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Search results 301 to 400 out of 420 for Rad50

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0.049s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Strain
MGI:5905639 | B6;129S7-Rad50<tm1Jpt>/Mmjax
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5524059 | B6.129S7(Cg)-Rad50<tm3Jpt>/J
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:6344866 | C57BL/6N-A<tm1Brd> Rint1<tm1b(KOMP)Wtsi>/JMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:6344865 | C57BL/6N-A<tm1Brd> Rint1<tm1a(KOMP)Wtsi>/JMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:5515225 | B6.129S6-Rad50<tm2.1Flv>
Attribute String: congenic, mutant strain, targeted mutation
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Strain
MGI:5515226 | B6.129S6-Rad50<tm2.2Flv>
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5515224 | B6.129S6-Rad50<tm3.1Flv>
Attribute String: mutant strain, targeted mutation, congenic
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Strain
MGI:5515223 | B6.129S6-Rad50<tm4.1Flv>
Attribute String: targeted mutation, congenic, mutant strain
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Strain
MGI:7767648 | C57BL/6JSmoc-Rad50<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: either: (involves: 129S6/SvEvTac * 129S7/SvEvBrd) or (involves: 129S7/SvEvBrd * C57BL/6)
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rint1/Rint1<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: involves: 129S6/SvEvTac * C3H * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: B6.129S6-Rad50
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: B6.129S6-Rad50
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: B6.129S6-Rad50
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rint1/Rint1<+>
Background: C57BL/6N-Rint1/J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rint1/Rint1 Tg(Pax6-cre,GFP)2Pgr/?
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Publication
26383973 | J:239805
First Author: Grigaravicius P
Year: 2016
Journal: Cell Death Differ
Title: Rint1 inactivation triggers genomic instability, ER stress and autophagy inhibition in the brain.
Volume: 23
Issue: 3
Pages: 454-68
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Publication
9590181 | -
First Author: Carney JP
Year: 1998
Journal: Cell
Title: The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response.
Volume: 93
Issue: 3
Pages: 477-86
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Publication
15296753 | -
First Author: Ciapponi L
Year: 2004
Journal: Curr Biol
Title: The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.
Volume: 14
Issue: 15
Pages: 1360-6
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Publication
11454871 | -
First Author: Trujillo KM
Year: 2001
Journal: J Biol Chem
Title: DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex.
Volume: 276
Issue: 38
Pages: 35458-64
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Publication
24168161 | -
First Author: Berardinelli F
Year: 2014
Journal: Int J Radiat Biol
Title: Radiation-induced telomere length variations in normal and in Nijmegen Breakage Syndrome cells.
Volume: 90
Issue: 1
Pages: 45-52
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Publication
23671188 | -
First Author: Yin Y
Year: 2013
Journal: Mol Cell Biol
Title: Impaired resection of meiotic double-strand breaks channels repair to nonhomologous end joining in Caenorhabditis elegans.
Volume: 33
Issue: 14
Pages: 2732-47
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Protein Domain
IPR004584 | Rad50_eukaryotes
Type: Family
Description: RAD50 is involved in DNA double-strand break repair (DSBR), telomere maintenance and meiotic recombination [, , ]. The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity [, ]. RAD50 provides ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the MRE11 active site [, , ]. This entry represents the eukaryotic Rad50 that is distantly related to the SbcC family of bacterial proteins.In Saccharomyces cerevisiae, Rad50 forms the MRX complex with Mre11 and Xrs2. In humans, RAD50 forms the MRN complex with MRE11 and NBN (also known as NBS1). Mutations in the RAD50 gene cause the Nijmegen breakage syndrome-like disorder (NBSLD) []. The genetic variations in the RAD50 gene have been linked to susceptibility to asthma [].
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Publication
19574546 | J:152194
First Author: Oikarinen SI
Year: 2009
Journal: Carcinogenesis
Title: Genetic mapping of Mom5, a novel modifier of Apc(Min)-induced intestinal tumorigenesis.
Volume: 30
Issue: 9
Pages: 1591-6
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Publication
9651580 | J:48255
First Author: Paull TT
Year: 1998
Journal: Mol Cell
Title: The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks.
Volume: 1
Issue: 7
Pages: 969-79
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Genotype
Genotype
Symbol: Nbn/Nbn Rad50/Rad50
Background: involves: 129S7/SvEvBrd * 129/Sv
Zygosity: cx
Has Mutant Allele: true
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Protein Domain
IPR007281 | Mre11_DNA-bd
Type: Domain
Description: The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication []. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1 [].
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Strain
MGI:5825161 | B6.129S(Cg)-Rad50<tm2Jpt> Elf4<tm1Nim>/J
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Rad50/Rad50 Trp53/Trp53
Background: involves: 129S2/SvPas * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mre11a/Mre11a Rad50/Rad50
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atm/Atm Rad50/Rad50
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atm/Atm<+> Rad50/Rad50
Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn Rad50/Rad50
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn<+> Rad50/Rad50
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50 Tg(BCL2)22Wehi/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6JWehi * SJL/JWehi
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chek2/Chek2 Rad50/Rad50
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Chek2/Chek2<+> Rad50/Rad50
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50 Smc1a/Smc1a
Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Nbn/Nbn<+> Rad50/Rad50
Background: involves: 129S7/SvEvBrd * 129/Sv
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50
Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rint1/Rint1 Tg(Pax6-cre,GFP)2Pgr/? Trp53/Trp53
Background: involves: 129P2/OlaHsd
Zygosity: cn
Has Mutant Allele: true
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Publication
10823903 | -
First Author: Paull TT
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: A mechanistic basis for Mre11-directed DNA joining at microhomologies.
Volume: 97
Issue: 12
Pages: 6409-14
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Publication
11988766 | -
First Author: D'Amours D
Year: 2002
Journal: Nat Rev Mol Cell Biol
Title: The Mre11 complex: at the crossroads of dna repair and checkpoint signalling.
Volume: 3
Issue: 5
Pages: 317-27
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Publication
22705791 | -
First Author: Schiller CB
Year: 2012
Journal: Nat Struct Mol Biol
Title: Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Volume: 19
Issue: 7
Pages: 693-700
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Protein Domain
IPR038487 | Mre11_capping_dom
Type: Homologous_superfamily
Description: The Mre11 complex is a multi-subunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2, and is involved in checkpoint signalling and DNA replication []. Mre11 has an intrinsic DNA-binding activity that is stimulated by Rad50 on its own or in combination with Nbs1 [].Mre11 dimerizes via phosphodiesterase domains flanked by a alpha/beta capping domain, process which creates a U-shaped particle with a broad DNA/Rad50 binding cleft []. This superfamily represents the Mre11 capping domain.
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Protein Domain
IPR045171 | ABC_Rad50
Type: Domain
Description: The catalytic domains of Rad50 are similar to the ATP-binding cassette of ABC transporters, but are not associated with membrane-spanning domains. The conserved ATP-binding motifs common to Rad50 and the ABC transporter family include the Walker A and Walker B motifs, the Q loop, a histidine residue in the switch region, a D-loop, and a conserved LSGG sequence. This conserved sequence, LSGG, is the most specific and characteristic motif of this family and is thus known as the ABC signature sequence [].
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Publication
32548123 | J:299723
 
First Author: Kafer GR
Year: 2020
Journal: Front Cell Dev Biol
Title: A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis.
Volume: 8
Pages: 416
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Protein
Q3V0R5
Organism: Mus musculus/domesticus
Length: 261  
Fragment?: false
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Protein
Q3UNL2
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Genotype
Genotype
Symbol: Mre11a/Mre11a<+> Rad50/Rad50
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50 Tg(Mx1-cre)1Cgn/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50 Tg(Pcp2-cre)2Mpin/?
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50 Tg(Cd4-cre)1Cwi/?
Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atm/Atm Rad50/Rad50<+>
Background: involves: 129/Sv * 129S6/SvEvTac * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50<+> Spo11/Spo11
Background: involves: 129/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein
F6RX99
Organism: Mus musculus/domesticus
Length: 170  
Fragment?: true
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Protein Domain
IPR038734 | YhaN_AAA
Type: Domain
Description: This AAA domain is found in a group of uncharacterised proteins, including YhaN from Bacillus subtilis and DNA double-strand break repair Rad50 ATPase from Archaeoglobus fulgidus.AAA ATPases belong to the AAA+ superfamily of ringshaped P-loop NTPases, which exert their activity through the energy-dependent unfolding of macromolecules [].
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Allele
Tg(A94G6)1Rub | MGI:3615509
Name: transgene insertion 1, Edward M Rubin
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Rad50/Rad50
Background: involves: 129/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rad50/Rad50 Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
7789757 | -
First Author: Johzuka K
Year: 1995
Journal: Genetics
Title: Interaction of Mre11 and Rad50: two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae.
Volume: 139
Issue: 4
Pages: 1521-32
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Publication
7885834 | -
First Author: Tavassoli M
Year: 1995
Journal: Nucleic Acids Res
Title: Cloning and characterisation of the Schizosaccharomyces pombe rad32 gene: a gene required for repair of double strand breaks and recombination.
Volume: 23
Issue: 3
Pages: 383-8
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Publication
9799249 | -
First Author: Furuse M
Year: 1998
Journal: EMBO J
Title: Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination.
Volume: 17
Issue: 21
Pages: 6412-25
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Protein Domain
IPR003701 | Mre11
Type: Family
Description: Mre11 and Rad50 are two proteins required for DNA repair and meiosis-specific double-strand break formation in Saccharomyces cerevisiae. Mre11 by itself has 3' to 5' exonuclease activity that is increased when Mre11 is in a complex with Rad50 []. These eukaryotic proteins contain one metallo-phosphoesterase domain followed by an Mre11 DNA-binding domain. S. cerevisiae Mre11 is required for DNA repair and meiosis-specificdouble-strand break (DSB) formation []and has both 3' to 5' exonuclease activity (whichincreases when in complex with Rad50) and endonuclease activity. The N-terminal phosphoesterase domain isrequired for DSB repair, and the carboxyl-terminal dsDNA-binding domain is essential during meiosis forchromatin modification and DSB formation []. Schizosaccharomyces pombe rad32 is required for repair of double strand breaks and recombination [].
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Publication
9705271 | -
First Author: Trujillo KM
Year: 1998
Journal: J Biol Chem
Title: Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95.
Volume: 273
Issue: 34
Pages: 21447-50
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Protein
Q61216
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
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Protein
Q8BRV3
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: true
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Protein
Q3URU4
Organism: Mus musculus/domesticus
Length: 706  
Fragment?: false
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Protein
Q3UJN6
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
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Protein Domain
IPR004592 | SbcC_gammaproteobac_type
Type: Family
Description: This entry represents a small group of nuclease SbcCD subunit C (SbcC) proteins, mainly from gammaproteobacteria. SbcC are known are part of an exonuclease complex with sbcD homologues. SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity [].The entry also includes a small number of proteins annotated as probable DNA double-strand break repair Rad50 ATPase, but which are experimentally uncharacterised.
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Publication
28076792 | J:251434
First Author: Kim JH
Year: 2017
Journal: Cell Rep
Title: The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression.
Volume: 18
Issue: 2
Pages: 496-507
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Publication
12871646 | J:132533
First Author: Lee GR
Year: 2003
Journal: Immunity
Title: Regulation of the Th2 cytokine locus by a locus control region.
Volume: 19
Issue: 1
Pages: 145-53
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Publication
12949583 | -
First Author: van den Bosch M
Year: 2003
Journal: EMBO Rep
Title: The MRN complex: coordinating and mediating the response to broken chromosomes.
Volume: 4
Issue: 9
Pages: 844-9
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Publication
11741547 | -
First Author: de Jager M
Year: 2001
Journal: Mol Cell
Title: Human Rad50/Mre11 is a flexible complex that can tether DNA ends.
Volume: 8
Issue: 5
Pages: 1129-35
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Protein Domain
IPR013134 | Zn_hook_RAD50
Type: Domain
Description: The MRN complex (Mre11-Rad50-Nbs1) plays an important role in many DNA metabolic events that involve DNA double-stranded breaks. MRN is one of the first factors to be localised to DNA lesions where it might have a structural role by tethering and stabilising broken chromosomes [, ]. Rad50 is a split ABC-type ATPase; its centre contains a long heptad repeat that folds into an antiparallel coiled coil, bringing the N-terminal (Walker A) and the C-terminal (Walker B) domains in close proximity []. The apex of the coiled coil contains a dimerization interface, a conserved Cys-X-X-Cys motif in a hook-shaped domain that dimerizes with a second hook domain via cysteine-mediated zinc ion coordination. This zinc dependent dimerization event allows the formation of a complex that has appropriate lengths and conformational proporties to link sister chromatids in homologous recombination and DNA ends in non-homologous end-joining.
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Strain
MGI:3615513 | STOCK Del(11Irf1-D11Mit23)1Rub Tg(A94G6)1Rub/Mmucd
Attribute String: deletion, mutant stock, transgenic, targeted mutation
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Genotype
Genotype
Symbol: Del(11Irf1-D11Mit23)1Rub/Del(11Irf1-D11Mit23)1Rub Tg(A94G6)1Rub/?
Background: involves: 129S6/SvEvTac * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
22693585 | J:187422
First Author: Collin GB
Year: 2012
Journal: PLoS One
Title: The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway.
Volume: 7
Issue: 5
Pages: e37925
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Publication
10867876 | J:62597
First Author: Loseva EF
Year: 2000
Journal: Genetika
Title: [Cloning of a new murine gene coding for a protein immunologically related to RecA protein from Escherichia coli].
Volume: 36
Issue: 5
Pages: 613-21
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Publication
9303542 | J:43074
First Author: Nairz K
Year: 1997
Journal: Genes Dev
Title: mre11S--a yeast mutation that blocks double-strand-break processing and permits nonhomologous synapsis in meiosis.
Volume: 11
Issue: 17
Pages: 2272-90
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Publication
9931460 | J:52030
First Author: Chamankhah M
Year: 1998
Journal: Gene
Title: Isolation of hMRE11B: failure to complement yeast mre11 defects due to species-specific protein interactions.
Volume: 225
Issue: 1-2
Pages: 107-16
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Publication
17082765 | J:119965
First Author: Yang YG
Year: 2006
Journal: EMBO J
Title: Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks.
Volume: 25
Issue: 23
Pages: 5527-38
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Publication
23997114 | J:207571
First Author: Solaimani P
Year: 2013
Journal: Toxicol Sci
Title: Genome-wide RNAi high-throughput screen identifies proteins necessary for the AHR-dependent induction of CYP1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
Volume: 136
Issue: 1
Pages: 107-19
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Publication
17704228 | -
First Author: Chen Z
Year: 2007
Journal: J Bacteriol
Title: The sbcDC locus mediates repression of type 5 capsule production as part of the SOS response in Staphylococcus aureus.
Volume: 189
Issue: 20
Pages: 7343-50
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Publication
8334998 | -
First Author: Sweet DJ
Year: 1993
Journal: EMBO J
Title: The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p.
Volume: 12
Issue: 7
Pages: 2831-40
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Publication
11096100 | -
First Author: Xiao J
Year: 2001
Journal: J Biol Chem
Title: RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control.
Volume: 276
Issue: 9
Pages: 6105-11
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Publication
16600870 | -
First Author: Kong LJ
Year: 2006
Journal: Mol Cell
Title: The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
Volume: 22
Issue: 1
Pages: 63-71
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Publication
16571679 | -
First Author: Arasaki K
Year: 2006
Journal: Mol Biol Cell
Title: RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.
Volume: 17
Issue: 6
Pages: 2780-8
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Publication
17194767 | -
First Author: Li L
Year: 2006
Journal: Plant Cell
Title: MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana.
Volume: 18
Issue: 12
Pages: 3535-47
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Protein Domain
IPR007528 | RINT1_Tip20
Type: Family
Description: This entry includes RINT-1 from animals, Tip20 from yeasts and MAIGO2 (Mag2) from plants. They play a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity []. They are part of the CATCHR (complexes associated with tethering containing helical rods) family which comprises the exocyst, COG, GARP, and DSL1 complexes and share a similar structure organisation with an N-terminal coiled-coil and a C-terminal α-helical bundle, which might be a protein-protein interaction module necessary for the formation of functional complexes.RINT-1 interacts with Rad50 only during late S and G2/M phases and participates in radiation induced checkpoint control []. RINT-1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [, , ].Tip20 is involved in the retrograde transport from the Golgi to the ER [, ].Arabidopsis Mag2 functions in the transport of storage protein precursors between the ER and Golgi complex in plants [, ].
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Publication
35153719 | J:326998
 
First Author: Ding M
Year: 2021
Journal: Front Aging Neurosci
Title: The Essential DNA Damage Response Complex MRN Is Dispensable for the Survival and Function of Purkinje Neurons.
Volume: 13
Pages: 786199
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Publication
24118572 | -
First Author: Li L
Year: 2013
Journal: Plant J
Title: MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana.
Volume: 76
Issue: 5
Pages: 781-91
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