| Type |
Details |
Score |
| GXD Expression |
| Probe: |
MGI:3716606 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-01-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2622020 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:6386389 |
| Age: |
embryonic day 12.5 |
| Image: |
S1B/C |
|
| Specimen Label: |
S1B/C |
| Detected: |
true |
| Specimen Num: |
10 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3716606 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-01-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2622021 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6386390 |
| Age: |
embryonic day 13.5 |
| Image: |
8G/H |
| Note: |
Expression maintained in surrounding mesenchyme. |
| Specimen Label: |
8G/H |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3716606 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2020-01-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:2622021 |
| Pattern: |
Not Specified |
| Stage: |
TS21 |
| Assay Id: |
MGI:6386390 |
| Age: |
embryonic day 13.5 |
| Image: |
8D/E |
|
| Specimen Label: |
8D/E |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:3716606 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2007-07-30 |
| Strength: |
Weak |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3287326 |
| Pattern: |
Regionally restricted |
| Stage: |
TS26 |
| Assay Id: |
MGI:3716615 |
| Age: |
embryonic day 18.5 |
| Image: |
2g |
| Note: |
Weak, but detectable, expression in intestinal villous epithelial cells, and in a subset of mesenchymal cells. |
| Specimen Label: |
2g |
| Detected: |
true |
| Specimen Num: |
7 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2991528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888214 |
|
| Specimen Label: |
UC Davis_1888214 |
| Detected: |
true |
| Specimen Num: |
53 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:2991528 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888215 |
|
| Specimen Label: |
UC Davis_1888215 |
| Detected: |
true |
| Specimen Num: |
54 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6194397 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-08-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1689420 |
| Pattern: |
Not Specified |
| Stage: |
TS20 |
| Assay Id: |
MGI:6194398 |
| Age: |
embryonic day 12.5 |
|
|
| Specimen Label: |
3A |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1796228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888211 |
|
| Specimen Label: |
UC Davis_1888211 |
| Detected: |
true |
| Specimen Num: |
50 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1796228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888212 |
|
| Specimen Label: |
UC Davis_1888212 |
| Detected: |
true |
| Specimen Num: |
51 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888291 |
|
| Specimen Label: |
UC Davis_1888291 |
| Detected: |
true |
| Specimen Num: |
118 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1868228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888292 |
|
| Specimen Label: |
UC Davis_1888292 |
| Detected: |
true |
| Specimen Num: |
119 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888154 |
|
| Specimen Label: |
UC Davis_1888154 |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Female |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888155 |
|
| Specimen Label: |
UC Davis_1888155 |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888220 |
|
| Specimen Label: |
UC Davis_1888220 |
| Detected: |
true |
| Specimen Num: |
58 |
|
•
•
•
•
•
|
| GXD Expression |
|
| Assay Type: |
In situ reporter (knock in) |
| Annotation Date: |
2021-04-16 |
| Strength: |
Present |
| Sex: |
Male |
| Emaps: |
EMAPS:1881228 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6691840 |
| Age: |
postnatal adult |
| Image: |
UC Davis_1888221 |
|
| Specimen Label: |
UC Davis_1888221 |
| Detected: |
true |
| Specimen Num: |
59 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6194397 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-08-14 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3787828 |
| Pattern: |
Not Specified |
| Stage: |
TS28 |
| Assay Id: |
MGI:6194398 |
| Age: |
postnatal day 23 |
|
| Note: |
Expression is particularly prominent in the matrix of the early-anagen hair follicles of the new hair cycle. |
| Specimen Label: |
5E |
| Detected: |
true |
| Specimen Num: |
17 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6194397 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-08-14 |
| Strength: |
Strong |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3787828 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:6194398 |
| Age: |
postnatal day 28 |
|
| Note: |
Expression is particularly prominent in the matrix of the mid-anagen hair follicles of the new hair cycle. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
15 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:6194397 |
| Assay Type: |
RNA in situ |
| Annotation Date: |
2018-08-14 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:3787628 |
| Pattern: |
Regionally restricted |
| Stage: |
TS28 |
| Assay Id: |
MGI:6194398 |
| Age: |
postnatal day 21 |
|
| Note: |
Expression is in the stem cell-containing bulge that lines the club hair. |
| Specimen Label: |
5D |
| Detected: |
true |
| Specimen Num: |
16 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li B |
| Year: |
2004 |
| Journal: |
Genomics |
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Cloning and developmental expression of mouse pygopus 2, a putative Wnt signaling component. |
| Volume: |
84 |
| Issue: |
2 |
| Pages: |
398-405 |
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•
•
•
•
•
|
| Publication |
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Mieszczanek J |
| Year: |
2019 |
| Journal: |
Nat Commun |
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Bcl9 and Pygo synergise downstream of Apc to effect intestinal neoplasia in FAP mouse models. |
| Volume: |
10 |
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1 |
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724 |
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•
•
•
•
•
|
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Zimmerli D |
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2020 |
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Elife |
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TBX3 acts as tissue-specific component of the Wnt/β-catenin transcriptional complex. |
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9 |
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|
•
•
•
•
•
|
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Cantù C |
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2018 |
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Genes Dev |
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Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling. |
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32 |
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21-22 |
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1443-1458 |
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•
•
•
•
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Cantù C |
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2014 |
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Genes Dev |
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Pax6-dependent, but β-catenin-independent, function of Bcl9 proteins in mouse lens development. |
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1879-84 |
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•
•
•
•
|
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PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation. |
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149 |
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4 |
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•
•
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•
•
•
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2021 |
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Pygo1 regulates pathological cardiac hypertrophy via a β-catenin-dependent mechanism. |
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320 |
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4 |
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H1634-H1645 |
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•
•
•
•
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| Type: |
gene |
| Organism: |
macaque, rhesus |
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•
•
•
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Mouse Genome Informatics Scientific Curators |
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2001 |
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Gene Ontology Annotation by the MGI Curatorial Staff |
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Mouse Genome Informatics Scientific Curators |
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2003 |
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Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
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The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
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International Knockout Mouse Consortium |
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Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals) |
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Wellcome Trust Sanger Institute |
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Database Release |
| Title: |
SWISS-PROT Annotated protein sequence database |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| Publication |
| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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| Allele |
| Name: |
pygopus 2; targeted mutation 1.1, Xing Dai |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
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| HT Experiment |
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| Experiment Type: |
RNA-Seq |
| Study Type: |
WT vs. Mutant |
| Source: |
GEO |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
259
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| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
90
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| Fragment?: |
true |
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| Publication |
| First Author: |
Willis TG |
| Year: |
1998 |
| Journal: |
Blood |
| Title: |
Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21. |
| Volume: |
91 |
| Issue: |
6 |
| Pages: |
1873-81 |
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| Protein Domain |
| Type: |
Family |
| Description: |
BCL9 is associated with B-cell acute lymphoblastic leukemia []. This entry includes BCL9 and BCL9L. They are tissue-specific transcriptional cofactors that cooperate with beta-catenin. In the nucleus, Bcl9 and Bcl9l simultaneously bind beta-catenin and the transcriptional activator Pygo2 to promote the transcription of a subset of Wnt target genes. They may also have a cytoplasmic role []. |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1494
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| Fragment?: |
false |
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1425
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| Fragment?: |
false |
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