|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 452 for Relb

<< First    < Previous  |  Next >    Last >>
0.01s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318222
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318260
Age: postnatal week 5
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318222
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586628
Stage: TS28
Assay Id: MGI:5318261
Age: postnatal week 5
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318258
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586628
Stage: TS28
Assay Id: MGI:5318262
Age: postnatal week 5
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318259
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3586628
Stage: TS28
Assay Id: MGI:5318263
Age: postnatal week 5
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318259
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318264
Age: postnatal week 5
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5318258
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318265
Age: postnatal week 5
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318271
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318275
Age: postnatal adult
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318272
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318277
Age: postnatal adult
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318274
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318278
Age: postnatal adult
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318273
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3578628
Stage: TS28
Assay Id: MGI:5318279
Age: postnatal adult
Image: 2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318258
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3263428
Stage: TS28
Assay Id: MGI:5318286
Age: postnatal day 3-7
Image: S2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318259
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3263428
Stage: TS28
Assay Id: MGI:5318287
Age: postnatal day 3-7
Image: S2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318222
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3263428
Stage: TS28
Assay Id: MGI:5318288
Age: postnatal day 3-7
Image: S2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5318223
Assay Type: RT-PCR
Annotation Date: 2012-05-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3263428
Stage: TS28
Assay Id: MGI:5318289
Age: postnatal day 3-7
Image: S2
Specimen Label: RelB +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
12123459 | -
First Author: Pedersen K
Year: 2002
Journal: Mol Microbiol
Title: Rapid induction and reversal of a bacteriostatic condition by controlled expression of toxins and antitoxins.
Volume: 45
Issue: 2
Pages: 501-10
•
•
•
•
•
Publication
22981948 | -
First Author: Bøggild A
Year: 2012
Journal: Structure
Title: The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Volume: 20
Issue: 10
Pages: 1641-8
•
•
•
•
•
Protein Domain
IPR007337 | RelB/DinJ
Type: Family
Description: Plasmids may be maintained stably in bacterial populations through the action of addiction modules, in which a toxin and antidote are encoded in a cassette on the plasmid. In any daughter cell that lacks the plasmid, the toxin persists and is lethal after the antidote protein is depleted. Toxin/antitoxin pairs are also found on main chromosomes, and likely represent selfish DNA. Sequences in the seed for this alignment all were found adjacent to toxin genes. Several toxin/antitoxin pairs may occur in a single species. RelE and RelB form a toxin-antitoxin system; RelE cleaves mRNA during translation on the ribosome [, , ]. RelB binds and inhibits RelE and it regulates transcription by operator binding and conditional cooperativity controlled by RelE. RelE and RelB form a V-shaped heterotetrameric complex which has a ribbon-helix-helix (RHH) dimerization domain at the apex. [].DinJ is an antitoxin component of a toxin-antitoxin (TA) module. It is a labile antitoxin that counteracts the effect of the YafQ toxin []. It forms a heterotetrameric complex with YafQ and the structure of this complex revealed that the N-terminal region of DinJ folds into a ribbon-helix-helix motif that dimerises for DNA recognition, and the C-terminal portion of each DinJ wraps around a YafQ molecule []. Together, they they bind their own promoter, and by analogy to other TA modules probably repress its expression. Cell death governed by the mazEF and dinJ-yafQ TA modules seems to play a role in biofilm formation [, , ].
•
•
•
•
•
Publication
12874295 | -
First Author: Maier HJ
Year: 2003
Journal: J Biol Chem
Title: Critical role of RelB serine 368 for dimerization and p100 stabilization.
Volume: 278
Issue: 40
Pages: 39242-50
•
•
•
•
•
Publication
19707553 | -
First Author: Kolodkin-Gal I
Year: 2009
Journal: PLoS One
Title: A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation.
Volume: 4
Issue: 8
Pages: e6785
•
•
•
•
•
Publication
24923448 | -
First Author: Liang Y
Year: 2014
Journal: J Biol Chem
Title: Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ.
Volume: 289
Issue: 30
Pages: 21191-202
•
•
•
•
•
Publication
31399573 | J:279459
First Author: Costa TDF
Year: 2019
Journal: Nat Commun
Title: PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer.
Volume: 10
Issue: 1
Pages: 3589
•
•
•
•
•
Publication
21873235 | J:175215
First Author: Hailfinger S
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines.
Volume: 108
Issue: 35
Pages: 14596-601
•
•
•
•
•
Publication
16192349 | J:102492
First Author: Jacque E
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: RelA repression of RelB activity induces selective gene activation downstream of TNF receptors.
Volume: 102
Issue: 41
Pages: 14635-40
•
•
•
•
•
Publication
36110848 | J:330834
 
First Author: Kuhn LB
Year: 2022
Journal: Front Immunol
Title: RelB contributes to the survival, migration and lymphomagenesis of B cells with constitutively active CD40 signaling.
Volume: 13
Pages: 913275
•
•
•
•
•
Publication
32622933 | J:343936
 
First Author: Hsu KH
Year: 2020
Journal: Immunol Lett
Title: Upregulation of RelB in the miR-122 knockout mice contributes to increased levels of proinflammatory chemokines/cytokines in the liver and macrophages.
Volume: 226
Pages: 22-30
•
•
•
•
•
Publication
17263853 | -
First Author: Motiejūnaite R
Year: 2007
Journal: FEMS Microbiol Lett
Title: Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module.
Volume: 268
Issue: 1
Pages: 112-9
•
•
•
•
•
Publication
19210620 | -
First Author: Prysak MH
Year: 2009
Journal: Mol Microbiol
Title: Bacterial toxin YafQ is an endoribonuclease that associates with the ribosome and blocks translation elongation through sequence-specific and frame-dependent mRNA cleavage.
Volume: 71
Issue: 5
Pages: 1071-87
•
•
•
•
•
Allele
Relb<em1Smoc> | MGI:7292011
Name: avian reticuloendotheliosis viral (v-rel) oncogene related B; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6476160 | C57BL/6JSmoc-Relb<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Allele
Gt(ROSA)26Sor<tm1(Relb)Rie> | MGI:6729309
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Marc Riemann
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
•
•
•
•
•
DO Term
DOID:0111992 | immunodeficiency 53
•
•
•
•
•
Publication
16480837 | -
First Author: Phan HH
Year: 2006
Journal: Gene
Title: CD14-dependent modulation of NF-kappaB alternative splicing in the lung after burn injury.
Volume: 371
Issue: 1
Pages: 121-9
•
•
•
•
•
HT Experiment
E-GEOD-43154 | Comparison of RelB-/- and RelB+/- thymi
Series Id: GSE43154
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
HT Experiment
GSE77374 | RNA-seq data from murine eGFP+ relbfl/flnfkb2fl/flCg1-Cre and Cg1-Cre splenic germinal center B cells purified by fluorescent activated cell sorting.
Series Id: E-GEOD-77374
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Protein Domain
IPR035424 | Antitoxin_RelB
Type: Family
Description: This family represents the RelB antitoxin of toxin-antitoxin stability system or prevent-host death system. Together RelE toxin and the RelB antitoxin form a non-toxic complex. Although toxin-antitoxin gene cassettes were first found in plasmids, it is clear that these loci are abundant in free-living prokaryotes, including many pathogenic bacteria, and these toxin-antitoxin loci provide a control mechanism that helps free-living prokaryotes cope with nutritional stress [, ].
•
•
•
•
•
Allele
Relb<tm1.1Fwei> | MGI:5441212
Name: avian reticuloendotheliosis viral (v-rel) oncogene related B; targeted mutation 1.1, Falk Weih
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Tg(Relb-cre)53Rie | MGI:6729308
Name: transgene insertion 53, Marc Riemann
Allele Type: Transgenic
Attribute String: Recombinase, Reporter
•
•
•
•
•
Genotype
Genotype
Symbol: Relb/Relb Tg(Lck-cre)I57Jxm/?
Background: involves: ICR
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
HT Experiment
E-GEOD-58455 | Polyadenylated RNA Sequencing of C57BL/6J Embryonic, Adult and Pressure-Overloaded Hearts
Series Id: GSE58455
Experiment Type: RNA-Seq
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
Genotype
Genotype
Symbol: Relb/Relb Tg(Cd4-cre)1Cwi/?
Background: involves: C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Relb-cre)53Rie/?
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
15864262 | -
First Author: Gerdes K
Year: 2005
Journal: Nat Rev Microbiol
Title: Prokaryotic toxin-antitoxin stress response loci.
Volume: 3
Issue: 5
Pages: 371-82
•
•
•
•
•
Publication
14707043 | J:87356
First Author: Speirs K
Year: 2004
Journal: J Immunol
Title: Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function.
Volume: 172
Issue: 2
Pages: 752-6
•
•
•
•
•
Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Relb-cre)53Rie/?
Background: involves: 129S4/SvJaeSor * C57BL/6
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Publication
26933955 | J:248134
First Author: Sun H
Year: 2016
Journal: PLoS Pathog
Title: A Family of Salmonella Type III Secretion Effector Proteins Selectively Targets the NF-κB Signaling Pathway to Preserve Host Homeostasis.
Volume: 12
Issue: 3
Pages: e1005484
•
•
•
•
•
Publication
27492902 | J:241269
 
First Author: Zhao Y
Year: 2016
Journal: Nat Commun
Title: Dectin-1-activated dendritic cells trigger potent antitumour immunity through the induction of Th9 cells.
Volume: 7
Pages: 12368
•
•
•
•
•
Publication
21333553 | J:168977
First Author: Wuerzberger-Davis SM
Year: 2011
Journal: Immunity
Title: Nuclear export of the NF-κB inhibitor IκBα is required for proper B cell and secondary lymphoid tissue formation.
Volume: 34
Issue: 2
Pages: 188-200
•
•
•
•
•
Publication
19917778 | J:155688
First Author: Tusche MW
Year: 2009
Journal: J Exp Med
Title: Differential requirement of MALT1 for BAFF-induced outcomes in B cell subsets.
Volume: 206
Issue: 12
Pages: 2671-83
•
•
•
•
•
Publication
15539150 | J:93890
First Author: Grech AP
Year: 2004
Journal: Immunity
Title: TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells.
Volume: 21
Issue: 5
Pages: 629-42
•
•
•
•
•
Publication
21469094 | J:175408
First Author: Azukizawa H
Year: 2011
Journal: Eur J Immunol
Title: Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.
Volume: 41
Issue: 5
Pages: 1420-34
•
•
•
•
•
Publication
31243287 | J:279665
First Author: Li J
Year: 2019
Journal: Nat Commun
Title: TGFβ-induced degradation of TRAF3 in mesenchymal progenitor cells causes age-related osteoporosis.
Volume: 10
Issue: 1
Pages: 2795
•
•
•
•
•
Publication
25367573 | J:254663
First Author: Moriwaki K
Year: 2014
Journal: Immunity
Title: The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair.
Volume: 41
Issue: 4
Pages: 567-78
•
•
•
•
•
Publication
28498098 | J:258588
   
First Author: Zhang TT
Year: 2017
Journal: Elife
Title: Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help.
Volume: 6
•
•
•
•
•
Publication
31522122 | J:342866
 
First Author: Ahad A
Year: 2019
Journal: iScience
Title: NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance.
Volume: 19
Pages: 996-1011
•
•
•
•
•
Publication
30301887 | J:268666
First Author: Stone OA
Year: 2018
Journal: Nat Commun
Title: Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Volume: 9
Issue: 1
Pages: 4077
•
•
•
•
•
Publication
34282331 | J:321291
First Author: Khoyratty TE
Year: 2021
Journal: Nat Immunol
Title: Distinct transcription factor networks control neutrophil-driven inflammation.
Volume: 22
Issue: 9
Pages: 1093-1106
•
•
•
•
•
Publication
9597130 | J:51176
 
First Author: Ghosh S
Year: 1998
Journal: Annu Rev Immunol
Title: NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.
Volume: 16
Pages: 225-60
•
•
•
•
•
Publication
10837071 | -
 
First Author: Karin M
Year: 2000
Journal: Annu Rev Immunol
Title: Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity.
Volume: 18
Pages: 621-63
•
•
•
•
•
Publication
12360211 | -
First Author: Li Q
Year: 2002
Journal: Nat Rev Immunol
Title: NF-kappaB regulation in the immune system.
Volume: 2
Issue: 10
Pages: 725-34
•
•
•
•
•
Publication
7530332 | -
First Author: Ghosh G
Year: 1995
Journal: Nature
Title: Structure of NF-kappa B p50 homodimer bound to a kappa B site.
Volume: 373
Issue: 6512
Pages: 303-10
•
•
•
•
•
Publication
2018779 | -
First Author: Baeuerle PA
Year: 1991
Journal: Biochim Biophys Acta
Title: The inducible transcription activator NF-kappa B: regulation by distinct protein subunits.
Volume: 1072
Issue: 1
Pages: 63-80
•
•
•
•
•
Publication
17114415 | -
First Author: Sen R
Year: 2006
Journal: J Immunol
Title: Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986. 46: 705-716.
Volume: 177
Issue: 11
Pages: 7485-96
•
•
•
•
•
Publication
15371334 | -
First Author: Hayden MS
Year: 2004
Journal: Genes Dev
Title: Signaling to NF-kappaB.
Volume: 18
Issue: 18
Pages: 2195-224
•
•
•
•
•
Publication
25305492 | J:220199
First Author: Mise-Omata S
Year: 2014
Journal: Biochem Biophys Res Commun
Title: p100, a precursor of NF-κB2, inhibits c-Rel and reduces the expression of IL-23 in dendritic cells.
Volume: 453
Issue: 3
Pages: 332-7
•
•
•
•
•
Publication
9315679 | -
First Author: Li Z
Year: 1997
Journal: Mol Cell Biol
Title: A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription.
Volume: 17
Issue: 10
Pages: 6184-90
•
•
•
•
•
Publication
16477006 | -
First Author: Song YJ
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation.
Volume: 103
Issue: 8
Pages: 2689-94
•
•
•
•
•
Protein Domain
IPR000451 | NFkB/Dor
Type: Family
Description: The transcription factor NF-kB (Nuclear Factor-kappaB) was first identified as a DNA-binding protein specific for the 10-base pair kB site in the immunoglobulin k light-chain enhancer of B lymphocytes [], but has subsequently been found in many different cell types. NF-kB represents a group of structurally related proteins that share a 300 amino acid `Rel homology domain' (RHD) []: members include p50 (NF-kB1), p52 (NF-kB2), p65 (RelA), c-Rel, v-Rrel, RelB, and the Drosophila proteins Dorsal and Dif. These proteins exist as homo- and heterodimers that bind to kB sites in the enhancer regions of several target genes, most of which are involved in cellular defence mechanisms and differentiation.The RHD, which is located N-terminally, is responsible for proteindimerisation, DNA binding and nuclear localisation. The more variableC-terminal transactivation domain is found in RelA, RelB and c-Rel, but not in p50 or p52. Nevertheless, p50 and p52 play critical roles in modulatingthe specificity of NF-kB function. DNA binding requires the entire RHD, by contrast with other eukaryotic and prokaryotic transcription factors, where muchsmaller DNA-binding domains confer full specificity and bindingaffinity for the target []. The structure of the transcription factor NF-kB p50 homodimer bound to a palindromic kB site shows the RHD to fold into 2 distinct subdomains, similar to the β-sandwich structure of the immunoglobulins [].NF-kB is expressed in the cytoplasm of virtually all cell types, where its activity is controlled by a family of regulatory proteins, called inhibitors of NF-kB (IkB) [, ].
•
•
•
•
•
Protein Domain
IPR030497 | NFkB_p100
Type: Family
Description: This entry represents the NF-kappaB subunit precursor p100, which can be processed to produce a 52kDa protein (p52). p52 can form homodimers. It can also form heterodimers with different NF-kappaB family members, such as RelB, p65 and c-Rel [, ]. p100 inhibits c-Rel and reduces the expression of IL-23 in dendritic cells [].NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [].NF-kB1 and NF-kB2 are synthesised as large precursors, called p105 and p100, which undergo processing to generate the NF-kB subunits p50 and p52, respectively []. The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway, and involves selective degradation of their C-terminal regions containing ankyrin repeats []. Unlike RelA, RelB and c-Rel, p50 and p52 do not contain transactivation domains in their C-termini. Nevertheless, they play critical roles in modulating the specificity of NF-kB function [].
•
•
•
•
•
Protein Domain
IPR030503 | NF-kB_p105
Type: Family
Description: This entry represents the NF-kappaB subunit precursor p105, which can undergo cotranslational processing by the 26S proteasome to produce a 50kDa protein (p50). p50 is a DNA binding subunit of the NF-kappaB (NF-kappaB) protein complex [].NF-kappaB is a pleiotropic transcription factor present in almost all cell types. It is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RelA/p65, RelB, NFKB1/p50, c-Rel and NFKB2/p52 []. Each individual NF-kappaB subunit, and perhaps each dimer, carries out unique functions in regulating transcription. Dimer-specific functions can be conferred by selective protein-protein interactions with other transcription factors, coregulatory proteins, and chromatin proteins [].NF-kB1 and NF-kB2 are synthesised as large precursors, called p105 and p100, which undergo processing to generate the NF-kB subunits p50 and p52, respectively []. The processing of p105 and p100 is mediated by the ubiquitin/proteasome pathway, and involves selective degradation of their C-terminal regions containing ankyrin repeats []. Unlike RelA, RelB and c-Rel, p50 and p52 do not contain transactivation domains in their C-termini. Nevertheless, they play critical roles in modulating the specificity of NF-kB function [].
•
•
•
•
•
Publication
16644679 | J:108658
First Author: Starkey JM
Year: 2006
Journal: Diabetes
Title: Diabetes-induced activation of canonical and noncanonical nuclear factor-kappaB pathways in renal cortex.
Volume: 55
Issue: 5
Pages: 1252-9
•
•
•
•
•
Publication
17327424 | J:122028
First Author: Moloney F
Year: 2007
Journal: Diabetes
Title: Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue.
Volume: 56
Issue: 3
Pages: 574-82
•
•
•
•
•
Publication
22070873 | J:181379
First Author: Guindi C
Year: 2012
Journal: Cell Immunol
Title: Differential role of NF-κB, ERK1/2 and AP-1 in modulating the immunoregulatory functions of bone marrow-derived dendritic cells from NOD mice.
Volume: 272
Issue: 2
Pages: 259-68
•
•
•
•
•
Publication
23766559 | J:316061
 
First Author: Bhattacharyya S
Year: 2013
Journal: Mediators Inflamm
Title: Carrageenan-induced colonic inflammation is reduced in Bcl10 null mice and increased in IL-10-deficient mice.
Volume: 2013
Pages: 397642
•
•
•
•
•
Publication
17322371 | J:118646
First Author: Thatcher TH
Year: 2007
Journal: Am J Pathol
Title: Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB.
Volume: 170
Issue: 3
Pages: 855-64
•
•
•
•
•
Publication
22351927 | J:181685
First Author: Bakkar N
Year: 2012
Journal: J Cell Biol
Title: IKKα and alternative NF-κB regulate PGC-1β to promote oxidative muscle metabolism.
Volume: 196
Issue: 4
Pages: 497-511
•
•
•
•
•
Publication
12075355 | J:77233
First Author: Pasparakis M
Year: 2002
Journal: Nature
Title: TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2.
Volume: 417
Issue: 6891
Pages: 861-6
•
•
•
•
•
Publication
30949517 | J:290737
 
First Author: Du Y
Year: 2019
Journal: J Immunol Res
Title: CD38 Deficiency Downregulates the Onset and Pathogenesis of Collagen-Induced Arthritis through the NF-κB Pathway.
Volume: 2019
Pages: 7026067
•
•
•
•
•
Publication
20231695 | J:159873
First Author: Penzo M
Year: 2010
Journal: J Immunol
Title: Inhibitor of NF-kappa B kinases alpha and beta are both essential for high mobility group box 1-mediated chemotaxis [corrected].
Volume: 184
Issue: 8
Pages: 4497-509
•
•
•
•
•
Publication
24747690 | J:217042
First Author: Penzo M
Year: 2014
Journal: Biochim Biophys Acta
Title: Cell migration to CXCL12 requires simultaneous IKKα and IKKβ-dependent NF-κB signaling.
Volume: 1843
Issue: 9
Pages: 1796-1804
•
•
•
•
•
Publication
31200979 | J:317405
First Author: Koliesnik IO
Year: 2019
Journal: Immunobiology
Title: Alternative NF-κB signaling controls peripheral homeostasis and function of regulatory T cells.
Volume: 224
Issue: 5
Pages: 687-696
•
•
•
•
•
Publication
31554891 | J:284665
First Author: Dhar A
Year: 2019
Journal: Sci Rep
Title: Role of NF-kappaB2-p100 in regulatory T cell homeostasis and activation.
Volume: 9
Issue: 1
Pages: 13867
•
•
•
•
•
Publication
29061763 | J:258322
First Author: Mukherjee T
Year: 2017
Journal: EMBO J
Title: A TNF-p100 pathway subverts noncanonical NF-κB signaling in inflamed secondary lymphoid organs.
Volume: 36
Issue: 23
Pages: 3501-3516
•
•
•
•
•
Publication
36878304 | J:335711
First Author: Pflug KM
Year: 2023
Journal: Biochim Biophys Acta Mol Basis Dis
Title: NF-κB-inducing kinase maintains mitochondrial efficiency and systemic metabolic homeostasis.
Volume: 1869
Issue: 5
Pages: 166682
•
•
•
•
•
Publication
30894749 | J:283421
First Author: Liu Z
Year: 2019
Journal: Nature
Title: A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-κB.
Volume: 568
Issue: 7751
Pages: 249-253
•
•
•
•
•
Publication
21734075 | J:179170
First Author: Yu M
Year: 2011
Journal: J Immunol
Title: NF-κB signaling participates in both RANKL- and IL-4-induced macrophage fusion: receptor cross-talk leads to alterations in NF-κB pathways.
Volume: 187
Issue: 4
Pages: 1797-806
•
•
•
•
•
Publication
17923499 | J:126113
First Author: Hövelmeyer N
Year: 2007
Journal: J Exp Med
Title: Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD.
Volume: 204
Issue: 11
Pages: 2615-27
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom