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Search results 301 to 314 out of 314 for Ros1

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Type

Details

Score

Publication

30275307 | -

First Author:	Liu J
Year:	2018
Journal:	Proc Natl Acad Sci U S A
Title:	Mutations in the DNA demethylase OsROS1 result in a thickened aleurone and improved nutritional value in rice grains.
Volume:	115
Issue:	44
Pages:	11327-11332

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Publication

32528522 | -

First Author:	Kong W
Year:	2020
Journal:	Front Genet
Title:	Impact of DNA Demethylases on the DNA Methylation and Transcription of Arabidopsis NLR Genes.
Volume:	11

Pages:	460

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Publication

29784956 | -

First Author:	Zhang H
Year:	2018
Journal:	Nat Rev Mol Cell Biol
Title:	Dynamics and function of DNA methylation in plants.
Volume:	19
Issue:	8
Pages:	489-506

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Publication

12526807 | -

First Author:	Gong Z
Year:	2002
Journal:	Cell
Title:	ROS1, a repressor of transcriptional gene silencing in Arabidopsis, encodes a DNA glycosylase/lyase.
Volume:	111
Issue:	6
Pages:	803-14

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Protein Domain

IPR044811 | DME/ROS1

Type:

Family

Description:

DNA glycosylases are required to regulate the DNA methylation pathway at discrete regions across the plant genome, and probably protect the genome from excess methylation []. Arabidopsis encodes four active demethylases with 5-methylcytosine DNA glycosylase/lyase activities, namely DEMETER (DME), DME-Like 1 (DML1)/ROS1 (Repressor of Silencing 1), DML2 and DML3 [, , , ]. Both ROS1 and DME actively remove DNA methylation in all methylated cytosine contexts through a base excision repair (BER) mechanism [, ]. DML2/3 and ROS1 play important roles in the regulation of nucleotide-binding leucine-rich repeat (NLR) genes, a class of important plant disease resistance genes [].DEMETER functions mainly in the central cells of female gametophytes involved in gene imprinting, which allows the expression of the maternal copy of the imprinted MEA gene before fertilization, possibly by antagonizing or suppressing DNA methylation on target promoter []and acts in a sequence nonspecific manner. The other three demethylases, ROS1, DML2, and DML3, were shown to be largely active in somatic cells []. ROS1 is constitutively expressed and regulates gene expression by preventing the spread of DNA methylation and transcriptional silencing from transposons and is involved in UV-B induced- and oxidative DNA damage repair []. It also regulates defence genes by demethylation of RMG1 (disease resistance gene) and RLP43 (an orphan immune receptor gene) promoters [].

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Publication

26964870 | J:231770

First Author:	Inoue M
Year:	2016
Journal:	Carcinogenesis
Title:	Mouse models for ROS1-fusion-positive lung cancers and their application to the analysis of multikinase inhibitor efficiency.
Volume:	37
Issue:	5
Pages:	452-60

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Publication

24132104 | J:205211

First Author:	Shaw AT
Year:	2013
Journal:	Nat Rev Cancer
Title:	Tyrosine kinase gene rearrangements in epithelial malignancies.
Volume:	13
Issue:	11
Pages:	772-87

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Publication

24154728 | J:202905

First Author:	Saborowski A
Year:	2013
Journal:	Proc Natl Acad Sci U S A
Title:	Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target.
Volume:	110
Issue:	48
Pages:	19513-8

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Publication

37244438 | J:336409

First Author:	Giaccone G
Year:	2023
Journal:	Semin Cancer Biol
Title:	Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.
Volume:	94

Pages:	1-10

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Publication

21507349 | -

First Author:	Iyer LM
Year:	2011
Journal:	Prog Mol Biol Transl Sci
Title:	Natural history of eukaryotic DNA methylation systems.
Volume:	101

Pages:	25-104

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Publication

23418494 | J:199415

First Author:	Arai Y
Year:	2013
Journal:	PLoS One
Title:	Mouse model for ROS1-rearranged lung cancer.
Volume:	8
Issue:	2
Pages:	e56010

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Publication

29610289 | J:260707

First Author:	Bajrami I
Year:	2018
Journal:	Cancer Discov
Title:	E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.
Volume:	8
Issue:	4
Pages:	498-515

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Publication

32238360 | J:290437

First Author:	Clarke M
Year:	2020
Journal:	Cancer Discov
Title:	Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.
Volume:	10
Issue:	7
Pages:	942-963

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Publication

38169386 | J:356235

First Author:	Kiyozumi D
Year:	2024
Journal:	Reprod Biol Endocrinol
Title:	Expression of NELL2/NICOL-ROS1 lumicrine signaling-related molecules in the human male reproductive tract.
Volume:	22
Issue:	1
Pages:	3

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