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Search results 301 to 392 out of 392 for Rspo4

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:3698282
Assay Type: RNA in situ
Annotation Date: 2007-03-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1802423
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3698281
Age: embryonic day 15.5
Specimen Label: Table 1 E15.5
Detected: true
Specimen Num: 20
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•
GXD Expression
GXD Expression
Probe: MGI:6182627
Assay Type: RNA in situ
Annotation Date: 2022-06-28
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689421
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7294312
Age: embryonic day 13.5
Image: S1D
Note: Not expressed in the ventral midbrain, but present in other structures.
Specimen Label: S1D
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2981628
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: false
Specimen Num: 3
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•
•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3155625
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: true
Specimen Num: 1
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•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2978625
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: false
Specimen Num: 1
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:2978628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:3226225
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: false
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:3226228
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: false
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3229825
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: true
Specimen Num: 1
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3229828
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: true
Specimen Num: 3
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:3229125
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14267
Specimen Label: GUDMAP:14267
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
   
Probe: MGI:3698282
Assay Type: RNA in situ
Annotation Date: 2007-03-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1768023
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:3698281
Age: embryonic day 15.5
Specimen Label: Table 1 E15.5
Detected: true
Specimen Num: 20
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•
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•
GXD Expression
GXD Expression
   
Probe: MGI:3698282
Assay Type: RNA in situ
Annotation Date: 2007-03-01
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1768025
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:3698281
Age: embryonic day 17.5
Specimen Label: Table 1 E17.5
Detected: true
Specimen Num: 21
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•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:3226325
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: false
Specimen Num: 1
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•
•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:3226328
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: false
Specimen Num: 3
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•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Female
Emaps: EMAPS:3228225
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14267
Specimen Label: GUDMAP:14267
Detected: false
Specimen Num: 2
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•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3227025
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: true
Specimen Num: 1
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•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3231225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3231228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Female
Emaps: EMAPS:3227225
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14267
Specimen Label: GUDMAP:14267
Detected: true
Specimen Num: 2
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•
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•
GXD Expression
GXD Expression
 
Probe: MGI:3696459
Assay Type: RNA in situ
Annotation Date: 2007-02-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3264923
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:3696460
Age: embryonic day 15.5
Note: Expression is in the mesenchyme from which the nails are derived, with some expression in the whisker pad and no detectable expression in other tissues.
Specimen Label: Not shown
Detected: true
Specimen Num: 3
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•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3229325
Pattern: Not Specified
Stage: TS25
Assay Id: MGI:5543134
Age: embryonic day 17.0
Image: GUDMAP:14266
Specimen Label: GUDMAP:14266
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:5508422
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Present
Sex: Male
Emaps: EMAPS:3229328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5543134
Age: postnatal day 5
Image: GUDMAP:14268
Specimen Label: GUDMAP:14268
Detected: true
Specimen Num: 3
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:6144010
Assay Type: RNA in situ
Annotation Date: 2018-03-21
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:3808022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:6144021
Age: embryonic day 14.5
Image: 1S
Note: Weak expression in cervical loop epithelium.
Specimen Label: 1S
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6144010
Assay Type: RNA in situ
Annotation Date: 2018-03-21
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3808026
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:6144021
Age: embryonic day 18.5
Image: 3C
Note: Expression in lingual aspect of cervical loop.
Specimen Label: 3C
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7580799
Assay Type: RNA in situ
Annotation Date: 2024-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3814220
Stage: TS20
Assay Id: MGI:7580815
Age: embryonic day 12.5
Image: 1H.ii
Specimen Label: 1H.ii
Detected: false
Specimen Num: 3
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•
GXD Expression
GXD Expression
   
Probe: MGI:7580799
Assay Type: RNA in situ
Annotation Date: 2024-02-08
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3814222
Stage: TS22
Assay Id: MGI:7580815
Age: embryonic day 14.5
Image: 1T
Specimen Label: 1T
Detected: false
Specimen Num: 7
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Publication
32926477 | J:306915
First Author: Liu S
Year: 2020
Journal: FASEB J
Title: Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
Volume: 34
Issue: 11
Pages: 14946-14959
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Publication
22610508 | J:188812
First Author: Neufeld S
Year: 2012
Journal: Genesis
Title: A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.
Volume: 50
Issue: 10
Pages: 741-9
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Publication
17035101 | J:116140
First Author: Nam JS
Year: 2007
Journal: Gene Expr Patterns
Title: Dynamic expression of R-spondin family genes in mouse development.
Volume: 7
Issue: 3
Pages: 306-12
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Publication
17914453 | J:133475
First Author: Nakamura M
Year: 2008
Journal: J Invest Dermatol
Title: The localization of label-retaining cells in mouse nails.
Volume: 128
Issue: 3
Pages: 728-30
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Publication
24616052 | J:210988
First Author: Kawasaki M
Year: 2014
Journal: Dev Dyn
Title: R-spondins/Lgrs expression in tooth development.
Volume: 243
Issue: 6
Pages: 844-51
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Publication
37651925 | J:341172
 
First Author: Watanabe K
Year: 2023
Journal: Gene Expr Patterns
Title: Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon.
Volume: 49
Pages: 119333
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Publication
34449628 | J:309519
 
First Author: Dasgupta K
Year: 2021
Journal: J Dev Biol
Title: R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development.
Volume: 9
Issue: 3
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Publication
23192966 | J:191199
First Author: Mulvaney JF
Year: 2013
Journal: Dev Dyn
Title: Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea.
Volume: 242
Issue: 2
Pages: 179-88
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Publication
32468660 | J:312814
First Author: Fernandez Vallone V
Year: 2020
Journal: EMBO Rep
Title: LGR5 controls extracellular matrix production by stem cells in the developing intestine.
Volume: 21
Issue: 7
Pages: e49224
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Publication
26655896 | J:259735
First Author: Rocha AS
Year: 2015
Journal: Cell Rep
Title: The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.
Volume: 13
Issue: 9
Pages: 1757-64
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Publication
27313319 | J:233303
First Author: Vidal V
Year: 2016
Journal: Genes Dev
Title: The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.
Volume: 30
Issue: 12
Pages: 1389-94
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Publication
19282366 | J:148515
First Author: Miyagawa S
Year: 2009
Journal: Mol Endocrinol
Title: Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.
Volume: 23
Issue: 6
Pages: 871-80
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Publication
22956684 | J:187747
First Author: Miyoshi H
Year: 2012
Journal: Science
Title: Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.
Volume: 338
Issue: 6103
Pages: 108-13
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Publication
32324134 | J:290543
   
First Author: Vidal VP
Year: 2020
Journal: Elife
Title: R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.
Volume: 9
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Publication
31772170 | J:283792
First Author: Seishima R
Year: 2019
Journal: Nat Commun
Title: Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.
Volume: 10
Issue: 1
Pages: 5378
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Publication
21936019 | J:177133
First Author: Mehta V
Year: 2011
Journal: Dev Dyn
Title: Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.
Volume: 240
Issue: 11
Pages: 2548-60
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Publication
24151333 | J:202907
First Author: Grigoryan T
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.
Volume: 110
Issue: 45
Pages: 18174-9
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Publication
19243017 | J:152211
First Author: Coulpier F
Year: 2009
Journal: Glia
Title: Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers.
Volume: 57
Issue: 13
Pages: 1450-7
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Publication
28813421 | J:253067
First Author: Sigal M
Year: 2017
Journal: Nature
Title: Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.
Volume: 548
Issue: 7668
Pages: 451-455
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Publication
34671097 | J:312414
First Author: Yogosawa S
Year: 2021
Journal: Commun Biol
Title: Mice lacking DYRK2 exhibit congenital malformations with lung hypoplasia and altered Foxf1 expression gradient.
Volume: 4
Issue: 1
Pages: 1204
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
26238476 | J:226028
First Author: Lewandowski JP
Year: 2015
Journal: Dev Biol
Title: Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Volume: 406
Issue: 1
Pages: 92-103
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Publication
- | J:342609
       
First Author: UniProt
Year: 2021
Title: Electronic Gene Ontology annotations created by ARBA machine learning models
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Publication
30973865 | J:274872
First Author: Ingham NJ
Year: 2019
Journal: PLoS Biol
Title: Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Volume: 17
Issue: 4
Pages: e3000194
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
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Pages: 337-42
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
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Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
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Pages: e1000582
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
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First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
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First Author: Allen Institute for Brain Science
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Title: Allen Brain Atlas: mouse riboprobes
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
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First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
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First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Rspo4<em1Smoc> | MGI:7292135
Name: R-spondin 4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7718236 | C57BL/6JSmoc-Rspo4<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
24349440 | J:287053
First Author: Peng WC
Year: 2013
Journal: PLoS One
Title: Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling.
Volume: 8
Issue: 12
Pages: e83110
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Publication
29752411 | J:265323
First Author: Park S
Year: 2018
Journal: J Biol Chem
Title: Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling.
Volume: 293
Issue: 25
Pages: 9759-9769
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Publication
32184465 | J:286852
First Author: Nashef A
Year: 2020
Journal: Sci Rep
Title: Translation of mouse model to human gives insights into periodontitis etiology.
Volume: 10
Issue: 1
Pages: 4892
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Publication
26123262 | -
First Author: Zebisch M
Year: 2015
Journal: J Struct Biol
Title: Crystal structure of R-spondin 2 in complex with the ectodomains of its receptors LGR5 and ZNRF3.
Volume: 191
Issue: 2
Pages: 149-55
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Publication
19238248 | -
First Author: Ayadi L
Year: 2008
Journal: Bioinformation
Title: Molecular modelling of the TSR domain of R-spondin 4.
Volume: 3
Issue: 3
Pages: 119-23
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Protein Domain
IPR042993 | RSPO2/4
Type: Family
Description: The R-spondin (RSPO) family is a small group of four secreted proteins (RSPO1-RSPO4) that have pleiotropic functions in development and stem cell growth by strongly enhancing Wnt pathway activation. They contain an N-terminal secretory signal peptide sequence, two tandem furin-like cysteine-rich (Fu-CRD) domains, a thrombospondin type I repeat (TSP) domain, and a C-terminal basic amino acid-rich (BR) domain. Leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4), LGR5, and LGR6 have been identified as receptors for RSPOs [].RSPO2 is a secreted protein that belongs to the R-spondin (RSPO) family. Interestingly, it is one of the two members (RSPO2 and RSPO3) of the family capable of potentiating WNT signaling in cells lacking all three LGRs (Leucine-rich repeat-containing G-protein-coupled receptor 4/5/6) []. It plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form []. It has been shown to promote midbrain dopaminergic neurogenesis and differentiation in human stem cells []. Its structures in complex with the ectodomains of its receptors LGR5 and ZNRF3 have been revealed []. RSPO4 is a secreted protein that belongs to the R-spondin (RSPO) family. It has been associated with embryonic nail development [, ].
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Publication
29405118 | J:259879
   
First Author: Lebensohn AM
Year: 2018
Journal: Elife
Title: R-spondins can potentiate WNT signaling without LGRs.
Volume: 7
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Publication
23756652 | -
First Author: Wang D
Year: 2013
Journal: Genes Dev
Title: Structural basis for R-spondin recognition by LGR4/5/6 receptors.
Volume: 27
Issue: 12
Pages: 1339-44
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Publication
29769720 | J:262420
First Author: Szenker-Ravi E
Year: 2018
Journal: Nature
Title: RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
Volume: 557
Issue: 7706
Pages: 564-569
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Protein
Q8BJ73
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q0P5Y9
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q8BFU0
Organism: Mus musculus/domesticus
Length: 243  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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