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Search results 301 to 371 out of 371 for Ptbp1

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Type Details Score
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
38915624 | J:355818
     
First Author: Wang Y
Year: 2024
Journal: bioRxiv
Title: PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators.
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HT Experiment
GSE267924 | PTBP1 mediates Sertoli cell actin cytoskeleton organization through regulating alternative splicing of actin regulators
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
27770549 | J:269154
First Author: Zhang L
Year: 2017
Journal: Hepatology
Title: Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay.
Volume: 65
Issue: 2
Pages: 604-615
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Publication
35944999 | J:355382
First Author: Guo T
Year: 2022
Journal: J Neurosci
Title: Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models.
Volume: 42
Issue: 38
Pages: 7309-7317
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Publication
31387917 | J:282738
First Author: Sun YM
Year: 2019
Journal: Blood
Title: circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression.
Volume: 134
Issue: 18
Pages: 1533-1546
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HT Experiment
GSE84803 | Transcriptome of the mouse neocortices
 
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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HT Experiment
GSE252835 | Activation of quiescent neurogenic niches of aging brain
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Publication
25940628 | J:306204
First Author: Tan LY
Year: 2015
Journal: Nucleic Acids Res
Title: Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.
Volume: 43
Issue: 11
Pages: 5586-600
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Publication
15341728 | -
First Author: Simpson PJ
Year: 2004
Journal: Structure
Title: Structure and RNA interactions of the N-terminal RRM domains of PTB.
Volume: 12
Issue: 9
Pages: 1631-43
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Publication
16179478 | -
First Author: Oberstrass FC
Year: 2005
Journal: Science
Title: Structure of PTB bound to RNA: specific binding and implications for splicing regulation.
Volume: 309
Issue: 5743
Pages: 2054-7
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Publication
22817740 | -
First Author: Kafasla P
Year: 2012
Journal: Biochem Soc Trans
Title: Defining the roles and interactions of PTB.
Volume: 40
Issue: 4
Pages: 815-20
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Protein Domain
IPR035000 | PTBP1_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of polypyrimidine tract-binding protein 1 (PTBP1). PTBP1 (also known as PTB) is involved in numerous post-transcriptional steps in gene expression in both the nucleus and cytoplasm. It can act as a negative regulator of alternative splicing and as an activator of translation driven by IRESs (internal ribosome entry segments) []. It contains four RNA recognition motifs (RRM). RRM1 and RRM2 are independent from each other and separated by flexible linkers. By contrast, there is an unusual and conserved interdomain interaction between RRM3 and RRM4. It is widely held that only RRMs 3 and 4 are involved in RNA binding and RRM2 mediates PTB homodimer formation. However, new evidence shows that the RRMs 1 and 2 also contribute substantially to RNA binding. Moreover, PTB may not always dimerize to repress splicing. It is a monomer in solution [, ].
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Publication
34582787 | J:313611
First Author: Wang LL
Year: 2021
Journal: Cell
Title: Revisiting astrocyte to neuron conversion with lineage tracing in vivo.
Volume: 184
Issue: 21
Pages: 5465-5481.e16
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Publication
32272060 | J:291146
First Author: Zhou H
Year: 2020
Journal: Cell
Title: Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice.
Volume: 181
Issue: 3
Pages: 590-603.e16
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Publication
33357424 | J:306495
First Author: Desideri F
Year: 2020
Journal: Cell Rep
Title: Intronic Determinants Coordinate Charme lncRNA Nuclear Activity through the Interaction with MATR3 and PTBP1.
Volume: 33
Issue: 12
Pages: 108548
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Publication
30174313 | J:317782
First Author: Sun Z
Year: 2018
Journal: Stem Cell Reports
Title: The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway.
Volume: 11
Issue: 3
Pages: 741-755
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Publication
27882870 | J:239172
   
First Author: Wongpalee SP
Year: 2016
Journal: Elife
Title: Large-scale remodeling of a repressed exon ribonucleoprotein to an exon definition complex active for splicing.
Volume: 5
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Publication
37845485 | J:344824
First Author: Feng Z
Year: 2024
Journal: Nat Cancer
Title: An in vitro-transcribed circular RNA targets the mitochondrial inner membrane cardiolipin to ablate EIF4G2(+)/PTBP1(+) pan-adenocarcinoma.
Volume: 5
Issue: 1
Pages: 30-46
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Publication
38879605 | J:349888
First Author: Zhang J
Year: 2024
Journal: Nat Commun
Title: m(5)C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis.
Volume: 15
Issue: 1
Pages: 5136
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Protein Domain
IPR021790 | PTBP1-like_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of polypyrimidine tract-binding protein 1 (PTBP1) and related proteins. Proteins containing this domain include PTBP1/2/3 (or PTB1/2/3) and heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) proteins. PTB can shuttle between nucleus and cytoplasm. It is a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. It is also involved in internal ribosome entry site (IRES)-mediated translation initiation. It may also be involved in the 3'-end processing, localization, and stability of several mRNAs. Two PTB homologues, PTBP2 and PTBP3, are generally expressed in mammalian tissues. PTBP2 is expressed at high levels in adult brain, muscle and testis, while PTBP3 is expressed preferentially in haematopoietic cells []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, MicroRNA miR-124 downregulates PTBP1 expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development []. PTBP3 may be involved in nonsense-mediated mRNA decay [].
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Protein Domain
IPR034798 | PTBP1/2/3_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of polypyrimidine tract-binding protein 1 (PTB or hnRNP I), polypyrimidine tract-binding protein 2 (PTBP2 or nPTB), polypyrimidine tract-binding protein 3 (PTBP3 or Rod1), and similar proteins found in Metazoa.PTB can shuttle between nucleus and cytoplasm. It is a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. It is also involved in internal ribosome entry site (IRES)-mediated translation initiation. It may also be involved in the 3'-end processing, localization, and stability of several mRNAs. Two PTB homologues, PTBP2 and PTBP3, are generally expressed in mammalian tissues. PTBP2 is expressed at high levels in adult brain, muscle and testis, while PTBP3 is expressed preferentially in haematopoietic cells []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, MicroRNA miR-124 downregulates PTBP1 expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development []. PTBP3 may be involved in nonsense-mediated mRNA decay [].
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Publication
21062284 | J:167625
First Author: Smith P
Year: 2011
Journal: J Neurochem
Title: In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.
Volume: 116
Issue: 2
Pages: 240-7
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Publication
25403273 | J:230299
First Author: Ohsawa N
Year: 2015
Journal: Genes Cells
Title: ABLIM1 splicing is abnormal in skeletal muscle of patients with DM1 and regulated by MBNL, CELF and PTBP1.
Volume: 20
Issue: 2
Pages: 121-34
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Publication
37531413 | J:343618
First Author: Dery KJ
Year: 2023
Journal: Sci Transl Med
Title: Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.
Volume: 15
Issue: 707
Pages: eadf2059
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Publication
39297407 | J:361035
First Author: Xie X
Year: 2024
Journal: Adv Sci (Weinh)
Title: PARN Maintains RNA Stability to Regulate Insulin Maturation and GSIS in Pancreatic β Cells.
Volume: 11
Issue: 42
Pages: e2407774
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HT Experiment
E-GEOD-51738 | Microarray analysis of alternative splicing in PTBP2 knockout mouse brain
Series Id: GSE51738
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-51733 | RNAseq analysis of alternative splicing in PTBP2 knockout mouse brain
Series Id: GSE51733
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22575643 | -
First Author: Brazão TF
Year: 2012
Journal: FEBS Lett
Title: A new function of ROD1 in nonsense-mediated mRNA decay.
Volume: 586
Issue: 8
Pages: 1101-10
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Protein
P17225
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q922I7
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3UBR5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q3T984
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q5RJV5
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q8C2R5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q8K144
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3TQW3
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
Q6NZB8
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3U5I2
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
E9QMW9
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Protein
Q80T07
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
Q8BGJ5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q8CB58
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q8R509
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
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Protein
G3UZ01
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
A0A0G2JGW0
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
G3UY95
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Publication
24264039 | -
First Author: Romanelli MG
Year: 2013
Journal: Int J Mol Sci
Title: New insights into functional roles of the polypyrimidine tract-binding protein.
Volume: 14
Issue: 11
Pages: 22906-32
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Publication
24688880 | -
 
First Author: Joshi A
Year: 2014
Journal: PeerJ
Title: Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB).
Volume: 2
Pages: e305
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Protein
Q3TBR4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
Q8BHD7
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
Q91Z31
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Protein
G3UXA6
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Protein
G8JL74
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Protein
Q921F4
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q8R081
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Protein
Q3UMT7
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: false
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Protein
Q8BI42
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
Q3V328
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Protein
G5E924
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: true
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Protein
Q9CSH0
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: true
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Protein
G3UY56
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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Protein
G3UY38
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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Protein
V9GXB6
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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Cambridge CB2 3EH, United Kingdom