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Search results 301 to 400 out of 420 for Poli

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Stat3/Stat3<+> Tg(Myh6-cre)2182Mds/?
Background: involves: 129P2/OlaHsd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcb4/Abcb4 Stat3/Stat3 Tg(Alb1-cre)7Gsc/?
Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Abcb4/Abcb4 Stat3/Stat3
Background: involves: 129P2/OlaHsd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Allele
Poli<tm1Pjg> | MGI:6140111
Name: polymerase (DNA directed), iota; targeted mutation 1, Patricia Gearhart
Allele Type: Targeted
Attribute String: Not Specified
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Publication
16322561 | J:103923
First Author: Hublitz P
Year: 2005
Journal: Genes Dev
Title: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
Volume: 19
Issue: 23
Pages: 2912-24
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Publication
29074498 | J:259065
First Author: Truman-Rosentsvit M
Year: 2018
Journal: Blood
Title: Ferritin is secreted via 2 distinct nonclassical vesicular pathways.
Volume: 131
Issue: 3
Pages: 342-352
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Publication
20201032 | J:267888
First Author: Hoelbl A
Year: 2010
Journal: EMBO Mol Med
Title: Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.
Volume: 2
Issue: 3
Pages: 98-110
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Publication
35838338 | J:333766
First Author: Pires-Afonso Y
Year: 2022
Journal: Mol Oncol
Title: Elucidating tumour-associated microglia/macrophage diversity along glioblastoma progression and under ACOD1 deficiency.
Volume: 16
Issue: 17
Pages: 3167-3191
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Publication
27301576 | J:239890
 
First Author: Fagnocchi L
Year: 2016
Journal: Nat Commun
Title: A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity.
Volume: 7
Pages: 11903
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Publication
35181688 | J:343960
First Author: Tsoyi K
Year: 2022
Journal: Sci Rep
Title: Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts.
Volume: 12
Issue: 1
Pages: 2847
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Publication
31840053 | J:356089
First Author: Raredon MSB
Year: 2019
Journal: Sci Adv
Title: Single-cell connectomic analysis of adult mammalian lungs.
Volume: 5
Issue: 12
Pages: eaaw3851
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Protein
A0A1Y7VK37
Organism: Mus musculus/domesticus
Length: 69  
Fragment?: false
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Protein Domain
IPR021752 | TF_Rrn7_Zf
Type: Domain
Description: This entry represents the zinc-finger found in the N terminus of the Rrn7 protein. Rrn7 is a transcription binding factor that associates strongly with both Rrn6 and Rrn11 to form a complex which itself binds the TATA-binding protein and is required for transcription by the core domain of the RNA PolI promoter [, ].
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Allele
Polh<tm1.1Rak> | MGI:3614412
Name: polymerase (DNA directed), eta (RAD 30 related); targeted mutation 1.1, Raju Kucherlapati
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6142888 | C57BL/6-Poli<tm1Pjg>/Mmucd
Attribute String: mutant strain, coisogenic, chemically induced mutation
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Publication
12509437 | J:91064
First Author: Wuestefeld T
Year: 2003
Journal: J Biol Chem
Title: Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration.
Volume: 278
Issue: 13
Pages: 11281-8
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Publication
9688988 | J:48865
First Author: Leon LR
Year: 1998
Journal: Am J Physiol
Title: Role of IL-6 and TNF in thermoregulation and survival during sepsis in mice.
Volume: 275
Issue: 1 Pt 2
Pages: R269-77
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Publication
12456789 | J:125450
First Author: Grimm SL
Year: 2002
Journal: Mol Endocrinol
Title: Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development.
Volume: 16
Issue: 12
Pages: 2675-91
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Publication
24398427 | J:320713
First Author: Stuart E
Year: 2014
Journal: Mol Cancer Ther
Title: Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice.
Volume: 13
Issue: 2
Pages: 468-74
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Publication
27670591 | J:237259
First Author: Yang R
Year: 2016
Journal: J Exp Med
Title: IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.
Volume: 213
Issue: 11
Pages: 2281-2291
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Publication
25974216 | J:223311
   
First Author: Yang R
Year: 2015
Journal: Elife
Title: Mitochondrial Ca²⁺ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.
Volume: 4
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Publication
25283994 | J:217705
First Author: Sargeant TJ
Year: 2014
Journal: Nat Cell Biol
Title: Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization.
Volume: 16
Issue: 11
Pages: 1057-1068
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Publication
32795415 | J:328941
First Author: Ndoja A
Year: 2020
Journal: Cell
Title: Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia.
Volume: 182
Issue: 5
Pages: 1156-1169.e12
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Publication
16751774 | J:112664
First Author: Hirai H
Year: 2006
Journal: Nat Immunol
Title: C/EBPbeta is required for 'emergency' granulopoiesis.
Volume: 7
Issue: 7
Pages: 732-9
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Publication
24983622 | J:218939
First Author: Robker RL
Year: 2014
Journal: PLoS One
Title: Identification of sites of STAT3 action in the female reproductive tract through conditional gene deletion.
Volume: 9
Issue: 7
Pages: e101182
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Publication
32323921 | J:294705
First Author: Oberhuber M
Year: 2020
Journal: Mol Syst Biol
Title: STAT3-dependent analysis reveals PDK4 as independent predictor of recurrence in prostate cancer.
Volume: 16
Issue: 4
Pages: e9247
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Genotype
Genotype
Symbol: Stat3/Stat3 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA * BALB/cAn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Stat3/Stat3 Speer6-ps1/Speer6-ps1<+>
Background: involves: 129P2/OlaHsd * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Publication
8057832 | J:20760
First Author: Reeder RH
Year: 1994
Journal: Mol Microbiol
Title: The mechanism of transcription termination by RNA polymerase I.
Volume: 12
Issue: 1
Pages: 11-5
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Strain
MGI:3717182 | B6;129-Polh<tm1.1Rak>/Nci
Attribute String: targeted mutation, mutant stock
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Publication
16585153 | J:108222
First Author: Hagendoorn J
Year: 2006
Journal: Cancer Res
Title: Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis.
Volume: 66
Issue: 7
Pages: 3360-4
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Publication
18381412 | J:133309
First Author: Busuttil RA
Year: 2008
Journal: Cancer Res
Title: Mutation frequencies and spectra in DNA polymerase eta-deficient mice.
Volume: 68
Issue: 7
Pages: 2081-4
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Publication
26240351 | J:226564
First Author: Chen YW
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities.
Volume: 112
Issue: 33
Pages: E4556-64
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Genotype
Genotype
Symbol: Polh/Polh
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Polh/Polh<+>
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
36049541 | J:330382
     
First Author: De Logu F
Year: 2022
Journal: J Invest Dermatol
Title: miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4.
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Publication
35148201 | J:339093
First Author: Davidson S
Year: 2022
Journal: Sci Immunol
Title: Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24.
Volume: 7
Issue: 68
Pages: eabi6763
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Publication
39014482 | J:351962
First Author: Lind-Holm Mogensen F
Year: 2024
Journal: J Neuroinflammation
Title: PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation.
Volume: 21
Issue: 1
Pages: 174
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Publication
35078977 | J:353658
First Author: Sauler M
Year: 2022
Journal: Nat Commun
Title: Characterization of the COPD alveolar niche using single-cell RNA sequencing.
Volume: 13
Issue: 1
Pages: 494
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Publication
23291536 | J:214204
 
First Author: Parmentier-Batteur S
Year: 2014
Journal: Neuropharmacology
Title: Mechanism based neurotoxicity of mGlu5 positive allosteric modulators--development challenges for a promising novel antipsychotic target.
Volume: 82
Pages: 161-73
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Publication
25512545 | J:216928
First Author: Jiang K
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: STAT3 promotes survival of mutant photoreceptors in inherited photoreceptor degeneration models.
Volume: 111
Issue: 52
Pages: E5716-23
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Publication
21960530 | J:177869
First Author: Harker JA
Year: 2011
Journal: Science
Title: Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection.
Volume: 334
Issue: 6057
Pages: 825-9
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Publication
32238474 | J:328906
First Author: Viau A
Year: 2020
Journal: J Am Soc Nephrol
Title: Tubular STAT3 Limits Renal Inflammation in Autosomal Dominant Polycystic Kidney Disease.
Volume: 31
Issue: 5
Pages: 1035-1049
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Publication
20585009 | J:178593
First Author: Hilfiker-Kleiner D
Year: 2010
Journal: Circulation
Title: Continuous glycoprotein-130-mediated signal transducer and activator of transcription-3 activation promotes inflammation, left ventricular rupture, and adverse outcome in subacute myocardial infarction.
Volume: 122
Issue: 2
Pages: 145-55
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Publication
38170993 | J:352256
First Author: Hogan CH
Year: 2024
Journal: mBio
Title: Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models.
Volume: 15
Issue: 2
Pages: e0299823
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Publication
21816364 | J:175859
First Author: Hoch M
Year: 2011
Journal: Cell Stem Cell
Title: Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies.
Volume: 9
Issue: 2
Pages: 131-43
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Publication
18805458 | J:155075
First Author: Sims NA
Year: 2009
Journal: Mol Cell Endocrinol
Title: gp130 signaling in bone cell biology: multiple roles revealed by analysis of genetically altered mice.
Volume: 310
Issue: 1-2
Pages: 30-9
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Publication
30454647 | J:267427
First Author: Grohmann M
Year: 2018
Journal: Cell
Title: Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC.
Volume: 175
Issue: 5
Pages: 1289-1306.e20
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Publication
33637536 | J:335838
 
First Author: Dodd GT
Year: 2021
Journal: Sci Adv
Title: Insulin signaling in AgRP neurons regulates meal size to limit glucose excursions and insulin resistance.
Volume: 7
Issue: 9
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Publication
26595889 | J:234689
First Author: Rankin LC
Year: 2016
Journal: Nat Immunol
Title: Complementarity and redundancy of IL-22-producing innate lymphoid cells.
Volume: 17
Issue: 2
Pages: 179-86
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Publication
27524624 | J:236983
First Author: Aden K
Year: 2016
Journal: Cell Rep
Title: Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.
Volume: 16
Issue: 8
Pages: 2208-2218
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Publication
26837764 | J:231629
First Author: Thiem S
Year: 2016
Journal: Cancer Res
Title: Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model.
Volume: 76
Issue: 8
Pages: 2277-87
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Publication
30585358 | J:272499
First Author: Rakers C
Year: 2019
Journal: Glia
Title: Stroke target identification guided by astrocyte transcriptome analysis.
Volume: 67
Issue: 4
Pages: 619-633
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Genotype
Genotype
Symbol: Ptpn11/Ptpn11 Stat3/Stat3 Speer6-ps1/Speer6-ps1<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA
Zygosity: cn
Has Mutant Allele: true
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Publication
35148840 | J:337169
First Author: Borriello F
Year: 2022
Journal: Cell
Title: An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity.
Volume: 185
Issue: 4
Pages: 614-629.e21
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Publication
22733395 | J:193520
First Author: Brun J
Year: 2013
Journal: Int J Cancer
Title: Oncolytic Vaccinia virus safely and effectively treats skin tumors in mouse models of xeroderma pigmentosum.
Volume: 132
Issue: 3
Pages: 726-31
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Publication
16397220 | J:105034
First Author: Lin Q
Year: 2006
Journal: Cancer Res
Title: Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.
Volume: 66
Issue: 1
Pages: 87-94
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Publication
35440634 | J:325750
First Author: Fleig S
Year: 2022
Journal: Nat Commun
Title: Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Volume: 13
Issue: 1
Pages: 2022
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Protein
P97358
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Publication
8887672 | -
First Author: Lin CW
Year: 1996
Journal: Mol Cell Biol
Title: A novel 66-kilodalton protein complexes with Rrn6, Rrn7, and TATA-binding protein to promote polymerase I transcription initiation in Saccharomyces cerevisiae.
Volume: 16
Issue: 11
Pages: 6436-43
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Publication
39885289 | J:361605
First Author: Cao R
Year: 2025
Journal: Sci Rep
Title: Genes related to neural tube defects and glioblastoma.
Volume: 15
Issue: 1
Pages: 3777
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Publication
21204268 | J:232020
First Author: Ermakova O
Year: 2011
Journal: EMBO Mol Med
Title: Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice.
Volume: 3
Issue: 1
Pages: 50-66
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Publication
26006013 | J:260611
First Author: Hernández PP
Year: 2015
Journal: Nat Immunol
Title: Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
Volume: 16
Issue: 7
Pages: 698-707
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Publication
30700914 | J:278479
First Author: Gronke K
Year: 2019
Journal: Nature
Title: Interleukin-22 protects intestinal stem cells against genotoxic stress.
Volume: 566
Issue: 7743
Pages: 249-253
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Publication
27578791 | J:237343
First Author: Laresgoiti U
Year: 2016
Journal: Development
Title: Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate.
Volume: 143
Issue: 20
Pages: 3686-3699
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Publication
9288107 | -
First Author: Gray MD
Year: 1997
Journal: Nat Genet
Title: The Werner syndrome protein is a DNA helicase.
Volume: 17
Issue: 1
Pages: 100-3
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Publication
9697700 | -
First Author: Yan H
Year: 1998
Journal: Nat Genet
Title: Replication focus-forming activity 1 and the Werner syndrome gene product.
Volume: 19
Issue: 4
Pages: 375-8
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Publication
9224595 | -
First Author: Suzuki N
Year: 1997
Journal: Nucleic Acids Res
Title: DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system.
Volume: 25
Issue: 15
Pages: 2973-8
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Publication
33926956 | -
First Author: Pezo V
Year: 2021
Journal: Science
Title: Noncanonical DNA polymerization by aminoadenine-based siphoviruses.
Volume: 372
Issue: 6541
Pages: 520-524
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Publication
15377656 | -
First Author: Andraos N
Year: 2004
Journal: J Biol Chem
Title: The highly processive DNA polymerase of bacteriophage T5. Role of the unique N and C termini.
Volume: 279
Issue: 48
Pages: 50609-18
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Publication
7958901 | -
First Author: Keys DA
Year: 1994
Journal: Genes Dev
Title: RRN6 and RRN7 encode subunits of a multiprotein complex essential for the initiation of rDNA transcription by RNA polymerase I in Saccharomyces cerevisiae.
Volume: 8
Issue: 19
Pages: 2349-62
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Protein Domain
IPR002562 | 3'-5'_exonuclease_dom
Type: Domain
Description: This entry represents the domain that is responsible for the 3'-5' exonuclease proofreading activity of Escherichia coli DNA polymerase I (polI) and other enzymes which catalyse the hydrolysis of unpaired or mismatched nucleotides. This domain consists of the amino-terminal half of the Klenow fragment in E. coli polI and is also found in the Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (also known as Werner syndrome helicase), focus forming activity 1 protein (FFA-1) and ribonuclease D (RNase D) [].Werner syndrome is a human genetic disorder causing premature ageing; the WRN protein has helicase activity in the 3'-5' direction [, ]. The FFA-1 protein is required for formation of a replication foci and also has helicase activity; it is a homologue of the WRN protein []. RNase D is a 3'-5' exonuclease involved in tRNA processing. Also found in this family is the autoantigen PM/Scl thought to be involved in polymyositis-scleroderma overlap syndrome.This domain is also found in some DNA polymerases from phages, including the DNA polymerase from Escherichia phage T5, exonucleolytic activity [], and the DNA polymerase DpoZ from Acinetobacter phage SH-Ab 15497, which preferentially incorporates the non-canonical base aminoadenine/dZTP instead of adenine into the synthesized DNA [].
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Protein Coding Gene
MGI:2146571 | Rfc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97891 | Rfc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919401 | Rfc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341868 | Rfc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916513 | Rfc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9D0F6
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Protein
Q9WUK4
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q8R323
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
P35601
Organism: Mus musculus/domesticus
Length: 1131  
Fragment?: false
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Protein
Q99J62
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
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Publication
38658806 | J:349464
First Author: Fortelny N
Year: 2024
Journal: Nat Immunol
Title: JAK-STAT signaling maintains homeostasis in T cells and macrophages.
Volume: 25
Issue: 5
Pages: 847-859
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Protein Coding Gene
MGI:1915525 | Rpa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97503 | Pcna
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339939 | Rpa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915490 | Rpa3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P17918
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q9CQ71
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
Q62193
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q8VEE4
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Protein
Q8CDF7
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q8VEG4
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
Q3TZ13
Organism: Mus musculus/domesticus
Length: 265  
Fragment?: true
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Protein
B2RWQ8
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
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Protein
Q3UIJ1
Organism: Mus musculus/domesticus
Length: 650  
Fragment?: false
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Protein
A0A1W2P7Q1
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
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Publication
32428860 | J:336999
First Author: Riedelberger M
Year: 2020
Journal: iScience
Title: Type I Interferons Ameliorate Zinc Intoxication of Candida glabrata by Macrophages and Promote Fungal Immune Evasion.
Volume: 23
Issue: 5
Pages: 101121
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Publication
32075740 | J:349194
First Author: Riedelberger M
Year: 2020
Journal: Cell Host Microbe
Title: Type I Interferon Response Dysregulates Host Iron Homeostasis and Enhances Candida glabrata Infection.
Volume: 27
Issue: 3
Pages: 454-466.e8
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Publication
29688375 | J:250512
   
First Author: Li J
Year: 2018
Journal: Database (Oxford)
Title: CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice.
Volume: 2018
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