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Search results 301 to 400 out of 2635 for Prc1

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Type Details Score
Publication
18588675 | -
 
First Author: Sanchez-Pulido L
Year: 2008
Journal: BMC Genomics
Title: RAWUL: a new ubiquitin-like domain in PRC1 ring finger proteins that unveils putative plant and worm PRC1 orthologs.
Volume: 9
Pages: 308
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Publication
27495811 | -
First Author: Molitor AM
Year: 2016
Journal: Plant Cell
Title: The Arabidopsis hnRNP-Q Protein LIF2 and the PRC1 Subunit LHP1 Function in Concert to Regulate the Transcription of Stress-Responsive Genes.
Volume: 28
Issue: 9
Pages: 2197-2211
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Publication
22496869 | -
First Author: Illingworth RS
Year: 2012
Journal: PLoS One
Title: PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.
Volume: 7
Issue: 4
Pages: e34848
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Protein Coding Gene
MGI:2181434 | Phc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917087 | Pcgf1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1353589 | Cbx8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1196439 | Cbx7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1101770 | Ring1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923203 | Samd7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2446220 | Samd11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88289 | Cbx2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3512628 | Cbx6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1918291 | Pcgf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916837 | Pcgf3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103248 | Phc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
16359901 | J:104662
First Author: Cao R
Year: 2005
Journal: Mol Cell
Title: Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing.
Volume: 20
Issue: 6
Pages: 845-54
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Protein Coding Gene
MGI:99161 | Pcgf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1195985 | Cbx4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923505 | Pcgf5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1101759 | Rnf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21059868 | J:170279
First Author: Li X
Year: 2011
Journal: Mol Cell Biol
Title: Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes.
Volume: 31
Issue: 2
Pages: 351-64
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Protein Coding Gene
MGI:88174 | Bmi1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15525528 | J:94519
First Author: de Napoles M
Year: 2004
Journal: Dev Cell
Title: Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation.
Volume: 7
Issue: 5
Pages: 663-76
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Publication
24986859 | -
 
First Author: Bonasio R
Year: 2014
Journal: Elife
Title: Interactions with RNA direct the Polycomb group protein SCML2 to chromatin where it represses target genes.
Volume: 3
Pages: e02637
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Protein Domain
IPR033763 | SCML2_RBR
Type: Domain
Description: SCML2 is a mammalian Polycomb-group protein, which associates with the Polycomb repressive complex-1 (PRC1) that is essential for the epigenetic regulation of gene expression. Isoform SCML2A has been shown to bind to PRC1 via its SPM domain and to interact with ncRNAs through a novel RNA-binding region (RBR). The RBR is necessary for targeting of SCML2A to chromatin and PRC1 recruitment, suggesting a role for ncRNAs in regulating SCML2 function [].This entry represents the RNA-binding region of SCML2, also found in other Polycomb-group proteins.
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Publication
20543829 | J:245293
First Author: El Messaoudi-Aubert S
Year: 2010
Journal: Nat Struct Mol Biol
Title: Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
Volume: 17
Issue: 7
Pages: 862-8
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Publication
26385961 | J:283578
First Author: Illingworth RS
Year: 2015
Journal: Genes Dev
Title: The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.
Volume: 29
Issue: 18
Pages: 1897-902
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Publication
17070805 | J:117714
First Author: Arrigoni R
Year: 2006
Journal: FEBS Lett
Title: The Polycomb-associated protein Rybp is a ubiquitin binding protein.
Volume: 580
Issue: 26
Pages: 6233-41
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Publication
23502315 | J:197636
First Author: Klauke K
Year: 2013
Journal: Nat Cell Biol
Title: Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation.
Volume: 15
Issue: 4
Pages: 353-62
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Protein Domain
IPR037937 | RING2
Type: Family
Description: E3 ubiquitin-protein ligase RING2 () mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub) [], which is a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals []. RING2 is a component of the PRC1 complex [], and other chromatin-associated Polycomb (PcG) complexes such as BCOR []. It is also a component of the MLL1/MLL complex [].
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Protein Domain
IPR025894 | Mtf2_C_dom
Type: Domain
Description: Mammalian Polycomb-like gene MTF2/PCL2 forms a complex with Polycomb repressive complex-2 (PRC2) and collaborates with PRC1 to achieve repression of Hox gene expression []. The human MTF2 gene is expressed inthree splicing variants, each of them contains the short C-terminal domain defined here.
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Publication
26468281 | J:228575
First Author: Abdouh M
Year: 2016
Journal: J Biol Chem
Title: The Polycomb Repressive Complex 1 Protein BMI1 Is Required for Constitutive Heterochromatin Formation and Silencing in Mammalian Somatic Cells.
Volume: 291
Issue: 1
Pages: 182-97
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Publication
30209188 | J:266631
First Author: Okuyama Y
Year: 2018
Journal: J Immunol
Title: Bmi1 Regulates IκBα Degradation via Association with the SCF Complex.
Volume: 201
Issue: 8
Pages: 2264-2272
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Publication
19170609 | J:172960
First Author: Neira JL
Year: 2009
Journal: Biochemistry
Title: The transcriptional repressor RYBP is a natively unfolded protein which folds upon binding to DNA.
Volume: 48
Issue: 6
Pages: 1348-60
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Publication
28924034 | J:247530
First Author: Maezawa S
Year: 2017
Journal: Genes Dev
Title: Polycomb directs timely activation of germline genes in spermatogenesis.
Volume: 31
Issue: 16
Pages: 1693-1703
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Publication
22499591 | J:183934
First Author: Posfai E
Year: 2012
Journal: Genes Dev
Title: Polycomb function during oogenesis is required for mouse embryonic development.
Volume: 26
Issue: 9
Pages: 920-32
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Publication
16786585 | J:111614
First Author: Vogel T
Year: 2006
Journal: Dev Dyn
Title: Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes.
Volume: 235
Issue: 9
Pages: 2574-85
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Publication
22325148 | J:186106
First Author: Tavares L
Year: 2012
Journal: Cell
Title: RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.
Volume: 148
Issue: 4
Pages: 664-78
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Publication
20471950 | J:162930
First Author: Eskeland R
Year: 2010
Journal: Mol Cell
Title: Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.
Volume: 38
Issue: 3
Pages: 452-64
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HT Experiment
E-GEOD-55060 | SCML2 Establishes the Male Germline Epigenome
Series Id: GSE55060
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
24194518 | J:207230
First Author: Wu HA
Year: 2013
Journal: J Biol Chem
Title: Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7.
Volume: 288
Issue: 51
Pages: 36398-408
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Publication
25500566 | J:222656
First Author: Creppe C
Year: 2014
Journal: PLoS Genet
Title: A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation.
Volume: 10
Issue: 12
Pages: e1004851
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Publication
17214966 | J:117852
First Author: Negishi M
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Bmi1 cooperates with Dnmt1-associated protein 1 in gene silencing.
Volume: 353
Issue: 4
Pages: 992-8
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Protein
D3Z791
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: false
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Protein
D3YY47
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Protein
F6UK33
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Publication
12591913 | -
First Author: Schuyler SC
Year: 2003
Journal: J Cell Biol
Title: The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.
Volume: 160
Issue: 4
Pages: 517-28
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Publication
16014384 | -
First Author: Chang HY
Year: 2005
Journal: J Cell Sci
Title: Dynamic interaction of NtMAP65-1a with microtubules in vivo.
Volume: 118
Issue: Pt 14
Pages: 3195-201
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Publication
15908607 | -
First Author: Mao T
Year: 2005
Journal: Plant Physiol
Title: Two microtubule-associated proteins of the Arabidopsis MAP65 family function differently on microtubules.
Volume: 138
Issue: 2
Pages: 654-62
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Publication
16098102 | -
First Author: Mao G
Year: 2005
Journal: Plant J
Title: Modulated targeting of GFP-AtMAP65-1 to central spindle microtubules during division.
Volume: 43
Issue: 4
Pages: 469-78
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Publication
17011227 | -
First Author: Sasabe M
Year: 2006
Journal: Curr Opin Plant Biol
Title: MAP65: a bridge linking a MAP kinase to microtubule turnover.
Volume: 9
Issue: 6
Pages: 563-70
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Publication
16847052 | -
First Author: Smertenko AP
Year: 2006
Journal: J Cell Sci
Title: Control of the AtMAP65-1 interaction with microtubules through the cell cycle.
Volume: 119
Issue: Pt 15
Pages: 3227-37
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Protein Domain
IPR007145 | MAP65_Ase1_PRC1
Type: Family
Description: This is a family of microtubule associated proteins, including MAP65 (MAP65-1/2/3/4/5/6/7/8/9) from Arabidopsis, Ase1 from yeast, and PRC1 from mammals.Ase1 is required for spindle elongation and stabilisation. It is cell cycle-regulated by anaphase promoting complex []. It is a potential Cdc28p substrate []. MAP65-1 plays a role in stabilising anti-parallel microtubules in the central spindle at anaphase to early cytokinesis. MAP65-1 is cell cycle regulated by phosphorylation [, , , , ].PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone []. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [, ]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [, , ]and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle [].
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Publication
19636380 | J:151469
First Author: Maertens GN
Year: 2009
Journal: PLoS One
Title: Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.
Volume: 4
Issue: 7
Pages: e6380
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Protein
B1AR14
Organism: Mus musculus/domesticus
Length: 158  
Fragment?: false
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Protein Domain
IPR032443 | RAWUL
Type: Domain
Description: The RAWUL domain is found at the C terminus of poly-comb group RING finger proteins. It contains a variant ubiquitin-like fold with a distinct conserved surface region. The conserved surface found in this domain is responsible for interaction with Cbx members of the PRC1 (polycomb repression complex 1) and homodimer formation []. The RAWUL domain binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor). BCOR has emerged as an important player in development and health [].
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Publication
17726103 | J:248225
First Author: Xi S
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Lsh controls Hox gene silencing during development.
Volume: 104
Issue: 36
Pages: 14366-71
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Publication
28596365 | J:243420
First Author: Almeida M
Year: 2017
Journal: Science
Title: PCGF3/5-PRC1 initiates Polycomb recruitment in X chromosome inactivation.
Volume: 356
Issue: 6342
Pages: 1081-1084
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Publication
30428357 | J:271122
First Author: Jansz N
Year: 2018
Journal: Cell Rep
Title: Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway.
Volume: 25
Issue: 7
Pages: 1912-1923.e9
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Publication
36443290 | J:350070
First Author: Takano J
Year: 2022
Journal: Nat Commun
Title: PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment.
Volume: 13
Issue: 1
Pages: 7159
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Publication
23395003 | J:197096
First Author: Wu X
Year: 2013
Journal: Mol Cell
Title: Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation.
Volume: 49
Issue: 6
Pages: 1134-46
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Publication
27010239 | J:236834
 
First Author: Koya J
Year: 2016
Journal: Nat Commun
Title: DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.
Volume: 7
Pages: 10924
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Publication
16710298 | J:119024
First Author: Buchwald G
Year: 2006
Journal: EMBO J
Title: Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b.
Volume: 25
Issue: 11
Pages: 2465-74
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Publication
18366140 | J:134271
First Author: Courel M
Year: 2008
Journal: Dev Dyn
Title: E2f6 and Bmi1 cooperate in axial skeletal development.
Volume: 237
Issue: 5
Pages: 1232-42
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Publication
20601937 | J:163381
First Author: Maertens GN
Year: 2010
Journal: EMBO J
Title: Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
Volume: 29
Issue: 15
Pages: 2553-65
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Publication
33602871 | J:324264
First Author: Cohen I
Year: 2021
Journal: Genes Dev
Title: Polycomb complexes redundantly maintain epidermal stem cell identity during development.
Volume: 35
Issue: 5-6
Pages: 354-366
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Publication
18339675 | J:135982
First Author: Endoh M
Year: 2008
Journal: Development
Title: Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity.
Volume: 135
Issue: 8
Pages: 1513-24
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Publication
38389850 | J:345616
First Author: Gao M
Year: 2024
Journal: Theranostics
Title: Polycomb repressive complex 1 modulates granulosa cell proliferation in early folliculogenesis to support female reproduction.
Volume: 14
Issue: 4
Pages: 1371-1389
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Publication
24728135 | J:213248
 
First Author: Piunti A
Year: 2014
Journal: Nat Commun
Title: Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication.
Volume: 5
Pages: 3649
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Publication
28602614 | J:264926
First Author: Liu PP
Year: 2017
Journal: Stem Cell Reports
Title: MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells.
Volume: 9
Issue: 1
Pages: 190-202
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Publication
19503595 | J:149818
First Author: Kallin EM
Year: 2009
Journal: PLoS Genet
Title: Genome-wide uH2A localization analysis highlights Bmi1-dependent deposition of the mark at repressed genes.
Volume: 5
Issue: 6
Pages: e1000506
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Publication
22562112 | J:185803
First Author: Lapthanasupkul P
Year: 2012
Journal: Dev Biol
Title: Ring1a/b polycomb proteins regulate the mesenchymal stem cell niche in continuously growing incisors.
Volume: 367
Issue: 2
Pages: 140-53
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Publication
21402785 | J:173970
First Author: Ren X
Year: 2011
Journal: Mol Cell Biol
Title: REST interacts with Cbx proteins and regulates polycomb repressive complex 1 occupancy at RE1 elements.
Volume: 31
Issue: 10
Pages: 2100-10
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Publication
23273917 | J:196328
First Author: Morey L
Year: 2013
Journal: Cell Rep
Title: RYBP and Cbx7 define specific biological functions of polycomb complexes in mouse embryonic stem cells.
Volume: 3
Issue: 1
Pages: 60-9
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Protein
A0A087WP87
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Publication
19791798 | -
First Author: Bezsonova I
Year: 2009
Journal: Biochemistry
Title: Ring1B contains a ubiquitin-like docking module for interaction with Cbx proteins.
Volume: 48
Issue: 44
Pages: 10542-8
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Publication
22226355 | -
First Author: Morey L
Year: 2012
Journal: Cell Stem Cell
Title: Nonoverlapping functions of the Polycomb group Cbx family of proteins in embryonic stem cells.
Volume: 10
Issue: 1
Pages: 47-62
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Protein
D3YYK4
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: true
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Publication
21047797 | -
First Author: Kaustov L
Year: 2011
Journal: J Biol Chem
Title: Recognition and specificity determinants of the human cbx chromodomains.
Volume: 286
Issue: 1
Pages: 521-9
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Publication
24793759 | -
First Author: Ma RG
Year: 2014
Journal: J Zhejiang Univ Sci B
Title: Epigenetic regulation by polycomb group complexes: focus on roles of CBX proteins.
Volume: 15
Issue: 5
Pages: 412-28
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Protein Domain
IPR039958 | RYBP/YAF2
Type: Family
Description: Proteins included in this entry have an N-terminal RanBP2-type zinc finger and a Yaf2/RYBP C-terminal binding motif. Proteins with these regions include Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation [].
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Protein Domain
IPR043000 | CBX7
Type: Family
Description: PcG proteins form large multiprotein complexes (PcG bodies) which are involved in the stable repression of genes involved in development, signaling or cancer via chromatin-based epigenetic modifications. Mammalian PRC1 includes canonical (cPRC1) and non-canonical complexes; cPRC1, contains four core subunits including one CBX protein (CBX2, CBX4, and CBX6-CBX8) that binds H3K27me3. CBX family members have different affinity for H3K27me3, with CBX7 having the highest binding capability [, ].This entry represents CBX7 []. In pluripotent cells, CBX7 is the main PRC1-associated Cbx protein and plays an important role in the maintenance of pluripotency [].
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Protein Domain
IPR033774 | YAF2_RYBP
Type: Conserved_site
Description: This motif is found in the C-terminal region of the Yaf2 and RYBP proteins, which are homologous parts of the PRC1 complex [].RYBP is a zinc finger protein with an essential role during embryonic development, which binds transcriptional factors, Polycomb products, and mediators of apoptosisis []. RYBP also binds ubiquitin and Cbx proteins via the C-terminal docking module [, ]. RYBP is natively unstructured until it binds to the C-terminal region of the Polycomb protein Ring1B or to DNA []. Yaf2 binds to MYC and inhibits MYC-mediated transactivation [].
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Publication
36413948 | J:331694
First Author: Liang Q
Year: 2022
Journal: Dev Cell
Title: Essential role of MESP1-RING1A complex in cardiac differentiation.
Volume: 57
Issue: 22
Pages: 2533-2549.e7
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Publication
27773671 | J:309670
 
First Author: Sheikh BN
Year: 2017
Journal: Exp Hematol
Title: MOZ and BMI1 act synergistically to maintain hematopoietic stem cells.
Volume: 47
Pages: 83-97.e8
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Publication
25379404 | J:223080
First Author: Cannon CE
Year: 2014
Journal: Mol Metab
Title: The Polycomb protein, Bmi1, regulates insulin sensitivity.
Volume: 3
Issue: 8
Pages: 794-802
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Publication
20351251 | J:159302
First Author: Zaaroor-Regev D
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome.
Volume: 107
Issue: 15
Pages: 6788-93
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Publication
17215307 | J:119909
First Author: Takada Y
Year: 2007
Journal: Development
Title: Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.
Volume: 134
Issue: 3
Pages: 579-90
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Publication
25703348 | J:225041
First Author: Hasegawa K
Year: 2015
Journal: Dev Cell
Title: SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination.
Volume: 32
Issue: 5
Pages: 574-88
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Publication
24457600 | J:345192
 
First Author: Cao Q
Year: 2014
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Title: The central role of EED in the orchestration of polycomb group complexes.
Volume: 5
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HT Experiment
GSE171206 | Diverse epigenetic mechanisms maintain parental imprints within the embryonic and extraembryonic lineages
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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HT Experiment
GSE222464 | KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors (RNA-Seq)
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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First Author: Gao Z
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Journal: Nature
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Year: 2021
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Title: NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.
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20696397 | -
First Author: Wang R
Year: 2010
Journal: Structure
Title: Polycomb group targeting through different binding partners of RING1B C-terminal domain.
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First Author: Li Z
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Title: Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex.
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First Author: Wang H
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First Author: Gearhart MD
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Journal: Mol Cell Biol
Title: Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.
Volume: 26
Issue: 18
Pages: 6880-9
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