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Search results 301 to 368 out of 368 for Rock1

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Type Details Score
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Rock1<tm1.1Bicrq> | MGI:6696418
 
Name: Rho-associated coiled-coil containing protein kinase 1; targeted mutation 1.1, Cancer Research UK Beatson Institute
Allele Type: Targeted
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UniProt Feature
UniProt Feature
Begin: 265
Description: Phosphothreonine; by ROCK1
Type: modified residue
End: 265
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UniProt Feature
UniProt Feature
Begin: 315
Description: Phosphoserine; by ROCK1
Type: modified residue
End: 315
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UniProt Feature
UniProt Feature
Begin: 365
Description: Phosphoserine; by ROCK1
Type: modified residue
End: 365
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UniProt Feature
UniProt Feature
Begin: 508
Description: Phosphothreonine; by ROCK1
Type: modified residue
End: 508
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UniProt Feature
UniProt Feature
Begin: 138
Description: Phosphoserine; by ROCK1
Type: modified residue
End: 138
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UniProt Feature
UniProt Feature
Begin: 76
Description: Phosphothreonine; by ROCK1
Type: modified residue
End: 76
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UniProt Feature
UniProt Feature
Begin: 77
Description: Phosphothreonine; by ROCK1
Type: modified residue
End: 77
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UniProt Feature
UniProt Feature
Begin: 383
Description: Phosphothreonine; by ROCK1
Type: modified residue
End: 383
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UniProt Feature
UniProt Feature
Begin: 382
Description: Phosphothreonine; by ROCK1
Type: modified residue
End: 382
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UniProt Feature
UniProt Feature
Begin: 380
Description: Phosphoserine; by ROCK1
Type: modified residue
End: 380
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Publication
24803490 | J:213741
First Author: Zhang JY
Year: 2014
Journal: Reproduction
Title: Distinct roles of ROCK1 and ROCK2 during development of porcine preimplantation embryos.
Volume: 148
Issue: 1
Pages: 99-107
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UniProt Feature
UniProt Feature
Begin: 12
Description: Phosphoserine; by AURKB and ROCK1
Type: modified residue
End: 12
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UniProt Feature
UniProt Feature
Begin: 35
Description: Phosphoserine; by AURKB and ROCK1
Type: modified residue
End: 35
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UniProt Feature
UniProt Feature
Begin: 7
Description: Phosphothreonine; by AURKB and ROCK1
Type: modified residue
End: 7
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UniProt Feature
UniProt Feature
Begin: 17
Description: Phosphothreonine; by AURKB and ROCK1
Type: modified residue
End: 17
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UniProt Feature
UniProt Feature
Begin: 505
Description: Phosphothreonine; by ROCK1 and CDC42BP
Type: modified residue
End: 505
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UniProt Feature
UniProt Feature
Begin: 153
Description: Phosphoserine; by PKA, PKC, PKG/PRKG1 and ROCK1
Type: modified residue
End: 153
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Publication
19036714 | -
First Author: Ongusaha PP
Year: 2008
Journal: Sci Signal
Title: Identification of ROCK1 as an upstream activator of the JIP-3 to JNK signaling axis in response to UVB damage.
Volume: 1
Issue: 47
Pages: ra14
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Protein Domain
IPR037310 | ROCK1_HR1
Type: Domain
Description: Rho-associated protein kinases (ROCKs) were originally identified as small GTPase Rho effectors. Later, ROCKs were found actively phosphorylating many actin-binding proteins and intermediate filament proteins to modulate their functions []. Two ROCK isoforms have been identified:ROCK1 (ROKb, p160ROCK) and ROCK2. As major downstream effectors of the small GTPase RhoA, they regulate cellular contraction, motility, morphology, polarity, cell division, and gene expression [, , ].This entry represents the HR1 domain found in Rho-associated protein kinase 1 (ROCK1), which is essential for the formation of stress fibres []. ROCK1 contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a Rho-binding HR1 domain and a pleckstrin homology (PH) domain. ROCK1 is auto-inhibited by HR1 and PH domains interacting with the catalytic domain. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family [].
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Publication
23601011 | -
First Author: Schofield AV
Year: 2013
Journal: Crit Rev Biochem Mol Biol
Title: Rho-associated coiled-coil kinase (ROCK) signaling and disease.
Volume: 48
Issue: 4
Pages: 301-16
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Publication
19907920 | -
First Author: Hahmann C
Year: 2010
Journal: Cell Mol Life Sci
Title: Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity.
Volume: 67
Issue: 2
Pages: 171-7
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Publication
23950574 | -
First Author: Amin E
Year: 2013
Journal: Biol Chem
Title: Rho-kinase: regulation, (dys)function, and inhibition.
Volume: 394
Issue: 11
Pages: 1399-410
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Publication
20803696 | -
First Author: Amano M
Year: 2010
Journal: Cytoskeleton (Hoboken)
Title: Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity.
Volume: 67
Issue: 9
Pages: 545-54
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Publication
16043513 | -
First Author: Yoneda A
Year: 2005
Journal: J Cell Biol
Title: The Rho kinases I and II regulate different aspects of myosin II activity.
Volume: 170
Issue: 3
Pages: 443-53
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HT Experiment
GSE102026 | mTORC1 Loss Impairs Epidermal Adhesion via Rho Kinase Activation
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
37216099 | J:338922
First Author: Reilly L
Year: 2023
Journal: iScience
Title: Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.
Volume: 26
Issue: 5
Pages: 106623
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Publication
28739902 | J:244650
First Author: Dyberg C
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Rho-associated kinase is a therapeutic target in neuroblastoma.
Volume: 114
Issue: 32
Pages: E6603-E6612
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Publication
38711089 | J:348951
First Author: Li Y
Year: 2024
Journal: Cell Commun Signal
Title: Aberrant activation of TGF-β/ROCK1 enhances stemness during prostatic stromal hyperplasia.
Volume: 22
Issue: 1
Pages: 257
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Publication
29496740 | J:261168
 
First Author: Zhong Z
Year: 2018
Journal: EMBO J
Title: Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells.
Volume: 37
Issue: 6
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Publication
25007875 | J:214236
First Author: Matoba K
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Rho-kinase regulation of TNF-α-induced nuclear translocation of NF-κB RelA/p65 and M-CSF expression via p38 MAPK in mesangial cells.
Volume: 307
Issue: 5
Pages: F571-80
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Publication
23011471 | J:210071
First Author: Zhou Q
Year: 2012
Journal: Circulation
Title: Rho-associated coiled-coil-containing kinase 2 deficiency in bone marrow-derived cells leads to increased cholesterol efflux and decreased atherosclerosis.
Volume: 126
Issue: 18
Pages: 2236-47
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Publication
22903063 | J:189922
First Author: Lallemend F
Year: 2012
Journal: EMBO J
Title: Positional differences of axon growth rates between sensory neurons encoded by Runx3.
Volume: 31
Issue: 18
Pages: 3718-29
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Publication
22846914 | J:191321
First Author: Patel RA
Year: 2012
Journal: Cancer Res
Title: RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Volume: 72
Issue: 19
Pages: 5025-34
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Publication
28031255 | J:240629
First Author: Rath N
Year: 2017
Journal: EMBO Mol Med
Title: ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth.
Volume: 9
Issue: 2
Pages: 198-218
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Publication
27775859 | J:237624
First Author: Samuel MS
Year: 2016
Journal: Genesis
Title: Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.
Volume: 54
Issue: 12
Pages: 636-646
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Publication
16751189 | J:116473
First Author: Qin W
Year: 2006
Journal: J Biol Chem
Title: Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction.
Volume: 281
Issue: 31
Pages: 21745-54
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Publication
25910808 | J:224630
First Author: Soliman H
Year: 2015
Journal: Am J Physiol Heart Circ Physiol
Title: Partial deletion of ROCK2 protects mice from high-fat diet-induced cardiac insulin resistance and contractile dysfunction.
Volume: 309
Issue: 1
Pages: H70-81
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Publication
24135024 | J:222206
First Author: Shimizu T
Year: 2013
Journal: Arterioscler Thromb Vasc Biol
Title: Crucial role of ROCK2 in vascular smooth muscle cells for hypoxia-induced pulmonary hypertension in mice.
Volume: 33
Issue: 12
Pages: 2780-91
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Publication
28945203 | J:255466
First Author: Asrani K
Year: 2017
Journal: J Clin Invest
Title: mTORC1 loss impairs epidermal adhesion via TGF-β/Rho kinase activation.
Volume: 127
Issue: 11
Pages: 4001-4017
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Publication
30234377 | J:272261
First Author: Yin J
Year: 2019
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Connexin 40 regulates lung endothelial permeability in acute lung injury via the ROCK1-MYPT1- MLC20 pathway.
Volume: 316
Issue: 1
Pages: L35-L44
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Publication
31239325 | J:330072
 
First Author: Henderson BW
Year: 2019
Journal: Sci Signal
Title: Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid.
Volume: 12
Issue: 587
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Publication
20627935 | J:169345
First Author: Reiniger N
Year: 2010
Journal: Diabetes
Title: Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse.
Volume: 59
Issue: 8
Pages: 2043-54
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Publication
24305806 | J:255339
First Author: Herskowitz JH
Year: 2013
Journal: J Neurosci
Title: Pharmacologic inhibition of ROCK2 suppresses amyloid-β production in an Alzheimer's disease mouse model.
Volume: 33
Issue: 49
Pages: 19086-98
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Publication
36755029 | J:340161
First Author: Kang S
Year: 2023
Journal: Nat Commun
Title: TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity.
Volume: 14
Issue: 1
Pages: 700
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Publication
19564418 | J:152614
First Author: Shu L
Year: 2009
Journal: Mol Cell Biol
Title: The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts.
Volume: 29
Issue: 17
Pages: 4691-700
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Publication
25858457 | J:221425
First Author: Cao Z
Year: 2015
Journal: Development
Title: Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage.
Volume: 142
Issue: 9
Pages: 1606-15
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Publication
25908861 | J:232660
First Author: Hyder CL
Year: 2015
Journal: J Cell Sci
Title: Sphingolipids inhibit vimentin-dependent cell migration.
Volume: 128
Issue: 11
Pages: 2057-69
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Publication
26519207 | J:233203
First Author: Lambert JA
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Ozone-induced airway hyperresponsiveness: roles of ROCK isoforms.
Volume: 309
Issue: 12
Pages: L1394-7
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Publication
29382705 | J:260723
First Author: Unbekandt M
Year: 2018
Journal: Cancer Res
Title: Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer.
Volume: 78
Issue: 8
Pages: 2096-2114
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Publication
31295018 | J:291210
First Author: Wei S
Year: 2019
Journal: FASEB J
Title: RIP3 deficiency alleviates liver fibrosis by inhibiting ROCK1-TLR4-NF-κB pathway in macrophages.
Volume: 33
Issue: 10
Pages: 11180-11193
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Publication
30902967 | J:291445
First Author: Wang YC
Year: 2019
Journal: Exp Mol Med
Title: Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway.
Volume: 51
Issue: 3
Pages: 1-11
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Publication
31446620 | J:314678
First Author: McKerracher L
Year: 2020
Journal: Transl Stroke Res
Title: A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
Volume: 11
Issue: 3
Pages: 365-376
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Publication
34768920 | J:315055
 
First Author: Llamas-Granda P
Year: 2021
Journal: Int J Mol Sci
Title: Tenofovir Modulates Semaphorin 4D Signaling and Regulates Bone Homeostasis, Which Can Be Counteracted by Dipyridamole and Adenosine A2A Receptor.
Volume: 22
Issue: 21
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Publication
10619026 | -
First Author: Maesaki R
Year: 1999
Journal: Mol Cell
Title: The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.
Volume: 4
Issue: 5
Pages: 793-803
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Publication
29024000 | J:359805
First Author: Lu L
Year: 2018
Journal: Hepatology
Title: Myeloid Notch1 deficiency activates the RhoA/ROCK pathway and aggravates hepatocellular damage in mouse ischemic livers.
Volume: 67
Issue: 3
Pages: 1041-1055
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Publication
35198058 | J:327756
First Author: Tak J
Year: 2022
Journal: Theranostics
Title: Gα12 overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation.
Volume: 12
Issue: 4
Pages: 1570-1588
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Publication
38505605 | J:347106
First Author: Tak J
Year: 2024
Journal: Theranostics
Title: Dual regulation of NEMO by Nrf2 and miR-125a inhibits ferroptosis and protects liver from endoplasmic reticulum stress-induced injury.
Volume: 14
Issue: 5
Pages: 1841-1859
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Publication
23052206 | J:196918
First Author: Iskratsch T
Year: 2013
Journal: Cell Mol Life Sci
Title: Two distinct phosphorylation events govern the function of muscle FHOD3.
Volume: 70
Issue: 5
Pages: 893-908
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Publication
30444969 | J:268560
First Author: Tang J
Year: 2019
Journal: Exp Cell Res
Title: ARHGEF10L contributes to liver tumorigenesis through RhoA-ROCK1 signaling and the epithelial-mesenchymal transition.
Volume: 374
Issue: 1
Pages: 46-68
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Publication
31339573 | J:280870
First Author: Peng Z
Year: 2019
Journal: J Neurochem
Title: Inhibition of Notch1 signaling promotes neuronal differentiation and improves functional recovery in spinal cord injury through suppressing the activation of Ras homolog family member A.
Volume: 150
Issue: 6
Pages: 709-722
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Protein
A0A3Q4EGR2
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: false
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Protein
P70335
Organism: Mus musculus/domesticus
Length: 1354  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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