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Search results 301 to 400 out of 419 for Rhob

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q80TH2
Organism: Mus musculus/domesticus
Length: 1402  
Fragment?: false
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Protein
Q80U35
Organism: Mus musculus/domesticus
Length: 2057  
Fragment?: false
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Protein
A2AWP8
Organism: Mus musculus/domesticus
Length: 1280  
Fragment?: false
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Protein
O08917
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
E9Q394
Organism: Mus musculus/domesticus
Length: 2776  
Fragment?: false
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Protein
Q60875
Organism: Mus musculus/domesticus
Length: 985  
Fragment?: false
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Protein
O08808
Organism: Mus musculus/domesticus
Length: 1255  
Fragment?: false
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Protein
Q9Z207
Organism: Mus musculus/domesticus
Length: 1171  
Fragment?: false
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Protein
Q9Z206
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Protein
Q61210
Organism: Mus musculus/domesticus
Length: 920  
Fragment?: false
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Protein
Q99J31
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Protein
Q8C033
Organism: Mus musculus/domesticus
Length: 1345  
Fragment?: false
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Protein
Q60634
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
Q07139
Organism: Mus musculus/domesticus
Length: 913  
Fragment?: false
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Protein
Q8BPM0
Organism: Mus musculus/domesticus
Length: 1077  
Fragment?: false
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Protein
P70268
Organism: Mus musculus/domesticus
Length: 946  
Fragment?: false
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Protein
Q8R2Y2
Organism: Mus musculus/domesticus
Length: 648  
Fragment?: false
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Protein
Q5FWK3
Organism: Mus musculus/domesticus
Length: 439  
Fragment?: false
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Protein
P97393
Organism: Mus musculus/domesticus
Length: 1501  
Fragment?: false
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Protein
Q6ZQ82
Organism: Mus musculus/domesticus
Length: 814  
Fragment?: false
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Protein
Q6DFV3
Organism: Mus musculus/domesticus
Length: 1944  
Fragment?: false
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Protein
Q811P8
Organism: Mus musculus/domesticus
Length: 2089  
Fragment?: false
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Protein
P59281
Organism: Mus musculus/domesticus
Length: 1107  
Fragment?: false
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Protein
Q9Z0U1
Organism: Mus musculus/domesticus
Length: 1167  
Fragment?: false
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Protein
P54116
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: false
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Protein Coding Gene
MGI:1277173 | Arhgef25
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107771 | Abr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2145425 | Depdc1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1349423 | Racgap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98822 | Tfrc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109356 | Snap23
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3040696 | Prex1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2441869 | Arhgef11
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2159344 | Vangl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109211 | Pkn2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858952 | Arhgef5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103263 | Mcf2l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106624 | Myo9b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916882 | Arhgef12
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96932 | Mcf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80Z96
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
Q5SSL4
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
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Protein
E9Q7D5
Organism: Mus musculus/domesticus
Length: 1581  
Fragment?: false
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Protein
Q8R4H2
Organism: Mus musculus/domesticus
Length: 1543  
Fragment?: false
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Protein
Q9WVM1
Organism: Mus musculus/domesticus
Length: 628  
Fragment?: false
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Protein
Q9CWR0
Organism: Mus musculus/domesticus
Length: 618  
Fragment?: false
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Protein
Q64096
Organism: Mus musculus/domesticus
Length: 1149  
Fragment?: false
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Protein
Q8BH88
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q8BWW9
Organism: Mus musculus/domesticus
Length: 983  
Fragment?: false
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Protein
Q69ZK0
Organism: Mus musculus/domesticus
Length: 1650  
Fragment?: false
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Protein
Q62351
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
O09044
Organism: Mus musculus/domesticus
Length: 210  
Fragment?: false
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Protein
Q9QY06
Organism: Mus musculus/domesticus
Length: 2114  
Fragment?: false
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Protein
Q8BLE2
Organism: Mus musculus/domesticus
Length: 1031  
Fragment?: false
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Protein
Q68FM7
Organism: Mus musculus/domesticus
Length: 1552  
Fragment?: false
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Protein
Q60992
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein Domain
IPR035732 | VAV2_SH3_2
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the second SH3 domain of VAV2.
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Protein Domain
IPR035733 | VAV2_SH3_1
Type: Domain
Description: VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42 []. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others [, , , , ]. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The SH3 domain of VAV is involved in the localization of proteins to specific sites within the cell, by interacting with proline-rich sequences within target proteins [, , ].This entry represents the first SH3 domain of VAV2.
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Publication
22204307 | -
 
First Author: Krause-Gruszczynska M
Year: 2011
Journal: Cell Commun Signal
Title: The signaling pathway of Campylobacter jejuni-induced Cdc42 activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange factor Vav2.
Volume: 9
Pages: 32
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Publication
20298788 | -
First Author: Moon MS
Year: 2010
Journal: Mol Cell Neurosci
Title: Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.
Volume: 44
Issue: 2
Pages: 118-28
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Publication
20140013 | -
First Author: Thalappilly S
Year: 2010
Journal: Oncogene
Title: VAV2 regulates epidermal growth factor receptor endocytosis and degradation.
Volume: 29
Issue: 17
Pages: 2528-39
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Publication
20038798 | J:156698
First Author: Sauzeau V
Year: 2010
Journal: J Clin Invest
Title: The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.
Volume: 120
Issue: 1
Pages: 315-30
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Publication
19451809 | -
First Author: Holthusen K
Year: 2009
Journal: Am J Ther
Title: Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease.
Volume: 16
Issue: 6
Pages: 496-507
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Publication
18434624 | -
First Author: Arora PD
Year: 2008
Journal: Am J Physiol Cell Physiol
Title: Collagen phagocytosis is regulated by the guanine nucleotide exchange factor Vav2.
Volume: 295
Issue: 1
Pages: C130-7
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Protein Coding Gene
MGI:96650 | Jup
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107926 | Rock2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107927 | Rock1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1321389 | Vamp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929494 | Arhgap35
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P63024
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: false
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Protein
Q02257
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
P70336
Organism: Mus musculus/domesticus
Length: 1388  
Fragment?: false
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Protein
P70335
Organism: Mus musculus/domesticus
Length: 1354  
Fragment?: false
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Protein
Q91YM2
Organism: Mus musculus/domesticus
Length: 1499  
Fragment?: false
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Publication
12221096 | -
First Author: Arthur WT
Year: 2002
Journal: J Biol Chem
Title: XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.
Volume: 277
Issue: 45
Pages: 42964-72
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Protein Domain
IPR044129 | PH_RhoGEF3_XPLN
Type: Domain
Description: PH domains have diverse functions, but in general are involved in targeting proteins to the appropriate cellular location or in the interaction with a binding partner []. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. Less than 10% of PH domains bind phosphoinositide phosphates (PIPs) with high affinity and specificity []. PH domains are distinguished from other PIP-binding domains by their specific high-affinity binding to PIPs with two vicinal phosphate groups: PtdIns(3,4)P2, PtdIns(4,5)P2 or PtdIns(3,4,5)P3 which results in targeting some PH domain proteins to the plasma membrane []. A few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes [].ARHGEF3 (also known as XPLN) is a guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases []. It contains a tandem Dbl homology and a PH domain. This entry represents the PH domain.
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Protein Coding Gene
MGI:102718 | Vav2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102709 | Cav1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P49817
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Publication
19713215 | J:157812
First Author: Wang Z
Year: 2009
Journal: J Biol Chem
Title: Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5.
Volume: 284
Issue: 42
Pages: 28599-606
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Publication
8094051 | J:25192
First Author: Albright CF
Year: 1993
Journal: EMBO J
Title: Characterization of a guanine nucleotide dissociation stimulator for a ras-related GTPase.
Volume: 12
Issue: 1
Pages: 339-47
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Publication
11684651 | J:72300
First Author: Dottori M
Year: 2001
Journal: Development
Title: The winged-helix transcription factor Foxd3 suppresses interneuron differentiation and promotes neural crest cell fate.
Volume: 128
Issue: 21
Pages: 4127-38
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Publication
22371328 | J:198097
First Author: Parikh VN
Year: 2012
Journal: Circulation
Title: MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach.
Volume: 125
Issue: 12
Pages: 1520-32
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Publication
31931138 | J:303478
 
First Author: Stankiewicz TR
Year: 2020
Journal: Neurobiol Dis
Title: Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis.
Volume: 136
Pages: 104743
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Publication
21209320 | J:182206
First Author: Jackson B
Year: 2011
Journal: Mol Biol Cell
Title: RhoA is dispensable for skin development, but crucial for contraction and directed migration of keratinocytes.
Volume: 22
Issue: 5
Pages: 593-605
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Publication
15767687 | J:97638
First Author: Behrends J
Year: 2005
Journal: Mol Cell Biol
Title: Normal thyroid structure and function in rhophilin 2-deficient mice.
Volume: 25
Issue: 7
Pages: 2846-52
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Publication
21454503 | J:172252
First Author: Melendez J
Year: 2011
Journal: J Biol Chem
Title: RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts.
Volume: 286
Issue: 17
Pages: 15132-7
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Publication
32619581 | J:331654
 
First Author: Reichova A
Year: 2020
Journal: Mol Cell Endocrinol
Title: Abnormal neuronal morphology and altered synaptic proteins are restored by oxytocin in autism-related SHANK3 deficient model.
Volume: 518
Pages: 110924
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Publication
1594588 | J:1136
First Author: Krzyzosiak WJ
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Isolation of genes specifically expressed in flat revertant cells derived from activated ras-transformed NIH 3T3 cells by treatment with azatyrosine.
Volume: 89
Issue: 11
Pages: 4879-83
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Publication
8416955 | J:36104
First Author: Miura Y
Year: 1993
Journal: J Biol Chem
Title: Regulation of morphology by rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in Swiss 3T3 cells.
Volume: 268
Issue: 1
Pages: 510-5
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Publication
9444953 | J:45452
First Author: del Peso L
Year: 1997
Journal: Oncogene
Title: Rho proteins induce metastatic properties in vivo.
Volume: 15
Issue: 25
Pages: 3047-57
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Publication
28923399 | J:248766
 
First Author: Huang GX
Year: 2017
Journal: Cancer Lett
Title: Up-regulation of Rho-associated kinase 1/2 by glucocorticoids promotes migration, invasion and metastasis of melanoma.
Volume: 410
Pages: 1-11
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Publication
28941704 | J:257616
 
First Author: Du J
Year: 2017
Journal: Int J Dev Neurosci
Title: MiR-194 is involved in morphogenesis of spiral ganglion neurons in inner ear by rearranging actin cytoskeleton via targeting RhoB.
Volume: 63
Pages: 16-26
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Publication
15569686 | J:326703
First Author: Müller FU
Year: 2005
Journal: J Biol Chem
Title: Heart-directed expression of a human cardiac isoform of cAMP-response element modulator in transgenic mice.
Volume: 280
Issue: 8
Pages: 6906-14
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Publication
9115846 | -
First Author: Romero F
Year: 1996
Journal: Cell Signal
Title: Structure and function of vav.
Volume: 8
Issue: 8
Pages: 545-53
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Publication
12789266 | J:83978
First Author: DuHadaway JB
Year: 2003
Journal: Oncogene
Title: Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1.
Volume: 22
Issue: 23
Pages: 3578-88
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Publication
23826144 | J:225052
First Author: Shi C
Year: 2013
Journal: PLoS One
Title: MicroRNA-21 knockout improve the survival rate in DSS induced fatal colitis through protecting against inflammation and tissue injury.
Volume: 8
Issue: 6
Pages: e66814
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Publication
28589100 | J:289550
 
First Author: Johnston DGW
Year: 2017
Journal: Front Cell Infect Microbiol
Title: MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection.
Volume: 7
Pages: 201
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Protein Coding Gene
MGI:1098772 | Pik3r2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O08908
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom