|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 406 for Sdha

<< First    < Previous  |  Next >    Last >>
0.028s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
31167115 | J:278355
 
First Author: Moysés-Oliveira M
Year: 2019
Journal: Gene
Title: Search for appropriate reference genes for quantitative reverse transcription PCR studies in somite, prosencephalon and heart of early mouse embryo.
Volume: 710
Pages: 148-155
•
•
•
•
•
Publication
32480041 | J:306165
 
First Author: Delavallée L
Year: 2020
Journal: Mol Metab
Title: Mitochondrial AIF loss causes metabolic reprogramming, caspase-independent cell death blockade, embryonic lethality, and perinatal hydrocephalus.
Volume: 40
Pages: 101027
•
•
•
•
•
Publication
36983072 | J:334467
 
First Author: Sun X
Year: 2023
Journal: Int J Mol Sci
Title: Mitochondrial Methionyl-tRNA Formyltransferase Deficiency Alleviates Metaflammation by Modulating Mitochondrial Activity in Mice.
Volume: 24
Issue: 6
•
•
•
•
•
Publication
19837698 | J:155116
First Author: Yang H
Year: 2010
Journal: Hum Mol Genet
Title: Analysis of mouse models of cytochrome c oxidase deficiency owing to mutations in Sco2.
Volume: 19
Issue: 1
Pages: 170-80
•
•
•
•
•
Publication
39482367 | J:357841
First Author: Ohanele C
Year: 2024
Journal: Commun Biol
Title: The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart.
Volume: 7
Issue: 1
Pages: 1422
•
•
•
•
•
Publication
19808025 | J:153657
First Author: Forner F
Year: 2009
Journal: Cell Metab
Title: Proteome differences between brown and white fat mitochondria reveal specialized metabolic functions.
Volume: 10
Issue: 4
Pages: 324-35
•
•
•
•
•
Publication
16120479 | J:109661
First Author: Schilling B
Year: 2006
Journal: Biochim Biophys Acta
Title: Proteomic analysis of succinate dehydrogenase and ubiquinol-cytochrome c reductase (Complex II and III) isolated by immunoprecipitation from bovine and mouse heart mitochondria.
Volume: 1762
Issue: 2
Pages: 213-22
•
•
•
•
•
Publication
28173120 | J:238642
First Author: Vrbacký M
Year: 2016
Journal: Hum Mol Genet
Title: Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice.
Volume: 25
Issue: 21
Pages: 4674-4685
•
•
•
•
•
Publication
26430214 | J:233771
First Author: Chen HH
Year: 2015
Journal: J Cell Sci
Title: NRIP is newly identified as a Z-disc protein, activating calmodulin signaling for skeletal muscle contraction and regeneration.
Volume: 128
Issue: 22
Pages: 4196-209
•
•
•
•
•
Publication
21780252 | J:190206
First Author: Baris OR
Year: 2011
Journal: Stem Cells
Title: The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells.
Volume: 29
Issue: 9
Pages: 1459-68
•
•
•
•
•
Publication
29988383 | J:266272
 
First Author: Hilse KE
Year: 2018
Journal: Front Physiol
Title: The Expression of Uncoupling Protein 3 Coincides With the Fatty Acid Oxidation Type of Metabolism in Adult Murine Heart.
Volume: 9
Pages: 747
•
•
•
•
•
Publication
25158167 | J:216158
First Author: Rastetter RH
Year: 2014
Journal: Dev Biol
Title: Marker genes identify three somatic cell types in the fetal mouse ovary.
Volume: 394
Issue: 2
Pages: 242-52
•
•
•
•
•
Publication
28188211 | J:249661
First Author: Schatton D
Year: 2017
Journal: J Cell Biol
Title: CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.
Volume: 216
Issue: 3
Pages: 675-693
•
•
•
•
•
Publication
38414851 | J:345617
First Author: Beutner G
Year: 2024
Journal: iScience
Title: Coordinated metabolic responses to cyclophilin D deletion in the developing heart.
Volume: 27
Issue: 3
Pages: 109157
•
•
•
•
•
Publication
22844512 | J:189715
First Author: Chen H
Year: 2012
Journal: PLoS One
Title: Identification of novel markers of mouse fetal ovary development.
Volume: 7
Issue: 7
Pages: e41683
•
•
•
•
•
Publication
35013307 | J:317822
First Author: Chern T
Year: 2022
Journal: Nat Commun
Title: Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin metabolism and ribosomopathy.
Volume: 13
Issue: 1
Pages: 134
•
•
•
•
•
Publication
31241463 | J:290696
   
First Author: López-Tello J
Year: 2019
Journal: Elife
Title: Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice.
Volume: 8
•
•
•
•
•
Publication
21985497 | J:178848
 
First Author: An CI
Year: 2011
Journal: BMC Dev Biol
Title: Genome-wide mapping of Sox6 binding sites in skeletal muscle reveals both direct and indirect regulation of muscle terminal differentiation by Sox6.
Volume: 11
Pages: 59
•
•
•
•
•
Publication
25348719 | J:224310
First Author: Ishihara T
Year: 2015
Journal: Mol Cell Biol
Title: Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.
Volume: 35
Issue: 1
Pages: 211-23
•
•
•
•
•
Publication
26299309 | J:224980
 
First Author: Lee KY
Year: 2015
Journal: Nat Commun
Title: Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism.
Volume: 6
Pages: 8054
•
•
•
•
•
Publication
26876175 | J:301859
First Author: Poché RA
Year: 2016
Journal: Cell Rep
Title: RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina.
Volume: 14
Issue: 7
Pages: 1684-1697
•
•
•
•
•
Publication
38418556 | J:346910
First Author: Ayyangar U
Year: 2024
Journal: EMBO J
Title: Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin.
Volume: 43
Issue: 7
Pages: 1113-1134
•
•
•
•
•
Publication
17276355 | J:129766
First Author: Sano M
Year: 2007
Journal: Cell Metab
Title: Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.
Volume: 5
Issue: 2
Pages: 129-42
•
•
•
•
•
Publication
36220812 | J:336417
First Author: Chong D
Year: 2022
Journal: Cell Discov
Title: Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming.
Volume: 8
Issue: 1
Pages: 106
•
•
•
•
•
Publication
39181129 | J:353791
     
First Author: Xu L
Year: 2024
Journal: Cell Stem Cell
Title: Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.
•
•
•
•
•
Publication
30030361 | J:320063
First Author: Signes A
Year: 2018
Journal: Essays Biochem
Title: Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.
Volume: 62
Issue: 3
Pages: 255-270
•
•
•
•
•
Publication
26697723 | J:233841
First Author: Inoue M
Year: 2016
Journal: Endocrinology
Title: Isolation and Characterization of Fetal Leydig Progenitor Cells of Male Mice.
Volume: 157
Issue: 3
Pages: 1222-33
•
•
•
•
•
Publication
26644517 | J:230728
First Author: Kumar V
Year: 2015
Journal: J Cell Biol
Title: A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
Volume: 211
Issue: 5
Pages: 1057-75
•
•
•
•
•
Publication
17626619 | J:125993
 
First Author: Cankaya M
Year: 2007
Journal: BMC Genomics
Title: An analysis of expression patterns of genes encoding proteins with catalytic activities.
Volume: 8
Pages: 232
•
•
•
•
•
Publication
27215380 | J:236179
First Author: Bowman CE
Year: 2016
Journal: Mol Cell Biol
Title: Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Volume: 36
Issue: 15
Pages: 2089-104
•
•
•
•
•
Publication
12865426 | J:100953
First Author: Da Cruz S
Year: 2003
Journal: J Biol Chem
Title: Proteomic analysis of the mouse liver mitochondrial inner membrane.
Volume: 278
Issue: 42
Pages: 41566-71
•
•
•
•
•
Publication
27689697 | J:235644
First Author: Wu Y
Year: 2016
Journal: PLoS Genet
Title: Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury.
Volume: 12
Issue: 9
Pages: e1006355
•
•
•
•
•
Publication
28245920 | J:240028
First Author: Bulusu V
Year: 2017
Journal: Dev Cell
Title: Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Volume: 40
Issue: 4
Pages: 331-341.e4
•
•
•
•
•
Publication
17634366 | J:145263
First Author: Werner HB
Year: 2007
Journal: J Neurosci
Title: Proteolipid protein is required for transport of sirtuin 2 into CNS myelin.
Volume: 27
Issue: 29
Pages: 7717-30
•
•
•
•
•
Publication
28700664 | J:246066
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
•
•
•
•
•
Publication
14651853 | J:86816
First Author: Mootha VK
Year: 2003
Journal: Cell
Title: Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria.
Volume: 115
Issue: 5
Pages: 629-40
•
•
•
•
•
Publication
18614015 | J:151002
First Author: Pagliarini DJ
Year: 2008
Journal: Cell
Title: A mitochondrial protein compendium elucidates complex I disease biology.
Volume: 134
Issue: 1
Pages: 112-23
•
•
•
•
•
Publication
- | J:342601
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniPathway vocabulary mapping
•
•
•
•
•
Publication
- | J:68100
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: RIKEN Data Curation in Mouse Genome Informatics
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
•
•
•
•
•
Publication
- | J:84900
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Journal: Database Download
Title: Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:188991
     
First Author: The Jackson Laboratory
Year: 2012
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by The Jackson Laboratory
•
•
•
•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
DO Term
DOID:0110435 | dilated cardiomyopathy 1GG
•
•
•
•
•
Allele
Tg(CMV-cat,-SDHA*Y215F)1Hom | MGI:7520826
Name: transgene insertion 1, Yoshimi Homma
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
Allele
Tg(Sdha-EGFP)LU59Gsat | MGI:4847403
Name: transgene insertion LU59, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
•
•
•
•
•
Strain
MGI:6147281 | C57BL/6J-Tg(CMV-cat,-SDHA*Y215F)1Hom/HomRbrc
Attribute String: mutant strain, coisogenic, transgenic
•
•
•
•
•
Gene
644096 | SDHAF1
Type: gene
Organism: human
•
•
•
•
•
Strain
MGI:5004231 | STOCK Tg(Sdha-EGFP)LU59Gsat/Mmucd
Attribute String: mutant stock, transgenic
•
•
•
•
•
Gene
6390 | SDHB
Type: gene
Organism: human
•
•
•
•
•
Gene
6392 | SDHD
Type: gene
Organism: human
•
•
•
•
•
DO Term
DOID:0060537 | mitochondrial complex II deficiency
•
•
•
•
•
Publication
27883180 | J:246252
First Author: Ogura M
Year: 2017
Journal: Eur J Immunol
Title: Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.
Volume: 47
Issue: 2
Pages: 406-418
•
•
•
•
•
Protein Domain
IPR036714 | SDH_sf
Type: Homologous_superfamily
Description: This superfamily includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE.Both yeast and human Sdh5/SDHAF2, which are mitochondrial succinate dehydrogenase assembly factors, interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans []. Bacterial homologues of Sdh5, termed FAD assembly factor SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria [].
•
•
•
•
•
Protein
A0A494B8X4
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: false
•
•
•
•
•
Protein
Q8C6I2
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
•
•
•
•
•
Protein
A0A494B9B9
Organism: Mus musculus/domesticus
Length: 166  
Fragment?: false
•
•
•
•
•
Publication
19628817 | -
First Author: Hao HX
Year: 2009
Journal: Science
Title: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.
Volume: 325
Issue: 5944
Pages: 1139-42
•
•
•
•
•
Publication
22474332 | -
First Author: McNeil MB
Year: 2012
Journal: J Biol Chem
Title: SdhE is a conserved protein required for flavinylation of succinate dehydrogenase in bacteria.
Volume: 287
Issue: 22
Pages: 18418-28
•
•
•
•
•
Protein Domain
IPR005631 | SDH
Type: Family
Description: This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE.Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans []. Bacterial homologues of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterised as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria [].This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true.
•
•
•
•
•
Publication
29125827 | J:250109
First Author: Lin H
Year: 2017
Journal: Dis Model Mech
Title: Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia.
Volume: 10
Issue: 11
Pages: 1343-1352
•
•
•
•
•
Publication
29162555 | J:256655
     
First Author: Verma M
Year: 2017
Journal: Brain Behav Immun
Title: 11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation.
•
•
•
•
•
Publication
32439544 | J:298664
 
First Author: Sun Z
Year: 2020
Journal: Neuroscience
Title: Characterization of Age-dependent Behavior Deficits in the PGC-1α Knockout Mouse, in Relevance to the Parkinson's Disease Model.
Volume: 440
Pages: 39-47
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom