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Search results 301 to 400 out of 431 for Rictor

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Type Details Score
Publication
26633882 | J:269511
   
First Author: Roy A
Year: 2015
Journal: Elife
Title: Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy.
Volume: 4
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Publication
28069738 | J:244710
 
First Author: Yamauchi T
Year: 2017
Journal: Mol Cell Biol
Title: FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Volume: 37
Issue: 8
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Publication
23637172 | J:197151
First Author: Cloëtta D
Year: 2013
Journal: J Neurosci
Title: Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis.
Volume: 33
Issue: 18
Pages: 7799-810
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Publication
22056141 | J:177840
First Author: Magri L
Year: 2011
Journal: Cell Stem Cell
Title: Sustained activation of mTOR pathway in embryonic neural stem cells leads to development of tuberous sclerosis complex-associated lesions.
Volume: 9
Issue: 5
Pages: 447-62
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Publication
27807348 | J:242729
 
First Author: Ding X
Year: 2016
Journal: Nat Commun
Title: mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.
Volume: 7
Pages: 13226
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Publication
32866472 | J:297164
First Author: Nie X
Year: 2020
Journal: Dev Biol
Title: mTOR plays a pivotal role in multiple processes of enamel organ development principally through the mTORC1 pathway and in part via regulating cytoskeleton dynamics.
Volume: 467
Issue: 1-2
Pages: 77-87
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Publication
34193412 | J:314221
 
First Author: Wang Q
Year: 2021
Journal: Sci Adv
Title: Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.
Volume: 7
Issue: 27
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Publication
23342106 | J:195854
First Author: Zhu Y
Year: 2013
Journal: PLoS One
Title: Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth.
Volume: 8
Issue: 1
Pages: e54221
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Publication
28576773 | J:242899
First Author: Sinagoga KL
Year: 2017
Journal: Development
Title: Distinct roles for the mTOR pathway in postnatal morphogenesis, maturation and function of pancreatic islets.
Volume: 144
Issue: 13
Pages: 2402-2414
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
36438564 | J:348724
 
First Author: Li H
Year: 2022
Journal: Front Cell Dev Biol
Title: Rictor maintains endothelial integrity under shear stress.
Volume: 10
Pages: 963866
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Publication
22777355 | -
First Author: Agarwal NK
Year: 2013
Journal: Oncogene
Title: Rictor regulates cell migration by suppressing RhoGDI2.
Volume: 32
Issue: 20
Pages: 2521-6
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Publication
29955840 | J:266028
     
First Author: Gkountakos A
Year: 2018
Journal: Carcinogenesis
Title: Unmasking the impact of Rictor in cancer: novel insights of mTORC2 complex.
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HT Experiment
E-GEOD-67077 | Deletion of Rictor in brain and fat alters peripheral clock gene expression and increases blood pressure
Series Id: GSE67077
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22285861 | J:181254
First Author: Guo Z
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.
Volume: 418
Issue: 2
Pages: 426-32
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HT Experiment
E-GEOD-46515 | Expression data from mouse model using targeted deletion of hepatic RICTOR (Albumin-Cre Rictor LoxP/LoxP)
Series Id: GSE46515
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
31595162 | J:319589
First Author: Liu Z
Year: 2019
Journal: Int J Biol Sci
Title: Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation.
Volume: 15
Issue: 11
Pages: 2448-2460
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Allele
Rictor<em2Smoc> | MGI:7292055
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6771118 | C57BL/6JSmoc-Rictor<em2Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Rictor<em1Smoc> | MGI:7292054
Name: RPTOR independent companion of MTOR, complex 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Rictor<Gt(RRR347)Byg> | MGI:3775093
Name: RPTOR independent companion of MTOR, complex 2; gene trap RRR347, BayGenomics
Allele Type: Gene trapped
Attribute String: Null/knockout, Reporter
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Protein Domain
IPR028267 | Pianissimo_N
Type: Domain
Description: The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].This domain is the N-terminal conserved section that may include several individual domains.
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Protein Domain
IPR029451 | RICTOR_M
Type: Domain
Description: This domain is found in the more conserved central section of Rictor (rapamycin-insensitive companion of mTOR) that may include several individual domains. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR029452 | RICTOR_V
Type: Domain
Description: This entry represent the conserved domain 5 of the Rictor (Rapamycin-insensitive companion of mTOR) protein. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Protein Domain
IPR029453 | Rictor_IV
Type: Domain
Description: This entry represents the domain 4 of the Rictor (rapamycin-insensitive companion of mTOR) protein. It is found in the more conserved central section that may include several individual domainsThe mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. Rictor (rapamycin-insensitive companion of mTOR) is a component of mTORC2 []. There is a regulatory link between the two mTOR complexes, whereby Rictor phosphorylation by mTORC1 regulates mTORC2 signalling []. Over-expression of Rictor increases mTORC2 activity and promotes cell growth and motility [].
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Publication
18089801 | -
First Author: Masri J
Year: 2007
Journal: Cancer Res
Title: mTORC2 activity is elevated in gliomas and promotes growth and cell motility via overexpression of rictor.
Volume: 67
Issue: 24
Pages: 11712-20
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GO Term
GO:0038203 | TORC2 signaling
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Publication
20418915 | -
First Author: Sparks CA
Year: 2010
Journal: Oncogene
Title: Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy.
Volume: 29
Issue: 26
Pages: 3733-44
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Protein Domain
IPR029259 | RICTOR_phospho
Type: PTM
Description: The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTORC1 and mTORC2, important for nutrient- and growth-factor signalling []. Rictor (rapamycin-insensitive companion of mTOR) is an essential component of the complex mTORC2 []. It appears to serve as a scaffolding protein important for maintaining mTORC2 integrity. Rictor interacts with 14-3-3 in a Thr1135-dependent manner []. Rictor can be inhibited by short-term rapamycin treatment, showing that Thr1135 is an mTORC1-regulated site [].This short region is the phoshorylation site of Rictor.
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Strain
MGI:6476181 | C57BL/6JSmoc-Rictor<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rictor/Rictor
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rictor/Rictor<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Protein
Q8R5D5
Organism: Mus musculus/domesticus
Length: 796  
Fragment?: true
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Protein
Q6QI06
Organism: Mus musculus/domesticus
Length: 1708  
Fragment?: false
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Protein
Q0VAV3
Organism: Mus musculus/domesticus
Length: 1157  
Fragment?: false
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Publication
16079174 | -
First Author: Lee S
Year: 2005
Journal: Mol Biol Cell
Title: TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.
Volume: 16
Issue: 10
Pages: 4572-83
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Publication
15809876 | -
First Author: Ho HL
Year: 2005
Journal: Curr Genet
Title: Saccharomyces cerevisiaeTSC11/AVO3 participates in regulating cell integrity and functionally interacts with components of the Tor2 complex.
Volume: 47
Issue: 5
Pages: 273-88
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Publication
17261596 | -
First Author: Matsuo T
Year: 2007
Journal: Mol Cell Biol
Title: Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
Volume: 27
Issue: 8
Pages: 3154-64
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Protein Domain
IPR028268 | Pianissimo_fam
Type: Family
Description: Protein pianissimo (PiaA) is a component of the target of rapamycin complex 2 (TORC2) in Dictyostelium []. This complex regulates cell growth, chemotaxis, signal relay and the actin cytoskeleton. Homologues of PiaA are found in Saccharomyces cerevisiae (TSC11/AVO3) [], Schizosaccaromyces pombe (Ste20) [], and vertebrates, where it is also known as Rictor (rapamycin-insensitive companion of mTOR) [, ].Rictor, together with Sin1, is believed to function as an adaptor protein controlling the mTORC2 substrate binding and specificity. Rictor is known to have a role in cytoskeleton regulation and cell migration [, ]. It is likely that rictor regulates cell morphology and migration by playing a role as the indispensable component of mTORC2 and also by carrying mTORC2-independent functions.
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Protein
Q8CB99
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
Q8C2V9
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Protein
Q9D2K3
Organism: Mus musculus/domesticus
Length: 255  
Fragment?: false
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GO Term
GO:0031932 | TORC2 complex
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Genotype
Genotype
Symbol: Pten/Pten<+> Rictor/Rictor<+>
Background: involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Protein Coding Gene
MGI:1922675 | Tti1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924714 | Prr5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919696 | Prr5l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922997 | Sesn3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
33378666 | J:306498
First Author: Wrobel L
Year: 2020
Journal: Cell Rep
Title: mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR.
Volume: 33
Issue: 13
Pages: 108564
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Publication
24078700 | J:206233
First Author: Perkey E
Year: 2013
Journal: J Immunol
Title: Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function.
Volume: 191
Issue: 9
Pages: 4648-55
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Publication
38016952 | J:360598
First Author: Ji Y
Year: 2023
Journal: Nat Commun
Title: The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer.
Volume: 14
Issue: 1
Pages: 7794
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Publication
37649699 | J:357682
First Author: Zhao Y
Year: 2023
Journal: iScience
Title: mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway.
Volume: 26
Issue: 9
Pages: 107540
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Publication
20876733 | J:164880
First Author: Lee DY
Year: 2010
Journal: Genes Dev
Title: Neurofibromatosis-1 regulates neuroglial progenitor proliferation and glial differentiation in a brain region-specific manner.
Volume: 24
Issue: 20
Pages: 2317-29
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Publication
25388284 | J:218209
First Author: Phung TL
Year: 2015
Journal: Cancer Res
Title: Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth.
Volume: 75
Issue: 1
Pages: 40-50
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Publication
35601917 | J:325003
First Author: Serna R
Year: 2022
Journal: iScience
Title: c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity.
Volume: 25
Issue: 6
Pages: 104325
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Publication
33766857 | J:306989
 
First Author: Liu M
Year: 2021
Journal: Science
Title: WAVE2 suppresses mTOR activation to maintain T cell homeostasis and prevent autoimmunity.
Volume: 371
Issue: 6536
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Publication
27758884 | J:238010
First Author: Driscoll DR
Year: 2016
Journal: Cancer Res
Title: mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer.
Volume: 76
Issue: 23
Pages: 6911-6923
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Publication
32707034 | J:305278
First Author: Kim D
Year: 2020
Journal: Immunity
Title: Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism.
Volume: 53
Issue: 3
Pages: 581-596.e5
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Publication
24036451 | J:201730
First Author: Kamano Y
Year: 2013
Journal: FEBS Lett
Title: PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription.
Volume: 587
Issue: 20
Pages: 3303-8
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Publication
23792225 | J:204216
First Author: Sun SY
Year: 2013
Journal: Cancer Lett
Title: mTOR kinase inhibitors as potential cancer therapeutic drugs.
Volume: 340
Issue: 1
Pages: 1-8
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Publication
30733433 | J:270456
First Author: Körner A
Year: 2019
Journal: Nat Commun
Title: Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A.
Volume: 10
Issue: 1
Pages: 633
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Publication
35869262 | J:327347
First Author: Wang Y
Year: 2022
Journal: Commun Biol
Title: mTOR contributes to endothelium-dependent vasorelaxation by promoting eNOS expression and preventing eNOS uncoupling.
Volume: 5
Issue: 1
Pages: 726
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Publication
36220823 | J:329956
First Author: Wan S
Year: 2022
Journal: Cell Death Dis
Title: mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation.
Volume: 13
Issue: 10
Pages: 862
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Protein Coding Gene
MGI:1929514 | Mlst8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444554 | Mapkap1
Type: protein_coding_gene
Organism: mouse, laboratory
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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