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Search results 301 to 400 out of 1091 for Pth

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Type Details Score
Publication
38316336 | J:360442
 
First Author: Kawao N
Year: 2024
Journal: Bone
Title: Tmem119 is involved in bone anabolic effects of PTH through enhanced osteoblastic bone formation in mice.
Volume: 181
Pages: 117040
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Publication
27704638 | J:284501
First Author: Delgado-Calle J
Year: 2017
Journal: J Bone Miner Res
Title: Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor.
Volume: 32
Issue: 3
Pages: 522-535
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Publication
18086008 | J:150177
First Author: Yamashita J
Year: 2008
Journal: J Bone Miner Res
Title: Role of Bcl2 in osteoclastogenesis and PTH anabolic actions in bone.
Volume: 23
Issue: 5
Pages: 621-32
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Publication
20808842 | J:208749
First Author: Tawfeek H
Year: 2010
Journal: PLoS One
Title: Disruption of PTH receptor 1 in T cells protects against PTH-induced bone loss.
Volume: 5
Issue: 8
Pages: e12290
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Publication
15765183 | J:111276
First Author: Bouxsein ML
Year: 2005
Journal: J Bone Miner Res
Title: beta-Arrestin2 regulates the differential response of cortical and trabecular bone to intermittent PTH in female mice.
Volume: 20
Issue: 4
Pages: 635-43
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Publication
38331475 | J:345249
 
First Author: Aydin A
Year: 2024
Journal: Life Sci Alliance
Title: ADAM19 cleaves the PTH receptor and associates with brachydactyly type E.
Volume: 7
Issue: 4
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Publication
16138191 | J:100918
First Author: Miao D
Year: 2005
Journal: J Clin Invest
Title: Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34.
Volume: 115
Issue: 9
Pages: 2402-11
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Publication
30716510 | J:276686
 
First Author: Yoon SH
Year: 2019
Journal: Bone
Title: Intermittent PTH treatment improves bone and muscle in glucocorticoid treated Mdx mice: A model of Duchenne Muscular Dystrophy.
Volume: 121
Pages: 232-242
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Publication
29127344 | J:257268
First Author: Siddiqui JA
Year: 2017
Journal: Sci Rep
Title: Catabolic Effects of Human PTH (1-34) on Bone: Requirement of Monocyte Chemoattractant Protein-1 in Murine Model of Hyperparathyroidism.
Volume: 7
Issue: 1
Pages: 15300
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Publication
29401593 | J:273809
First Author: Delgado-Calle J
Year: 2018
Journal: FASEB J
Title: MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production.
Volume: 32
Issue: 5
Pages: 2878-2890
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Publication
22319626 | J:224060
First Author: Anour R
Year: 2012
Journal: PLoS One
Title: Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo.
Volume: 7
Issue: 2
Pages: e31376
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Publication
26409319 | J:227215
 
First Author: Pacheco-Costa R
Year: 2015
Journal: Bone
Title: Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain.
Volume: 81
Pages: 632-43
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Publication
22586700 | J:323156
First Author: Wade-Gueye NM
Year: 2012
Journal: Bone
Title: Absence of bone sialoprotein (BSP) impairs primary bone formation and resorption: the marrow ablation model under PTH challenge.
Volume: 50
Issue: 5
Pages: 1064-73
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Publication
16675960 | J:111733
First Author: Diamond AG
Year: 2006
Journal: J Invest Dermatol
Title: Parathyroid hormone hormone-related protein and the PTH receptor regulate angiogenesis of the skin.
Volume: 126
Issue: 9
Pages: 2127-34
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Publication
26191777 | J:257114
First Author: Panaroni C
Year: 2015
Journal: J Bone Miner Res
Title: PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization.
Volume: 30
Issue: 12
Pages: 2273-86
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Publication
11779203 | J:74925
First Author: Zhang X
Year: 2002
Journal: Biochem Biophys Res Commun
Title: FGF-2 increases colony formation, PTH receptor, and IGF-1 mRNA in mouse marrow stromal cells.
Volume: 290
Issue: 1
Pages: 526-31
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Publication
22634226 | J:187313
First Author: Xie Y
Year: 2012
Journal: Hum Mol Genet
Title: Intermittent PTH (1-34) injection rescues the retarded skeletal development and postnatal lethality of mice mimicking human achondroplasia and thanatophoric dysplasia.
Volume: 21
Issue: 18
Pages: 3941-55
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Publication
16987995 | J:119876
First Author: Capuano P
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice.
Volume: 292
Issue: 2
Pages: C927-34
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Publication
15942053 | J:101246
First Author: Cunningham R
Year: 2005
Journal: Am J Physiol Renal Physiol
Title: Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media.
Volume: 289
Issue: 4
Pages: F933-8
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Publication
21806973 | J:175755
First Author: Fei Y
Year: 2011
Journal: Biochem Biophys Res Commun
Title: The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Volume: 412
Issue: 1
Pages: 160-4
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Publication
31693237 | J:323303
First Author: Noda H
Year: 2020
Journal: J Bone Miner Res
Title: An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen's Metaphyseal Chondrodysplasia.
Volume: 35
Issue: 3
Pages: 540-549
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Publication
32325250 | J:293075
 
First Author: Kosugi K
Year: 2020
Journal: Bone
Title: Disruption of the aldehyde dehydrogenase 2 gene increases the bone anabolic response to intermittent PTH treatment in an ovariectomized mouse model.
Volume: 136
Pages: 115370
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MP Term
MP:0002904 | increased circulating parathyroid hormone level
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MP Term
MP:0002903 | abnormal circulating parathyroid hormone level
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Publication
29104492 | J:287963
First Author: Chen H
Year: 2017
Journal: Int J Biol Sci
Title: PTH 1-34 Ameliorates the Osteopenia and Delayed Healing of Stabilized Tibia Fracture in Mice with Achondroplasia Resulting from Gain-Of-Function Mutation of FGFR3.
Volume: 13
Issue: 10
Pages: 1254-1265
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Publication
29482068 | J:262530
 
First Author: Tajima T
Year: 2018
Journal: Bone
Title: Cortical bone loss due to skeletal unloading in aldehyde dehydrogenase 2 gene knockout mice is associated with decreased PTH receptor expression in osteocytes.
Volume: 110
Pages: 254-266
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Publication
23515284 | J:197919
First Author: Guo J
Year: 2013
Journal: Endocrinology
Title: Activation of a non-cAMP/PKA signaling pathway downstream of the PTH/PTHrP receptor is essential for a sustained hypophosphatemic response to PTH infusion in male mice.
Volume: 154
Issue: 5
Pages: 1680-9
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Publication
25631045 | J:220559
First Author: Fei Y
Year: 2015
Journal: J Biol Chem
Title: Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts.
Volume: 290
Issue: 13
Pages: 8373-82
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Allele
Pth<em1Smoc> | MGI:7291887
Name: parathyroid hormone; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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MP Term
MP:0002905 | decreased circulating parathyroid hormone level
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GO Term
GO:2000830 | positive regulation of parathyroid hormone secretion
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GO Term
GO:2000828 | regulation of parathyroid hormone secretion
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GO Term
GO:2000829 | negative regulation of parathyroid hormone secretion
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DO Term
DOID:0080020 | Jansen's metaphyseal chondrodysplasia
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Publication
33607650 | J:303673
First Author: Zhu M
Year: 2021
Journal: PLoS One
Title: Selective deletion of the receptor for CSF1, c-fms, in osteoclasts results in a high bone mass phenotype, smaller osteoclasts in vivo and an impaired response to an anabolic PTH regimen.
Volume: 16
Issue: 2
Pages: e0247199
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DO Term
DOID:0111387 | familial isolated hypoparathyroidism
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Gene
8675 | STX16
Type: gene
Organism: human
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Gene
149775 | GNAS-AS1
Type: gene
Organism: human
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Gene
9247 | GCM2
Type: gene
Organism: human
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Strain
MGI:6429444 | C57BL/6JSmoc-Pth<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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HT Experiment
GSE222203 | MMP14 cleaves PTH1R in the chondrocyte derived osteoblast lineage, curbing signaling intensity for proper bone anabolism
 
Experiment Type: RNA-Seq
Study Type: Baseline
Source: GEO
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Allele
Tg(PTH-cre)4167Slib | MGI:2683304
Name: transgene insertion 4167, Steven K Libutti
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
22700192 | -
First Author: Jeyabalan J
Year: 2012
Journal: J Endocrinol
Title: Mice lacking AMP-activated protein kinase α1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment.
Volume: 214
Issue: 3
Pages: 349-58
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Publication
31619668 | J:281350
First Author: Centeno PP
Year: 2019
Journal: Nat Commun
Title: Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion.
Volume: 10
Issue: 1
Pages: 4693
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Publication
16988000 | J:116986
First Author: Wettschureck N
Year: 2007
Journal: Mol Endocrinol
Title: Parathyroid-specific double knockout of Gq and G11 alpha-subunits leads to a phenotype resembling germline knockout of the extracellular Ca2+ -sensing receptor.
Volume: 21
Issue: 1
Pages: 274-80
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Strain
MGI:3610735 | 129;FVB-Tg(PTH-cre)4167Slib/J
Attribute String: mutant stock, transgenic
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MP Term
MP:0013572 | abnormal parathyroid gland chief cell morphology
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DO Term
DOID:0080222 | pseudohypoparathyroidism type 1B
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Gene
5745 | PTH1R
Type: gene
Organism: human
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Publication
19692484 | J:154002
First Author: Meir T
Year: 2009
Journal: Am J Physiol Renal Physiol
Title: Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology.
Volume: 297
Issue: 5
Pages: F1192-8
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Publication
30916761 | J:275644
First Author: Nagata Y
Year: 2019
Journal: Endocrinology
Title: Attenuated Dentin Matrix Protein 1 Enhances Fibroblast Growth Factor 23 in Calvaria in a Primary Hyperparathyroidism Model.
Volume: 160
Issue: 5
Pages: 1348-1358
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Publication
15928311 | J:101378
First Author: Mallya SM
Year: 2005
Journal: Mol Endocrinol
Title: Abnormal parathyroid cell proliferation precedes biochemical abnormalities in a mouse model of primary hyperparathyroidism.
Volume: 19
Issue: 10
Pages: 2603-9
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Publication
17855636 | J:148146
First Author: Kawata T
Year: 2007
Journal: J Am Soc Nephrol
Title: Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism.
Volume: 18
Issue: 10
Pages: 2683-8
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Publication
26054367 | J:225525
First Author: Shilo V
Year: 2015
Journal: FASEB J
Title: Parathyroid-specific deletion of dicer-dependent microRNAs abrogates the response of the parathyroid to acute and chronic hypocalcemia and uremia.
Volume: 29
Issue: 9
Pages: 3964-76
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Allele
Tg(PTH-CCND1)PC2Anar | MGI:3844257
Name: transgene insertion PC2, Andrew Arnold
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(MSMg01-047A16)#Yuwa | MGI:6192650
Name: transgene insertion, Yuichi Wakabayashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(MSMg01-466J23)#Yuwa | MGI:6192651
Name: transgene insertion, Yuichi Wakabayashi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Men1/Men1 Tg(PTH-cre)4167Slib/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Casr/Casr<+> Tg(PTH-cre)4167Slib/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Casr/Casr Tg(PTH-cre)4167Slib/?
Background: involves: 129S4/SvJae * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
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Strain
MGI:5697080 | FVB/N-Tg(PTH-CCND1)PC2Anar/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:3844338 | FVB/N-Tg(PTH-CCND1)PC2Anar
Attribute String: coisogenic, transgenic
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Publication
11342573 | J:69423
First Author: Imanishi Y
Year: 2001
Journal: J Clin Invest
Title: Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice.
Volume: 107
Issue: 9
Pages: 1093-102
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Genotype
Genotype
Symbol: Tg(PTH-CCND1)PC2Anar/?
Background: FVB/N-Tg(PTH-CCND1)PC2Anar
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdc73/Cdc73<+> Tg(PTH-cre)4167Slib/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdc73/Cdc73 Tg(PTH-cre)4167Slib/?
Background: Not Specified
Zygosity: cn
Has Mutant Allele: true
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Publication
28094278 | J:256662
 
First Author: Kawakami K
Year: 2017
Journal: Sci Rep
Title: Persistent fibroblast growth factor 23 signalling in the parathyroid glands for secondary hyperparathyroidism in mice with chronic kidney disease.
Volume: 7
Pages: 40534
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Publication
29618612 | J:261413
First Author: Fan Y
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Interrelated role of Klotho and calcium-sensing receptor in parathyroid hormone synthesis and parathyroid hyperplasia.
Volume: 115
Issue: 16
Pages: E3749-E3758
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Publication
28288139 | J:243366
First Author: Walls GV
Year: 2017
Journal: Oncogene
Title: Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.
Volume: 36
Issue: 28
Pages: 4025-4036
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Genotype
Genotype
Symbol: Gna11/Gna11 Gnaq/Gnaq Tg(PTH-cre)4167Slib/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gna11/Gna11<+> Gnaq/Gnaq Tg(PTH-cre)4167Slib/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gna11/Gna11 Gnaq/Gnaq<+> Tg(PTH-cre)4167Slib/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Bgeo/ALPP)1Lbe/? Tg(PTH-cre)4167Slib/?
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Bmal1/Bmal1 Tg(PTH-cre)4167Slib/?
Background: involves: 129S4/SvJae * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR018171 | Pept_tRNA_hydro_CS
Type: Conserved_site
Description: Peptidyl-tRNA hydrolase () (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA which drop off the ribosome during protein synthesis [, ]. Bacterial PTH has been found to be evolutionary related to a yeast protein [].
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Publication
18813283 | J:162715
First Author: Pi M
Year: 2008
Journal: Kidney Int
Title: Parathyroid-specific interaction of the calcium-sensing receptor and G alpha q.
Volume: 74
Issue: 12
Pages: 1548-56
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(PTH-cre)4167Slib/?
Background: involves: 129S6/SvEvTac * C57BL/6NCr
Zygosity: cn
Has Mutant Allele: true
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Gene
2778 | GNAS
Type: gene
Organism: human
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Protein
P22858
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q540C1
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q811S6
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Protein
Q924X4
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: false
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Publication
2682846 | -
 
First Author: Martin TJ
Year: 1989
Journal: Recent Prog Horm Res
Title: Parathyroid hormone-related protein: isolation, molecular cloning, and mechanism of action.
Volume: 45
Pages: 467-502; discussion 502-6
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Publication
11760831 | J:112521
First Author: Suda N
Year: 2001
Journal: J Bone Miner Res
Title: Parathyroid hormone-related protein is required for normal intramembranous bone development.
Volume: 16
Issue: 12
Pages: 2182-91
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Publication
28148780 | -
First Author: Suarez-Bregua P
Year: 2017
Journal: FASEB J
Title: Pth4, an ancient parathyroid hormone lost in eutherian mammals, reveals a new brain-to-bone signaling pathway.
Volume: 31
Issue: 2
Pages: 569-583
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Protein Domain
IPR001415 | PTH/PTH-rel
Type: Family
Description: Parathyroid hormone (PTH) is a polypeptidic hormone that elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Parathyroid hormone-related protein (PTH-rP) is structurally related to PTH []and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and endochondral bone formation [].PTH and PTH-rP bind to the same G-protein coupled receptor.This entry represents parathyroid hormone and parathyroid hormone-related protein.
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Protein Domain
IPR003626 | PTH-rel
Type: Family
Description: Parathyroid hormone-related protein (PTH-rP) is structurally related to parathyroid hormone (PTH) []and seems to play a physiological role in lactation, possibly as a hormone for the mobilisation and/or transfer of calcium to the milk. It also regulates chondrocytic differentiation and bone formation [].This family also includes the zebrafish PTH family member Pth4, unique to noneutherian vertebrates, which is a regulator of bone mineral accrual acting through phosphate homeostasis []..
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Protein Domain
IPR001328 | Pept_tRNA_hydro
Type: Family
Description: Peptidyl-tRNA hydrolase () (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA which drop off the ribosome during protein synthesis [, ]. Bacterial PTH has been found to be evolutionary related to a yeast protein [].This group also contains chloroplast RNA splicing 2 (CRS2), which is closely related nuclear-encoded protein required for the splicing of nine group II introns in chloroplasts [, , ].
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Publication
1833189 | -
First Author: García-Villegas MR
Year: 1991
Journal: EMBO J
Title: Peptidyl-tRNA hydrolase is involved in lambda inhibition of host protein synthesis.
Volume: 10
Issue: 11
Pages: 3549-55
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Publication
8635758 | -
First Author: De La Vega FM
Year: 1996
Journal: Gene
Title: Microbial genes homologous to the peptidyl-tRNA hydrolase-encoding gene of Escherichia coli.
Volume: 169
Issue: 1
Pages: 97-100
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Publication
8563640 | -
First Author: Ouzounis C
Year: 1995
Journal: Protein Sci
Title: New protein functions in yeast chromosome VIII.
Volume: 4
Issue: 11
Pages: 2424-8
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Publication
19925797 | J:155553
First Author: Park H
Year: 2010
Journal: FEBS Lett
Title: PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts.
Volume: 584
Issue: 1
Pages: 173-80
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Protein Domain
IPR036416 | Pept_tRNA_hydro_sf
Type: Homologous_superfamily
Description: Peptidyl-tRNA hydrolase () (PTH) is a bacterial enzyme that cleaves peptidyl-tRNA or N-acyl-aminoacyl-tRNA to yield free peptides or N-acyl-amino acids and tRNA. The natural substrate for this enzyme may be peptidyl-tRNA which drop off the ribosome during protein synthesis [, ]. Bacterial PTH has been found to be evolutionary related to a yeast protein [].This group also contains chloroplast RNA splicing 2 (CRS2), which is closely related nuclear-encoded protein required for the splicing of nine group II introns in chloroplasts [, , ].The structure of hydrolases consists of three layers (alpha/beta/alpha) with mixed sheets of five strands where the strand 4 is antiparallel to the rest, and contains crossover loops.
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Publication
14633735 | J:86642
First Author: Libutti SK
Year: 2003
Journal: Cancer Res
Title: Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism.
Volume: 63
Issue: 22
Pages: 8022-8
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Publication
18765830 | J:180651
First Author: Chang W
Year: 2008
Journal: Sci Signal
Title: The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development.
Volume: 1
Issue: 35
Pages: ra1
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Protein
Q3V206
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: false
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Publication
9303320 | -
First Author: Schmitt E
Year: 1997
Journal: EMBO J
Title: Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.
Volume: 16
Issue: 15
Pages: 4760-9
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Publication
15078105 | -
First Author: Goodall JJ
Year: 2004
Journal: Biochemistry
Title: Essential role of histidine 20 in the catalytic mechanism of Escherichia coli peptidyl-tRNA hydrolase.
Volume: 43
Issue: 15
Pages: 4583-91
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Publication
26456334 | J:299572
First Author: Li JY
Year: 2015
Journal: Cell Metab
Title: IL-17A Is Increased in Humans with Primary Hyperparathyroidism and Mediates PTH-Induced Bone Loss in Mice.
Volume: 22
Issue: 5
Pages: 799-810
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Publication
21040899 | J:167538
First Author: Wu X
Year: 2010
Journal: Cell Stem Cell
Title: Inhibition of Sca-1-positive skeletal stem cell recruitment by alendronate blunts the anabolic effects of parathyroid hormone on bone remodeling.
Volume: 7
Issue: 5
Pages: 571-80
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