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Search results 301 to 400 out of 689 for Ptpn11

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:7788445
Assay Type: Immunohistochemistry
Annotation Date: 2024-12-18
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3574228
Stage: TS28
Assay Id: MGI:7788476
Age: postnatal day 21
Note: Absent in all layers.
Specimen Label: 6J
Detected: false
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7788445
Assay Type: Immunohistochemistry
Annotation Date: 2024-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Widespread
Stage: TS28
Assay Id: MGI:7788476
Age: postnatal day 21
Specimen Label: 3B WT
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:7788445
Assay Type: Immunohistochemistry
Annotation Date: 2024-12-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3573928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7788476
Age: postnatal day 21
Specimen Label: 6H
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4886680
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1754028
Stage: TS28
Assay Id: MGI:4945014
Age: postnatal day 7
Image: g00459 P7
Specimen Label: g00459 P7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4886680
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280923
Stage: TS23
Assay Id: MGI:4945014
Age: embryonic day 15.5
Image: g00459 E15.5
Specimen Label: g00459 E15.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4886680
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3280928
Stage: TS28
Assay Id: MGI:4945014
Age: postnatal day 7
Image: g00459 P7
Specimen Label: g00459 P7
Detected: false
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:4886680
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3266523
Stage: TS23
Assay Id: MGI:4945014
Age: embryonic day 15.5
Image: g00459 E15.5
Specimen Label: g00459 E15.5
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:4886680
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757723
Stage: TS23
Assay Id: MGI:4945014
Age: embryonic day 15.5
Image: g00459 E15.5
Specimen Label: g00459 E15.5
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:4886680
Assay Type: RNA in situ
Annotation Date: 2011-04-11
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1757728
Stage: TS28
Assay Id: MGI:4945014
Age: postnatal day 7
Image: g00459 P7
Specimen Label: g00459 P7
Detected: false
Specimen Num: 3
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Publication
22641383 | J:189115
First Author: Yokosuka T
Year: 2012
Journal: J Exp Med
Title: Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2.
Volume: 209
Issue: 6
Pages: 1201-17
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Publication
14967142 | J:88290
First Author: Zhang SQ
Year: 2004
Journal: Mol Cell
Title: Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment.
Volume: 13
Issue: 3
Pages: 341-55
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Publication
8810330 | J:36295
First Author: Ohnishi H
Year: 1996
Journal: J Biol Chem
Title: Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.
Volume: 271
Issue: 41
Pages: 25569-74
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Publication
27935860 | J:309015
First Author: Liu W
Year: 2017
Journal: Oncotarget
Title: T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice.
Volume: 8
Issue: 5
Pages: 7586-7597
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Publication
28751523 | J:249376
First Author: Dong L
Year: 2017
Journal: Blood
Title: CCL3 is a key mediator for the leukemogenic effect of Ptpn11-activating mutations in the stem-cell microenvironment.
Volume: 130
Issue: 12
Pages: 1471-1474
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Publication
32697817 | J:340210
First Author: Cai Z
Year: 2020
Journal: Blood Adv
Title: Role of lncRNA Morrbid in PTPN11(Shp2)E76K-driven juvenile myelomonocytic leukemia.
Volume: 4
Issue: 14
Pages: 3246-3251
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Publication
25127857 | J:234895
First Author: Tao B
Year: 2014
Journal: J Immunol
Title: Myeloid-specific disruption of tyrosine phosphatase Shp2 promotes alternative activation of macrophages and predisposes mice to pulmonary fibrosis.
Volume: 193
Issue: 6
Pages: 2801-11
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Publication
31782850 | J:292681
First Author: Ouyang W
Year: 2020
Journal: Cell Prolif
Title: SHP2 deficiency promotes Staphylococcus aureus pneumonia following influenza infection.
Volume: 53
Issue: 1
Pages: e12721
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Publication
23236157 | J:192542
First Author: He Z
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase.
Volume: 110
Issue: 1
Pages: E79-88
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Publication
16738330 | J:109602
First Author: Bard-Chapeau EA
Year: 2006
Journal: Mol Cell Biol
Title: Concerted functions of Gab1 and Shp2 in liver regeneration and hepatoprotection.
Volume: 26
Issue: 12
Pages: 4664-74
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Publication
22660330 | J:186638
First Author: Zheng J
Year: 2012
Journal: Nature
Title: Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.
Volume: 485
Issue: 7400
Pages: 656-60
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Publication
29617671 | J:271069
First Author: Rota G
Year: 2018
Journal: Cell Rep
Title: Shp-2 Is Dispensable for Establishing T Cell Exhaustion and for PD-1 Signaling In Vivo.
Volume: 23
Issue: 1
Pages: 39-49
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Publication
35983034 | J:348543
 
First Author: Cammann C
Year: 2022
Journal: Front Immunol
Title: T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation.
Volume: 13
Pages: 958616
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Publication
27422603 | J:238666
First Author: Holm CK
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Lack of SIRPα phosphorylation and concomitantly reduced SHP-2-PI3K-Akt2 signaling decrease osteoblast differentiation.
Volume: 478
Issue: 1
Pages: 268-273
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Publication
28481957 | J:246366
First Author: Qiu Z
Year: 2017
Journal: PLoS One
Title: Deletion of Shp2 in bronchial epithelial cells impairs IL-25 production in vitro, but has minor influence on asthmatic inflammation in vivo.
Volume: 12
Issue: 5
Pages: e0177334
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Publication
29217681 | J:257043
First Author: Ahrendsen JT
Year: 2018
Journal: J Neurosci
Title: The Protein Tyrosine Phosphatase Shp2 Regulates Oligodendrocyte Differentiation and Early Myelination and Contributes to Timely Remyelination.
Volume: 38
Issue: 4
Pages: 787-802
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Publication
24550486 | J:207407
First Author: Heuberger J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Shp2/MAPK signaling controls goblet/paneth cell fate decisions in the intestine.
Volume: 111
Issue: 9
Pages: 3472-7
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Publication
36828281 | J:338388
First Author: Du L
Year: 2023
Journal: Cell Mol Gastroenterol Hepatol
Title: Shp2 Deficiency in Kupffer Cells and Hepatocytes Aggravates Hepatocarcinogenesis by Recruiting Non-Kupffer Macrophages.
Volume: 15
Issue: 6
Pages: 1351-1369
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Publication
21068439 | J:169264
First Author: Bauler TJ
Year: 2011
Journal: Dis Model Mech
Title: Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations.
Volume: 4
Issue: 2
Pages: 228-39
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Publication
34237430 | J:310462
 
First Author: Jingu D
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Protein tyrosine phosphatase Shp2 positively regulates cold stress-induced tyrosine phosphorylation of SIRPα in neurons.
Volume: 569
Pages: 72-78
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Publication
12482708 | J:80747
First Author: Chen B
Year: 2002
Journal: Dev Biol
Title: SHP-2 mediates target-regulated axonal termination and NGF-dependent neurite growth in sympathetic neurons.
Volume: 252
Issue: 2
Pages: 170-87
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Publication
17440960 | J:126196
First Author: Roubelakis MG
Year: 2007
Journal: J Cell Biochem
Title: The murine ortholog of the SHP-2 binding molecule, PZR accelerates cell migration on fibronectin and is expressed in early embryo formation.
Volume: 102
Issue: 4
Pages: 955-69
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Publication
9670943 | J:200346
First Author: Nakamura K
Year: 1998
Journal: J Immunol
Title: B cell antigen receptor (BCR)-mediated formation of a SHP-2-pp120 complex and its inhibition by Fc gamma RIIB1-BCR coligation.
Volume: 161
Issue: 2
Pages: 684-91
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Publication
19275884 | J:147368
First Author: Yo K
Year: 2009
Journal: Biochem Biophys Res Commun
Title: SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration.
Volume: 382
Issue: 1
Pages: 210-4
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Publication
23129808 | J:192830
First Author: Mercan F
Year: 2013
Journal: Mol Cell Biol
Title: Novel role for SHP-2 in nutrient-responsive control of S6 kinase 1 signaling.
Volume: 33
Issue: 2
Pages: 293-306
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Publication
24216759 | J:207765
First Author: Okur MN
Year: 2014
Journal: Mol Cell Biol
Title: Receptor tyrosine kinase ubiquitylation involves the dynamic regulation of Cbl-Spry2 by intersectin 1 and the Shp2 tyrosine phosphatase.
Volume: 34
Issue: 2
Pages: 271-9
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Publication
9110989 | J:39778
First Author: Liu L
Year: 1997
Journal: J Biol Chem
Title: Interleukin-3 induces the association of the inositol 5-phosphatase SHIP with SHP2.
Volume: 272
Issue: 17
Pages: 10998-1001
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Publication
16885344 | J:112094
First Author: Charest A
Year: 2006
Journal: Cancer Res
Title: ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
Volume: 66
Issue: 15
Pages: 7473-81
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Publication
19948503 | J:231275
First Author: Müller MM
Year: 2009
Journal: J Cell Biol
Title: Homophilic adhesion and CEACAM1-S regulate dimerization of CEACAM1-L and recruitment of SHP-2 and c-Src.
Volume: 187
Issue: 4
Pages: 569-81
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Publication
11159516 | J:67405
First Author: Qu CK
Year: 2001
Journal: Blood
Title: Requirement of Shp-2 tyrosine phosphatase in lymphoid and hematopoietic cell development.
Volume: 97
Issue: 4
Pages: 911-4
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Publication
22566685 | J:186664
First Author: Sharma N
Year: 2012
Journal: Mol Cell Biol
Title: SH2 domain-containing phosphatase 2 is a critical regulator of connective tissue mast cell survival and homeostasis in mice.
Volume: 32
Issue: 14
Pages: 2653-63
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Publication
27183387 | J:237071
First Author: Wang J
Year: 2016
Journal: J Clin Invest
Title: Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus.
Volume: 126
Issue: 6
Pages: 2077-92
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Publication
10411909 | J:75413
First Author: Qu CK
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Genetic evidence that Shp-2 tyrosine phosphatase is a signal enhancer of the epidermal growth factor receptor in mammals.
Volume: 96
Issue: 15
Pages: 8528-33
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Publication
24675817 | J:214268
First Author: Yamashita H
Year: 2014
Journal: PLoS One
Title: Role of the protein tyrosine phosphatase Shp2 in homeostasis of the intestinal epithelium.
Volume: 9
Issue: 3
Pages: e92904
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Publication
15520383 | J:94738
First Author: Zhang EE
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism.
Volume: 101
Issue: 45
Pages: 16064-9
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Publication
18246201 | J:135265
First Author: Konieczna I
Year: 2008
Journal: J Clin Invest
Title: Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemia.
Volume: 118
Issue: 3
Pages: 853-67
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Publication
34758313 | J:320924
First Author: Chen WS
Year: 2021
Journal: Cell Rep
Title: Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment.
Volume: 37
Issue: 6
Pages: 109974
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Publication
30610104 | J:273052
First Author: Xiao P
Year: 2019
Journal: J Exp Med
Title: Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10.
Volume: 216
Issue: 2
Pages: 337-349
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Publication
25593124 | J:220894
First Author: Zhou Y
Year: 2015
Journal: FASEB J
Title: SHP2 regulates osteoclastogenesis by promoting preosteoclast fusion.
Volume: 29
Issue: 5
Pages: 1635-45
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Publication
36581713 | J:337757
First Author: Christofides A
Year: 2023
Journal: Nat Immunol
Title: SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses.
Volume: 24
Issue: 1
Pages: 55-68
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Publication
29141219 | J:251825
First Author: Lee J
Year: 2017
Journal: Cell Rep
Title: Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions.
Volume: 21
Issue: 7
Pages: 1870-1882
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Publication
26460004 | J:227187
First Author: Zhu HH
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Shp2 and Pten have antagonistic roles in myeloproliferation but cooperate to promote erythropoiesis in mammals.
Volume: 112
Issue: 43
Pages: 13342-7
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Publication
31843886 | J:289849
     
First Author: Wang G
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: A tumorigenic index for quantitative analysis of liver cancer initiation and progression.
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Publication
21884940 | J:176211
First Author: Karisch R
Year: 2011
Journal: Cell
Title: Global proteomic assessment of the classical protein-tyrosine phosphatome and "Redoxome".
Volume: 146
Issue: 5
Pages: 826-40
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Publication
21575863 | J:172422
First Author: Bard-Chapeau EA
Year: 2011
Journal: Cancer Cell
Title: Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis.
Volume: 19
Issue: 5
Pages: 629-39
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Publication
9171349 | J:43740
First Author: Saxton TM
Year: 1997
Journal: EMBO J
Title: Abnormal mesoderm patterning in mouse embryos mutant for the SH2 tyrosine phosphatase Shp-2.
Volume: 16
Issue: 9
Pages: 2352-64
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Publication
20417562 | J:160620
First Author: Hoff H
Year: 2010
Journal: Mol Immunol
Title: CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch.
Volume: 47
Issue: 10
Pages: 1875-81
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Publication
31201283 | J:277746
 
First Author: Kim Y
Year: 2019
Journal: J Cell Sci
Title: Tau interacts with SHP2 in neuronal systems and in Alzheimer's disease brains.
Volume: 132
Issue: 14
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Publication
30413615 | J:269303
First Author: Mehta M
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Themis-associated phosphatase activity controls signaling in T cell development.
Volume: 115
Issue: 48
Pages: E11331-E11340
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Publication
17961593 | J:130276
First Author: Hagiwara Y
Year: 2007
Journal: J Mol Cell Cardiol
Title: SHP2-mediated signaling cascade through gp130 is essential for LIF-dependent I CaL, [Ca2+]i transient, and APD increase in cardiomyocytes.
Volume: 43
Issue: 6
Pages: 710-6
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Publication
35025868 | J:322516
First Author: Cheng J
Year: 2022
Journal: PLoS Genet
Title: Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy.
Volume: 18
Issue: 1
Pages: e1010018
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Publication
29659837 | J:265107
First Author: Tajan M
Year: 2018
Journal: Hum Mol Genet
Title: Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.
Volume: 27
Issue: 13
Pages: 2276-2289
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Publication
32092146 | J:299385
First Author: Kadekar D
Year: 2020
Journal: Eur J Immunol
Title: The immune checkpoint receptor associated phosphatases SHP-1 and SHP-2 are not required for γδT17 cell development, activation, or skin inflammation.
Volume: 50
Issue: 6
Pages: 873-879
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Publication
22942432 | J:190550
First Author: Wu X
Year: 2012
Journal: J Immunol
Title: Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis.
Volume: 189
Issue: 7
Pages: 3497-507
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Publication
32546483 | J:300120
First Author: Liu W
Year: 2020
Journal: J Biol Chem
Title: Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels.
Volume: 295
Issue: 31
Pages: 10842-10856
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Publication
24052308 | J:201126
First Author: Kim T
Year: 2013
Journal: Science
Title: Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model.
Volume: 341
Issue: 6152
Pages: 1399-404
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Publication
23509158 | J:197924
First Author: Mazharian A
Year: 2013
Journal: Blood
Title: Megakaryocyte-specific deletion of the protein-tyrosine phosphatases Shp1 and Shp2 causes abnormal megakaryocyte development, platelet production, and function.
Volume: 121
Issue: 20
Pages: 4205-20
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Publication
22389718 | J:198408
First Author: Owen C
Year: 2012
Journal: PLoS One
Title: Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis.
Volume: 7
Issue: 2
Pages: e32700
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Publication
8955893 | J:37951
First Author: Park KS
Year: 1996
Journal: Biochem Mol Biol Int
Title: Molecular cloning and expression of a cDNA encoding a protein tyrosine phosphatase from mouse brain.
Volume: 40
Issue: 5
Pages: 1025-32
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Publication
11684012 | J:200332
First Author: Lu W
Year: 2001
Journal: Mol Cell
Title: Site-specific incorporation of a phosphotyrosine mimetic reveals a role for tyrosine phosphorylation of SHP-2 in cell signaling.
Volume: 8
Issue: 4
Pages: 759-69
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Publication
19393645 | J:151267
First Author: Li J
Year: 2009
Journal: Exp Cell Res
Title: Hepatocyte growth factor (HGF) signals through SHP2 to regulate primary mouse myoblast proliferation.
Volume: 315
Issue: 13
Pages: 2284-92
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Publication
19698715 | J:153127
First Author: de Oliveira MV
Year: 2009
Journal: FEBS Lett
Title: SHP-2 regulates myogenesis by coupling to FAK signaling pathway.
Volume: 583
Issue: 18
Pages: 2975-81
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Publication
19887591 | J:154765
First Author: Miyata M
Year: 2009
Journal: J Cell Sci
Title: Localization of nectin-free afadin at the leading edge and its involvement in directional cell movement induced by platelet-derived growth factor.
Volume: 122
Issue: Pt 23
Pages: 4319-29
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Publication
28768764 | J:246018
First Author: Zhang B
Year: 2017
Journal: J Biol Chem
Title: Src homology 2 domain-containing phosphotyrosine phosphatase 2 (Shp2) controls surface GluA1 protein in synaptic homeostasis.
Volume: 292
Issue: 37
Pages: 15481-15488
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Publication
29891536 | J:265927
First Author: Geer MJ
Year: 2018
Journal: Blood
Title: Uncoupling ITIM receptor G6b-B from tyrosine phosphatases Shp1 and Shp2 disrupts murine platelet homeostasis.
Volume: 132
Issue: 13
Pages: 1413-1425
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Publication
32437509 | J:291319
 
First Author: Xu X
Year: 2020
Journal: J Cell Biol
Title: PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2.
Volume: 219
Issue: 6
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Publication
33045063 | J:306126
 
First Author: Fedele C
Year: 2021
Journal: J Exp Med
Title: SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.
Volume: 218
Issue: 1
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Publication
9422771 | J:45156
First Author: Kuroiwa A
Year: 1998
Journal: J Biol Chem
Title: Association of tyrosine phosphatases SHP-1 and SHP-2, inositol 5-phosphatase SHIP with gp49B1, and chromosomal assignment of the gene.
Volume: 273
Issue: 2
Pages: 1070-4
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Publication
10026201 | J:314643
First Author: Lu-Kuo JM
Year: 1999
Journal: J Biol Chem
Title: gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization.
Volume: 274
Issue: 9
Pages: 5791-6
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Publication
9973385 | J:314642
First Author: Wang LL
Year: 1999
Journal: J Immunol
Title: Specificity of the SH2 domains of SHP-1 in the interaction with the immunoreceptor tyrosine-based inhibitory motif-bearing receptor gp49B.
Volume: 162
Issue: 3
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