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Search results 301 to 338 out of 338 for Rfng

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Type Details Score
Genotype
Genotype
Symbol: Rfng/Rfng
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Lfng/Lfng Rfng/Rfng
Background: involves: 129S1/SvImJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rfng/Rfng<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1 Rfng/Rfng
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1 Rfng/Rfng
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Allele
Tg(Rfng-EGFP)IC128Gsat | MGI:4847375
Name: transgene insertion IC128, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Genotype
Genotype
Symbol: Lfng/Lfng Mfng/Mfng Rfng/Rfng
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1 Rfng/Rfng<+>
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1 Rfng/Rfng<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: En1/En1<+> Rfng/Rfng
Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Jag1/Jag1<+> Rfng/Rfng<+>
Background: involves: 129S1/Sv
Zygosity: cx
Has Mutant Allele: true
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Strain
MGI:5003859 | STOCK Tg(Rfng-EGFP)IC128Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Protein Domain
IPR017374 | Fringe
Type: Family
Description: The Notch receptor is a large, cell surface transmembrane protein involved in a wide variety of developmental processes in higher organisms []. It becomes activated when its extracellular region binds to ligands located on adjacent cells. Much of this extracellular region is composed of EGF-like repeats, many of which can be O-fucosylated. A number of these O-fucosylated repeats can in turn be further modified by the action of a beta-1,3-N-acetylglucosaminyltransferase enzyme known as Fringe []. Fringe potentiates the activation of Notch by Delta ligands, while inhibiting activation by Serrate/Jagged ligands. This regulation of Notch signalling by Fringe is important in many processes [].Four distinct Fringe proteins have so far been studied in detail; Drosophila Fringe (Dfng) and its three mammalian homologues Lunatic Fringe (Lfng), Radical Fringe (Rfng) and Manic Fringe (Mfng). Dfng, Lfng and Rfng have all been shown to play important roles in developmental processes within their host, though the phenotype of mutants can vary between species eg Rfng mutants are retarded in wing development in chickens, but have no obvious phenotype in mice [, , ]. Mfng mutants have not, so far, been charcterised. Biochemical studies indicate that the Fringe proteins are fucose-specific transferases requiring manganese for activity and utilising UDP-N-acetylglucosamine as a donor substrate []. The three mammalian proteins show distinct variations in their catalytic efficiencies with different substrates.
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Protein
O09009
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
O09010
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Protein
O09008
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
Q3UPI0
Organism: Mus musculus/domesticus
Length: 321  
Fragment?: false
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Protein
B2RRW2
Organism: Mus musculus/domesticus
Length: 378  
Fragment?: false
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Publication
12417415 | -
First Author: Haltiwanger RS
Year: 2002
Journal: Biochim Biophys Acta
Title: Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase.
Volume: 1573
Issue: 3
Pages: 328-35
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Publication
14570055 | -
First Author: Haines N
Year: 2003
Journal: Nat Rev Mol Cell Biol
Title: Glycosylation regulates Notch signalling.
Volume: 4
Issue: 10
Pages: 786-97
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Publication
7954826 | -
First Author: Irvine KD
Year: 1994
Journal: Cell
Title: fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.
Volume: 79
Issue: 4
Pages: 595-606
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Publication
9121551 | -
First Author: Rodriguez-Esteban C
Year: 1997
Journal: Nature
Title: Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb.
Volume: 386
Issue: 6623
Pages: 360-6
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Publication
16899492 | -
First Author: Sato T
Year: 2006
Journal: Glycobiology
Title: Molecular cloning and characterization of a novel human beta1,3-glucosyltransferase, which is localized at the endoplasmic reticulum and glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domain.
Volume: 16
Issue: 12
Pages: 1194-206
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Protein
Q08EF2
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: false
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Publication
10899003 | -
First Author: Munro S
Year: 2000
Journal: Curr Biol
Title: The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD.
Volume: 10
Issue: 14
Pages: 813-20
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Publication
11673471 | -
First Author: Ju T
Year: 2002
Journal: J Biol Chem
Title: Purification, characterization, and subunit structure of rat core 1 Beta1,3-galactosyltransferase.
Volume: 277
Issue: 1
Pages: 169-77
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Protein Domain
IPR003378 | Fringe-like
Type: Family
Description: The Notch receptor is a large, cell surface transmembrane protein involved in a wide variety of developmental processes in higher organisms []. It becomes activated when its extracellular region binds to ligands located on adjacent cells. Much of this extracellular region is composed of EGF-like repeats, many of which can be O-fucosylated. A number of these O-fucosylated repeats can in turn be further modified by the action of a beta-1,3-N-acetylglucosaminyltransferase enzyme known as Fringe []. Fringe potentiates the activation of Notch by Delta ligands, while inhibiting activation by Serrate/Jagged ligands. This regulation of Notch signalling by Fringe is important in many processes [].Four distinct Fringe proteins have so far been studied in detail; Drosophila Fringe (Dfng) and its three mammalian homologues Lunatic Fringe (Lfng), Radical Fringe (Rfng) and Manic Fringe (Mfng). Dfng, Lfng and Rfng have all been shown to play important roles in developmental processes within their host, though the phenotype of mutants can vary between species e.g. Rfng mutants are retarded in wing development in chickens, but have no obvious phenotype in mice [, , ]. Mfng mutants have not, so far, been charcterised. Biochemical studies indicate that the Fringe proteins are fucose-specific transferases requiring manganese for activity and utilising UDP-N-acetylglucosamine as a donor substrate []. The three mammalian proteins show distinct variations in their catalytic efficiencies with different substrates.Dfng is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands which is localised to the Golgi apparatus [](not secreted as previously thought). Modification of Notch occurs through glycosylation by Dfng. This entry consists of Fringe proteins and related glycosyltransferase enzymes including:Beta-1,3-glucosyltransferase, which glucosylates O-linked fucosylglycan on thrombospondin type 1 repeat domains [].Core 1 beta1,3-galactosyltransferase 1, generates the core T antigen, which is a precursor for many extended O-glycans in glycoproteins and plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development [].
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Publication
37329502 | J:338825
     
First Author: LoPilato RK
Year: 2023
Journal: Glycobiology
Title: Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis.
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Protein
Q9JJ06
Organism: Mus musculus/domesticus
Length: 363  
Fragment?: false
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Protein
Q8BHT6
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Publication
10221902 | -
First Author: Artavanis-Tsakonas S
Year: 1999
Journal: Science
Title: Notch signaling: cell fate control and signal integration in development.
Volume: 284
Issue: 5415
Pages: 770-6
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Publication
- | J:100256
     
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data
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