| Type |
Details |
Score |
| Publication |
| First Author: |
The Australian Phenomics Facility at The Australian National University |
| Year: |
2006 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Heritable mouse mutants from the ENU mutagenesis program at the Australian Phenomics Facility at The Australian National University |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bailey PJ |
| Year: |
2006 |
| Journal: |
Exp Cell Res |
| Title: |
A global genomic transcriptional code associated with CNS-expressed genes. |
| Volume: |
312 |
| Issue: |
16 |
| Pages: |
3108-19 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2003 |
|
| Title: |
Data Curation Using Mouse Genome Assembly |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2018 |
| Journal: |
Database Release |
| Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lennon G |
| Year: |
1999 |
| Journal: |
Database Download |
| Title: |
WashU-HHMI Mouse EST Project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI and IMPC |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Load of Molecular Notes for Endonuclease-Mediated (CRISPR) Alleles from the International Mouse Phenotyping Consortium (IMPC) |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Carninci P |
| Year: |
2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
309 |
| Issue: |
5740 |
| Pages: |
1559-63 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shanghai Model Organisms Center |
| Year: |
2017 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cyagen Biosciences Inc. |
| Year: |
2022 |
|
| Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GOA curators |
| Year: |
2016 |
|
| Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
| Year: |
2011 |
|
| Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
| Year: |
2004 |
| Journal: |
Database Release |
| Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
GemPharmatech |
| Year: |
2020 |
|
| Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Ontology Consortium |
| Year: |
2010 |
|
| Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
e1000582 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
|
| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGI Genome Annotation Group and UniGene Staff |
| Year: |
2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
UniProt-GOA |
| Year: |
2012 |
|
| Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
| Year: |
2000 |
| Journal: |
Database Release |
| Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics and Ensembl Genome Database Project |
| Year: |
2026 |
| Journal: |
Database Release |
| Title: |
MGI Strain Genome Feature and Gene Model Load from Ensembl. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
|
| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bairoch A |
| Year: |
1999 |
| Journal: |
Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
| Journal: |
Database Procedure |
| Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
|
•
•
•
•
•
|
| Interaction Experiment |
| Description: |
Role of the hepatocyte nuclear factor-1beta (HNF-1beta) C-terminal domain in Pkhd1 (ARPKD) gene transcription and renal cystogenesis. |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion 1, Peter Igarashi |
| Allele Type: |
Transgenic |
| Attribute String: |
Recombinase |
|
•
•
•
•
•
|
| Allele |
| Name: |
polycystic kidney and hepatic disease 1; endonuclease-mediated mutation 4, Harwell |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Not Specified |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kuo IY |
| Year: |
2019 |
| Journal: |
Sci Signal |
| Title: |
Polycystin 2 regulates mitochondrial Ca(2+) signaling, bioenergetics, and dynamics through mitofusin 2. |
| Volume: |
12 |
| Issue: |
580 |
|
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
Not Specified |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: C57BL/6 |
| Zygosity: |
ot |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
Not Specified |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Snhg5/Snhg5 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Raman A |
| Year: |
2017 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Integrin-Linked Kinase Signaling Promotes Cyst Growth and Fibrosis in Polycystic Kidney Disease. |
| Volume: |
28 |
| Issue: |
9 |
| Pages: |
2708-2719 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mirc1/Mirc1 Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S4/SvJae * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mir214/Mir214 Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
Not Specified |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sato S |
| Year: |
2023 |
| Journal: |
J Biol Chem |
| Title: |
Human TMEM2 is not a catalytic hyaluronidase, but a regulator of hyaluronan metabolism via HYBID (KIAA1199/CEMIP) and HAS2 expression. |
| Volume: |
299 |
| Issue: |
6 |
| Pages: |
104826 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
He QY |
| Year: |
2006 |
| Journal: |
Bioinformatics |
| Title: |
G8: a novel domain associated with polycystic kidney disease and non-syndromic hearing loss. |
| Volume: |
22 |
| Issue: |
18 |
| Pages: |
2189-91 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
This entry represents a domain found in disease proteins PKHD1 and CEMIP2 (also known as KIAA1199) and is named G8 after its 8 conserved glycines. It is predicted to contain 10 ��-strands and an ��-helix [, ]. CEMIP2 is an inactive cell surface hyaluronidase that, unlike its mouse orthologue, has no catalytic hyaluronic acid-degrading activity, but acts as a regulator of hyaluronan (HA) metabolism through regulation of expression of CEMIP and HAS2, two enzymes involved in HA depolymerization and HA synthesis, respectively [, ]. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Q |
| Year: |
2018 |
| Journal: |
Kidney Int |
| Title: |
Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease. |
| Volume: |
93 |
| Issue: |
2 |
| Pages: |
403-415 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhou X |
| Year: |
2015 |
| Journal: |
Hum Mol Genet |
| Title: |
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. |
| Volume: |
24 |
| Issue: |
14 |
| Pages: |
3982-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li LX |
| Year: |
2022 |
| Journal: |
Cells |
| Title: |
Single-Cell and CellChat Resolution Identifies Collecting Duct Cell Subsets and Their Communications with Adjacent Cells in PKD Kidneys. |
| Volume: |
12 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cao Y |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models. |
| Volume: |
106 |
| Issue: |
51 |
| Pages: |
21819-24 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd1/Pkd1 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: C57BL/6 * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Snhg5/Snhg5 Pkd1/Pkd1 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: C57BL/6 * C57BL/6J * SJL |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Pkd2/Pkd2 Tg(Pkd1)248Som/? Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: C57BL/6J * SJL/J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hnf1b/Hnf1b Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S2/SvPas * C57BL/6 |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Mir21a/Mir21a Pkd2/Pkd2 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S/SvEv |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ward CJ |
| Year: |
2002 |
| Journal: |
Nat Genet |
| Title: |
The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. |
| Volume: |
30 |
| Issue: |
3 |
| Pages: |
259-69 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kakade VR |
| Year: |
2016 |
| Journal: |
J Mol Cell Biol |
| Title: |
A cAMP and CREB-mediated feed-forward mechanism regulates GSK3? in polycystic kidney disease. |
| Volume: |
8 |
| Issue: |
6 |
| Pages: |
464-476 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grosch M |
| Year: |
2021 |
| Journal: |
J Cell Sci |
| Title: |
A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts. |
| Volume: |
134 |
| Issue: |
16 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aboudehen K |
| Year: |
2017 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Hepatocyte Nuclear Factor-1? Regulates Urinary Concentration and Response to Hypertonicity. |
| Volume: |
28 |
| Issue: |
10 |
| Pages: |
2887-2900 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aboudehen K |
| Year: |
2018 |
| Journal: |
J Biol Chem |
| Title: |
Long noncoding RNA Hoxb3os is dysregulated in autosomal dominant polycystic kidney disease and regulates mTOR signaling. |
| Volume: |
293 |
| Issue: |
24 |
| Pages: |
9388-9398 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ye H |
| Year: |
2017 |
| Journal: |
Am J Physiol Renal Physiol |
| Title: |
The regulatory 1? subunit of protein kinase A modulates renal cystogenesis. |
| Volume: |
313 |
| Issue: |
3 |
| Pages: |
F677-F686 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Hoxb3os/Hoxb3os Pkd1/Pkd1 Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S4/SvJae * C57BL/6J |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
194
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hogan MC |
| Year: |
2003 |
| Journal: |
Hum Mol Genet |
| Title: |
PKHDL1, a homolog of the autosomal recessive polycystic kidney disease gene, encodes a receptor with inducible T lymphocyte expression. |
| Volume: |
12 |
| Issue: |
6 |
| Pages: |
685-98 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Besse W |
| Year: |
2017 |
| Journal: |
J Clin Invest |
| Title: |
Isolated polycystic liver disease genes define effectors of polycystin-1 function. |
| Volume: |
127 |
| Issue: |
5 |
| Pages: |
1772-1785 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Niu M |
| Year: |
2023 |
| Journal: |
Wellcome Open Res |
| Title: |
Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity. |
| Volume: |
8 |
|
| Pages: |
76 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ferr? S |
| Year: |
2019 |
| Journal: |
Kidney Int |
| Title: |
Renal tubular cell spliced X-box binding protein 1 (Xbp1s) has a unique role in sepsis-induced acute kidney injury and inflammation. |
| Volume: |
96 |
| Issue: |
6 |
| Pages: |
1359-1373 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lakhia R |
| Year: |
2020 |
| Journal: |
JCI Insight |
| Title: |
Interstitial microRNA miR-214 attenuates inflammation and polycystic kidney disease progression. |
| Volume: |
5 |
| Issue: |
7 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen L |
| Year: |
2015 |
| Journal: |
J Clin Invest |
| Title: |
Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. |
| Volume: |
125 |
| Issue: |
6 |
| Pages: |
2399-412 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Flowers EM |
| Year: |
2018 |
| Journal: |
Nat Commun |
| Title: |
Lkb1 deficiency confers glutamine dependency in polycystic kidney disease. |
| Volume: |
9 |
| Issue: |
1 |
| Pages: |
814 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Cai Y |
| Year: |
2014 |
| Journal: |
J Clin Invest |
| Title: |
Altered trafficking and stability of polycystins underlie polycystic kidney disease. |
| Volume: |
124 |
| Issue: |
12 |
| Pages: |
5129-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
D'Amico S |
| Year: |
2026 |
| Journal: |
Sci Rep |
| Title: |
Loss of Snhg5 disrupts cell-cycle regulation without altering cystogenesis in a mouse model of polycystic kidney disease. |
| Volume: |
16 |
| Issue: |
1 |
| Pages: |
4869 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ishikawa Y |
| Year: |
2019 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of Sec63 in Collecting Ducts. |
| Volume: |
30 |
| Issue: |
3 |
| Pages: |
443-459 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jamadar A |
| Year: |
2025 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Circadian Clock Disruption and Growth of Kidney Cysts in Autosomal Dominant Polycystic Kidney Disease. |
| Volume: |
36 |
| Issue: |
3 |
| Pages: |
378-392 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kif3a/Kif3a<+> Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hajarnis S |
| Year: |
2017 |
| Journal: |
Nat Commun |
| Title: |
microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism. |
| Volume: |
8 |
|
| Pages: |
14395 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang C |
| Year: |
2021 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease. |
| Volume: |
32 |
| Issue: |
1 |
| Pages: |
41-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hajarnis S |
| Year: |
2018 |
| Journal: |
J Am Soc Nephrol |
| Title: |
Suppression of microRNA Activity in Kidney Collecting Ducts Induces Partial Loss of Epithelial Phenotype and Renal Fibrosis. |
| Volume: |
29 |
| Issue: |
2 |
| Pages: |
518-531 |
|
•
•
•
•
•
|
| Genotype |
| Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kif3a/Kif3a Tg(Pkhd1-cre)1Igr/? |
| Background: |
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ |
| Zygosity: |
cn |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Patel V |
| Year: |
2008 |
| Journal: |
Hum Mol Genet |
| Title: |
Acute kidney injury and aberrant planar cell polarity induce cyst formation in mice lacking renal cilia. |
| Volume: |
17 |
| Issue: |
11 |
| Pages: |
1578-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shibazaki S |
| Year: |
2008 |
| Journal: |
Hum Mol Genet |
| Title: |
Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1. |
| Volume: |
17 |
| Issue: |
11 |
| Pages: |
1505-16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lakhia R |
| Year: |
2016 |
| Journal: |
J Am Soc Nephrol |
| Title: |
MicroRNA-21 Aggravates Cyst Growth in a Model of Polycystic Kidney Disease. |
| Volume: |
27 |
| Issue: |
8 |
| Pages: |
2319-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li Y |
| Year: |
2023 |
| Journal: |
Elife |
| Title: |
Inactivation of Invs/Nphp2 in renal epithelial cells drives infantile nephronophthisis like phenotypes in mouse. |
| Volume: |
12 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ma M |
| Year: |
2013 |
| Journal: |
Nat Genet |
| Title: |
Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease. |
| Volume: |
45 |
| Issue: |
9 |
| Pages: |
1004-12 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1383
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1361
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
4059
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
4060
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
4059
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang C |
| Year: |
2024 |
| Journal: |
Nat Commun |
| Title: |
Glis2 is an early effector of polycystin signaling and a target for therapy in polycystic kidney disease. |
| Volume: |
15 |
| Issue: |
1 |
| Pages: |
3698 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
4249
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
4249
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
4247
 |
| Fragment?: |
false |
|
•
•
•
•
•
|