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Search results 301 to 388 out of 388 for Psen2

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Type Details Score
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
30892128 | J:319592
First Author: Fedeli C
Year: 2019
Journal: Autophagy
Title: PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
Volume: 15
Issue: 12
Pages: 2044-2062
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DO Term
DOID:0110427 | dilated cardiomyopathy 1V
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Allele
Psen2<em1Smoc> | MGI:7291863
Name: presenilin 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Tg(Prnp-PSEN2*N141I)30Jgr | MGI:4839766
Name: transgene insertion 30, J Richards
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:6429435 | C57BL/6JSmoc-Psen2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
32075767 | J:288098
First Author: Rossi A
Year: 2020
Journal: Cell Rep
Title: Defective Mitochondrial Pyruvate Flux Affects Cell Bioenergetics in Alzheimer's Disease-Related Models.
Volume: 30
Issue: 7
Pages: 2332-2348.e10
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Allele
Tg(Eno2-PSEN2)2348Ykk | MGI:5052116
Name: transgene insertion 2348, Yong K Kim
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Psen2<tm1Ber> | MGI:1930939
Name: presenilin 2; targeted mutation 1, Alan Bernstein
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz | MGI:4412048
Name: transgene insertion 152H, Laurence Ozmen
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(Eno2-PSEN2*)1480Ykk | MGI:5052118
Name: transgene insertion 1480, Yong K Kim
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Tg(Eno2-PSEN2)2348Ykk/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Allele
Psen2<tm1Bdes> | MGI:2149117
Name: presenilin 2; targeted mutation 1, Bart de Strooper
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:4412388 | C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Attribute String: coisogenic, mutant strain, transgenic
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Publication
28197095 | J:276720
 
First Author: Brendel M
Year: 2017
Journal: Front Aging Neurosci
Title: Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis.
Volume: 9
Pages: 8
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Publication
27097852 | J:324345
 
First Author: Srinivasan K
Year: 2016
Journal: Nat Commun
Title: Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses.
Volume: 7
Pages: 11295
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Publication
36906584 | J:339796
First Author: Ballweg A
Year: 2023
Journal: J Neuroinflammation
Title: [(18)F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.
Volume: 20
Issue: 1
Pages: 68
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Publication
15922048 | J:98909
First Author: Woolley ML
Year: 2005
Journal: Behav Brain Res
Title: Age-related impairments in operant DMTP performance in the PS2APP mouse, a transgenic mouse model of Alzheimer's disease.
Volume: 161
Issue: 2
Pages: 220-8
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Publication
17008022 | J:116044
First Author: Güntert A
Year: 2006
Journal: Neuroscience
Title: High sensitivity analysis of amyloid-beta peptide composition in amyloid deposits from human and PS2APP mouse brain.
Volume: 143
Issue: 2
Pages: 461-75
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Strain
MGI:4839904 | B6.Cg-Tg(Prnp-PSEN2*N141I)30Jgr Tg(Thy1-APPSwe)71Jgr
Attribute String: congenic, mutant strain, transgenic
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Publication
17251422 | J:117779
First Author: Lopez-Lopez C
Year: 2007
Journal: J Neurosci
Title: Disturbed cross talk between insulin-like growth factor I and AMP-activated protein kinase as a possible cause of vascular dysfunction in the amyloid precursor protein/presenilin 2 mouse model of Alzheimer's disease.
Volume: 27
Issue: 4
Pages: 824-31
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Publication
20969897 | J:180848
First Author: Um HS
Year: 2011
Journal: Neurosci Res
Title: Treadmill exercise represses neuronal cell death in an aged transgenic mouse model of Alzheimer's disease.
Volume: 69
Issue: 2
Pages: 161-73
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Genotype
Genotype
Symbol: Psen2/Psen2
Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/?
Background: C57BL/6-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Prnp-PSEN2*N141I)30Jgr/? Tg(Thy1-APPSwe)71Jgr/?
Background: B6.Cg-Tg(Prnp-PSEN2*N141I)30Jgr Tg(Thy1-APPSwe)71Jgr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Eno2-PSEN2*)1480Ykk/?
Background: involves: C57BL/6 * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Publication
16219351 | J:106749
First Author: Hao X
Year: 2006
Journal: Leuk Res
Title: Histologic and molecular characterizations of megakaryocytic leukemia in mice.
Volume: 30
Issue: 4
Pages: 397-406
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Strain
MGI:3849018 | B6.129P2-Psen2<tm1Bdes>/Cnrm
Attribute String: congenic, targeted mutation
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Strain
MGI:3606220 | B6.129P-Psen2<tm1Bdes>/J
Attribute String: congenic, mutant strain, targeted mutation
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Publication
25484285 | J:219296
 
First Author: Hanson JE
Year: 2015
Journal: Neurobiol Dis
Title: Altered GluN2B NMDA receptor function and synaptic plasticity during early pathology in the PS2APP mouse model of Alzheimer's disease.
Volume: 74
Pages: 254-62
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Publication
22805202 | J:218149
First Author: Kipanyula MJ
Year: 2012
Journal: Aging Cell
Title: Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2.
Volume: 11
Issue: 5
Pages: 885-93
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Publication
19066434 | J:154969
First Author: Ozmen L
Year: 2009
Journal: Neurodegener Dis
Title: Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.
Volume: 6
Issue: 1-2
Pages: 29-36
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Genotype
Genotype
Symbol: Psen2/Psen2
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen2/Psen2
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * SJL/J
Zygosity: hm
Has Mutant Allele: true
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Publication
27293189 | J:234652
First Author: Sannerud R
Year: 2016
Journal: Cell
Title: Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.
Volume: 166
Issue: 1
Pages: 193-208
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Publication
21374699 | J:283974
First Author: Sutcliffe JG
Year: 2011
Journal: J Neurosci Res
Title: Peripheral reduction of β-amyloid is sufficient to reduce brain β-amyloid: implications for Alzheimer's disease.
Volume: 89
Issue: 6
Pages: 808-14
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Publication
14523101 | J:88193
First Author: Richards JG
Year: 2003
Journal: J Neurosci
Title: PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
Volume: 23
Issue: 26
Pages: 8989-9003
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Publication
20615468 | J:165986
First Author: Poirier R
Year: 2010
Journal: Neurobiol Dis
Title: Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis.
Volume: 40
Issue: 2
Pages: 386-93
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Publication
34522221 | J:324397
First Author: Biechele G
Year: 2021
Journal: Theranostics
Title: Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
Volume: 11
Issue: 18
Pages: 8964-8976
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Publication
35431893 | J:323890
 
First Author: Blume T
Year: 2022
Journal: Front Aging Neurosci
Title: Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.
Volume: 14
Pages: 854031
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Publication
- | J:303205
     
First Author: Magusali N
Year: 2021
Journal: bioRxiv
Title: Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes.
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2 Tg(Camk2a-cre)T29-1Stl/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2<+>
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1<+> Psen2/Psen2<+>
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1<+> Psen2/Psen2
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2
Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2 Tg(Camk2a-cre)T29-1Stl/?
Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
35269588 | J:327470
 
First Author: Martínez-Iglesias O
Year: 2022
Journal: Int J Mol Sci
Title: Epigenetic Studies in the Male APP/BIN1/COPS5 Triple-Transgenic Mouse Model of Alzheimer's Disease.
Volume: 23
Issue: 5
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Publication
24269917 | J:259960
 
First Author: Koldamova R
Year: 2014
Journal: Neurobiol Dis
Title: Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
Volume: 63
Pages: 107-14
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Strain
MGI:5614055 | B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Attribute String: transgenic, mutant strain, congenic
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Publication
33675684 | J:304468
First Author: Lee SH
Year: 2021
Journal: Neuron
Title: Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Volume: 109
Issue: 8
Pages: 1283-1301.e6
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Publication
19897719 | J:154750
First Author: Rhein V
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.
Volume: 106
Issue: 47
Pages: 20057-62
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Publication
34965428 | J:321071
First Author: Lee SH
Year: 2021
Journal: Cell Rep
Title: TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.
Volume: 37
Issue: 13
Pages: 110158
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Publication
19781645 | J:154968
First Author: Grueninger F
Year: 2010
Journal: Neurobiol Dis
Title: Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.
Volume: 37
Issue: 2
Pages: 294-306
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Publication
31980586 | J:285719
First Author: Meilandt WJ
Year: 2020
Journal: J Neurosci
Title: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
Volume: 40
Issue: 9
Pages: 1956-1974
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Genotype
Genotype
Symbol: Psen1/Psen1<+> Psen2/Psen2
Background: involves: 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz/? Tg(Thy1-MAPT)183Gotz/?
Background: B6.Cg-Tg(Thy1-APPSwe,Prnp-PSEN2*N141I)152HLaoz Tg(Thy1-MAPT)183Gotz
Zygosity: cx
Has Mutant Allele: true
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Publication
24278307 | J:209782
First Author: Guo Q
Year: 2013
Journal: PLoS One
Title: Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tau.
Volume: 8
Issue: 11
Pages: e80706
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Publication
28636676 | J:247444
First Author: Newman M
Year: 2017
Journal: PLoS One
Title: Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's disease.
Volume: 12
Issue: 6
Pages: e0179859
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Publication
38164158 | J:344429
First Author: Um JH
Year: 2024
Journal: Theranostics
Title: Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models.
Volume: 14
Issue: 1
Pages: 56-74
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Publication
34644146 | J:324411
First Author: Xiang X
Year: 2021
Journal: Sci Transl Med
Title: Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases.
Volume: 13
Issue: 615
Pages: eabe5640
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Genotype
Genotype
Symbol: Psen1/Psen1 Psen2/Psen2 Tg(Prrx1-cre)1Cjt/?
Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Publication
26494278 | J:255120
First Author: Bien-Ly N
Year: 2015
Journal: Neuron
Title: Lack of Widespread BBB Disruption in Alzheimer's Disease Models: Focus on Therapeutic Antibodies.
Volume: 88
Issue: 2
Pages: 289-97
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Publication
24806669 | J:211050
First Author: Kallop DY
Year: 2014
Journal: J Neurosci
Title: A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.
Volume: 34
Issue: 19
Pages: 6425-37
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Publication
25706990 | J:226301
First Author: Brendel M
Year: 2015
Journal: PLoS One
Title: Cross-sectional comparison of small animal [18F]-florbetaben amyloid-PET between transgenic AD mouse models.
Volume: 10
Issue: 2
Pages: e0116678
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Publication
29346778 | J:324542
First Author: Friedman BA
Year: 2018
Journal: Cell Rep
Title: Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer's Disease Not Evident in Mouse Models.
Volume: 22
Issue: 3
Pages: 832-847
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Publication
33891876 | J:306299
First Author: Bourdenx M
Year: 2021
Journal: Cell
Title: Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
Volume: 184
Issue: 10
Pages: 2696-2714.e25
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Publication
28814543 | J:250614
 
First Author: Le Pichon CE
Year: 2017
Journal: Sci Transl Med
Title: Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.
Volume: 9
Issue: 403
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Publication
37118504 | J:337860
First Author: Dejanovic B
Year: 2022
Journal: Nat Aging
Title: Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer's disease mouse models.
Volume: 2
Issue: 9
Pages: 837-850
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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