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Search results 301 to 400 out of 418 for Prdm9

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Type Details Score
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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UniProt Feature
UniProt Feature
Begin: 1
Description: Histone-lysine N-methyltransferase PRDM9
Type: chain
End: 843
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Protein
Q96EQ9
Organism: Mus musculus/domesticus
Length: 843  
Fragment?: false
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Protein
Q96EQ9-4
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Protein
Q96EQ9-2
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
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Protein
Q96EQ9-3
Organism: Mus musculus/domesticus
Length: 418  
Fragment?: false
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Protein
Q05CM8
Organism: Mus musculus/domesticus
Length: 287  
Fragment?: false
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Protein
W0TXY3
Organism: Mus musculus/domesticus
Length: 817  
Fragment?: false
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Protein
W0TX95
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
W0TX90
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
W0TYI2
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
W0TXY0
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
C1J0N3
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
D2KI92
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
W0TXX7
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Protein
W0TY47
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
W0TWU8
Organism: Mus musculus/domesticus
Length: 903  
Fragment?: false
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Publication
26351520 | J:355976
 
First Author: Walker M
Year: 2015
Journal: Epigenetics Chromatin
Title: Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage.
Volume: 8
Pages: 31
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HT Experiment
E-GEOD-61613 | Affinity-seq detects genome-wide PRDM9 binding sites and reveals the impact of prior chromatin modifications on mammalian recombination hotspot usage
Series Id: GSE61613
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
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Protein
C4MLH8
Organism: Mus musculus/domesticus
Length: 875  
Fragment?: false
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Protein
E9Q4V2
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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Publication
28336543 | -
First Author: Grey C
Year: 2017
Journal: Genome Res
Title: In vivo binding of PRDM9 reveals interactions with noncanonical genomic sites.
Volume: 27
Issue: 4
Pages: 580-590
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Publication
21460839 | -
First Author: Smagulova F
Year: 2011
Journal: Nature
Title: Genome-wide analysis reveals novel molecular features of mouse recombination hotspots.
Volume: 472
Issue: 7343
Pages: 375-8
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Allele
Prdm9<em1Smoc> | MGI:7291791
Name: PR domain containing 9; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
28126738 | -
First Author: Koh-Stenta X
Year: 2017
Journal: Biochem J
Title: Discovery and characterisation of the automethylation properties of PRDM9.
Volume: 474
Issue: 6
Pages: 971-982
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Strain
MGI:6476078 | C57BL/6JSmoc-Prdm9<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
35162997 | -
 
First Author: Lorenz P
Year: 2022
Journal: Int J Mol Sci
Title: The KRAB Domain of ZNF10 Guides the Identification of Specific Amino Acids That Transform the Ancestral KRAB-A-Related Domain Present in Human PRDM9 into a Canonical Modern KRAB-A Domain.
Volume: 23
Issue: 3
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Allele
Tg(RP23-159N6*)43Bdm | MGI:5311010
Name: transgene insertion 43, Bernard de Massy
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:5311825 | C57BL/6J-Tg(RP23-159N6*)43Bdm
Attribute String: transgenic, mutant strain, coisogenic
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Allele
Tg(RP23-159N6*)23Bdm | MGI:5565212
Name: transgene insertion 23, Bernard de Massy
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Prdm9<tm1.1Kpgn> | MGI:5699103
 
Name: PR domain containing 9; targeted mutation 1.1, Kenneth Paigen
Allele Type: Targeted
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Allele
Prdm9<tm1Kpgn> | MGI:5698925
 
Name: PR domain containing 9; targeted mutation 1, Kenneth Paigen
Allele Type: Targeted
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Allele
Prdm9<tm1.1(PRDM9)Wthg> | MGI:5708566
Name: PR domain containing 9; targeted mutation 1.1, Benjamin Davies
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Prdm9<tm1(PRDM9)Wthg> | MGI:5609598
Name: PR domain containing 9; targeted mutation 1, Benjamin Davies
Allele Type: Targeted
Attribute String: Humanized sequence, RMCE-ready
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Strain
MGI:5699108 | B6.Cg-Prdm9<tm1.1Kpgn>
Attribute String: targeted mutation, mutant strain, congenic
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Genotype
Genotype
Symbol: Prdm9/Prdm9
Background: B6.Cg-Prdm9
Zygosity: hm
Has Mutant Allele: true
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Publication
27129774 | -
First Author: Blazer LL
Year: 2016
Journal: J Biol Chem
Title: PR Domain-containing Protein 7 (PRDM7) Is a Histone 3 Lysine 4 Trimethyltransferase.
Volume: 291
Issue: 26
Pages: 13509-19
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Publication
29499130 | -
First Author: Kang R
Year: 2018
Journal: Mol Cell
Title: Missing the Mark: PRDM9-Dependent Methylation Is Required for Meiotic DSB Targeting.
Volume: 69
Issue: 5
Pages: 725-727
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Protein Domain
IPR044417 | PRDM7_9_PR-SET
Type: Domain
Description: This entry represents the PR/SET domain found in PR domain zinc finger protein 7 and 9 (PRDM7/9). PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyses the trimethylation of H3 lysine 4 (H3K4me3) []. PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is associated with genome instability in cancer [, , , ]. PRDM9 has also been shown to be able to performs intramolecular automethylation on multiple lysine residues localised to a lysine-rich region on the post-SET domain [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes [].
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Publication
32352380 | J:290646
   
First Author: Mahgoub M
Year: 2020
Journal: Elife
Title: Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice.
Volume: 9
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Publication
34260899 | J:316849
First Author: Pratto F
Year: 2021
Journal: Cell
Title: Meiotic recombination mirrors patterns of germline replication in mice and humans.
Volume: 184
Issue: 16
Pages: 4251-4267.e20
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Publication
35320728 | J:324909
First Author: Xu J
Year: 2022
Journal: Cell Rep
Title: ZFP541 maintains the repression of pre-pachytene transcriptional programs and promotes male meiosis progression.
Volume: 38
Issue: 12
Pages: 110540
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Publication
21604305 | -
First Author: Briknarová K
Year: 2011
Journal: Proteins
Title: The PR/SET domain in PRDM4 is preceded by a zinc knuckle.
Volume: 79
Issue: 7
Pages: 2341-5
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Protein Domain
IPR041493 | PRDM4_Znf_knuckle
Type: Domain
Description: This is a zinc knuckle motif found in PRDM4 (Schwann cell factor 1, SC-1), a member of the PR protein family. PRDM4 is a transcriptional regulator that has been implied in transduction of nerve growth factor signals via the p75 neurotrophin receptor and in cell growth arrest. The short motif is also present in several other PR proteins including human PRDM6 (PRISM), PRDM7, PRDM9 (meisetz), PRDM10 (tristanin), PRDM11, and PRDM15. The conservation of cysteine and histidine residues suggested that this 20 amino acid motif binds zinc, hence the name 'PR zinc knuckle' to distinguish it from the longer (30 amino acid) C2H2-like zinc fingers that are located C-terminally of the PR domain. The PR zinc knuckle fold is similar to that of Gag-knuckles (a β-hairpin providing two zinc ligands followed by a short helix or a loop providing the other two zinc ligands) and zinc ribbons (two β-hairpins, each providing two zinc ligands) [].
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Publication
23870400 | J:202231
 
First Author: Smagulova F
Year: 2013
Journal: BMC Genomics
Title: Suppression of genetic recombination in the pseudoautosomal region and at subtelomeres in mice with a hypomorphic Spo11 allele.
Volume: 14
Pages: 493
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Publication
27821479 | J:244148
 
First Author: Getun IV
Year: 2017
Journal: Mol Cell Biol
Title: Functional Roles of Acetylated Histone Marks at Mouse Meiotic Recombination Hot Spots.
Volume: 37
Issue: 3
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Publication
24516397 | J:210891
First Author: Bhattacharyya T
Year: 2014
Journal: PLoS Genet
Title: X chromosome control of meiotic chromosome synapsis in mouse inter-subspecific hybrids.
Volume: 10
Issue: 2
Pages: e1004088
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Publication
32493902 | J:292550
First Author: Morimoto K
Year: 2020
Journal: Sci Rep
Title: Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.
Volume: 10
Issue: 1
Pages: 9060
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Publication
31562180 | J:333718
First Author: Lustyk D
Year: 2019
Journal: Genetics
Title: Genomic Structure of Hstx2 Modifier of Prdm9-Dependent Hybrid Male Sterility in Mice.
Volume: 213
Issue: 3
Pages: 1047-1063
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Publication
7539744 | -
First Author: Crew AJ
Year: 1995
Journal: EMBO J
Title: Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma.
Volume: 14
Issue: 10
Pages: 2333-40
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Publication
8697803 | -
First Author: de Leeuw B
Year: 1996
Journal: Cytogenet Cell Genet
Title: A novel Krüppel-associated box containing the SSX gene (SSX3) on the human X chromosome is not implicated in t(X;18)-positive synovial sarcomas.
Volume: 73
Issue: 3
Pages: 179-83
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Publication
9378559 | -
First Author: Gure AO
Year: 1997
Journal: Int J Cancer
Title: SSX: a multigene family with several members transcribed in normal testis and human cancer.
Volume: 72
Issue: 6
Pages: 965-71
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Publication
9788446 | -
First Author: Lim FL
Year: 1998
Journal: Oncogene
Title: A KRAB-related domain and a novel transcription repression domain in proteins encoded by SSX genes that are disrupted in human sarcomas.
Volume: 17
Issue: 15
Pages: 2013-8
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Protein Domain
IPR003655 | aKRAB
Type: Domain
Description: This domain of about 70 amino acid residues is related to the Krueppel-associated box (KRAB) domain and has been recently stratified as the ancestral KRAB domain (aKRAB). Sequence analysis revealed that these sequences have a motif that can also be traced in invertebrates, whose homologues still exist in mammals, including humans, in the PR/SET domain 9 (PRDM9) and synovial sarcoma X breakpoint (SSX) orthologous and paralogous groups []. This domain is found in the N-terminal ends of PRDM9 and proteins belonging to the SSX family [, , ]. Proteins of the SSX family lack the C2H2-type zinc finger which is invariably found in proteins containing the KRAB domain.Although the aKRAB domains of SSX1 and SSX2 contribute to the repressive activity of these proteins, transcriptional repression is mainly mediated by an auxiliary region located in their C terminus, called KRAB-B []. Hence, unlike the canonical KRAB domain, the aKRAB domain is only a weak transcriptional repression domain, as seen in human PRDM9, which neither silences transcription nor interacts with TRIM28/KAP1 [, ].
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Publication
21170346 | J:167718
First Author: Billings T
Year: 2010
Journal: PLoS One
Title: Patterns of recombination activity on mouse chromosome 11 revealed by high resolution mapping.
Volume: 5
Issue: 12
Pages: e15340
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Protein
D3YYH8
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
D3Z7Q9
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Publication
32290321 | -
 
First Author: Casamassimi A
Year: 2020
Journal: Int J Mol Sci
Title: Multifaceted Role of PRDM Proteins in Human Cancer.
Volume: 21
Issue: 7
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Protein
F2Y0K5
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
B1AUS7
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
C4MLI0
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
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Protein
C4MLH9
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: false
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Protein
Q6XAS4
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
B1AY40
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q9CPU1
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q6XAR7
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q5M8N5
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: true
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Protein
Q6XAR6
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q6XAR5
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q6XAS1
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
B7ZNZ3
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
F6QAV8
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: true
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Protein
Q6XAR4
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: true
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Protein
A2AHC8
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
A2BI73
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: false
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Protein
A2BI93
Organism: Mus musculus/domesticus
Length: 185  
Fragment?: false
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Protein
F6XK35
Organism: Mus musculus/domesticus
Length: 94  
Fragment?: false
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Protein
Q6XAR9
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
Q6XAS0
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: true
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Protein
A2BI74
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q6XAR8
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
A2AHC7
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
B7ZWB6
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
Q8C5Z3
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
Q80ZT4
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
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Protein
Q6XAS2
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Protein
Q6XAS3
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: false
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Protein
A0A5H1ZRK6
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
Q80V63
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: false
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Protein
Q80TC5
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
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Protein
E9Q3B2
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q8C0V8
Organism: Mus musculus/domesticus
Length: 719  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom