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Search results 301 to 400 out of 562 for Rhog

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Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein Coding Gene
MGP_FVBNJ_G0027052 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0027195 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0027069 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0027735 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0026158 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0026500 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
Protein Coding Gene
MGP_PahariEiJ_G0026475 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0025971 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
34849650 | J:331761
First Author: Zhu QM
Year: 2022
Journal: Cardiovasc Res
Title: Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
Volume: 118
Issue: 13
Pages: 2833-2846
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GXD Expression
GXD Expression
 
Probe: MGI:4426803
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822708
Age: embryonic day 14.5
Image: euxassay_016114_07
Specimen Label: euxassay_016114_07
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:4426803
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822708
Age: embryonic day 14.5
Image: euxassay_016114_08
Specimen Label: euxassay_016114_08
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:4426803
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822708
Age: embryonic day 14.5
Image: euxassay_016114_15
Specimen Label: euxassay_016114_15
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
 
Probe: MGI:4426803
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822708
Age: embryonic day 14.5
Image: euxassay_016114_16
Specimen Label: euxassay_016114_16
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:4426803
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1756623
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4822708
Age: embryonic day 14.5
Image: euxassay_016114_17
Specimen Label: euxassay_016114_17
Detected: true
Specimen Num: 5
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Protein
A2CG49
Organism: Mus musculus/domesticus
Length: 2964  
Fragment?: false
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Protein
Q8BUR4
Organism: Mus musculus/domesticus
Length: 1865  
Fragment?: false
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Protein Coding Gene
MGI:1927550 | Ykt6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2145425 | Depdc1b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109153 | Ktn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98822 | Tfrc
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2685385 | Kalrn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338069 | Itsn1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917611 | Lman1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1928483 | Stx5a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2153045 | Elmo2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:3040696 | Prex1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2159344 | Vangl1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1858952 | Arhgef5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1338801 | Cyfip1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103263 | Mcf2l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96932 | Mcf2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108117 | Emd
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105068 | Rab7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q80Z96
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
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Protein
E9Q7D5
Organism: Mus musculus/domesticus
Length: 1581  
Fragment?: false
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Protein
Q7TMB8
Organism: Mus musculus/domesticus
Length: 1253  
Fragment?: false
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Protein
P51150
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
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Protein
Q9Z0R4
Organism: Mus musculus/domesticus
Length: 1714  
Fragment?: false
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Protein
Q61595
Organism: Mus musculus/domesticus
Length: 1327  
Fragment?: false
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Protein
Q8BHL5
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
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Protein
O08579
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein
Q8BH88
Organism: Mus musculus/domesticus
Length: 529  
Fragment?: false
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Protein
Q9D0F3
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein
Q8K1E0
Organism: Mus musculus/domesticus
Length: 355  
Fragment?: false
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Protein
Q69ZK0
Organism: Mus musculus/domesticus
Length: 1650  
Fragment?: false
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Protein
Q62351
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
Q9CQW1
Organism: Mus musculus/domesticus
Length: 198  
Fragment?: false
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Protein
Q8BLE2
Organism: Mus musculus/domesticus
Length: 1031  
Fragment?: false
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Protein
Q0KL02
Organism: Mus musculus/domesticus
Length: 3102  
Fragment?: false
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Publication
20679435 | -
First Author: Hiramoto-Yamaki N
Year: 2010
Journal: J Cell Biol
Title: Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism.
Volume: 190
Issue: 3
Pages: 461-77
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Publication
25063526 | J:218482
First Author: Lee J
Year: 2014
Journal: Biochim Biophys Acta
Title: Arhgef16, a novel Elmo1 binding partner, promotes clearance of apoptotic cells via RhoG-dependent Rac1 activation.
Volume: 1843
Issue: 11
Pages: 2438-47
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Protein Domain
IPR035797 | ARHGEF16/ARHGEF26_SH3
Type: Domain
Description: ARHGEF16, also called ephexin-4, acts as a guanine nucleotide exchange factor (GEF) for RhoG, activating it by exchanging bound GDP for free GTP. RhoG is a small GTPase that is a crucial regulator of Rac in migrating cells. ARHGEF16 interacts directly with the ephrin receptor EphA2 and mediates cell migration and invasion in breast cancer cells by activating RhoG [, ]. ARHGEF26, also called SGEF (SH3 domain-containing GEF), also activates RhoG. It is highly expressed in liver and may play a role in regulating membrane dynamics []. ARHGEF16 and ARHGEF26 contain RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology(PH), and SH3 domains. The SH3 domains of ARHGEFs play an autoinhibitory role through intramolecular interactions with a proline-rich region N-terminal to the DH domain. The SH3 domain of ARHGEF16 also binds to Elmo, and this interaction may relieve the self-inhibitory state ofARHGEF16 [].This entry represents the SH3 domains of ARHGEF16 and ARHGEF26.
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Publication
26129894 | J:224385
 
First Author: Abraham S
Year: 2015
Journal: Nat Commun
Title: A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.
Volume: 6
Pages: 7286
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Protein
Q60992
Organism: Mus musculus/domesticus
Length: 868  
Fragment?: false
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Protein Coding Gene
MGI:2138281 | Lbr
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1927230 | Trio
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2157953 | Rbm39
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1321389 | Vamp3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929494 | Arhgap35
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913758 | Lamtor1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2429765 | Dock1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P63024
Organism: Mus musculus/domesticus
Length: 103  
Fragment?: false
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Protein
Q8VH51
Organism: Mus musculus/domesticus
Length: 530  
Fragment?: false
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Protein
Q3U9G9
Organism: Mus musculus/domesticus
Length: 626  
Fragment?: false
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Protein
Q9CQ22
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: false
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Protein
Q91YM2
Organism: Mus musculus/domesticus
Length: 1499  
Fragment?: false
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Protein
A2AW79
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
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Protein
Q8CBT1
Organism: Mus musculus/domesticus
Length: 362  
Fragment?: true
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Protein
F6ZJ55
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: true
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Protein
Q8CCF4
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein Domain
IPR026791 | DOCK
Type: Family
Description: DOCK family members are evolutionarily conserved guanine nucleotide exchange factors (GEFs) for Rho-family GTPases []. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. The N-terminal SH3 domain of the DOCK proteins functions as an inhibitor of GEF, which can be relieved upon its binding to the ELMO1-3 adaptor proteins, after their binding to active RhoG at the plasma membrane [, ]. DOCK family proteins are categorised into four subfamilies based on their sequence homology: DOCK-A subfamily (DOCK1/180, 2, 5), DOCK-B subfamily (DOCK3, 4), DOCK-C subfamily (DOCK6, 7, 8), DOCK-D subfamily (DOCK9, 10, 11) [].
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Protein Domain
IPR035532 | DBS_SH3
Type: Domain
Description: This entry represents the SH3 domain of DBS.DBS, also called MCF2L or OST, functions as a Rho GTPase guanine nucleotide exchange factor (RhoGEF), facilitating the exchange of GDP and GTP. It was originally isolated from a cDNA screen for sequences that cause malignant growth. It plays roles in regulating clathrin-mediated endocytosis and cell migration through its activation of Rac1 and Cdc42 [, ]. Depending on cell type, DBS can also activate RhoA and RhoG [, ]. DBS contains a Sec14-like domain [], spectrin-like repeats, a RhoGEF or Dbl homology (DH) domain, a Pleckstrin homology (PH) domain [], and an SH3 domain.
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Publication
12093789 | -
First Author: Chen Q
Year: 2002
Journal: J Cell Biol
Title: A novel mechanism for the regulation of amyloid precursor protein metabolism.
Volume: 158
Issue: 1
Pages: 79-89
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Publication
15274927 | -
First Author: Worthylake DK
Year: 2004
Journal: Structure
Title: Crystal structure of the DH/PH fragment of Dbs without bound GTPase.
Volume: 12
Issue: 6
Pages: 1078-86
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Protein
A0A571BG77
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Publication
17562712 | -
First Author: Ieguchi K
Year: 2007
Journal: J Biol Chem
Title: Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1.
Volume: 282
Issue: 32
Pages: 23296-305
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Protein
F7CVM6
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: true
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Protein
Q91YL4
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
A0A1D5RLB8
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: true
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Protein
Q3T9E0
Organism: Mus musculus/domesticus
Length: 106  
Fragment?: false
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Protein
Q3TQD2
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Publication
19366686 | -
First Author: Liu Z
Year: 2009
Journal: J Biol Chem
Title: The rho-specific guanine nucleotide exchange factor Dbs regulates breast cancer cell migration.
Volume: 284
Issue: 23
Pages: 15771-80
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Publication
15531584 | -
First Author: Kostenko EV
Year: 2005
Journal: J Biol Chem
Title: The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.
Volume: 280
Issue: 4
Pages: 2807-17
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Publication
14991610 | J:88383
First Author: Klinger MB
Year: 2004
Journal: Eur J Immunol
Title: The RhoA- and CDC42-specific exchange factor Dbs promotes expansion of immature thymocytes and deletion of double-positive and single-positive thymocytes.
Volume: 34
Issue: 3
Pages: 806-816
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Publication
25644601 | -
First Author: Yu JR
Year: 2015
Journal: Genes Dev
Title: TGF-β/Smad signaling through DOCK4 facilitates lung adenocarcinoma metastasis.
Volume: 29
Issue: 3
Pages: 250-61
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Publication
21788407 | J:177602
First Author: Schnoor M
Year: 2011
Journal: J Exp Med
Title: Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo.
Volume: 208
Issue: 8
Pages: 1721-35
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Publication
30787021 | J:295168
First Author: Patel A
Year: 2019
Journal: Blood Adv
Title: ELMO1 deficiency enhances platelet function.
Volume: 3
Issue: 4
Pages: 575-587
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Publication
36531963 | J:351058
 
First Author: Schäfer I
Year: 2022
Journal: Front Cell Dev Biol
Title: The guanine nucleotide exchange factor Vav3 intervenes in the migration pathway of oligodendrocyte precursor cells on tenascin-C.
Volume: 10
Pages: 1042403
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Publication
16377631 | J:109660
First Author: Grimsley CM
Year: 2006
Journal: J Biol Chem
Title: Characterization of a novel interaction between ELMO1 and ERM proteins.
Volume: 281
Issue: 9
Pages: 5928-37
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Publication
25748676 | J:220695
First Author: Goggs R
Year: 2015
Journal: Biochem J
Title: Platelet Rho GTPases-a focus on novel players, roles and relationships.
Volume: 466
Issue: 3
Pages: 431-42
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Publication
26234352 | J:312153
First Author: Nakaya M
Year: 2015
Journal: Yakugaku Zasshi
Title: [Research on Molecular Mechanisms of Engulfment of Apoptotic Cells].
Volume: 135
Issue: 8
Pages: 949-54
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Publication
15723800 | -
First Author: Lu M
Year: 2005
Journal: Curr Biol
Title: A Steric-inhibition model for regulation of nucleotide exchange via the Dock180 family of GEFs.
Volume: 15
Issue: 4
Pages: 371-7
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Publication
25022758 | -
First Author: Gadea G
Year: 2014
Journal: Eur J Cell Biol
Title: Dock-family exchange factors in cell migration and disease.
Volume: 93
Issue: 10-12
Pages: 466-77
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Protein Coding Gene
MGI:1339984 | Pak2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102718 | Vav2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1888518 | Vav3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:102709 | Cav1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8CIN4
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
P49817
Organism: Mus musculus/domesticus
Length: 178  
Fragment?: false
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Protein
Q9R0C8
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom