Type |
Details |
Score |
Publication |
First Author: |
Jensen P |
Year: |
2004 |
Journal: |
Brain Res Mol Brain Res |
Title: |
A neurogenomics approach to gene expression analysis in the developing brain. |
Volume: |
132 |
Issue: |
2 |
Pages: |
116-27 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taconic |
Year: |
2006 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from Taconic website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
McKee AE |
Year: |
2005 |
Journal: |
BMC Dev Biol |
Title: |
A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. |
Volume: |
5 |
|
Pages: |
14 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shanghai Model Organisms Center |
Year: |
2017 |
Journal: |
MGI Direct Data Submission |
Title: |
Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the Wellcome Trust Sanger Institute Mouse Genetics Project (MGP) |
Year: |
2011 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the Wellcome Trust Sanger Institute (WTSI) Mouse Resources Portal |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ingham NJ |
Year: |
2019 |
Journal: |
PLoS Biol |
Title: |
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. |
Volume: |
17 |
Issue: |
4 |
Pages: |
e3000194 |
|
•
•
•
•
•
|
Publication |
First Author: |
GO Central curators, GOA curators, Rhea curators |
Year: |
2020 |
|
Title: |
Automatic Gene Ontology annotation based on Rhea mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators, MGI curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation based on Enzyme Commission mapping |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Mouse Synonym Curation |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2016 |
|
Title: |
Automatic assignment of GO terms using logical inference, based on on inter-ontology links |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Visel A |
Year: |
2004 |
Journal: |
Nucleic Acids Res |
Title: |
GenePaint.org: an atlas of gene expression patterns in the mouse embryo. |
Volume: |
32 |
Issue: |
Database issue |
Pages: |
D552-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Velocigene |
Year: |
2008 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
448
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
The arginine methyltransferase PRMT2 binds RB and regulates E2F function. |
|
•
•
•
•
•
|
Allele |
Name: |
protein arginine N-methyltransferase 2; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
duplication, Chr 10, Y Eugene Yu 2 |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Allele |
Name: |
deletion, Chr 10, Y Eugene Yu 4 |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion IL152, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Allele |
Name: |
microRNA 678; endonuclease-mediated mutation 2, Mouse Clinical Institute |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, congenic, duplication, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, congenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, duplication |
|
•
•
•
•
•
|
Publication |
First Author: |
Block A |
Year: |
2015 |
Journal: |
Biol Sex Differ |
Title: |
Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome. |
Volume: |
6 |
|
Pages: |
24 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, deletion, coisogenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
deletion, Chr 10, Yann Herault 4 |
Allele Type: |
Targeted |
|
|
•
•
•
•
•
|
Allele |
Name: |
deletion, Chr 10, Yann Herault 1 |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dp(10Prmt2-Pdxk)2Yey/? |
Background: |
B6.129S7-Dp(10Prmt2-Pdxk)2Yey |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Del(10Prmt2-Pdxk)4Yey/+ |
Background: |
129S/SvEv-Del(10Prmt2-Pdxk)129S/SvEv-Del(10Prmt2-Pdxk)4Yey |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, targeted mutation, deletion, chromosome aberration |
|
•
•
•
•
•
|
Strain |
Attribute String: |
deletion, targeted mutation, chromosome aberration, mutant strain, congenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Del(10Prmt2-Cstb)4Yah/+ |
Background: |
involves: 129P2/OlaHsd * BALB/c * C3H/HeH * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Del(10Prmt2-Col6a1)1Yah/+ |
Background: |
involves: 129P2/OlaHsd * C57BL/6 * SJL |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
targeted mutation, mutant strain, duplication, congenic |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, duplication, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Gally F |
Year: |
2018 |
Journal: |
Biochim Biophys Acta |
Title: |
The TRPM2 ion channel contributes to cytokine hyperproduction in a mouse model of Down Syndrome. |
Volume: |
1864 |
Issue: |
1 |
Pages: |
126-132 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dp(10Prmt2-Pdxk)2Yey/? Dp(17Abcg1-Rrp1b)3Yey/? |
Background: |
B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(17Abcg1-Rrp1b)3Yey |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dp(10Prmt2-Pdxk)2Yey/? Dp(16Lipi-Zbtb21)1Yey/? |
Background: |
B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Del(10Prmt2-Cstb)4Yah/+ Tc(HSA21)1TybEmcf/? |
Background: |
involves: 129P2/OlaHsd * BALB/c * C3H/HeH * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, duplication, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Publication |
First Author: |
Powers RK |
Year: |
2019 |
Journal: |
Nat Commun |
Title: |
Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors. |
Volume: |
10 |
Issue: |
1 |
Pages: |
4766 |
|
•
•
•
•
•
|
Publication |
First Author: |
Donovan MG |
Year: |
2024 |
Journal: |
Cell Rep |
Title: |
Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. |
Volume: |
43 |
Issue: |
8 |
Pages: |
114599 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jewett CE |
Year: |
2023 |
Journal: |
Elife |
Title: |
Trisomy 21 induces pericentrosomal crowding delaying primary ciliogenesis and mouse cerebellar development. |
Volume: |
12 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Belichenko PV |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
Down Syndrome Cognitive Phenotypes Modeled in Mice Trisomic for All HSA 21 Homologues. |
Volume: |
10 |
Issue: |
7 |
Pages: |
e0134861 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu T |
Year: |
2010 |
Journal: |
Brain Res |
Title: |
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. |
Volume: |
1366 |
|
Pages: |
162-71 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tuttle KD |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome. |
Volume: |
33 |
Issue: |
7 |
Pages: |
108407 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2021 |
Journal: |
Genes (Basel) |
Title: |
Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions. |
Volume: |
12 |
Issue: |
8 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yu T |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions. |
Volume: |
19 |
Issue: |
14 |
Pages: |
2780-91 |
|
•
•
•
•
•
|
Publication |
First Author: |
Granno S |
Year: |
2019 |
Journal: |
Sci Rep |
Title: |
Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus. |
Volume: |
9 |
Issue: |
1 |
Pages: |
7322 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tosh JL |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models. |
Volume: |
11 |
Issue: |
1 |
Pages: |
5736 |
|
•
•
•
•
•
|
Publication |
First Author: |
Muza PM |
Year: |
2023 |
Journal: |
iScience |
Title: |
Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture. |
Volume: |
26 |
Issue: |
2 |
Pages: |
106073 |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Dp(10Prmt2-Pdxk)2Yey/? Dp(16Lipi-Zbtb21)1Yey/? Dp(17Abcg1-Rrp1b)3Yey/? |
Background: |
B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chang P |
Year: |
2020 |
Journal: |
Cell Rep |
Title: |
Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome. |
Volume: |
30 |
Issue: |
4 |
Pages: |
1152-1163.e4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang L |
Year: |
2014 |
Journal: |
Hum Mol Genet |
Title: |
Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits. |
Volume: |
23 |
Issue: |
3 |
Pages: |
578-89 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu C |
Year: |
2018 |
Journal: |
Oncotarget |
Title: |
Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors. |
Volume: |
9 |
Issue: |
4 |
Pages: |
4773-4786 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu Y |
Year: |
2023 |
Journal: |
Acta Neuropathol Commun |
Title: |
Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B. |
Volume: |
11 |
Issue: |
1 |
Pages: |
132 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bhutta MF |
Year: |
2013 |
Journal: |
Mamm Genome |
Title: |
Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media. |
Volume: |
24 |
Issue: |
11-12 |
Pages: |
439-45 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watson-Scales S |
Year: |
2018 |
Journal: |
PLoS Genet |
Title: |
Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. |
Volume: |
14 |
Issue: |
5 |
Pages: |
e1007383 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tateossian H |
Year: |
2025 |
Journal: |
Elife |
Title: |
DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. |
|
|
|
|
•
•
•
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•
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Publication |
First Author: |
Gupta M |
Year: |
2016 |
Journal: |
Mamm Genome |
Title: |
Mouse models of Down syndrome: gene content and consequences. |
Volume: |
27 |
Issue: |
11-12 |
Pages: |
538-555 |
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Publication |
First Author: |
Zhang L |
Year: |
2012 |
Journal: |
Bioeng Bugs |
Title: |
Genetic analysis of Down syndrome facilitated by mouse chromosome engineering. |
Volume: |
3 |
Issue: |
1 |
Pages: |
8-12 |
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Publication |
First Author: |
MGI and ICS/MCI |
Year: |
2024 |
Journal: |
Database Release |
Title: |
MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC) Generated by ICS/MCI |
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Publication |
First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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