|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 452 for Pin1

<< First    < Previous  |  Next >    Last >>
0.049s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGP_CASTEiJ_G0025405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_CBAJ_G0025918 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0026056 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0026019 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0026159 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0026043 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0026695 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0025140 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0025472 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0025466 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•
Protein Coding Gene
MGP_SPRETEiJ_G0024941 | -
Type: protein_coding_gene
Organism: Mus spretus
•
•
•
•
•
Publication
26887918 | -
First Author: Cui P
Year: 2016
Journal: Plant Cell
Title: The RNA Polymerase II C-Terminal Domain Phosphatase-Like Protein FIERY2/CPL1 Interacts with eIF4AIII and Is Essential for Nonsense-Mediated mRNA Decay in Arabidopsis.
Volume: 28
Issue: 3
Pages: 770-85
•
•
•
•
•
Publication
25041272 | -
First Author: Fukudome A
Year: 2014
Journal: Plant J
Title: Arabidopsis CPL4 is an essential C-terminal domain phosphatase that suppresses xenobiotic stress responses.
Volume: 80
Issue: 1
Pages: 27-39
•
•
•
•
•
Protein Domain
IPR039189 | Fcp1
Type: Family
Description: This entry represents Fcp1 and its homologues, including CTDP1 from humans and CPL1/2/3/4/5 from Arabidopsis. They are carboxy-terminal domain (CTD) phosphatases. CPL1 has been shown to interact with two NMD (nonsense-mediated decay) factors, eIF4AIII and UPF3, and is involved in the dephosphorylation of eIF4AIII []. CPL4 functions as a pol II CTD phosphatase and has been shown to dephosphorylate both Ser2- and Ser5-PO(4) of CTD in vitro []. Budding yeast Fcp1 has been shown to dephosphorylate RNA polymerase (RNAP) II subunit, and this interaction is modulated by the Pin1 protein [].
•
•
•
•
•
Protein
P26883
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Protein
Q9Z2I2
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Protein
Q6P9Q6
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
•
•
•
•
•
Protein
D6RDT0
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
•
•
•
•
•
Protein
H3BJI5
Organism: Mus musculus/domesticus
Length: 123  
Fragment?: false
•
•
•
•
•
Protein
Q80YW7
Organism: Mus musculus/domesticus
Length: 644  
Fragment?: false
•
•
•
•
•
Protein
Q810R7
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Protein
F6X9I3
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
•
•
•
•
•
Protein
Q3UKJ3
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
•
•
•
•
•
Protein
B2RQ18
Organism: Mus musculus/domesticus
Length: 1206  
Fragment?: false
•
•
•
•
•
Protein
Q3ULN5
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Protein
Q3UBA0
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
•
•
•
•
•
Protein
Q80YW9
Organism: Mus musculus/domesticus
Length: 756  
Fragment?: false
•
•
•
•
•
Protein
F6W360
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
•
•
•
•
•
Protein
Q80YW6
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
•
•
•
•
•
Protein
A0A6I8MWZ0
Organism: Mus musculus/domesticus
Length: 1044  
Fragment?: true
•
•
•
•
•
Protein
Q80YE1
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: false
•
•
•
•
•
Protein
A9E3L2
Organism: Mus musculus/domesticus
Length: 108  
Fragment?: false
•
•
•
•
•
Publication
14976191 | -
First Author: Vitikainen M
Year: 2004
Journal: J Biol Chem
Title: Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis.
Volume: 279
Issue: 18
Pages: 19302-14
•
•
•
•
•
Protein Domain
IPR030411 | Sp140
Type: Family
Description: The function of nuclear protein Sp140 is not known, though it contains several chromatin related modules such as plant homeodomain (PHD), bromodomain (BRD) and SAND domain, which suggests a role in chromatin-mediated regulation of gene expression []. It also harbours a nuclear localisation signal and a dimerisation domain (HSR or CARD domain). The PHD finger of Sp140 presents an atypical fold which does not bind to histone H3 tails but binds to peptidylprolyl isomerase Pin1. Pin1 catalyses the isomerisation of a phospho-Threonine-Proline bond in Sp140-PHD and thus may modulate Sp140 function [].Human Sp140 is an interferon inducible nuclear leukocyte-specific protein that may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection []. It localises to LYSP100-associated nuclear dots and is also a component of the promyelocytic leukemia nuclear body (PML-NBs) [, ]. The Sp140 locus has been identified as a lymphocytic leukemia (CLL) risk locus [].This family also includes protein Sp140-like (SP140L) [].
•
•
•
•
•
Publication
10037602 | J:140385
First Author: Lu PJ
Year: 1999
Journal: Science
Title: Function of WW domains as phosphoserine- or phosphothreonine-binding modules.
Volume: 283
Issue: 5406
Pages: 1325-8
•
•
•
•
•
Publication
30590041 | J:270746
First Author: Tornillo G
Year: 2018
Journal: Cell Rep
Title: Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells.
Volume: 25
Issue: 13
Pages: 3674-3692.e10
•
•
•
•
•
Publication
20080565 | J:156744
First Author: Penela P
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: G protein-coupled receptor kinase 2 (GRK2) modulation and cell cycle progression.
Volume: 107
Issue: 3
Pages: 1118-23
•
•
•
•
•
Publication
25818297 | J:228169
First Author: Luo ML
Year: 2015
Journal: Cell Rep
Title: The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Volume: 11
Issue: 1
Pages: 111-24
•
•
•
•
•
Publication
24267382 | -
First Author: Zucchelli C
Year: 2014
Journal: FEBS J
Title: Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1.
Volume: 281
Issue: 1
Pages: 216-31
•
•
•
•
•
Publication
20923397 | -
First Author: Yap KL
Year: 2010
Journal: Crit Rev Biochem Mol Biol
Title: Keeping it in the family: diverse histone recognition by conserved structural folds.
Volume: 45
Issue: 6
Pages: 488-505
•
•
•
•
•
Publication
8910577 | -
First Author: Bloch DB
Year: 1996
Journal: J Biol Chem
Title: Identification and characterization of a leukocyte-specific component of the nuclear body.
Volume: 271
Issue: 46
Pages: 29198-204
•
•
•
•
•
Publication
18758461 | -
First Author: Di Bernardo MC
Year: 2008
Journal: Nat Genet
Title: A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
Volume: 40
Issue: 10
Pages: 1204-10
•
•
•
•
•
Publication
8695863 | -
First Author: Dent AL
Year: 1996
Journal: Blood
Title: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.
Volume: 88
Issue: 4
Pages: 1423-6
•
•
•
•
•
Publication
26347895 | -
 
First Author: Saare M
Year: 2015
Journal: J Immunol Res
Title: SP140L, an Evolutionarily Recent Member of the SP100 Family, Is an Autoantigen in Primary Biliary Cirrhosis.
Volume: 2015
Pages: 526518
•
•
•
•
•
Protein
Q9D1M7
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
•
•
•
•
•
Protein
P45878
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
•
•
•
•
•
Protein
I6L993
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
•
•
•
•
•
Protein
Q3TND1
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
•
•
•
•
•
Protein
F7CAT1
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
•
•
•
•
•
Protein
B8JJC2
Organism: Mus musculus/domesticus
Length: 191  
Fragment?: true
•
•
•
•
•
Protein
A0A3B2WCL4
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: false
•
•
•
•
•
Protein
A0A1Y7VJ86
Organism: Mus musculus/domesticus
Length: 88  
Fragment?: true
•
•
•
•
•
Protein
Q3UND3
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
•
•
•
•
•
Publication
12429090 | -
First Author: Bitto E
Year: 2002
Journal: Structure
Title: Crystallographic structure of SurA, a molecular chaperone that facilitates folding of outer membrane porins.
Volume: 10
Issue: 11
Pages: 1489-98
•
•
•
•
•
Publication
17158931 | J:118244
First Author: Toledo F
Year: 2007
Journal: Mol Cell Biol
Title: Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression.
Volume: 27
Issue: 4
Pages: 1425-32
•
•
•
•
•
Publication
24161275 | J:207635
 
First Author: Lattanzio F
Year: 2014
Journal: Neuroscience
Title: Human apolipoprotein E4 modulates the expression of Pin1, Sirtuin 1, and Presenilin 1 in brain regions of targeted replacement apoE mice.
Volume: 256
Pages: 360-9
•
•
•
•
•
Publication
28365778 | J:240388
First Author: Kukalev A
Year: 2017
Journal: Cereb Cortex
Title: Deficiency of Cks1 Leads to Learning and Long-Term Memory Defects and p27 Dependent Formation of Neuronal Cofilin Aggregates.
Volume: 27
Issue: 1
Pages: 11-23
•
•
•
•
•
Publication
23109421 | J:192847
First Author: Bhaskaran N
Year: 2013
Journal: Mol Cell Biol
Title: Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylation.
Volume: 33
Issue: 1
Pages: 85-97
•
•
•
•
•
Publication
25197063 | J:216366
First Author: Nesti E
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
Volume: 111
Issue: 37
Pages: E3929-36
•
•
•
•
•
Publication
28082424 | J:252274
First Author: Behm M
Year: 2017
Journal: J Cell Sci
Title: Accumulation of nuclear ADAR2 regulates adenosine-to-inosine RNA editing during neuronal development.
Volume: 130
Issue: 4
Pages: 745-753
•
•
•
•
•
Publication
32801157 | J:296023
First Author: Culotta L
Year: 2020
Journal: J Neurosci
Title: SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex.
Volume: 40
Issue: 37
Pages: 7013-7026
•
•
•
•
•
Publication
34078745 | J:308507
 
First Author: Qiu C
Year: 2021
Journal: Sci Transl Med
Title: Cis P-tau underlies vascular contribution to cognitive impairment and dementia and can be effectively targeted by immunotherapy in mice.
Volume: 13
Issue: 596
•
•
•
•
•
Protein
Q9CWW6
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
•
•
•
•
•
Protein
D3YW40
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
•
•
•
•
•
Protein
Q8C308
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
•
•
•
•
•
Protein
F6V9G0
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: true
•
•
•
•
•
Publication
16803959 | -
First Author: Tosh K
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.
Volume: 103
Issue: 27
Pages: 10364-10368
•
•
•
•
•
Publication
21222611 | -
First Author: Cai L
Year: 2011
Journal: Med Chem
Title: Identification of proteins interacting with human SP110 during the process of viral infections.
Volume: 7
Issue: 2
Pages: 121-6
•
•
•
•
•
Publication
10913195 | -
First Author: Bloch DB
Year: 2000
Journal: Mol Cell Biol
Title: Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.
Volume: 20
Issue: 16
Pages: 6138-46
•
•
•
•
•
Publication
16648851 | -
First Author: Roscioli T
Year: 2006
Journal: Nat Genet
Title: Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.
Volume: 38
Issue: 6
Pages: 620-2
•
•
•
•
•
Protein Domain
IPR043563 | Sp110/Sp140/Sp140L
Type: Family
Description: This entry includes a group of nuclear dot-associated proteins, including Sp110/Sp140/Sp140L from humans. They are proteins with a constituent of nuclear domains, also known as nuclear dots (NDs). Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region) [].Sp110 is a leukocyte-specific component of the nuclear body []. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells []. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers [, ]. Sp110 gene polymorphisms may be associated with susceptibility to tuberculosis in Chinese population []. The function of nuclear protein Sp140 is not known, though it contains several chromatin related modules such as plant homeodomain (PHD), bromodomain (BRD) and SAND domain, which suggests a role in chromatin-mediated regulation of gene expression []. It also harbours a nuclear localisation signal and a dimerisation domain (HSR or CARD domain). The PHD finger of Sp140 presents an atypical fold which does not bind to histone H3 tails but binds to peptidylprolyl isomerase Pin1. Pin1 catalyses the isomerisation of a phospho-Threonine-Proline bond in Sp140-PHD and thus may modulate Sp140 function [].Human Sp140 is an interferon inducible nuclear leukocyte-specific protein that may be involved in the pathogenesis of acute promyelocytic leukemia and viral infection []. It localises to LYSP100-associated nuclear dots and is also a component of the promyelocytic leukemia nuclear body (PML-NBs) [, ]. The Sp140 locus has been identified as a lymphocytic leukemia (CLL) risk locus [].This family also includes protein Sp140-like (SP140L) [].
•
•
•
•
•
Publication
24586174 | J:246139
First Author: El Asmi F
Year: 2014
Journal: PLoS Pathog
Title: Implication of PMLIV in both intrinsic and innate immunity.
Volume: 10
Issue: 2
Pages: e1003975
•
•
•
•
•
Publication
11533036 | J:72543
First Author: He J
Year: 2001
Journal: J Biol Chem
Title: Phosphorylation and cell cycle-dependent regulation of Na+/H+ exchanger regulatory factor-1 by Cdc2 kinase.
Volume: 276
Issue: 45
Pages: 41559-65
•
•
•
•
•
Publication
34805153 | J:314765
 
First Author: Jiang X
Year: 2021
Journal: Front Cell Dev Biol
Title: RETSAT Mutation Selected for Hypoxia Adaptation Inhibits Tumor Growth.
Volume: 9
Pages: 744992
•
•
•
•
•
Protein
Q99388
Organism: Mus musculus/domesticus
Length: 208  
Fragment?: false
•
•
•
•
•
Protein
Q62446
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
•
•
•
•
•
Protein
E0CXN9
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
•
•
•
•
•
Protein
Q3UBU9
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: false
•
•
•
•
•
Protein
Q3UTB2
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: false
•
•
•
•
•
Protein
Q3TQS4
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
•
•
•
•
•
Protein
Q3TZR7
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
•
•
•
•
•
Protein
A0A1Y7VP01
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
•
•
•
•
•
Protein
E9PV05
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
•
•
•
•
•
Protein
E9Q422
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
•
•
•
•
•
Protein
Q4KKY3
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
•
•
•
•
•
Protein
E9Q4Y0
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
•
•
•
•
•
Protein
Q52KL8
Organism: Mus musculus/domesticus
Length: 53  
Fragment?: false
•
•
•
•
•
Protein
E9Q3M7
Organism: Mus musculus/domesticus
Length: 122  
Fragment?: true
•
•
•
•
•
Protein
Q8BNW8
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: true
•
•
•
•
•
Protein
Q8BS13
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
•
•
•
•
•
Protein
Q8C9H3
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
•
•
•
•
•
Protein
Q3UT50
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
•
•
•
•
•
Protein
Q7TSS9
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
•
•
•
•
•
Protein
D6RIJ4
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
•
•
•
•
•
Protein
E0CXL1
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: false
•
•
•
•
•
Protein
Q3UKD8
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
•
•
•
•
•
Protein
A0A1Y7VLK0
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
•
•
•
•
•
Protein
E0CY74
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
•
•
•
•
•
Protein
Q3KNJ6
Organism: Mus musculus/domesticus
Length: 263  
Fragment?: false
•
•
•
•
•
Protein
Q8C9T1
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom