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Search results 301 to 400 out of 472 for Pim1

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Type Details Score
DO Term
Allele
Name: transgene insertion 52, Maarten van Lohuizen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Anton Berns
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 6, Rene Bernards
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 54, Jean-Christophe Renauld
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Rene Bernards
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter
Publication
First Author: Pearson R
Year: 2000
Journal: EMBO J
Title: c-Myb regulates the proliferation of immature thymocytes following beta-selection.
Volume: 19
Issue: 22
Pages: 6112-20
Allele
Name: transgene insertion 33, Maarten van Lohuizen
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 5, Anton Berns
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Breuer M
Year: 1989
Journal: Nature
Title: Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice.
Volume: 340
Issue: 6228
Pages: 61-3
Publication
First Author: Utteridge TD
Year: 2002
Journal: Radiat Res
Title: Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence.
Volume: 158
Issue: 3
Pages: 357-64
Publication
First Author: Breuer M
Year: 1991
Journal: Cancer Res
Title: Carcinogen-induced lymphomagenesis in pim-1 transgenic mice: dose dependence and involvement of myc and ras.
Volume: 51
Issue: 3
Pages: 958-63
Publication
First Author: Möröy T
Year: 1991
Journal: Oncogene
Title: E mu N- and E mu L-myc cooperate with E mu pim-1 to generate lymphoid tumors at high frequency in double-transgenic mice.
Volume: 6
Issue: 11
Pages: 1941-8
Publication
First Author: Repacholi MH
Year: 1997
Journal: Radiat Res
Title: Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields.
Volume: 147
Issue: 5
Pages: 631-40
Allele
Name: transgene insertion 5, Jean-Christophe Renauld
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Grouwels G
Year: 2010
Journal: Diabetes
Title: Ectopic expression of E2F1 stimulates beta-cell proliferation and function.
Volume: 59
Issue: 6
Pages: 1435-44
Publication
First Author: Lange K
Year: 2003
Journal: Oncogene
Title: Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice.
Volume: 22
Issue: 4
Pages: 517-27
Publication
First Author: Fallon PG
Year: 2000
Journal: Infect Immun
Title: Expression of interleukin-9 leads to Th2 cytokine-dominated responses and fatal enteropathy in mice with chronic Schistosoma mansoni infections.
Volume: 68
Issue: 10
Pages: 6005-11
Allele
Name: transgene insertion, Jean-Christophe Renauld
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(Igh-Pim1)1Brn/?
Background: involves: C57BL/6LiA * CBA
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Dong Q
Year: 1999
Journal: Eur J Immunol
Title: IL-9 induces chemokine expression in lung epithelial cells and baseline airway eosinophilia in transgenic mice.
Volume: 29
Issue: 7
Pages: 2130-9
Publication
First Author: Faulkner H
Year: 1998
Journal: Infect Immun
Title: Interleukin-9 enhances resistance to the intestinal nematode Trichuris muris.
Volume: 66
Issue: 8
Pages: 3832-40
Publication
First Author: Louahed J
Year: 2001
Journal: Blood
Title: Interleukin 9 promotes influx and local maturation of eosinophils.
Volume: 97
Issue: 4
Pages: 1035-42
Publication
First Author: McLane MP
Year: 1998
Journal: Am J Respir Cell Mol Biol
Title: Interleukin-9 promotes allergen-induced eosinophilic inflammation and airway hyperresponsiveness in transgenic mice.
Volume: 19
Issue: 5
Pages: 713-20
Publication
First Author: van den Brûle S
Year: 2007
Journal: Am J Respir Cell Mol Biol
Title: Profibrotic effect of IL-9 overexpression in a model of airway remodeling.
Volume: 37
Issue: 2
Pages: 202-9
Publication
First Author: Arras M
Year: 2001
Journal: Am J Respir Cell Mol Biol
Title: Interleukin-9 reduces lung fibrosis and type 2 immune polarization induced by silica particles in a murine model.
Volume: 24
Issue: 4
Pages: 368-75
Genotype
Symbol: Tg(Pim1-Il9)5Jcrd/?
Background: involves: BALB/c * FVB/N
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Il2rg/Il2rg Tg(Igh-Pim1)1Brn/?
Background: either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N)
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Pim1-Il9)5Jcrd/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
Publication
First Author: Zheng HQ
Year: 2009
Journal: Oncogene
Title: Krüppel-like factor 5 promotes breast cell proliferation partially through upregulating the transcription of fibroblast growth factor binding protein 1.
Volume: 28
Issue: 42
Pages: 3702-13
Publication
First Author: Zhang Z
Year: 2003
Journal: Nucleic Acids Res
Title: Phosphorylation of Kruppel-like factor 5 (KLF5/IKLF) at the CBP interaction region enhances its transactivation function.
Volume: 31
Issue: 8
Pages: 2196-208
Protein Domain
Type: Family
Description: Krueppel-like factor 5 (KLF5) belongs to the Kruppel family, whose members bind GC-rich DNA elements and activate or repress their target genes in a promoter context and/or cellular environment-dependent manner []. KLF5 is a zinc-finger transcription factor promoting cell proliferation, cell-cycle progression and survival []. It regulates transcription of a number of genes, such as the platelet-derived growth factor-alpha (PDGF-alpha), CyclinD1, Pim1 and PPARgamma []. It has been implicated in pathways critical to carcinogenesis [].
Publication
First Author: Knoops L
Year: 2004
Journal: J Immunol
Title: IL-9-induced expansion of B-1b cells restores numbers but not function of B-1 lymphocytes in xid mice.
Volume: 172
Issue: 10
Pages: 6101-6
Publication
First Author: Arras M
Year: 2006
Journal: Am J Respir Cell Mol Biol
Title: B lymphocytes are critical for lung fibrosis control and prostaglandin E2 regulation in IL-9 transgenic mice.
Volume: 34
Issue: 5
Pages: 573-80
Publication
First Author: Arras M
Year: 2005
Journal: Am J Pathol
Title: IL-9 protects against bleomycin-induced lung injury: involvement of prostaglandins.
Volume: 166
Issue: 1
Pages: 107-15
Publication
First Author: McCormick DL
Year: 1998
Journal: Carcinogenesis
Title: Exposure to 60 Hz magnetic fields and risk of lymphoma in PIM transgenic and TSG-p53 (p53 knockout) mice.
Volume: 19
Issue: 9
Pages: 1649-53
Publication
First Author: Steenwinckel V
Year: 2007
Journal: J Immunol
Title: IL-13 mediates in vivo IL-9 activities on lung epithelial cells but not on hematopoietic cells.
Volume: 178
Issue: 5
Pages: 3244-51
Publication
First Author: Scheijen B
Year: 2003
Journal: Mol Cell Biol
Title: Constitutive E2F1 overexpression delays endochondral bone formation by inhibiting chondrocyte differentiation.
Volume: 23
Issue: 10
Pages: 3656-68
Publication
First Author: Bourouh C
Year: 2022
Journal: Cell Rep
Title: The transcription factor E2F1 controls the GLP-1 receptor pathway in pancreatic β cells.
Volume: 40
Issue: 6
Pages: 111170
Publication
First Author: Verbeek S
Year: 1991
Journal: Mol Cell Biol
Title: Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.
Volume: 11
Issue: 2
Pages: 1176-9
Genotype
Symbol: Rag2/Rag2 Tg(Igh-Pim1)1Brn/?
Background: involves: 129S/SvEv * C57BL/6LiA * CBA
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tmem163/?
Background: involves: 129P2/OlaHsd * FVB * FVB/N
Zygosity: cn
Has Mutant Allele: true
Publication
First Author: Li M
Year: 2005
Journal: Protein Sci
Title: Crystal structure of the N-terminal domain of E. coli Lon protease.
Volume: 14
Issue: 11
Pages: 2895-900
Publication
First Author: Li JK
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: The N-terminal substrate-recognition domain of a LonC protease exhibits structural and functional similarity to cytosolic chaperones.
Volume: 69
Issue: Pt 9
Pages: 1789-97
Publication
First Author: Vink A
Year: 1999
Journal: J Exp Med
Title: Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population.
Volume: 189
Issue: 9
Pages: 1413-23
Publication
First Author: Alkema MJ
Year: 1995
Journal: Nature
Title: Transformation of axial skeleton due to overexpression of bmi-1 in transgenic mice.
Volume: 374
Issue: 6524
Pages: 724-7
Publication
First Author: Alkema MJ
Year: 1997
Journal: Oncogene
Title: Pertubation of B and T cell development and predisposition to lymphomagenesis in Emu Bmi1 transgenic mice require the Bmi1 RING finger.
Volume: 15
Issue: 8
Pages: 899-910
Publication
First Author: Aplan PD
Year: 1997
Journal: EMBO J
Title: An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.
Volume: 16
Issue: 9
Pages: 2408-19
Publication
First Author: Knoops L
Year: 2005
Journal: J Immunol
Title: IL-9 promotes but is not necessary for systemic anaphylaxis.
Volume: 175
Issue: 1
Pages: 335-41
Publication
First Author: Godfraind C
Year: 1998
Journal: J Immunol
Title: Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice.
Volume: 160
Issue: 8
Pages: 3989-96
Publication
First Author: Lucero EM
Year: 2022
Journal: iScience
Title: Increased KIF11/kinesin-5 expression offsets Alzheimer Aβ-mediated toxicity and cognitive dysfunction.
Volume: 25
Issue: 11
Pages: 105288
Publication
First Author: Castillo A
Year: 2007
Journal: Cancer Res
Title: Overexpression of Eg5 causes genomic instability and tumor formation in mice.
Volume: 67
Issue: 21
Pages: 10138-47
Genotype
Symbol: Cd3g/Cd3g Tg(Igh-Pim1)1Brn/?
Background: involves: 129P2/OlaHsd * C57BL/6LiA * CBA
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Barakat S
Year: 1998
Journal: Plant Mol Biol
Title: Maize contains a Lon protease gene that can partially complement a yeast pim1-deletion mutant.
Volume: 37
Issue: 1
Pages: 141-54
Protein Domain
Type: Homologous_superfamily
Description: This entry represents the N-terminal substrate-binding domain of the Lon protease. This ATP-dependent enzyme, a serine peptidase belonging to the MEROPS peptidase family S16, is conserved in archaeal, bacterial and eukaryotic organisms and catalyses rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. In eukaryotes, the majority of the proteins are located in the mitochondrial matrix [, ]. In yeast, Pim1, is located in the mitochondrial matrix and required for mitochondrial function. It is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [].The structure of this domain has been determined and it represents a general protein and polypeptide interaction domain [, , , ].
Protein Domain
Type: Domain
Description: This entry represents the N-terminal substrate-binding domain of the Lon protease. This ATP-dependent enzyme, a serine peptidase belonging to the MEROPS peptidase family S16, is conserved in archaeal, bacterial and eukaryotic organisms and catalyses rapid turnover of short-lived regulatory proteins and many damaged or denatured proteins. In eukaryotes, the majority of the proteins are located in the mitochondrial matrix [, ]. In yeast, Pim1, is located in the mitochondrial matrix and required for mitochondrial function. It is constitutively expressed but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [].The structure of this domain has been determined and it represents a general protein and polypeptide interaction domain [, , , ].
Publication
First Author: Bertonati C
Year: 2009
Journal: Proteins
Title: Structural genomics reveals EVE as a new ASCH/PUA-related domain.
Volume: 75
Issue: 3
Pages: 760-73
Publication
First Author: Davoodi-Semiromi A
Year: 2004
Journal: J Biol Chem
Title: A mutant Stat5b with weaker DNA binding affinity defines a key defective pathway in nonobese diabetic mice.
Volume: 279
Issue: 12
Pages: 11553-61
Publication
First Author: Jonkers J
Year: 1997
Journal: EMBO J
Title: Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.
Volume: 16
Issue: 3
Pages: 441-50
Publication
First Author: Zeng S
Year: 2012
Journal: FASEB J
Title: Opposing roles of RAGE and Myd88 signaling in extensive liver resection.
Volume: 26
Issue: 2
Pages: 882-93
Publication
First Author: Sathyanarayana P
Year: 2008
Journal: Blood
Title: EPO receptor circuits for primary erythroblast survival.
Volume: 111
Issue: 11
Pages: 5390-9
Publication
First Author: Goldberg L
Year: 2013
Journal: Blood
Title: Genome-scale expression and transcription factor binding profiles reveal therapeutic targets in transgenic ERG myeloid leukemia.
Volume: 122
Issue: 15
Pages: 2694-703
Publication
First Author: Blyth K
Year: 2001
Journal: Oncogene
Title: Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral tagging.
Volume: 20
Issue: 3
Pages: 295-302
Publication
First Author: Heine D
Year: 1994
Journal: Genomics
Title: Analysis of recombinational hot spots associated with the p haplotype of the mouse MHC.
Volume: 23
Issue: 1
Pages: 168-77
Publication
First Author: Landais S
Year: 2005
Journal: J Virol
Title: Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene.
Volume: 79
Issue: 17
Pages: 11443-56
Publication
First Author: Liu N
Year: 2017
Journal: PLoS One
Title: PIM1-minicircle as a therapeutic treatment for myocardial infarction.
Volume: 12
Issue: 3
Pages: e0173963
Publication  
First Author: Jiménez-García MP
Year: 2016
Journal: Sci Rep
Title: The role of PIM1/PIM2 kinases in tumors of the male reproductive system.
Volume: 6
Pages: 38079
Publication
First Author: Baron BW
Year: 2014
Journal: Blood Cells Mol Dis
Title: GFI1B, EVI5, MYB--additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas.
Volume: 52
Issue: 1
Pages: 68-75
Protein
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: true
Publication
First Author: Cha SS
Year: 2010
Journal: EMBO J
Title: Crystal structure of Lon protease: molecular architecture of gated entry to a sequestered degradation chamber.
Volume: 29
Issue: 20
Pages: 3520-30
Publication
First Author: Steenwinckel V
Year: 2009
Journal: J Immunol
Title: IL-9 promotes IL-13-dependent paneth cell hyperplasia and up-regulation of innate immunity mediators in intestinal mucosa.
Volume: 182
Issue: 8
Pages: 4737-43
Publication
First Author: van der Lugt NM
Year: 1996
Journal: Mech Dev
Title: The Polycomb-group homolog Bmi-1 is a regulator of murine Hox gene expression.
Volume: 58
Issue: 1-2
Pages: 153-64
Publication  
First Author: Zhou X
Year: 2016
Journal: Sci Rep
Title: Overexpression of Bmi1 in Lymphocytes Stimulates Skeletogenesis by Improving the Osteogenic Microenvironment.
Volume: 6
Pages: 29171
Publication
First Author: Leduc I
Year: 2000
Journal: Int Immunol
Title: The Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 action.
Volume: 12
Issue: 10
Pages: 1389-96
Publication
First Author: Renauld JC
Year: 1994
Journal: Oncogene
Title: Thymic lymphomas in interleukin 9 transgenic mice.
Volume: 9
Issue: 5
Pages: 1327-32
Publication
First Author: Mikkers H
Year: 2002
Journal: Nat Genet
Title: High-throughput retroviral tagging to identify components of specific signaling pathways in cancer.
Volume: 32
Issue: 1
Pages: 153-9
Publication  
First Author: Kirschner AN
Year: 2015
Journal: J Natl Cancer Inst
Title: PIM kinase inhibitor AZD1208 for treatment of MYC-driven prostate cancer.
Volume: 107
Issue: 2
Publication
First Author: Roepman R
Year: 1996
Journal: Hum Mol Genet
Title: Positional cloning of the gene for X-linked retinitis pigmentosa 3: homology with the guanine-nucleotide-exchange factor RCC1.
Volume: 5
Issue: 7
Pages: 1035-41
Publication
First Author: Dasso M
Year: 1993
Journal: Trends Biochem Sci
Title: RCC1 in the cell cycle: the regulator of chromosome condensation takes on new roles.
Volume: 18
Issue: 3
Pages: 96-101
Publication
First Author: Wang N
Year: 1993
Journal: Proc Natl Acad Sci U S A
Title: A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.
Volume: 90
Issue: 23
Pages: 11247-51
Protein Domain
Type: Family
Description: Lon protease belongs to the S16 peptidase family and is an ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins, as well as certain short-lived regulatory proteins. It is required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress []. In pathogenic bacteria, it is required for the expression of virulence genes that promote cell infection [].Lon (La) protease was the first ATP-dependent protease to be purified fromE. coli [, , , ]. The enzyme is a homotetramer of 87kDa subunits, with one proteolytic and one ATP-binding site per monomer, making it structurally less complex than other known ATP-dependent proteases []. Despite this relative structural simplicity, Lon recognises its substrates directly, without delegating the task of substrate recognition to other enzymes []. This signature defines the bacterial and eukaryotic lon proteases. This family of sequences does not include the archaeal lon homologues, . In the eukaryotes the majority of the proteins are located in the mitochondrial matrix [, ]. The yeast homologue, Pim1, is required for mitochondrial function and is constitutively expressed, but is increased after thermal stress, suggesting that Pim1 may play a role in the heat shock response [].
Protein Domain
Type: Repeat
Description: The regulator of chromosome condensation (RCC1) []is a eukaryotic proteinwhich binds to chromatin and interacts with ran, a nuclear GTP-bindingprotein , to promote the loss of bound GDP and the uptake offresh GTP, thus acting as a guanine-nucleotide dissociation stimulator (GDS).The interaction of RCC1 with ran probably plays an important role in theregulation of gene expression.RCC1, known as PRP20 or SRM1 in yeast, pim1 in fission yeast and BJ1 inDrosophila, is a protein that contains seven tandem repeats of a domain ofabout 50 to 60 amino acids. As shown in the following schematicrepresentation, the repeats make up the major part of the length of theprotein. Outside the repeat region, there is just a small N-terminal domain ofabout 40 to 50 residues and, in the Drosophila protein only, a C-terminaldomain of about 130 residues.+----+-------+-------+-------+-------+-------+-------+-------+-------------+|N-t.|Rpt. 1 |Rpt. 2 |Rpt. 3 |Rpt. 4 |Rpt. 5 |Rpt. 6 |Rpt. 7 | C-terminal |+----+-------+-------+-------+-------+-------+-------+-------+-------------+The RCC1-type of repeat is also found in the X-linked retinitis pigmentosaGTPase regulator []. The RCC repeats form a β-propellerstructure.
Publication  
First Author: Giralt A
Year: 2018
Journal: Mol Metab
Title: E2F1 promotes hepatic gluconeogenesis and contributes to hyperglycemia during diabetes.
Volume: 11
Pages: 104-112
Publication
First Author: Poulin LF
Year: 2005
Journal: Eur Cytokine Netw
Title: Interleukin-9 stimulates the production of interleukin-5 in CD4+ T cells.
Volume: 16
Issue: 3
Pages: 233-9
Protein
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 421  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 1001  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 965  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1203  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 77  
Fragment?: true