymes can be further subdivided into five sequence clusters, groups I-V, each of which may contain more than one cytochrome P450 family (eg, CYP1 and CYP2 are both found in group I). The divergence of the cytochrome P450 superfamily into B- and E-classes, and further divergence into stable clusters within the E-class, appears to be very ancient, occurring before the appearance of eukaryotes.This entry represents the CYP2A family from group I, class E, cytochrome P450 proteins, as well as other CYP2 family proteins. The CYP2 family comprises 15 subfamilies (A-H, J-N, P and Q). The first five (A-E) are present in mammalian liver, but in differing amounts and with different inducibilities. These five subfamilies show varied substrate specificities, with some degree of overlap. CYP2A proteins are responsible of metabolising a variety of drugs, which in pigs appears to be gender-dependent (influenced by sex hormones), the highest activity being in females []. |
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•
•
•
•
|
Publication |
First Author: |
Graw J |
Year: |
2009 |
Journal: |
Exp Eye Res |
Title: |
Genetics of crystallins: cataract and beyond. |
Volume: |
88 |
Issue: |
2 |
Pages: |
173-89 |
|
•
•
•
•
•
|
Publication |
|
Year: |
2005 |
Journal: |
Int J Toxicol |
Title: |
Final amended report on the safety assessment of Octyldodecyl Stearoyl Stearate. |
Volume: |
24 Suppl 3 |
|
Pages: |
65-74 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1292
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1042
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1042
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1095
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Elmore AR |
Year: |
2005 |
Journal: |
Int J Toxicol |
Title: |
Final report of the safety assessment of L-Ascorbic Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium Ascorbyl Phosphate, Sodium Ascorbate, and Sodium Ascorbyl Phosphate as used in cosmetics. |
Volume: |
24 Suppl 2 |
|
Pages: |
51-111 |
|
•
•
•
•
•
|
Publication |
First Author: |
Walker T |
Year: |
1996 |
Journal: |
Mouse Genome |
Title: |
Methylglyoxal dehydrogenase (EC 1.2.1.23): No enzyme detection in mouse inbred strains |
Volume: |
94 |
Issue: |
1 |
Pages: |
149-51 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
501
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
493
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
457
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
323
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
494
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
492
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
McLean KJ |
Year: |
2005 |
Journal: |
Biochem Soc Trans |
Title: |
Biodiversity of cytochrome P450 redox systems. |
Volume: |
33 |
Issue: |
Pt 4 |
Pages: |
796-801 |
|
•
•
•
•
•
|
Publication |
First Author: |
Munro AW |
Year: |
2007 |
Journal: |
Biochim Biophys Acta |
Title: |
Cytochrome P450--redox partner fusion enzymes. |
Volume: |
1770 |
Issue: |
3 |
Pages: |
345-59 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nelson DR |
Year: |
2004 |
Journal: |
Pharmacogenetics |
Title: |
Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. |
Volume: |
14 |
Issue: |
1 |
Pages: |
1-18 |
|
•
•
•
•
•
|
Publication |
First Author: |
Degtyarenko KN |
Year: |
1995 |
Journal: |
Protein Eng |
Title: |
Structural domains of P450-containing monooxygenase systems. |
Volume: |
8 |
Issue: |
8 |
Pages: |
737-47 |
|
•
•
•
•
•
|