|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 470 for Sarm1

<< First    < Previous  |  Next >    Last >>
0.018s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
18089857 | -
First Author: Dalod M
Year: 2007
Journal: Sci STKE
Title: Studies of SARM1 uncover similarities between immune and neuronal responses to danger.
Volume: 2007
Issue: 417
Pages: pe73
•
•
•
•
•
Publication
27797810 | -
First Author: Geisler S
Year: 2016
Journal: Brain
Title: Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice.
Volume: 139
Issue: Pt 12
Pages: 3092-3108
•
•
•
•
•
Publication
34403688 | J:337118
 
First Author: Sasaki Y
Year: 2021
Journal: Exp Neurol
Title: Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection.
Volume: 345
Pages: 113842
•
•
•
•
•
Publication
35493328 | J:325448
 
First Author: Crawford CL
Year: 2022
Journal: Front Mol Neurosci
Title: SARM1 Depletion Slows Axon Degeneration in a CNS Model of Neurotropic Viral Infection.
Volume: 15
Pages: 860410
•
•
•
•
•
Publication
24744698 | J:312012
 
First Author: Lin CW
Year: 2014
Journal: Front Cell Neurosci
Title: Sarm1 deficiency impairs synaptic function and leads to behavioral deficits, which can be ameliorated by an mGluR allosteric modulator.
Volume: 8
Pages: 87
•
•
•
•
•
Allele
Sarm1<em1Smoc> | MGI:7292166
Name: sterile alpha and HEAT/Armadillo motif containing 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Publication
22837513 | -
First Author: Yu XM
Year: 2012
Journal: Science
Title: Neuroscience. dSarm-ing axon degeneration.
Volume: 337
Issue: 6093
Pages: 418-9
•
•
•
•
•
Publication
26686637 | -
First Author: Loreto A
Year: 2015
Journal: Cell Rep
Title: Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca(2+) Influx but Only Modestly Influenced by Mitochondria.
Volume: 13
Issue: 11
Pages: 2539-2552
•
•
•
•
•
Publication
26423149 | -
First Author: Mukherjee P
Year: 2015
Journal: J Immunol
Title: SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons.
Volume: 195
Issue: 10
Pages: 4913-21
•
•
•
•
•
Publication
26912636 | -
First Author: Henninger N
Year: 2016
Journal: Brain
Title: Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1.
Volume: 139
Issue: Pt 4
Pages: 1094-105
•
•
•
•
•
Strain
MGI:7623478 | C57BL/6JSmoc-Sarm1<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Publication
36287209 | J:335315
 
First Author: Dingwall CB
Year: 2022
Journal: J Clin Invest
Title: Macrophage depletion blocks congenital SARM1-dependent neuropathy.
Volume: 132
Issue: 23
•
•
•
•
•
Publication
29669278 | J:270690
First Author: Wang Q
Year: 2018
Journal: Cell Rep
Title: Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries.
Volume: 23
Issue: 3
Pages: 716-724
•
•
•
•
•
Publication
34659244 | J:312710
 
First Author: Son S
Year: 2021
Journal: Front Immunol
Title: Neutrophils Facilitate Prolonged Inflammasome Response in the DAMP-Rich Inflammatory Milieu.
Volume: 12
Pages: 746032
•
•
•
•
•
Publication
25564448 | J:230985
First Author: Chintala SK
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Activation of TLR3 promotes the degeneration of retinal ganglion cells by upregulating the protein levels of JNK3.
Volume: 56
Issue: 1
Pages: 505-14
•
•
•
•
•
Publication
30150401 | J:265888
First Author: Summers DW
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.
Volume: 115
Issue: 37
Pages: E8746-E8754
•
•
•
•
•
Publication
29395922 | -
First Author: Essuman K
Year: 2018
Journal: Curr Biol
Title: TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.
Volume: 28
Issue: 3
Pages: 421-430.e4
•
•
•
•
•
Publication
34184985 | -
   
First Author: Loring HS
Year: 2021
Journal: Elife
Title: A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration.
Volume: 10
•
•
•
•
•
Protein Domain
IPR000157 | TIR_dom
Type: Domain
Description: This entry represents the Toll/interleukin-1 receptor (TIR) domain, which is the conserved cytoplasmic domain of approximately 200 amino acids, found in Toll-like receptors (TLRs) and their adaptors. Proteins containing this domain can also be found in plants, where they mediate disease resistance [], and in bacteria, where they have been associated with virulence. Interestingly, the TIR domains from proteins present in all three major domains of life have been shown to cleave nicotinamide adenine dinucleotide (NAD+). In plants, TIR domains require self-association interfaces and a putative catalytic glutamic acid that is conserved in both bacterial TIR NAD+-cleaving enzymes (NADases) and the mammalian SARM1 (sterile alpha and TIR motif containing 1) NADase for cell death induction and NAD+ cleavage activity [, ]. It has been suggested that the primordial function of the TIR domain is the enzymatic cleavage of NAD+ and that the scaffolding function, which is best characterised in mammalian TIR domains involved in innate immunity, may be a more recent evolutionary adaptation [].Toll proteins or Toll-like receptors (TLRs) and the interleukin-1 receptor (IL-1R) superfamily are both involved in innate antibacterial and antifungalimmunity in insects as well as in mammals. These receptors share a conserved cytoplasmic domain of approximately 200 amino acids, known as the Toll/IL-1R homologous region (TIR). The similarity between TLRs and IL-1Rs is not restricted to sequence homology since these proteins also share a similar signalling pathway. They both induce the activation of a Rel type transcription factor via an adaptor protein and a protein kinase []. Interestingly, MyD88, a cytoplasmic adaptor protein found in mammals, contains a TIR domain associated to a DEATH domain [, , ]. Besides the mammalian and Drosophila proteins, a TIR domain is also found in a number of plant cytoplasmic proteins implicated in host defense [].Site directed mutagenesis and deletion analysis have shown that the TIR domain is essential for Toll and IL-1R activities. Sequence analysis have revealed the presence of three highly conserved regions among the different members of the family: box 1 (FDAFISY), box 2 (GYKLC-RD-PG), and box 3 (a conserved W surrounded by basic residues). It has been proposed that boxes 1 and 2 are involved in the binding of proteins involved in signalling, whereas box 3 is primarily involved in directing localization of receptor, perhaps through interactions with cytoskeletal element [].Resolution of the crystal structures of the TIR domains of human Toll-like receptors 1 and 2 has shown that they contain a central five-stranded parallel β-sheet that is surrounded by a total of five helices on both sides, with connecting loop structures []. The loop regions appear to play an important role in mediating the specificity of protein-protein interactions [, ].
•
•
•
•
•
Protein
Q80VH0
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
•
•
•
•
•
Protein
Q9EQ32
Organism: Mus musculus/domesticus
Length: 811  
Fragment?: false
•
•
•
•
•
Protein
Q80UF7
Organism: Mus musculus/domesticus
Length: 732  
Fragment?: false
•
•
•
•
•
Publication
10231569 | J:54928
First Author: Takeuchi O
Year: 1999
Journal: Gene
Title: TLR6: A novel member of an expanding toll-like receptor family.
Volume: 231
Issue: 1-2
Pages: 59-65
•
•
•
•
•
Protein
Q8BJQ4
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
•
•
•
•
•
Protein
Q99JY1
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
•
•
•
•
•
Protein
G3GHZ8
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
•
•
•
•
•
Protein
H3BKL1
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: false
•
•
•
•
•
Protein
G3GHZ7
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
•
•
•
•
•
Protein
Q0P699
Organism: Mus musculus/domesticus
Length: 783  
Fragment?: false
•
•
•
•
•
Protein
H3BLC8
Organism: Mus musculus/domesticus
Length: 219  
Fragment?: true
•
•
•
•
•
Protein
Q3UB38
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
•
•
•
•
•
Protein
A0A1S5WLF0
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: false
•
•
•
•
•
Protein
Q542S6
Organism: Mus musculus/domesticus
Length: 241  
Fragment?: false
•
•
•
•
•
Publication
8621445 | -
First Author: Mitcham JL
Year: 1996
Journal: J Biol Chem
Title: T1/ST2 signaling establishes it as a member of an expanding interleukin-1 receptor family.
Volume: 271
Issue: 10
Pages: 5777-83
•
•
•
•
•
Publication
9374458 | -
First Author: Muzio M
Year: 1997
Journal: Science
Title: IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling.
Volume: 278
Issue: 5343
Pages: 1612-5
•
•
•
•
•
Publication
10679407 | -
First Author: Anderson KV
Year: 2000
Journal: Curr Opin Immunol
Title: Toll signaling pathways in the innate immune response.
Volume: 12
Issue: 1
Pages: 13-9
•
•
•
•
•
Publication
9868361 | -
First Author: Van der Biezen EA
Year: 1998
Journal: Trends Biochem Sci
Title: Plant disease-resistance proteins and the gene-for-gene concept.
Volume: 23
Issue: 12
Pages: 454-6
•
•
•
•
•
Publication
10671496 | -
First Author: Slack JL
Year: 2000
Journal: J Biol Chem
Title: Identification of two major sites in the type I interleukin-1 receptor cytoplasmic region responsible for coupling to pro-inflammatory signaling pathways.
Volume: 275
Issue: 7
Pages: 4670-8
•
•
•
•
•
Publication
11081518 | J:114793
First Author: Xu Y
Year: 2000
Journal: Nature
Title: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains.
Volume: 408
Issue: 6808
Pages: 111-5
•
•
•
•
•
Publication
31439793 | -
First Author: Wan L
Year: 2019
Journal: Science
Title: TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.
Volume: 365
Issue: 6455
Pages: 799-803
•
•
•
•
•
Protein
P22366
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
Q9JLZ8
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
Q9EQU3
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
•
•
•
•
•
Protein
P58681
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
•
•
•
•
•
Protein
P58682
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
•
•
•
•
•
Protein
Q3U7M4
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
U5LLB3
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
•
•
•
•
•
Protein
Q0PM15
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
A0A1B0GS40
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
•
•
•
•
•
Protein
Q3UDG9
Organism: Mus musculus/domesticus
Length: 284  
Fragment?: true
•
•
•
•
•
Protein
Q3TIB3
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
Q3UKS3
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
Q3U6W5
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
Q0PM16
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
Q3V005
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
U5LLA9
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
•
•
•
•
•
Protein
U5LI18
Organism: Mus musculus/domesticus
Length: 1049  
Fragment?: true
•
•
•
•
•
Protein
Q548J0
Organism: Mus musculus/domesticus
Length: 1050  
Fragment?: false
•
•
•
•
•
Publication
15368895 | J:92575
First Author: Okazaki N
Year: 2004
Journal: DNA Res
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume: 11
Issue: 3
Pages: 205-18
•
•
•
•
•
Protein
P59823
Organism: Mus musculus/domesticus
Length: 695  
Fragment?: false
•
•
•
•
•
Protein
Q61098
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
•
•
•
•
•
Protein
Q9Z2B1
Organism: Mus musculus/domesticus
Length: 614  
Fragment?: false
•
•
•
•
•
Protein
P14719
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
•
•
•
•
•
Protein
Q6R5N8
Organism: Mus musculus/domesticus
Length: 991  
Fragment?: false
•
•
•
•
•
Protein
Q99MB1
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
•
•
•
•
•
Protein
Q6R5P0
Organism: Mus musculus/domesticus
Length: 926  
Fragment?: false
•
•
•
•
•
Protein
Q9EPW9
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
•
•
•
•
•
Protein
Q9EPQ1
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
•
•
•
•
•
Protein
Q9QUK6
Organism: Mus musculus/domesticus
Length: 835  
Fragment?: false
•
•
•
•
•
Protein
Q9QUN7
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: false
•
•
•
•
•
Protein
Q6QNU9
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
•
•
•
•
•
Protein
Q9JLF7
Organism: Mus musculus/domesticus
Length: 859  
Fragment?: false
•
•
•
•
•
Protein
Q61730
Organism: Mus musculus/domesticus
Length: 570  
Fragment?: false
•
•
•
•
•
Protein
U5LHT3
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
•
•
•
•
•
Protein
V9PC74
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
•
•
•
•
•
Protein
U5LIX2
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
•
•
•
•
•
Protein
V9PCB9
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
•
•
•
•
•
Protein
U5LIT5
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
•
•
•
•
•
Protein
U5LL62
Organism: Mus musculus/domesticus
Length: 749  
Fragment?: true
•
•
•
•
•
Protein
V9PC79
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
•
•
•
•
•
Protein
V9PCD3
Organism: Mus musculus/domesticus
Length: 748  
Fragment?: true
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom