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Search results 301 to 355 out of 355 for Ppy

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Type Details Score
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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MP Term
MP:0014568 | decreased circulating pancreatic peptide level
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MP Term
MP:0014567 | increased circulating pancreatic peptide level
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Allele
Tg(Ppy-cre)1Herr | MGI:2387565
Name: transgene insertion 1, Pedro Luis Herrera
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
33441399 | J:320474
 
First Author: Jain M
Year: 2021
Journal: eNeuro
Title: SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain.
Volume: 8
Issue: 1
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Publication
9722167 | J:69321
First Author: Herrera PL
Year: 1998
Journal: Mol Cell Endocrinol
Title: Two transgenic approaches to define the cell lineages in endocrine pancreas development.
Volume: 140
Issue: 1-2
Pages: 45-50
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Publication
3753985 | J:17768
First Author: Takeuchi T
Year: 1986
Journal: J Clin Invest
Title: Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.
Volume: 77
Issue: 3
Pages: 1038-41
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Publication
26178371 | J:225498
First Author: Solomou A
Year: 2015
Journal: J Biol Chem
Title: The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion.
Volume: 290
Issue: 35
Pages: 21432-42
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Publication
10804174 | J:78865
First Author: Herrera PL
Year: 2000
Journal: Development
Title: Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages.
Volume: 127
Issue: 11
Pages: 2317-22
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Publication
28550109 | J:249474
First Author: Stancill JS
Year: 2017
Journal: Diabetes
Title: Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca2+-Regulated Genes.
Volume: 66
Issue: 8
Pages: 2175-2187
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Publication
34289060 | J:309559
 
First Author: Gupta D
Year: 2021
Journal: Endocrinology
Title: High Coexpression of the Ghrelin and LEAP2 Receptor GHSR With Pancreatic Polypeptide in Mouse and Human Islets.
Volume: 162
Issue: 10
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Publication
15836633 | J:98144
First Author: Ko JL
Year: 2005
Journal: J Neurochem
Title: Poly C binding protein, a single-stranded DNA binding protein, regulates mouse mu-opioid receptor gene expression.
Volume: 93
Issue: 3
Pages: 749-61
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Publication
23531612 | J:198216
First Author: Crivello M
Year: 2013
Journal: Am J Physiol Endocrinol Metab
Title: Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors.
Volume: 304
Issue: 10
Pages: E1064-76
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Publication
34498099 | J:315692
First Author: Fukaishi T
Year: 2021
Journal: Diabetologia
Title: Characterisation of Ppy-lineage cells clarifies the functional heterogeneity of pancreatic beta cells in mice.
Volume: 64
Issue: 12
Pages: 2803-2816
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Protein
Q9EPS2
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
P57774
Organism: Mus musculus/domesticus
Length: 97  
Fragment?: false
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Protein
Q3V334
Organism: Mus musculus/domesticus
Length: 98  
Fragment?: false
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Protein
H3BK86
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Publication
1459125 | -
First Author: Jensen J
Year: 1992
Journal: Eur J Biochem
Title: Characterization of peptides related to neuropeptide tyrosine and peptide tyrosine-tyrosine from the brain and gastrointestinal tract of teleost fish.
Volume: 210
Issue: 2
Pages: 405-10
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Publication
1620652 | -
First Author: Conlon JM
Year: 1992
Journal: Peptides
Title: Primary structure of frog PYY: implications for the molecular evolution of the pancreatic polypeptide family.
Volume: 13
Issue: 1
Pages: 145-9
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Publication
6953409 | -
First Author: Tatemoto K
Year: 1982
Journal: Proc Natl Acad Sci U S A
Title: Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion.
Volume: 79
Issue: 8
Pages: 2514-8
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Publication
2070789 | -
First Author: Conlon JM
Year: 1991
Journal: Eur J Biochem
Title: Primary structure and conformational analysis of peptide methionine-tyrosine, a peptide related to neuropeptide Y and peptide YY isolated from lamprey intestine.
Volume: 199
Issue: 2
Pages: 293-8
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Publication
20631207 | -
First Author: Fry BG
Year: 2010
Journal: Mol Cell Proteomics
Title: Functional and structural diversification of the Anguimorpha lizard venom system.
Volume: 9
Issue: 11
Pages: 2369-90
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Protein Domain
IPR020392 | Pancreatic_hormone-like_CS
Type: Conserved_site
Description: Pancreatic hormone (PP) []is a peptide synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length []and has an amidated C terminus []. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an α-helix, held close to the first helix by hydrophobic interactions []. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution []. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively [].Pancreatic hormone is part of a wider family of active peptides that includes:Neuropeptide Y (NPY or melanostatin) [], one of the most abundant peptides in the mammalian nervous system. NPY is implicated in the control of feeding and the secretion of the gonadotropin-releasing hormone.Peptide YY (PYY) []. PPY is a gut peptide that inhibits exocrine pancreatic secretion, has a vasoconstrictor action and inhibits jejunal and colonic mobility. Known as goannatyrotoxin-Vere1 in the venom of the pygmy desert monitor lizard (Varanus eremius) where it has a triphasic action: rapid biphasic hypertension followed by prolonged hypotension in prey animals [].Various NPY and PYY-like polypeptides from fish and amphibians [, ].Neuropeptide F (NPF) from invertebrates such as worms and snail.Skin peptide Tyr-Tyr (SPYY) from the frog Phyllomedusa bicolor. SPYY shows a large spectra of antibacterial and antifungal activity.Polypeptide MY (peptide methionine-tyrosine). A regulatory peptide from the intestine of the sea lamprey (Petromyzon marinus) [].All these peptides are 36 to 39 amino acids long. Like most active peptides, their C-terminal is amidated and they are synthesized as larger protein precursors.This entry represents a conserved region corresponding to the C-terminal end of the active peptide.
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Protein Domain
IPR001955 | Pancreatic_hormone-like
Type: Family
Description: Pancreatic hormone (PP) []is a peptide synthesized in pancreatic islets of Langherhans, which acts as a regulator of pancreatic and gastrointestinal functions.The hormone is produced as a larger propeptide, which is enzymatically cleaved to yield the mature active peptide: this is 36 amino acids in length []and has an amidated C terminus []. The hormone has a globular structure, residues 2-8 forming a left-handed poly-proline-II-like helix, residues 9-13 a beta turn, and 14-32 an α-helix, held close to the first helix by hydrophobic interactions []. Unlike glucagon, another peptide hormone, the structure of pancreatic peptide is preserved in aqueous solution []. Both N and C termini are required for activity: receptor binding and activation functions may reside in the N and C termini respectively [].Pancreatic hormone is part of a wider family of active peptides that includes:Neuropeptide Y (NPY or melanostatin) [], one of the most abundant peptides in the mammalian nervous system. NPY is implicated in the control of feeding and the secretion of the gonadotropin-releasing hormone.Peptide YY (PYY) []. PPY is a gut peptide that inhibits exocrine pancreatic secretion, has a vasoconstrictor action and inhibits jejunal and colonic mobility. Known as goannatyrotoxin-Vere1 in the venom of the pygmy desert monitor lizard (Varanus eremius) where it has a triphasic action: rapid biphasic hypertension followed by prolonged hypotension in prey animals [].Various NPY and PYY-like polypeptides from fish and amphibians [, ].Neuropeptide F (NPF) from invertebrates such as worms and snail.Skin peptide Tyr-Tyr (SPYY) from the frog Phyllomedusa bicolor. SPYY shows a large spectra of antibacterial and antifungal activity.Polypeptide MY (peptide methionine-tyrosine). A regulatory peptide from the intestine of the sea lamprey (Petromyzon marinus) [].All these peptides are 36 to 39 amino acids long. Like most active peptides, their C-terminal is amidated and they are synthesized as larger protein precursors.
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Protein
P10601
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
Q3UW05
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Protein
Q496X5
Organism: Mus musculus/domesticus
Length: 100  
Fragment?: false
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Publication
2599092 | -
First Author: Sillard R
Year: 1989
Journal: FEBS Lett
Title: Sheep neuropeptide Y. A third structural type of a highly conserved peptide.
Volume: 258
Issue: 2
Pages: 263-5
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Publication
2067973 | -
First Author: Conlon JM
Year: 1991
Journal: Peptides
Title: Neuropeptide Y-related peptides from the pancreas of a teleostean (eel), holostean (bowfin) and elasmobranch (skate) fish.
Volume: 12
Issue: 2
Pages: 221-6
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Publication
3031687 | J:14598
First Author: Allen J
Year: 1987
Journal: Proc Natl Acad Sci U S A
Title: Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue.
Volume: 84
Issue: 8
Pages: 2532-6
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Publication
23823474 | J:199239
First Author: Magnuson MA
Year: 2013
Journal: Cell Metab
Title: Pancreas-specific Cre driver lines and considerations for their prudent use.
Volume: 18
Issue: 1
Pages: 9-20
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Publication
6107857 | -
First Author: Blundell TL
Year: 1980
Journal: Nature
Title: Hormone families: pancreatic hormones and homologous growth factors.
Volume: 287
Issue: 5785
Pages: 781-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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