MouseMine: Keyword Search

Publication

First Author:	Storm T
Year:	2019
Journal:	Invest Ophthalmol Vis Sci
Title:	Selective Ablation of Megalin in the Retinal Pigment Epithelium Results in Megaophthalmos, Macromelanosome Formation and Severe Retina Degeneration.
Volume:	60
Issue:	1
Pages:	322-330

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Publication

32721041 | J:329550

First Author:	Go YM
Year:	2020
Journal:	FASEB J
Title:	MTOR-initiated metabolic switch and degeneration in the retinal pigment epithelium.
Volume:	34
Issue:	9
Pages:	12502-12520

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Publication

35939707 | J:329551

First Author:	Cai J
Year:	2022
Journal:	Proc Natl Acad Sci U S A
Title:	DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
Volume:	119
Issue:	33
Pages:	e2207489119

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Publication

30867823 | J:280970

First Author:	Huang J
Year:	2019
Journal:	Theranostics
Title:	Abnormal mTORC1 signaling leads to retinal pigment epithelium degeneration.
Volume:	9
Issue:	4
Pages:	1170-1180

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Publication

26075877 | J:282249

First Author:	Yao J
Year:	2015
Journal:	Autophagy
Title:	Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.
Volume:	11
Issue:	6
Pages:	939-53

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Publication

28083894 | J:240969

First Author:	Shang P
Year:	2017
Journal:	Aging Cell
Title:	The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling.
Volume:	16
Issue:	2
Pages:	349-359

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Publication

28026019 | J:241888

First Author:	Ghosh S
Year:	2017
Journal:	J Pathol
Title:	Activating the AKT2-nuclear factor-κB-lipocalin-2 axis elicits an inflammatory response in age-related macular degeneration.
Volume:	241
Issue:	5
Pages:	583-588

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Publication

33605986 | J:302529

First Author:	Bullock J
Year:	2021
Journal:	Invest Ophthalmol Vis Sci
Title:	Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R).
Volume:	62
Issue:	2
Pages:	30

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Publication

24634209 | J:213177

First Author:	Masuda T
Year:	2014
Journal:	J Biol Chem
Title:	Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium.
Volume:	289
Issue:	18
Pages:	12908-21

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Publication

24468901 | J:215838

First Author:	Valapala M
Year:	2014
Journal:	Autophagy
Title:	Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling.
Volume:	10
Issue:	3
Pages:	480-96

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Publication

30462537 | J:269598

First Author:	Swarup A
Year:	2019
Journal:	Am J Physiol Cell Physiol
Title:	Modulating GLUT1 expression in retinal pigment epithelium decreases glucose levels in the retina: impact on photoreceptors and Müller glial cells.
Volume:	316
Issue:	1
Pages:	C121-C133

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Allele

Tg(BEST1-cre)1Jdun | MGI:4946605

Name:	transgene insertion 1, Joshua L Dunaief
Allele Type:	Transgenic
Attribute String:	Recombinase

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HT Experiment

GSE236219 | Age-related histone loss and altered histone acetylation in mouse retinal pigment epithelium. [polyA RNA]


Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	GEO

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HT Experiment

GSE236220 | Age-related histone loss and altered histone acetylation in mouse retinal pigment epithelium. [Total RNA]


Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	GEO

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HT Experiment

E-GEOD-43951 | Conditional knockdown of DNA methyltransferase-1 (Dnmt1) reveals a key role of retinal pigment epithelium integrity in photoreceptor outer segment morphogenesis

Series Id:	GSE43951
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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Publication

34502266 | J:337189

First Author:	Samra YA
Year:	2021
Journal:	Int J Mol Sci
Title:	Implication of N-Methyl-d-Aspartate Receptor in Homocysteine-Induced Age-Related Macular Degeneration.
Volume:	22
Issue:	17

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Publication

32112484 | J:287641

First Author:	Han JYS
Year:	2020
Journal:	FASEB J
Title:	Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.
Volume:	34
Issue:	4
Pages:	5401-5419

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Publication

33740621 | J:305583

First Author:	Ando S
Year:	2021
Journal:	Biochem Biophys Res Commun
Title:	Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration.
Volume:	551

Pages:	148-154

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Publication

25200140 | -

First Author:	Zhang J
Year:	2015
Journal:	Mol Cell Biochem
Title:	Effects of p75 neurotrophin receptor on regulating hypoxia-induced angiogenic factors in retinal pigment epithelial cells.
Volume:	398
Issue:	1-2
Pages:	123-34

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Publication

24481864 | -

First Author:	Tomellini E
Year:	2014
Journal:	Cell Mol Life Sci
Title:	Role of p75 neurotrophin receptor in stem cell biology: more than just a marker.
Volume:	71
Issue:	13
Pages:	2467-81

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Publication

17531524 | -

First Author:	Micera A
Year:	2007
Journal:	Cytokine Growth Factor Rev
Title:	Nerve growth factor and tissue repair remodeling: trkA(NGFR) and p75(NTR), two receptors one fate.
Volume:	18
Issue:	3-4
Pages:	245-56

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Publication

24226422 | -

First Author:	Furuta J
Year:	2014
Journal:	J Invest Dermatol
Title:	CD271 on melanoma cell is an IFN-γ-inducible immunosuppressive factor that mediates downregulation of melanoma antigens.
Volume:	134
Issue:	5
Pages:	1369-1377

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Publication

21762680 | -

First Author:	Zeng F
Year:	2011
Journal:	Biochem Pharmacol
Title:	Roles of p75NTR in the pathogenesis of Alzheimer's disease: a novel therapeutic target.
Volume:	82
Issue:	10
Pages:	1500-9

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Publication

25239528 | -

First Author:	Meeker R
Year:	2014
Journal:	J Neuroimmune Pharmacol
Title:	Dynamic nature of the p75 neurotrophin receptor in response to injury and disease.
Volume:	9
Issue:	5
Pages:	615-28

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Protein Domain

IPR034046 | TNFRSF16_N

Type:

Domain

Description:

Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75), CD271, or Gp80-LNGFR, is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency []. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways []. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex [].In melanoma cells, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens []. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation []. p75NTR is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia []. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.This entry represents the N-terminal domain of TNFRSF16. TNF-receptors are modular proteins. The N-terminal extracellular part contains a cysteine-rich region responsible for ligand-binding. This region is composed of small modules of about 40 residues containing 6 conserved cysteines; the number and type of modules can vary in different members of the family [, , ].

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Publication

12058047 | J:78632

First Author:	Marmorstein LY
Year:	2002
Journal:	J Biol Chem
Title:	Bestrophin interacts physically and functionally with protein phosphatase 2A.
Volume:	277
Issue:	34
Pages:	30591-7

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HT Experiment

GSE237309 | Oxidative stress induces lysosomal membrane permeabilization and ceramide accumulation in retinal pigment epithelial cells


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

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Publication

29100828 | J:279827

First Author:	Eblimit A
Year:	2018
Journal:	Exp Eye Res
Title:	Conditional loss of Spata7 in photoreceptors causes progressive retinal degeneration in mice.
Volume:	166

Pages:	120-130

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Publication

36674587 | J:337188

First Author:	Samra YA
Year:	2023
Journal:	Int J Mol Sci
Title:	Warburg Effect as a Novel Mechanism for Homocysteine-Induced Features of Age-Related Macular Degeneration.
Volume:	24
Issue:	2

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Publication

33795534 | J:306330

First Author:	Le D
Year:	2021
Journal:	Mol Cells
Title:	Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.
Volume:	44
Issue:	3
Pages:	168-178

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Publication

33305736 | J:316381

First Author:	Malsy J
Year:	2020
Journal:	Elife
Title:	Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization.
Volume:	9

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Publication

22342521 | J:196540

First Author:	Wolkow N
Year:	2012
Journal:	Am J Pathol
Title:	Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.
Volume:	180
Issue:	4
Pages:	1614-24

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Publication

31562844 | J:280448

First Author:	Klee K
Year:	2019
Journal:	Exp Eye Res
Title:	Systemic knockout of Tspo in mice does not affect retinal morphology, function and susceptibility to degeneration.
Volume:	188

Pages:	107816

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Publication

28104803 | J:241079

First Author:	Sundermeier TR
Year:	2017
Journal:	J Biol Chem
Title:	MicroRNA-processing Enzymes Are Essential for Survival and Function of Mature Retinal Pigmented Epithelial Cells in Mice.
Volume:	292
Issue:	8
Pages:	3366-3378

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Strain

MGI:5294331 | C57BL/6-Tg(BEST1-cre)1Jdun/J

Attribute String:

coisogenic, mutant strain, transgenic

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Strain

MGI:5311108 | C57BL/6-Tg(BEST1-cre)1Jdun

Attribute String:

coisogenic, mutant strain, transgenic

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Genotype

Symbol:	Tg(BEST1-cre)1Jdun/?
Background:	C57BL/6-Tg(BEST1-cre)1Jdun
Zygosity:	ot
Has Mutant Allele:	true

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Genotype

Symbol:	Tg(BEST1-cre)1Jdun/?
Background:	involves: C57BL/6 * C57BL/6J
Zygosity:	ot
Has Mutant Allele:	true

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Publication

21297615 | J:170350

First Author:	Kaneko H
Year:	2011
Journal:	Nature
Title:	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.
Volume:	471
Issue:	7338
Pages:	325-30

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HT Experiment

E-GEOD-65154 | Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in the mouse

Series Id:	GSE65154
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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Publication

21212186 | J:170522

First Author:	Iacovelli J
Year:	2011
Journal:	Invest Ophthalmol Vis Sci
Title:	Generation of Cre transgenic mice with postnatal RPE-specific ocular expression.
Volume:	52
Issue:	3
Pages:	1378-83

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Publication

39018199 | J:357738

First Author:	Liu Y
Year:	2024
Journal:	Proc Natl Acad Sci U S A
Title:	Cone photoreceptor differentiation regulated by thyroid hormone transporter MCT8 in the retinal pigment epithelium.
Volume:	121
Issue:	30
Pages:	e2402560121

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Publication

35758026 | J:327297

First Author:	Shao A
Year:	2022
Journal:	Dis Model Mech
Title:	Arap1 loss causes retinal pigment epithelium phagocytic dysfunction and subsequent photoreceptor death.
Volume:	15
Issue:	7

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HT Experiment

E-GEOD-53411 | Gene profiling studies in postnatal Mfrprd6 mutant eyes reveal differential expression of Prss56, a trypsin-like serine protease, and genes involved in visual and phototransduction pathways

Series Id:	GSE53411
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

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Publication

28814744 | J:256507

First Author:	Ma W
Year:	2017
Journal:	Sci Rep
Title:	Monocyte infiltration and proliferation reestablish myeloid cell homeostasis in the mouse retina following retinal pigment epithelial cell injury.
Volume:	7
Issue:	1
Pages:	8433

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Publication

31552301 | J:290053

First Author:	Ghosh S
Year:	2019
Journal:	Commun Biol
Title:	Neutrophils homing into the retina trigger pathology in early age-related macular degeneration.
Volume:	2

Pages:	348

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Publication

25257511 | J:215531

First Author:	Valapala M
Year:	2014
Journal:	Aging Cell
Title:	Increased Lipocalin-2 in the retinal pigment epithelium of Cryba1 cKO mice is associated with a chronic inflammatory response.
Volume:	13
Issue:	6
Pages:	1091-4

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Publication

25736717 | J:251467

First Author:	Valapala M
Year:	2015
Journal:	Sci Rep
Title:	βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.
Volume:	5

Pages:	8755

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Genotype

Symbol:	Heph/Heph Tg(BEST1-cre)1Jdun/?
Background:	involves: C57BL/6 * C57BL/6NTac
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Cryba1/Cryba1 Tg(BEST1-cre)1Jdun/?
Background:	involves: 129S6/SvEvTac * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Rb1cc1/Rb1cc1 Tg(BEST1-cre)1Jdun/?
Background:	involves: 129P2/OlaHsd * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Tfam/Tfam Tg(BEST1-cre)1Jdun/?
Background:	involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Clic4/Clic4 Tg(BEST1-cre)1Jdun/?
Background:	involves: C57BL/6 * C57BL/6J
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Tsc1/Tsc1 Tg(BEST1-cre)1Jdun/?
Background:	involves: 129S4/SvJae * C57BL/6J
Zygosity:	cn
Has Mutant Allele:	true

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Publication

37190767 | J:354453

First Author:	Kim JM
Year:	2023
Journal:	Mol Cells
Title:	Wnt/β-Catenin Signaling Pathway Is Necessary for the Specification but Not the Maintenance of the Mouse Retinal Pigment Epithelium.
Volume:	46
Issue:	7
Pages:	441-450

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Protein Domain

IPR000615 | Bestrophin

Type:

Family

Description:

Bestrophin is a 68kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a depressed light peak in the electrooculogram []. VMD2 encodes a 585-amino acid protein with an approximate mass of 68kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif. Bestrophin is a plasma membrane protein, localised to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of calcium-activated chloride channels (CaCC) [], indicating a direct role for bestrophin in generating the light peak [, , ]. Bestrophins are also permeable to other monovalent anions including bicarbonate, bromine, iodine, thiocyanate an nitrate [, ]. Structural analysis revealed thatN-terminal region of the proteins is highly conserved and sufficient for its CaCC activity. The C-terminal region has low sequence identity. The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal domain altering the electrophysiological properties of the channel [, ].

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Protein Domain

IPR021134 | Bestrophin/UPF0187

Type:

Family

Description:

Bestrophin is a 68kDa basolateral plasma membrane protein expressed in retinal pigment epithelial cells (RPE). It is encoded by the VMD2 gene, which is mutated in Best macular dystrophy, a disease characterised by a depressed light peak in the electrooculogram []. VMD2 encodes a 585-amino acid protein with an approximate mass of 68kDa which has been designated bestrophin. Bestrophin shares homology with the Caenorhabditis elegans RFP gene family, named for the presence of a conserved arginine (R), phenylalanine (F), proline (P), amino acid sequence motif. Bestrophin is a plasma membrane protein, localised to the basolateral surface of RPE cells consistent with a role for bestrophin in the generation or regulation of the EOG light peak. Bestrophin and other RFP family members represent a new class of calcium-activated chloride channels (CaCC) [], indicating a direct role for bestrophin in generating the light peak [, , ]. Bestrophins are also permeable to other monovalent anions including bicarbonate, bromine, iodine, thiocyanate an nitrate [, ]. Structural analysis revealed that N-terminal region of the proteins is highly conserved and sufficient for its CaCC activity. The C-terminal region has low sequence identity. The VMD2 gene underlying Best disease was shown to represent the first human member of the RFP-TM protein family. More than 97% of the disease-causing mutations are located in the N-terminal domain altering the electrophysiological properties of the channel [, ].This entry also includes uncharacterised proteins belonging to protein family UPF0187.

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Genotype

Symbol:	Cp/Cp Heph/Heph Tg(BEST1-cre)1Jdun/?
Background:	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Cp/Cp Heph/Heph Tg(BEST1-cre)1Jdun/? Tg(Rho-cre)#Yzl/?
Background:	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Spata7/Spata7 Tg(BEST1-cre)1Jdun/?
Background:	involves: 129S7/SvEvBrd * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

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Genotype

Symbol:	Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(BEST1-cre)1Jdun/?
Background:	involves: 129S4/SvJae * 129S4/SvJaeSor * C57BL/6
Zygosity:	cn
Has Mutant Allele:	true

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HT Experiment

GSE240018 | High-Fat Diet Alters the Retinal Transcriptome in the Absence of Gut Microbiota


Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	GEO

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HT Experiment

GSE219252 | Bulk RNA-seq of eyes isolated from wildtype and Stra6 knockout mice maintained on either a vitamin A sufficient or deficient diet


Experiment Type:	RNA-Seq
Study Type:	WT vs. Mutant
Source:	GEO

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HT Experiment

GSE135167 | Single cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid


Experiment Type:	RNA-Seq
Study Type:	Baseline
Source:	GEO

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Publication

15978262 | J:134368

First Author:	Kitamoto J
Year:	2005
Journal:	Exp Eye Res
Title:	Myosin VI is required for normal retinal function.
Volume:	81
Issue:	1
Pages:	116-20

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Publication

16289664 | J:112816

First Author:	Wollmann G
Year:	2006
Journal:	Vision Res
Title:	Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice.
Volume:	46
Issue:	5
Pages:	688-98

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Publication

18400985 | J:345037

First Author:	Qu Z
Year:	2008
Journal:	Am J Physiol Cell Physiol
Title:	Bestrophin Cl- channels are highly permeable to HCO3-.
Volume:	294
Issue:	6
Pages:	C1371-7

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Protein

Q8BGM5

Organism:	Mus musculus/domesticus
Length:	508
Fragment?:	false

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Protein

Q6H1V1

Organism:	Mus musculus/domesticus
Length:	669
Fragment?:	false

•

Protein

O88870

Organism:	Mus musculus/domesticus
Length:	551
Fragment?:	false

•

Protein

A0A494B8Z9

Organism:	Mus musculus/domesticus
Length:	420
Fragment?:	true

•

Protein

A0A0R4J0P0

Organism:	Mus musculus/domesticus
Length:	508
Fragment?:	false

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Publication

12032738 | J:98703

First Author:	Stöhr H
Year:	2002
Journal:	Eur J Hum Genet
Title:	Three novel human VMD2-like genes are members of the evolutionary highly conserved RFP-TM family.
Volume:	10
Issue:	4
Pages:	281-4

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Publication

12907679 | J:84780

First Author:	Tsunenari T
Year:	2003
Journal:	J Biol Chem
Title:	Structure-function analysis of the bestrophin family of anion channels.
Volume:	278
Issue:	42
Pages:	41114-25

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Publication

25337878 | -

First Author:	Kane Dickson V
Year:	2014
Journal:	Nature
Title:	Structure and insights into the function of a Ca(2+)-activated Cl(-) channel.
Volume:	516
Issue:	7530
Pages:	213-8

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Genotype

Symbol:	Slc16a2/Slc16a2 Tg(BEST1-cre)1Jdun/? Tyr/Tyr
Background:	involves: 129S1/SvImJ * C57BL/6J * C57BL/6N
Zygosity:	cn
Has Mutant Allele:	true

•

Genotype

Symbol:	Slc16a2/? Tg(BEST1-cre)1Jdun/? Tyr/Tyr
Background:	involves: 129S1/SvImJ * C57BL/6J * C57BL/6N
Zygosity:	cn
Has Mutant Allele:	true

•

HT Experiment

E-GEOD-22882 | microRNA profiling in Mouse Eye: Retina, Lens, Cornea, Retinal Pigment Epithelium

Series Id:	GSE22882
Experiment Type:	transcription profiling by array
Study Type:	Baseline
Source:	ArrayExpress

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Publication

10412977 | J:56317

First Author:	Weng J
Year:	1999
Journal:	Cell
Title:	Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice.
Volume:	98
Issue:	1
Pages:	13-23

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Publication

19409519 | J:150865

First Author:	Parry DA
Year:	2009
Journal:	Am J Hum Genet
Title:	Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice.
Volume:	84
Issue:	5
Pages:	683-91

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Publication

26691986 | J:227177

First Author:	Saksens NT
Year:	2016
Journal:	Nat Genet
Title:	Mutations in CTNNA1 cause butterfly-shaped pigment dystrophy and perturbed retinal pigment epithelium integrity.
Volume:	48
Issue:	2
Pages:	144-51

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Publication

9843205 | J:51293

First Author:	Redmond TM
Year:	1998
Journal:	Nat Genet
Title:	Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.
Volume:	20
Issue:	4
Pages:	344-51

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Publication

9647758 | J:48330

First Author:	Amae S
Year:	1998
Journal:	Biochem Biophys Res Commun
Title:	Identification of a novel isoform of microphthalmia-associated transcription factor that is enriched in retinal pigment epithelium.
Volume:	247
Issue:	3
Pages:	710-5

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Publication

18606814 | J:142021

First Author:	Imanishi Y
Year:	2008
Journal:	J Biol Chem
Title:	Retinyl ester homeostasis in the adipose differentiation-related protein-deficient retina.
Volume:	283
Issue:	36
Pages:	25091-102

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Publication

11520113 | J:115620

First Author:	Bumsted KM
Year:	2001
Journal:	Exp Eye Res
Title:	Defects in the MITF(mi/mi) apical surface are associated with a failure of outer segment elongation.
Volume:	73
Issue:	3
Pages:	383-92

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Publication

29249622 | J:253963

First Author:	Moon KH
Year:	2018
Journal:	Dev Cell
Title:	Differential Expression of NF2 in Neuroepithelial Compartments Is Necessary for Mammalian Eye Development.
Volume:	44
Issue:	1
Pages:	13-28.e3

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Publication

18582859 | J:139168

First Author:	Dakubo GD
Year:	2008
Journal:	Dev Biol
Title:	Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye.
Volume:	320
Issue:	1
Pages:	242-55

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Publication

25349431 | J:216768

First Author:	Kim Y
Year:	2014
Journal:	Proc Natl Acad Sci U S A
Title:	DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.
Volume:	111
Issue:	45
Pages:	16082-7

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Publication

18815272 | J:341624

First Author:	Rattner A
Year:	2008
Journal:	J Neurosci
Title:	The genomic response of the retinal pigment epithelium to light damage and retinal detachment.
Volume:	28
Issue:	39
Pages:	9880-9

•

Publication

22541070 | J:186198

First Author:	Tarallo V
Year:	2012
Journal:	Cell
Title:	DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88.
Volume:	149
Issue:	4
Pages:	847-59

•

Publication

22730183 | J:189533

First Author:	Mori M
Year:	2012
Journal:	Genesis
Title:	Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium.
Volume:	50
Issue:	11
Pages:	828-32

•

Publication

12756174 | J:83532

First Author:	Bäumer N
Year:	2003
Journal:	Development
Title:	Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6.
Volume:	130
Issue:	13
Pages:	2903-15

•

Publication

27875314 | J:237618

First Author:	Palczewska G
Year:	2016
Journal:	J Biol Chem
Title:	Receptor MER Tyrosine Kinase Proto-oncogene (MERTK) Is Not Required for Transfer of Bis-retinoids to the Retinal Pigmented Epithelium.
Volume:	291
Issue:	52
Pages:	26937-26949

•

Publication

36359858 | J:331432

First Author:	Ng ESY
Year:	2022
Journal:	Cells
Title:	Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration.
Volume:	11
Issue:	21

•

Publication

15277666 | J:99461

First Author:	Kim SR
Year:	2004
Journal:	Proc Natl Acad Sci U S A
Title:	Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.
Volume:	101
Issue:	32
Pages:	11668-72

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Publication

24706832 | J:208625

First Author:	Maeda A
Year:	2014
Journal:	Proc Natl Acad Sci U S A
Title:	Two-photon microscopy reveals early rod photoreceptor cell damage in light-exposed mutant mice.
Volume:	111
Issue:	14
Pages:	E1428-37

•

Publication

35271829 | J:324683

First Author:	Zhang KR
Year:	2022
Journal:	Exp Eye Res
Title:	Conditional knockout of hephaestin in the neural retina disrupts retinal iron homeostasis.
Volume:	218

Pages:	109028

•

Publication

19596317 | J:153566

First Author:	Fujimura N
Year:	2009
Journal:	Dev Biol
Title:	Spatial and temporal regulation of Wnt/beta-catenin signaling is essential for development of the retinal pigment epithelium.
Volume:	334
Issue:	1
Pages:	31-45

•

Publication

36755326 | J:339847

First Author:	Augustin S
Year:	2023
Journal:	J Neuroinflammation
Title:	Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker.
Volume:	20
Issue:	1
Pages:	28

•

Publication

16251428 | J:102398

First Author:	Marneros AG
Year:	2005
Journal:	Am J Pathol
Title:	Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function.
Volume:	167
Issue:	5
Pages:	1451-9

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