Type |
Details |
Score |
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 52, Maarten van Lohuizen |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Anton Berns |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 6, Rene Bernards |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 54, Jean-Christophe Renauld |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rene Bernards |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter |
|
•
•
•
•
•
|
Publication |
First Author: |
Pearson R |
Year: |
2000 |
Journal: |
EMBO J |
Title: |
c-Myb regulates the proliferation of immature thymocytes following beta-selection. |
Volume: |
19 |
Issue: |
22 |
Pages: |
6112-20 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 33, Maarten van Lohuizen |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 5, Anton Berns |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Breuer M |
Year: |
1989 |
Journal: |
Nature |
Title: |
Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. |
Volume: |
340 |
Issue: |
6228 |
Pages: |
61-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Utteridge TD |
Year: |
2002 |
Journal: |
Radiat Res |
Title: |
Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence. |
Volume: |
158 |
Issue: |
3 |
Pages: |
357-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Breuer M |
Year: |
1991 |
Journal: |
Cancer Res |
Title: |
Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras. |
Volume: |
51 |
Issue: |
3 |
Pages: |
958-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Möröy T |
Year: |
1991 |
Journal: |
Oncogene |
Title: |
E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice. |
Volume: |
6 |
Issue: |
11 |
Pages: |
1941-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Repacholi MH |
Year: |
1997 |
Journal: |
Radiat Res |
Title: |
Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields. |
Volume: |
147 |
Issue: |
5 |
Pages: |
631-40 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 5, Jean-Christophe Renauld |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Publication |
First Author: |
Grouwels G |
Year: |
2010 |
Journal: |
Diabetes |
Title: |
Ectopic expression of E2F1 stimulates beta-cell proliferation and function. |
Volume: |
59 |
Issue: |
6 |
Pages: |
1435-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lange K |
Year: |
2003 |
Journal: |
Oncogene |
Title: |
Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice. |
Volume: |
22 |
Issue: |
4 |
Pages: |
517-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fallon PG |
Year: |
2000 |
Journal: |
Infect Immun |
Title: |
Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections. |
Volume: |
68 |
Issue: |
10 |
Pages: |
6005-11 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Jean-Christophe Renauld |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Igh-Pim1)1Brn/? |
Background: |
involves: C57BL/6LiA * CBA |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Dong Q |
Year: |
1999 |
Journal: |
Eur J Immunol |
Title: |
IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice. |
Volume: |
29 |
Issue: |
7 |
Pages: |
2130-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Faulkner H |
Year: |
1998 |
Journal: |
Infect Immun |
Title: |
Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris. |
Volume: |
66 |
Issue: |
8 |
Pages: |
3832-40 |
|
•
•
•
•
•
|
Publication |
First Author: |
Louahed J |
Year: |
2001 |
Journal: |
Blood |
Title: |
Interleukin 9 promotes influx and local maturation of eosinophils. |
Volume: |
97 |
Issue: |
4 |
Pages: |
1035-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
McLane MP |
Year: |
1998 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice. |
Volume: |
19 |
Issue: |
5 |
Pages: |
713-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
van den Brûle S |
Year: |
2007 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Profibrotic effect of IL-9 overexpression in a model of airway remodeling. |
Volume: |
37 |
Issue: |
2 |
Pages: |
202-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arras M |
Year: |
2001 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
Interleukin-9 reduces lung fibrosis and type 2 immune polarization induced by silica particles in a murine model. |
Volume: |
24 |
Issue: |
4 |
Pages: |
368-75 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Pim1-Il9)5Jcrd/? |
Background: |
involves: BALB/c * FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Il2rg/Il2rg Tg(Igh-Pim1)1Brn/? |
Background: |
either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N) |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Pim1-Il9)5Jcrd/? |
Background: |
involves: FVB/N |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Zheng HQ |
Year: |
2009 |
Journal: |
Oncogene |
Title: |
Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1. |
Volume: |
28 |
Issue: |
42 |
Pages: |
3702-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2003 |
Journal: |
Nucleic Acids Res |
Title: |
Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function. |
Volume: |
31 |
Issue: |
8 |
Pages: |
2196-208 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
Krueppel-like factor 5 (KLF5) belongs to the Kruppel family, whose members bind GC-rich DNA elements and activate or repress their target genes in a promoter context and/or cellular environment-dependent manner []. KLF5 is a zinc-finger transcription factor promoting cell proliferation, cell-cycle progression and survival []. It regulates transcription of a number of genes, such as the platelet-derived growth factor-alpha (PDGF-alpha), CyclinD1, Pim1 and PPARgamma []. It has been implicated in pathways critical to carcinogenesis []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Knoops L |
Year: |
2004 |
Journal: |
J Immunol |
Title: |
IL-9-induced expansion of B-1b cells restores numbers but not function of B-1 lymphocytes in xid mice. |
Volume: |
172 |
Issue: |
10 |
Pages: |
6101-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arras M |
Year: |
2006 |
Journal: |
Am J Respir Cell Mol Biol |
Title: |
B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice. |
Volume: |
34 |
Issue: |
5 |
Pages: |
573-80 |
|
•
•
•
•
•
|
Publication |
First Author: |
Arras M |
Year: |
2005 |
Journal: |
Am J Pathol |
Title: |
IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins. |
Volume: |
166 |
Issue: |
1 |
Pages: |
107-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
McCormick DL |
Year: |
1998 |
Journal: |
Carcinogenesis |
Title: |
Exposure to 60 Hz magnetic fields and risk of lymphoma in PIM transgenic and TSG-p53 (p53 knockout) mice. |
Volume: |
19 |
Issue: |
9 |
Pages: |
1649-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steenwinckel V |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells. |
Volume: |
178 |
Issue: |
5 |
Pages: |
3244-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scheijen B |
Year: |
2003 |
Journal: |
Mol Cell Biol |
Title: |
Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation. |
Volume: |
23 |
Issue: |
10 |
Pages: |
3656-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bourouh C |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells. |
Volume: |
40 |
Issue: |
6 |
Pages: |
111170 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verbeek S |
Year: |
1991 |
Journal: |
Mol Cell Biol |
Title: |
Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally. |
Volume: |
11 |
Issue: |
2 |
Pages: |
1176-9 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rag2/Rag2 Tg(Igh-Pim1)1Brn/? |
Background: |
involves: 129S/SvEv * C57BL/6LiA * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tmem163/? |
Background: |
involves: 129P2/OlaHsd * FVB * FVB/N |
Zygosity: |
cn |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Li M |
Year: |
2005 |
Journal: |
Protein Sci |
Title: |
Crystal structure of the N-terminal domain of E. coli Lon protease. |
Volume: |
14 |
Issue: |
11 |
Pages: |
2895-900 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li JK |
Year: |
2013 |
Journal: |
Acta Crystallogr D Biol Crystallogr |
Title: |
The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones. |
Volume: |
69 |
Issue: |
Pt 9 |
Pages: |
1789-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Vink A |
Year: |
1999 |
Journal: |
J Exp Med |
Title: |
Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population. |
Volume: |
189 |
Issue: |
9 |
Pages: |
1413-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alkema MJ |
Year: |
1995 |
Journal: |
Nature |
Title: |
Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice. |
Volume: |
374 |
Issue: |
6524 |
Pages: |
724-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Alkema MJ |
Year: |
1997 |
Journal: |
Oncogene |
Title: |
Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger. |
Volume: |
15 |
Issue: |
8 |
Pages: |
899-910 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aplan PD |
Year: |
1997 |
Journal: |
EMBO J |
Title: |
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. |
Volume: |
16 |
Issue: |
9 |
Pages: |
2408-19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Knoops L |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
IL-9 promotes but is not necessary for systemic anaphylaxis. |
Volume: |
175 |
Issue: |
1 |
Pages: |
335-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Godfraind C |
Year: |
1998 |
Journal: |
J Immunol |
Title: |
Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice. |
Volume: |
160 |
Issue: |
8 |
Pages: |
3989-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lucero EM |
Year: |
2022 |
Journal: |
iScience |
Title: |
Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction. |
Volume: |
25 |
Issue: |
11 |
Pages: |
105288 |
|
•
•
•
•
•
|
Publication |
First Author: |
Castillo A |
Year: |
2007 |
Journal: |
Cancer Res |
Title: |
Overexpression of Eg5 causes genomic instability and tumor formation in mice. |
Volume: |
67 |
Issue: |
21 |
Pages: |
10138-47 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cd3g/Cd3g Tg(Igh-Pim1)1Brn/? |
Background: |
involves: 129P2/OlaHsd * C57BL/6LiA * CBA |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Barakat S |
Year: |
1998 |
Journal: |
Plant Mol Biol |
Title: |
Maize contains a Lon protease gene that can partially complement a yeast pim1-deletion mutant. |
Volume: |
37 |
Issue: |
1 |
Pages: |
141-54 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
This entry represents the N-terminal substrate-binding domain of the Lon protease. This ATP-dependent enzyme, a serine peptidase belonging to the MEROPS peptidase family S16, is conserved in archaeal, bacterial and eukaryotic organisms and catalyses rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. In eukaryotes, the majority of the proteins are located in the mitochondrial matrix [, ]. In yeast, Pim1, is located in the mitochondrial matrix and required for mitochondrial function. It is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [].The structure of this domain has been determined and it represents a general protein and polypeptide interaction domain [, , , ]. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the N-terminal substrate-binding domain of the Lon protease. This ATP-dependent enzyme, a serine peptidase belonging to the MEROPS peptidase family S16, is conserved in archaeal, bacterial and eukaryotic organisms and catalyses rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. In eukaryotes, the majority of the proteins are located in the mitochondrial matrix [, ]. In yeast, Pim1, is located in the mitochondrial matrix and required for mitochondrial function. It is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [].The structure of this domain has been determined and it represents a general protein and polypeptide interaction domain [, , , ]. |
|
•
•
•
•
•
|
Publication |
First Author: |
Bertonati C |
Year: |
2009 |
Journal: |
Proteins |
Title: |
Structural genomics reveals EVE as a new ASCH/PUA-related domain. |
Volume: |
75 |
Issue: |
3 |
Pages: |
760-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Davoodi-Semiromi A |
Year: |
2004 |
Journal: |
J Biol Chem |
Title: |
A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice. |
Volume: |
279 |
Issue: |
12 |
Pages: |
11553-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jonkers J |
Year: |
1997 |
Journal: |
EMBO J |
Title: |
Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. |
Volume: |
16 |
Issue: |
3 |
Pages: |
441-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zeng S |
Year: |
2012 |
Journal: |
FASEB J |
Title: |
Opposing roles of RAGE and Myd88 signaling in extensive liver resection. |
Volume: |
26 |
Issue: |
2 |
Pages: |
882-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sathyanarayana P |
Year: |
2008 |
Journal: |
Blood |
Title: |
EPO receptor circuits for primary erythroblast survival. |
Volume: |
111 |
Issue: |
11 |
Pages: |
5390-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goldberg L |
Year: |
2013 |
Journal: |
Blood |
Title: |
Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia. |
Volume: |
122 |
Issue: |
15 |
Pages: |
2694-703 |
|
•
•
•
•
•
|
Publication |
First Author: |
Blyth K |
Year: |
2001 |
Journal: |
Oncogene |
Title: |
Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging. |
Volume: |
20 |
Issue: |
3 |
Pages: |
295-302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heine D |
Year: |
1994 |
Journal: |
Genomics |
Title: |
Analysis of recombinational hot spots associated with the p haplotype of the mouse MHC. |
Volume: |
23 |
Issue: |
1 |
Pages: |
168-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Landais S |
Year: |
2005 |
Journal: |
J Virol |
Title: |
Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene. |
Volume: |
79 |
Issue: |
17 |
Pages: |
11443-56 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu N |
Year: |
2017 |
Journal: |
PLoS One |
Title: |
PIM1-minicircle as a therapeutic treatment for myocardial infarction. |
Volume: |
12 |
Issue: |
3 |
Pages: |
e0173963 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiménez-GarcÃa MP |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
The role of PIM1/PIM2 kinases in tumors of the male reproductive system. |
Volume: |
6 |
|
Pages: |
38079 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baron BW |
Year: |
2014 |
Journal: |
Blood Cells Mol Dis |
Title: |
GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas. |
Volume: |
52 |
Issue: |
1 |
Pages: |
68-75 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Cha SS |
Year: |
2010 |
Journal: |
EMBO J |
Title: |
Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber. |
Volume: |
29 |
Issue: |
20 |
Pages: |
3520-30 |
|
•
•
•
•
•
|
Publication |
First Author: |
Steenwinckel V |
Year: |
2009 |
Journal: |
J Immunol |
Title: |
IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa. |
Volume: |
182 |
Issue: |
8 |
Pages: |
4737-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
van der Lugt NM |
Year: |
1996 |
Journal: |
Mech Dev |
Title: |
The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression. |
Volume: |
58 |
Issue: |
1-2 |
Pages: |
153-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou X |
Year: |
2016 |
Journal: |
Sci Rep |
Title: |
Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment. |
Volume: |
6 |
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Pages: |
29171 |
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Publication |
First Author: |
Leduc I |
Year: |
2000 |
Journal: |
Int Immunol |
Title: |
The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action. |
Volume: |
12 |
Issue: |
10 |
Pages: |
1389-96 |
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Publication |
First Author: |
Renauld JC |
Year: |
1994 |
Journal: |
Oncogene |
Title: |
Thymic lymphomas in interleukin 9 transgenic mice. |
Volume: |
9 |
Issue: |
5 |
Pages: |
1327-32 |
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Publication |
First Author: |
Mikkers H |
Year: |
2002 |
Journal: |
Nat Genet |
Title: |
High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. |
Volume: |
32 |
Issue: |
1 |
Pages: |
153-9 |
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Publication |
First Author: |
Kirschner AN |
Year: |
2015 |
Journal: |
J Natl Cancer Inst |
Title: |
PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer. |
Volume: |
107 |
Issue: |
2 |
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Publication |
First Author: |
Roepman R |
Year: |
1996 |
Journal: |
Hum Mol Genet |
Title: |
Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1. |
Volume: |
5 |
Issue: |
7 |
Pages: |
1035-41 |
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Publication |
First Author: |
Dasso M |
Year: |
1993 |
Journal: |
Trends Biochem Sci |
Title: |
RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles. |
Volume: |
18 |
Issue: |
3 |
Pages: |
96-101 |
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Publication |
First Author: |
Wang N |
Year: |
1993 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. |
Volume: |
90 |
Issue: |
23 |
Pages: |
11247-51 |
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Protein Domain |
Type: |
Family |
Description: |
Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress []. In pathogenic bacteria, it is required for the expression of virulence genes that promote cell infection [].Lon (La) protease was the first ATP-dependent protease to be purified fromE. coli [, , , ]. The enzyme is a homotetramer of 87kDa subunits, with one proteolytic and one ATP-binding site per monomer, making it structurally less complex than other known ATP-dependent proteases []. Despite this relative structural simplicity, Lon recognises its substrates directly, without delegating the task of substrate recognition to other enzymes []. This signature defines the bacterial and eukaryotic lon proteases. This family of sequences does not include the archaeal lon homologues, . In the eukaryotes the majority of the proteins are located in the mitochondrial matrix [, ]. The yeast homologue, Pim1, is required for mitochondrial function and is constitutively expressed, but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response []. |
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Protein Domain |
Type: |
Repeat |
Description: |
The regulator of chromosome condensation (RCC1) []is a eukaryotic proteinwhich binds to chromatin and interacts with ran, a nuclear GTP-bindingprotein , to promote the loss of bound GDP and the uptake offresh GTP, thus acting as a guanine-nucleotide dissociation stimulator (GDS).The interaction of RCC1 with ran probably plays an important role in theregulation of gene expression.RCC1, known as PRP20 or SRM1 in yeast, pim1 in fission yeast and BJ1 inDrosophila, is a protein that contains seven tandem repeats of a domain ofabout 50 to 60 amino acids. As shown in the following schematicrepresentation, the repeats make up the major part of the length of theprotein. Outside the repeat region, there is just a small N-terminal domain ofabout 40 to 50 residues and, in the Drosophila protein only, a C-terminaldomain of about 130 residues.+----+-------+-------+-------+-------+-------+-------+-------+-------------+|N-t.|Rpt. 1 |Rpt. 2 |Rpt. 3 |Rpt. 4 |Rpt. 5 |Rpt. 6 |Rpt. 7 | C-terminal |+----+-------+-------+-------+-------+-------+-------+-------+-------------+The RCC1-type of repeat is also found in the X-linked retinitis pigmentosaGTPase regulator []. The RCC repeats form a β-propellerstructure. |
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Publication |
First Author: |
Giralt A |
Year: |
2018 |
Journal: |
Mol Metab |
Title: |
E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes. |
Volume: |
11 |
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Pages: |
104-112 |
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Publication |
First Author: |
Poulin LF |
Year: |
2005 |
Journal: |
Eur Cytokine Netw |
Title: |
Interleukin-9 stimulates the production of interleukin-5 in CD4+ T cells. |
Volume: |
16 |
Issue: |
3 |
Pages: |
233-9 |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
461
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
421
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
520
 |
Fragment?: |
false |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
377
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
464
 |
Fragment?: |
false |
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•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1001
 |
Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
94
 |
Fragment?: |
true |
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•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
576
 |
Fragment?: |
true |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
341
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
681
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
434
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
450
 |
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
965
 |
Fragment?: |
true |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
198
 |
Fragment?: |
true |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
1203
 |
Fragment?: |
true |
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•
•
•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
77
 |
Fragment?: |
true |
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