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Search results 301 to 368 out of 368 for S100a4

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Type Details Score
Allele
S100a4<em1(cre/ERT2)Smoc> | MGI:6758050
Name: S100 calcium binding protein A4; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Interaction Experiment
Lee DM (2012)
Description: SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation.
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Publication
11836260 | -
First Author: Kriajevska M
Year: 2002
Journal: J Biol Chem
Title: Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1).
Volume: 277
Issue: 7
Pages: 5229-35
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Strain
MGI:6429505 | C57BL/6JSmoc-S100a4<em1(cre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Protein Domain
IPR028496 | S100-A4
Type: Family
Description: S100A4 belong to the S100 calcium-binding family. S100A4 can regulate migration and invasion in cancers through different pathways such as matrix metalloproteinase 9 (MMP-9) and AKT/Slug signal pathway [, , ].
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Publication
22981438 | -
First Author: Lee DM
Year: 2012
Journal: Environ Toxicol Pharmacol
Title: SDS3 interacts with ARNT in an AhR ligand-specific manner regulating expression of cKrox and S100A4 in CD4+CD8+ DPK thymocytes differentiation.
Volume: 34
Issue: 3
Pages: 858-68
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Allele
Tg(S100a4-TK)M31Egn | MGI:4454421
Name: transgene insertion M31, Eric G Neilson
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Strain
MGI:4454768 | B6.Cg-Tg(S100a4-TK)M31Egn/YunkJ
Attribute String: transgenic, mutant strain, congenic
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Publication
11237671 | J:160213
First Author: Iwano M
Year: 2001
Journal: Mol Ther
Title: Conditional abatement of tissue fibrosis using nucleoside analogs to selectively corrupt DNA replication in transgenic fibroblasts.
Volume: 3
Issue: 2
Pages: 149-59
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Publication
14531805 | J:127916
First Author: Okada H
Year: 2003
Journal: Kidney Int
Title: Selective depletion of fibroblasts preserves morphology and the functional integrity of peritoneum in transgenic mice with peritoneal fibrosing syndrome.
Volume: 64
Issue: 5
Pages: 1722-32
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Publication
21224075 | J:168079
First Author: Zhang J
Year: 2011
Journal: Am J Pathol
Title: FSP1+ fibroblasts promote skin carcinogenesis by maintaining MCP-1-mediated macrophage infiltration and chronic inflammation.
Volume: 178
Issue: 1
Pages: 382-90
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Allele
S100a4<em1Ysfk> | MGI:6762164
Name: S100 calcium binding protein A4; endonuclease-mediated mutation 1, Yoshinori Fukui
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Genotype
Genotype
Symbol: Tg(S100a4-TK)M31Egn/?
Background: involves: BALB/c * C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(S100a4-flpo)3Lba | MGI:6723877
Name: transgene insertion 3, Laurent Bartholin
Allele Type: Transgenic
Attribute String: Recombinase
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Protein Domain
IPR037617 | Liprin-beta_SAM_rpt_1
Type: Domain
Description: Liprin-beta proteins contain three copies (repeats) of the SAM (sterile alpha motif) domain, which is a protein-protein interaction domain. This entry represents the repeat 1 domain. Liprin-beta may form heterodimers with liprin-alpha proteins through their SAM domains []. Liprin beta1 has been shown to interacts with metastasis-associated protein S100A4 (Mts1), and this interaction results in the inhibition of liprin-beta-1 phosphorylation by protein kinase C and protein kinase CK2 in vitro [].
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Protein Domain
IPR037618 | Liprin-beta_SAM_rpt_2
Type: Domain
Description: This entry represents the SAM (sterile alpha motif) domain repeat 2 of liprin-beta. Liprin-beta proteins contain three copies (repeats) of the SAM domain, which is a protein-protein interaction domain. They may form heterodimers with liprin-alpha proteins through their SAM domains []. Liprin beta1 has been shown to interacts with metastasis-associated protein S100A4 (Mts1), and this interaction results in the inhibition of liprin-beta-1 phosphorylation by protein kinase C and protein kinase CK2 in vitro [].
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Protein Domain
IPR037619 | Liprin-beta_SAM_rpt_3
Type: Domain
Description: This entry represents the SAM (sterile alpha motif) domain repeat 3 of liprin-beta protein. Liprin-beta proteins contain three copies (repeats) of SAM domain, which is a protein-protein interaction domain. They may form heterodimers with liprin-alpha proteins through their SAM domains []. Liprin beta1 has been shown to interacts with metastasis-associated protein S100A4 (Mts1), and this interaction results in the inhibition of liprin-beta-1 phosphorylation by protein kinase C and protein kinase CK2 in vitro [].
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Allele
Tg(MMTV-S100a4)463Oku | MGI:3620787
Name: transgene insertion 463, Olle Karlstrom
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(MMTV-S100a4)507Oku | MGI:3620788
Name: transgene insertion 507, Olle Karlstrom
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Publication
32191380 | J:286617
   
First Author: Cardot-Ruffino V
Year: 2020
Journal: Genesis
Title: Generation of an Fsp1 (fibroblast-specific protein 1)-Flpo transgenic mouse strain.
Pages: e23359
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Strain
MGI:5141493 | GRS.Cg-Tg(MMTV-S100a4)463Oku/Kctt
Attribute String: congenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(S100a4-flpo)3Lba/?
Background: involves: 129S4/SvJaeSor
Zygosity: cn
Has Mutant Allele: true
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Publication
18495963 | J:301779
First Author: Kie JH
Year: 2008
Journal: J Am Soc Nephrol
Title: Heme oxygenase-1 deficiency promotes epithelial-mesenchymal transition and renal fibrosis.
Volume: 19
Issue: 9
Pages: 1681-91
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Publication
36828915 | J:335437
First Author: Low RRJ
Year: 2023
Journal: Cell Death Differ
Title: S100 family proteins are linked to organoid morphology and EMT in pancreatic cancer.
Volume: 30
Issue: 5
Pages: 1155-1165
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Publication
35569719 | J:325139
 
First Author: Lampinen R
Year: 2022
Journal: Neurobiol Dis
Title: Neuron-astrocyte transmitophagy is altered in Alzheimer's disease.
Volume: 170
Pages: 105753
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Publication
38896625 | J:352367
First Author: Adjei-Sowah E
Year: 2024
Journal: Sci Adv
Title: Development of a nanoparticle-based tendon-targeting drug delivery system to pharmacologically modulate tendon healing.
Volume: 10
Issue: 25
Pages: eadn2332
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Publication
19965622 | -
First Author: Norrmén C
Year: 2010
Journal: Blood
Title: Liprin (beta)1 is highly expressed in lymphatic vasculature and is important for lymphatic vessel integrity.
Volume: 115
Issue: 4
Pages: 906-9
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Protein Domain
IPR030437 | PPFIBP1
Type: Family
Description: Liprin-beta-1 is a member of the LAR (leukocyte common antigen-related) protein tyrosine phosphatase-interacting protein (liprin) family []. Liprin-beta-1 interacts with metastasis-associated protein S100A4 (Mts1), and this interaction results in the inhibition of liprin-beta-1 phosphorylation by protein kinase C and protein kinase CK2 in vitro []. In Xenopus, it plays a role in the maintenance of lymphatic vessel integrity [].Liprin was originally identified as binding partners of the receptor protein tyrosine phosphatase LAR (leukocyte common antigen-related), which functions in axon guidance and mammary gland development []. In vertebrates, there are two families of liprins, liprin-alpha and liprin-beta, which have four (alpha1-4) and two (beta1-2) members. Liprins contain an N-terminal coiled-coil domain and a C-terminal liprin homology (LH) region comprised of three sterile alpha motif (SAM) domains. The N-terminal coiled coils of liprin-alpha act as binding regions for several synaptic protein, while the SAM repeats can bind to both phosphatases and protein kinases []. The autophosphorylation of liprin regulates its association with LAR []. Interestingly, all Liprin-alpha genes are subject to alternative splicing, which is regulated in a developmental manner []. The structure of the humanCASK/liprin-alpha/liprin-beta ternary complex has been revealed [].
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Publication
32127548 | J:294598
First Author: Cardot-Ruffino V
Year: 2020
Journal: Sci Rep
Title: Generation of a conditional Flpo/FRT mouse model expressing constitutively active TGFβ in fibroblasts.
Volume: 10
Issue: 1
Pages: 3880
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Protein
Q8C8U0
Organism: Mus musculus/domesticus
Length: 969  
Fragment?: false
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Protein
Q3UJ84
Organism: Mus musculus/domesticus
Length: 969  
Fragment?: false
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Protein
Q3U417
Organism: Mus musculus/domesticus
Length: 969  
Fragment?: false
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Protein
F6S1C4
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
A0A0N4SUZ5
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
F7CUU8
Organism: Mus musculus/domesticus
Length: 242  
Fragment?: true
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Protein
F6YZ95
Organism: Mus musculus/domesticus
Length: 193  
Fragment?: true
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Protein
O35711
Organism: Mus musculus/domesticus
Length: 882  
Fragment?: false
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Protein
G3X957
Organism: Mus musculus/domesticus
Length: 882  
Fragment?: false
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Publication
30897344 | J:290915
First Author: Potikha T
Year: 2019
Journal: FASEB J
Title: Lack of galectin-1 exacerbates chronic hepatitis, liver fibrosis, and carcinogenesis in murine hepatocellular carcinoma model.
Volume: 33
Issue: 7
Pages: 7995-8007
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Publication
31265437 | J:293112
   
First Author: Ren YA
Year: 2019
Journal: JCI Insight
Title: S100a4-Cre-mediated deletion of Patched1 causes hypogonadotropic hypogonadism: role of pituitary hematopoietic cells in endocrine regulation.
Volume: 5
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Publication
15836921 | J:97959
First Author: Zhu X
Year: 2005
Journal: Brain Res Mol Brain Res
Title: Gene expression profiling in phosphatidylethanolamine N-methyltransferase knockout mice.
Volume: 134
Issue: 2
Pages: 239-55
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Publication
19074870 | J:142242
First Author: Harris MA
Year: 2008
Journal: Cancer Res
Title: Cancer stem cells are enriched in the side population cells in a mouse model of glioma.
Volume: 68
Issue: 24
Pages: 10051-9
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Publication
19556518 | J:301916
First Author: Tanjore H
Year: 2009
Journal: Am J Respir Crit Care Med
Title: Contribution of epithelial-derived fibroblasts to bleomycin-induced lung fibrosis.
Volume: 180
Issue: 7
Pages: 657-65
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Publication
19950223 | J:162063
First Author: Hombach-Klonisch S
Year: 2010
Journal: Int J Cancer
Title: INSL3 has tumor-promoting activity in thyroid cancer.
Volume: 127
Issue: 3
Pages: 521-31
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Publication
26160957 | J:290152
First Author: Poduri A
Year: 2015
Journal: Arterioscler Thromb Vasc Biol
Title: Fibroblast Angiotensin II Type 1a Receptors Contribute to Angiotensin II-Induced Medial Hyperplasia in the Ascending Aorta.
Volume: 35
Issue: 9
Pages: 1995-2002
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Publication
21123492 | J:169327
First Author: Basile DP
Year: 2011
Journal: Am J Physiol Renal Physiol
Title: Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury.
Volume: 300
Issue: 3
Pages: F721-33
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Publication
20110411 | J:158518
First Author: Katoh H
Year: 2010
Journal: Am J Pathol
Title: COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.
Volume: 176
Issue: 3
Pages: 1469-83
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Publication
34160104 | J:321377
First Author: Ye Y
Year: 2021
Journal: FASEB J
Title: Pyruvate kinase M2 mediates fibroblast proliferation to promote tubular epithelial cell survival in acute kidney injury.
Volume: 35
Issue: 7
Pages: e21706
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Publication
27862618 | J:333489
First Author: Agarwal S
Year: 2017
Journal: Stem Cells
Title: Scleraxis-Lineage Cells Contribute to Ectopic Bone Formation in Muscle and Tendon.
Volume: 35
Issue: 3
Pages: 705-710
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Publication
30951381 | J:292646
First Author: Best KT
Year: 2019
Journal: FASEB J
Title: Scleraxis lineage cells contribute to organized bridging tissue during tendon healing and identify a subpopulation of resident tendon cells.
Volume: 33
Issue: 7
Pages: 8578-8587
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Publication
32869443 | J:301110
First Author: Honda M
Year: 2020
Journal: J Cell Mol Med
Title: Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.
Volume: 24
Issue: 20
Pages: 11984-11997
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Publication
26876012 | J:242374
 
First Author: Borniger JC
Year: 2016
Journal: Behav Brain Res
Title: Behavioral abnormalities in mice lacking mesenchyme-specific Pten.
Volume: 304
Pages: 80-5
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Publication
25290060 | J:318748
 
First Author: Schmid D
Year: 2014
Journal: ASN Neuro
Title: MAL overexpression leads to disturbed expression of genes that influence cytoskeletal organization and differentiation of Schwann cells.
Volume: 6
Issue: 5
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Publication
17970044 | J:133687
First Author: Yao R
Year: 2007
Journal: Anticancer Res
Title: Expression of S100 protein family members in the pathogenesis of bladder tumors.
Volume: 27
Issue: 5A
Pages: 3051-8
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Publication
21795396 | J:183025
First Author: Sack U
Year: 2011
Journal: Mol Biol Cell
Title: S100A4-induced cell motility and metastasis is restricted by the Wnt/β-catenin pathway inhibitor calcimycin in colon cancer cells.
Volume: 22
Issue: 18
Pages: 3344-54
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Publication
23525012 | J:301679
First Author: Sonnylal S
Year: 2013
Journal: J Cell Sci
Title: Connective tissue growth factor causes EMT-like cell fate changes in vivo and in vitro.
Volume: 126
Issue: Pt 10
Pages: 2164-75
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Publication
20099318 | J:301105
First Author: Lee PT
Year: 2010
Journal: Stem Cells
Title: Mouse kidney progenitor cells accelerate renal regeneration and prolong survival after ischemic injury.
Volume: 28
Issue: 3
Pages: 573-84
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Publication
37356123 | J:354258
 
First Author: Wu X
Year: 2023
Journal: Int Immunopharmacol
Title: Ficolin A knockout alleviates sepsis-induced severe lung injury in mice by restoring gut Akkermansia to inhibit S100A4/STAT3 pathway.
Volume: 121
Pages: 110548
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Publication
39664586 | J:359446
First Author: Liu T
Year: 2024
Journal: Int J Biol Sci
Title: Smad4 Deficiency in S100A4(+) Macrophages Enhances Colitis-associated Tumorigenesis by Promoting Macrophage Lipid Metabolism Augmented M2 Polarization.
Volume: 20
Issue: 15
Pages: 6114-6129
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Publication
17106243 | J:120791
First Author: Sugimoto H
Year: 2006
Journal: Cancer Biol Ther
Title: Identification of fibroblast heterogeneity in the tumor microenvironment.
Volume: 5
Issue: 12
Pages: 1640-6
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Protein
Q6IQY8
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
A0A0G2JGD2
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Publication
9624153 | -
First Author: Serra-Pagès C
Year: 1998
Journal: J Biol Chem
Title: Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins.
Volume: 273
Issue: 25
Pages: 15611-20
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Protein
P07091
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Protein
Q545V2
Organism: Mus musculus/domesticus
Length: 101  
Fragment?: false
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Publication
19013515 | J:146971
First Author: Zürner M
Year: 2009
Journal: Genomics
Title: The mouse and human Liprin-alpha family of scaffolding proteins: genomic organization, expression profiling and regulation by alternative splicing.
Volume: 93
Issue: 3
Pages: 243-53
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Publication
16313174 | -
First Author: Serra-Pagès C
Year: 2005
Journal: Biochemistry
Title: Liprin phosphorylation regulates binding to LAR: evidence for liprin autophosphorylation.
Volume: 44
Issue: 48
Pages: 15715-24
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Publication
21855798 | -
First Author: Wei Z
Year: 2011
Journal: Mol Cell
Title: Liprin-mediated large signaling complex organization revealed by the liprin-α/CASK and liprin-α/liprin-β complex structures.
Volume: 43
Issue: 4
Pages: 586-98
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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