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Search results 301 to 383 out of 383 for Ptbp2

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Type Details Score
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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HT Experiment
E-GEOD-47566 | Wild type vs. Ptbp2 KO mouse embryonic cortex RNA
Series Id: GSE47566
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-47565 | Wild type vs. Ptbp2 KO mouse E18.5 cortex RNA
Series Id: GSE47565
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-51738 | Microarray analysis of alternative splicing in PTBP2 knockout mouse brain
Series Id: GSE51738
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-51733 | RNAseq analysis of alternative splicing in PTBP2 knockout mouse brain
Series Id: GSE51733
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
GSE79105 | Ptbp2 controls an alternative splicing network required for cell communication during spermatogenesis [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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HT Experiment
GSE84803 | Transcriptome of the mouse neocortices
 
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: GEO
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Publication
25940628 | J:306204
First Author: Tan LY
Year: 2015
Journal: Nucleic Acids Res
Title: Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.
Volume: 43
Issue: 11
Pages: 5586-600
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Publication
12213192 | -
First Author: Rahman L
Year: 2002
Journal: Genomics
Title: Alternative splicing of brain-specific PTB defines a tissue-specific isoform pattern that predicts distinct functional roles.
Volume: 80
Issue: 3
Pages: 245-9
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Publication
17679092 | -
First Author: Spellman R
Year: 2007
Journal: Mol Cell
Title: Crossregulation and functional redundancy between the splicing regulator PTB and its paralogs nPTB and ROD1.
Volume: 27
Issue: 3
Pages: 420-34
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Publication
18081004 | -
First Author: Fairbrother WG
Year: 2008
Journal: Bioessays
Title: Repressing the neuron within.
Volume: 30
Issue: 1
Pages: 1-4
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Protein Domain
IPR035002 | PTBP2_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of PTBP2, also known as nPTB, highly homologous to polypyrimidine tract binding protein (PTB) and perhaps specific to the vertebrates []. Both PTB and PTBP2 are alternative splicing regulators []. Unlike PTB, PTBP2 is enriched in the brain and in some neural cell lines []. Interestingly, PTB directly suppresses expression of nPTB in nonneuronal cells by a mechanism that involves exon repression and mRNA silencing via nonsense-mediated decay (NMD) []. PTBP2 contains four RNA recognition motifs (RRMs).
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Protein Domain
IPR034799 | PTBP2_RRM3
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of polypyrimidine tract-binding protein 2 (PTBP2).PTBP2 is a homologue of PTB (PTBP1), a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. PTBP2 is expressed at high levels in adult brain, muscle and testis []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, microRNA miR-124 downregulates PTB expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development [].
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Protein Domain
IPR034800 | PTBP2_RRM4
Type: Domain
Description: This entry represents the RNA recognition motif 4 (RRM4) of polypyrimidine tract-binding protein 2 (PTBP2).PTBP2 is a homologue of PTB (PTBP1), a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. PTBP2 is expressed at high levels in adult brain, muscle and testis []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, microRNA miR-124 downregulates PTB expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development [].
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Protein Domain
IPR021790 | PTBP1-like_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of polypyrimidine tract-binding protein 1 (PTBP1) and related proteins. Proteins containing this domain include PTBP1/2/3 (or PTB1/2/3) and heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) proteins. PTB can shuttle between nucleus and cytoplasm. It is a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. It is also involved in internal ribosome entry site (IRES)-mediated translation initiation. It may also be involved in the 3'-end processing, localization, and stability of several mRNAs. Two PTB homologues, PTBP2 and PTBP3, are generally expressed in mammalian tissues. PTBP2 is expressed at high levels in adult brain, muscle and testis, while PTBP3 is expressed preferentially in haematopoietic cells []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, MicroRNA miR-124 downregulates PTBP1 expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development []. PTBP3 may be involved in nonsense-mediated mRNA decay [].
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Protein Domain
IPR034798 | PTBP1/2/3_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of polypyrimidine tract-binding protein 1 (PTB or hnRNP I), polypyrimidine tract-binding protein 2 (PTBP2 or nPTB), polypyrimidine tract-binding protein 3 (PTBP3 or Rod1), and similar proteins found in Metazoa.PTB can shuttle between nucleus and cytoplasm. It is a splicing repressor factor implicated in the control of alternative exon selection during mRNA processing of many different transcribed genes, including its own pre-mRNA. It is also involved in internal ribosome entry site (IRES)-mediated translation initiation. It may also be involved in the 3'-end processing, localization, and stability of several mRNAs. Two PTB homologues, PTBP2 and PTBP3, are generally expressed in mammalian tissues. PTBP2 is expressed at high levels in adult brain, muscle and testis, while PTBP3 is expressed preferentially in haematopoietic cells []. PTB and PTBP2 bind to the same RNA sequences and have similar effects on alternative splicing events. However, differential expression of PTB and PTBP2 can lead to the generation of alternatively spliced mRNAs []. During neuronal differentiation, MicroRNA miR-124 downregulates PTBP1 expression, which in turn leads to upregulation of PTBP2. Later in development, the expression of PTBP2 decreases and this leads to a second wave of alternative splicing changes characteristic of adult brain and essential for brain development []. PTBP3 may be involved in nonsense-mediated mRNA decay [].
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Publication
24264039 | -
First Author: Romanelli MG
Year: 2013
Journal: Int J Mol Sci
Title: New insights into functional roles of the polypyrimidine tract-binding protein.
Volume: 14
Issue: 11
Pages: 22906-32
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Publication
24688880 | -
 
First Author: Joshi A
Year: 2014
Journal: PeerJ
Title: Solution and crystal structures of a C-terminal fragment of the neuronal isoform of the polypyrimidine tract binding protein (nPTB).
Volume: 2
Pages: e305
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Protein
Q91Z31
Organism: Mus musculus/domesticus
Length: 531  
Fragment?: false
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Publication
22575643 | -
First Author: Brazão TF
Year: 2012
Journal: FEBS Lett
Title: A new function of ROD1 in nonsense-mediated mRNA decay.
Volume: 586
Issue: 8
Pages: 1101-10
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Protein
A0A0G2JGW0
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
Q8CB58
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q8R509
Organism: Mus musculus/domesticus
Length: 528  
Fragment?: false
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Protein
G3UZ01
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
G3UY95
Organism: Mus musculus/domesticus
Length: 146  
Fragment?: true
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Protein
Q3V328
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
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Protein
Q3TBR4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
P17225
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q8BHD7
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
Q922I7
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
G3UXA6
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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G8JL74
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: false
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Q3UBR5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q3T984
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q5RJV5
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q8C2R5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
Q8K144
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3TQW3
Organism: Mus musculus/domesticus
Length: 520  
Fragment?: false
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Protein
Q6NZB8
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
Q3U5I2
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: false
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Protein
E9QMW9
Organism: Mus musculus/domesticus
Length: 353  
Fragment?: false
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Q80T07
Organism: Mus musculus/domesticus
Length: 554  
Fragment?: false
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Q8BGJ5
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Q921F4
Organism: Mus musculus/domesticus
Length: 591  
Fragment?: false
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Protein
Q8R081
Organism: Mus musculus/domesticus
Length: 586  
Fragment?: false
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Protein
Q3UMT7
Organism: Mus musculus/domesticus
Length: 592  
Fragment?: false
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Protein
Q8BI42
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
G5E924
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: true
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Protein
Q9CSH0
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: true
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G3UY56
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: true
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G3UY38
Organism: Mus musculus/domesticus
Length: 456  
Fragment?: false
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V9GXB6
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: false
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Publication
25187368 | J:247247
First Author: Yip L
Year: 2015
Journal: Diabetes
Title: Inflammation and hyperglycemia mediate Deaf1 splicing in the pancreatic lymph nodes via distinct pathways during type 1 diabetes.
Volume: 64
Issue: 2
Pages: 604-17
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Publication
21807765 | J:175754
First Author: Smith PY
Year: 2011
Journal: Hum Mol Genet
Title: MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy.
Volume: 20
Issue: 20
Pages: 4016-24
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Publication
21062284 | J:167625
First Author: Smith P
Year: 2011
Journal: J Neurochem
Title: In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs.
Volume: 116
Issue: 2
Pages: 240-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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