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Search results 301 to 377 out of 377 for Pikfyve

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Type Details Score
Publication
25578879 | J:219972
First Author: Vicinanza M
Year: 2015
Journal: Mol Cell
Title: PI(5)P regulates autophagosome biogenesis.
Volume: 57
Issue: 2
Pages: 219-34
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Publication
28552585 | J:260958
First Author: Morioka S
Year: 2017
Journal: Exp Cell Res
Title: Phosphoinositide phosphatase Sac3 regulates the cell surface expression of scavenger receptor A and formation of lipid droplets in macrophages.
Volume: 357
Issue: 2
Pages: 252-259
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Publication
24359958 | J:265024
 
First Author: Lenk GM
Year: 2014
Journal: Methods Enzymol
Title: Mouse models of PI(3,5)P2 deficiency with impaired lysosome function.
Volume: 534
Pages: 245-60
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Publication
11895483 | -
First Author: Morishita M
Year: 2002
Journal: Genes Cells
Title: Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe.
Volume: 7
Issue: 2
Pages: 199-215
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Publication
30427760 | -
First Author: Miner GE
Year: 2019
Journal: Mol Biol Cell
Title: Phosphatidylinositol 3,5-bisphosphate regulates the transition between trans-SNARE complex formation and vacuole membrane fusion.
Volume: 30
Issue: 2
Pages: 201-208
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Publication
19846542 | -
First Author: Whitley P
Year: 2009
Journal: Plant Physiol
Title: Arabidopsis FAB1/PIKfyve proteins are essential for development of viable pollen.
Volume: 151
Issue: 4
Pages: 1812-22
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Publication
21412048 | -
First Author: Hirano T
Year: 2011
Journal: Plant Signal Behav
Title: Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters.
Volume: 6
Issue: 4
Pages: 583-5
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Publication
23757022 | -
First Author: Er EE
Year: 2013
Journal: Sci Signal
Title: AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.
Volume: 6
Issue: 279
Pages: ra45
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Protein Domain
IPR044769 | PIKfyve_PIPKc
Type: Domain
Description: This entry represents the C-terminal catalytic lipid kinase domain related to PtdInsP kinases (PIPKc domain) found in PIKfyve and related proteins.1-phosphatidylinositol-3-phosphate 5-kinase (), also called FYVE finger-containing phosphoinositide kinase (PIKfyve), forms a complex with its regulators, the scaffolding protein Vac14 and the lipid phosphatase Fig4. The complex synthesises phosphatidylinositol 3,5-bisphosphate [PtdIns(3,5)P2]through the phosphorylation of phosphatidylinositol 3-phosphate (PtdIns3P or PI3P) on the fifth hydroxyl of the myo-inositol ring. Then phosphatidylinositol-5-phosphate (PtdIns5P) is generated directly from PtdIns(3,5)P2. PtdIns(3,5)P2 and PtdIns5P regulate endosomal trafficking and responses to extracellular stimuli []. It is vital in early embryonic development and plays a role in different pathways, such as receptor tyrosine kinase (RTK) or EGFR degradation, regulation of the glutamate transporters EAAT2, EAAT3 and EAAT4 and the cystic fibrosis transmembrane conductance regulator (CFTR). It is also essential for systemic glucose homeostasis and insulin-regulated glucose uptake/GLUT4 translocation in skeletal muscle [, , ].The yeast orthologue of human PIKfyve, Fab1, is required for endocytic-vacuolar pathway and nuclear migration [, ]. The plant orthologues such as FAB1A-D from Arabidopsis are important for the maintenance of endomembrane homeostasis and for development of viable pollen [, ].PIKfyve and its orthologues share a similar architecture consisting of a N-terminal FYVE domain, a middle region related to the CCT/TCP-1/Cpn60 chaperonins that are involved in productive folding of actin and tubulin, a second middle domain that contains a number of conserved cysteine residues (CCR) unique to these proteins, and a C-terminal catalytic lipid kinase domain related to PtdInsP kinases (or the PIPKc domain).
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Protein Coding Gene
MGP_CAROLIEiJ_G0031560 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0034125 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0034104 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0034031 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0034098 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0033809 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2157980 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0034618 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0033136 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0033783 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0033938 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0033882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0034028 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0033928 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0034637 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0032839 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0033252 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0023159 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0032678 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
17956977 | J:127106
First Author: Zhang Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.
Volume: 104
Issue: 44
Pages: 17518-23
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Publication
11889142 | J:75446
First Author: Bonangelino CJ
Year: 2002
Journal: J Cell Biol
Title: Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p.
Volume: 156
Issue: 6
Pages: 1015-28
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GXD Expression
GXD Expression
     
Probe: MGI:1331964
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331965
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:1331964
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331965
Age: embryonic day 7.5
Specimen Label: 10x
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:1331964
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:1331965
Age: embryonic day 7.5
Specimen Label: 100x
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
     
Probe: MGI:1331964
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331965
Age: embryonic day 7.5
Specimen Label: 1x
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
     
Probe: MGI:1331964
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331965
Age: embryonic day 7.5
Specimen Label: 10x
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
     
Probe: MGI:1331964
Assay Type: RT-PCR
Annotation Date: 1999-03-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:1331965
Age: embryonic day 7.5
Specimen Label: 100x
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:456759
Assay Type: RNA in situ
Annotation Date: 2023-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3271122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7526702
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:456759
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603923
Pattern: Ubiquitous
Stage: TS23
Assay Id: MGI:4829145
Age: embryonic day 14.5
Image: euxassay_007286_11
Specimen Label: euxassay_007286_11
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:456759
Assay Type: RNA in situ
Annotation Date: 2023-09-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:7526702
Age: embryonic day 14.5
Specimen Label: Supplementary table 2
Detected: true
Specimen Num: 1
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Publication
27669461 | J:239553
First Author: Kim SM
Year: 2016
Journal: J Clin Invest
Title: Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.
Volume: 126
Issue: 11
Pages: 4088-4102
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Publication
23905686 | J:202702
First Author: Liu Y
Year: 2013
Journal: Biochem J
Title: Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.
Volume: 455
Issue: 2
Pages: 195-206
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Publication
25239130 | J:337115
First Author: Li X
Year: 2015
Journal: Int Immunol
Title: Mucolipin 1 positively regulates TLR7 responses in dendritic cells by facilitating RNA transportation to lysosomes.
Volume: 27
Issue: 2
Pages: 83-94
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Publication
31314175 | J:319692
First Author: Yordanov TE
Year: 2019
Journal: Traffic
Title: Biogenesis of lysosome-related organelles complex-1 (BORC) regulates late endosomal/lysosomal size through PIKfyve-dependent phosphatidylinositol-3,5-bisphosphate.
Volume: 20
Issue: 9
Pages: 674-696
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Publication
19578118 | J:154212
First Author: Ikonomov OC
Year: 2009
Journal: J Biol Chem
Title: Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytes.
Volume: 284
Issue: 36
Pages: 23961-71
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Publication
26405034 | J:227134
First Author: Ikonomov OC
Year: 2015
Journal: J Biol Chem
Title: The Protein Complex of Neurodegeneration-related Phosphoinositide Phosphatase Sac3 and ArPIKfyve Binds the Lewy Body-associated Synphilin-1, Preventing Its Aggregation.
Volume: 290
Issue: 47
Pages: 28515-29
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Publication
29030399 | J:270548
First Author: Gómez NM
Year: 2018
Journal: FASEB J
Title: Robust lysosomal calcium signaling through channel TRPML1 is impaired by lysosomal lipid accumulation.
Volume: 32
Issue: 2
Pages: 782-794
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Protein
Q8K279
Organism: Mus musculus/domesticus
Length: 347  
Fragment?: false
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Protein
A0A1D5RLN5
Organism: Mus musculus/domesticus
Length: 142  
Fragment?: false
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Protein
Q8C907
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
A0A1D5RLY2
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
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Publication
30917721 | J:313276
First Author: Fernandez-Mosquera L
Year: 2019
Journal: Autophagy
Title: Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis.
Volume: 15
Issue: 9
Pages: 1572-1591
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Publication
19793721 | J:154296
First Author: Ferguson CJ
Year: 2009
Journal: Hum Mol Genet
Title: Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.
Volume: 18
Issue: 24
Pages: 4868-78
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Publication
- | J:81516
     
First Author: Bronson R
Year: 2003
Journal: MGI Direct Data Submission
Title: Infantile gliosis (ingls) a new spontaneous mutation in the mouse. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine
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Publication
21655088 | J:173446
First Author: Lenk GM
Year: 2011
Journal: PLoS Genet
Title: Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J.
Volume: 7
Issue: 6
Pages: e1002104
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Publication
22842785 | J:188700
First Author: Zhang Y
Year: 2012
Journal: EMBO J
Title: Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)Pâ‚‚ and PI(5)P.
Volume: 31
Issue: 16
Pages: 3442-56
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Protein
Q80WQ2
Organism: Mus musculus/domesticus
Length: 782  
Fragment?: false
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Protein
Q8CCX6
Organism: Mus musculus/domesticus
Length: 680  
Fragment?: false
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Protein
Q8C6J5
Organism: Mus musculus/domesticus
Length: 205  
Fragment?: false
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Publication
26950892 | J:236650
First Author: Li X
Year: 2016
Journal: Nat Cell Biol
Title: A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.
Volume: 18
Issue: 4
Pages: 404-17
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Publication
29187380 | J:257575
First Author: Mayer L
Year: 2018
Journal: Blood
Title: Nbeal2 interacts with Dock7, Sec16a, and Vac14.
Volume: 131
Issue: 9
Pages: 1000-1011
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Publication
25471590 | J:218853
First Author: Cao M
Year: 2014
Journal: J Neurosci
Title: Upregulation of Parkin in endophilin mutant mice.
Volume: 34
Issue: 49
Pages: 16544-9
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Publication
- | J:72400
       
First Author: Mouse Genome Sequence and Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Mouse Genome Sequence Project Annotation
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:157064
     
First Author: University of California, Davis
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the University of California, Davis
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
- | J:81858
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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