Type |
Details |
Score |
Publication |
First Author: |
Sang C |
Year: |
2017 |
Journal: |
J Cell Physiol |
Title: |
TNF-α promotes osteoclastogenesis through JNK signaling-dependent induction of Semaphorin3D expression in estrogen-deficiency induced osteoporosis. |
Volume: |
232 |
Issue: |
12 |
Pages: |
3396-3408 |
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•
•
•
•
•
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Publication |
First Author: |
Shao A |
Year: |
2022 |
Journal: |
Sci Rep |
Title: |
Multiomics analysis reveals that hepatocyte nuclear factor 1β regulates axon guidance genes in the developing mouse kidney. |
Volume: |
12 |
Issue: |
1 |
Pages: |
17586 |
|
•
•
•
•
•
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Publication |
First Author: |
Schulz Y |
Year: |
2014 |
Journal: |
Hum Genet |
Title: |
CHD7, the gene mutated in CHARGE syndrome, regulates genes involved in neural crest cell guidance. |
Volume: |
133 |
Issue: |
8 |
Pages: |
997-1009 |
|
•
•
•
•
•
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Publication |
First Author: |
Lu WC |
Year: |
2018 |
Journal: |
Neural Regen Res |
Title: |
The protocadherin alpha cluster is required for axon extension and myelination in the developing central nervous system. |
Volume: |
13 |
Issue: |
3 |
Pages: |
427-433 |
|
•
•
•
•
•
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Publication |
First Author: |
Gu C |
Year: |
2005 |
Journal: |
Science |
Title: |
Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. |
Volume: |
307 |
Issue: |
5707 |
Pages: |
265-8 |
|
•
•
•
•
•
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Publication |
First Author: |
Jidigam VK |
Year: |
2022 |
Journal: |
Commun Biol |
Title: |
Neuronal Bmal1 regulates retinal angiogenesis and neovascularization in mice. |
Volume: |
5 |
Issue: |
1 |
Pages: |
792 |
|
•
•
•
•
•
|
Publication |
First Author: |
Quijada P |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Coordination of endothelial cell positioning and fate specification by the epicardium. |
Volume: |
12 |
Issue: |
1 |
Pages: |
4155 |
|
•
•
•
•
•
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Publication |
First Author: |
Kolk SM |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons and controls their fasciculation, channeling, rostral growth, and intracortical targeting. |
Volume: |
29 |
Issue: |
40 |
Pages: |
12542-57 |
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•
•
•
•
•
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Publication |
First Author: |
Katayama K |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons. |
Volume: |
8 |
Issue: |
8 |
Pages: |
e72512 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sar Shalom H |
Year: |
2019 |
Journal: |
Elife |
Title: |
Balance between BDNF and Semaphorins gates the innervation of the mammary gland. |
Volume: |
8 |
|
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|
•
•
•
•
•
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Publication |
First Author: |
Tian X |
Year: |
2013 |
Journal: |
Cell Res |
Title: |
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. |
Volume: |
23 |
Issue: |
9 |
Pages: |
1075-90 |
|
•
•
•
•
•
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Publication |
First Author: |
Payne S |
Year: |
2015 |
Journal: |
Dev Biol |
Title: |
A critical role for the chromatin remodeller CHD7 in anterior mesoderm during cardiovascular development. |
Volume: |
405 |
Issue: |
1 |
Pages: |
82-95 |
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•
•
•
•
•
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Publication |
First Author: |
Kuwajima T |
Year: |
2012 |
Journal: |
Neuron |
Title: |
Optic chiasm presentation of Semaphorin6D in the context of Plexin-A1 and Nr-CAM promotes retinal axon midline crossing. |
Volume: |
74 |
Issue: |
4 |
Pages: |
676-90 |
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•
•
•
•
•
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Publication |
First Author: |
Martins LF |
Year: |
2022 |
Journal: |
Neuron |
Title: |
Motor neurons use push-pull signals to direct vascular remodeling critical for their connectivity. |
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•
•
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Publication |
First Author: |
Coate TM |
Year: |
2015 |
Journal: |
Elife |
Title: |
Neuropilin-2/Semaphorin-3F-mediated repulsion promotes inner hair cell innervation by spiral ganglion neurons. |
Volume: |
4 |
|
|
|
•
•
•
•
•
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Publication |
First Author: |
Chung L |
Year: |
2007 |
Journal: |
Development |
Title: |
Semaphorin signaling facilitates cleft formation in the developing salivary gland. |
Volume: |
134 |
Issue: |
16 |
Pages: |
2935-45 |
|
•
•
•
•
•
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Publication |
First Author: |
Takahashi K |
Year: |
2008 |
Journal: |
Dev Dyn |
Title: |
Expression of the semaphorins Sema 3D and Sema 3F in the developing parathyroid and thymus. |
Volume: |
237 |
Issue: |
6 |
Pages: |
1699-708 |
|
•
•
•
•
•
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Publication |
First Author: |
Kay JN |
Year: |
2012 |
Journal: |
Nature |
Title: |
MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons. |
Volume: |
483 |
Issue: |
7390 |
Pages: |
465-9 |
|
•
•
•
•
•
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Publication |
First Author: |
Liu CF |
Year: |
2018 |
Journal: |
Development |
Title: |
SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. |
Volume: |
145 |
Issue: |
14 |
|
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•
•
•
•
•
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Publication |
First Author: |
Lee H |
Year: |
2015 |
Journal: |
Exp Neurol |
Title: |
Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. |
Volume: |
269 |
|
Pages: |
17-27 |
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•
•
•
•
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Publication |
First Author: |
van de Haar LL |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
Molecular signatures and cellular diversity during mouse habenula development. |
Volume: |
40 |
Issue: |
1 |
Pages: |
111029 |
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•
•
•
•
•
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Publication |
First Author: |
Cohen S |
Year: |
2005 |
Journal: |
Eur J Neurosci |
Title: |
A semaphorin code defines subpopulations of spinal motor neurons during mouse development. |
Volume: |
21 |
Issue: |
7 |
Pages: |
1767-76 |
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•
•
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•
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Publication |
First Author: |
Tarantino LM |
Year: |
2000 |
Journal: |
Genomics |
Title: |
A high-resolution radiation hybrid map of the proximal portion of mouse chromosome 5. |
Volume: |
66 |
Issue: |
1 |
Pages: |
55-64 |
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•
•
•
•
•
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Publication |
First Author: |
Xu C |
Year: |
2008 |
Journal: |
Gene Expr Patterns |
Title: |
Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. |
Volume: |
8 |
Issue: |
7-8 |
Pages: |
502-7 |
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•
•
•
•
•
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Publication |
First Author: |
Nishida S |
Year: |
2018 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Collagen VI suppresses fibronectin-induced enteric neural crest cell migration by downregulation of focal adhesion proteins. |
Volume: |
495 |
Issue: |
1 |
Pages: |
1461-1467 |
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•
•
•
•
•
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Publication |
First Author: |
Qiu C |
Year: |
2024 |
Journal: |
Nature |
Title: |
A single-cell time-lapse of mouse prenatal development from gastrula to birth. |
Volume: |
626 |
Issue: |
8001 |
Pages: |
1084-1093 |
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•
•
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•
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Publication |
First Author: |
Meadows SM |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. |
Volume: |
110 |
Issue: |
1 |
Pages: |
34-46 |
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•
•
•
•
•
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Publication |
First Author: |
Dasgupta K |
Year: |
2019 |
Journal: |
Dev Biol |
Title: |
Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling. |
Volume: |
455 |
Issue: |
2 |
Pages: |
434-448 |
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•
•
•
•
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Publication |
First Author: |
Wilkerson BA |
Year: |
2021 |
Journal: |
Elife |
Title: |
Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris. |
Volume: |
10 |
|
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•
•
•
•
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Publication |
First Author: |
Boyle MP |
Year: |
2011 |
Journal: |
J Comp Neurol |
Title: |
Cell-type-specific consequences of Reelin deficiency in the mouse neocortex, hippocampus, and amygdala. |
Volume: |
519 |
Issue: |
11 |
Pages: |
2061-89 |
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•
•
•
•
•
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Publication |
First Author: |
Yoshida Y |
Year: |
2006 |
Journal: |
Neuron |
Title: |
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. |
Volume: |
52 |
Issue: |
5 |
Pages: |
775-88 |
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•
•
•
•
•
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Publication |
First Author: |
Chen B |
Year: |
2005 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. |
Volume: |
102 |
Issue: |
47 |
Pages: |
17184-9 |
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•
•
•
•
•
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Publication |
First Author: |
Quina LA |
Year: |
2009 |
Journal: |
J Neurosci |
Title: |
Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development. |
Volume: |
29 |
Issue: |
45 |
Pages: |
14309-22 |
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•
•
•
•
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Publication |
First Author: |
Abonnenc M |
Year: |
2013 |
Journal: |
Circ Res |
Title: |
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. |
Volume: |
113 |
Issue: |
10 |
Pages: |
1138-47 |
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•
•
•
•
•
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Publication |
First Author: |
Memic F |
Year: |
2018 |
Journal: |
Gastroenterology |
Title: |
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. |
Volume: |
154 |
Issue: |
3 |
Pages: |
624-636 |
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•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
FANTOM2 Data Curation in Mouse Genome Informatics |
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•
•
•
•
•
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Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
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•
•
•
•
•
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Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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•
•
•
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•
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Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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•
•
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•
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Publication |
First Author: |
Wellcome Trust Sanger Institute |
Year: |
2009 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute |
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•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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•
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•
•
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Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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•
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•
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Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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•
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•
•
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Publication |
First Author: |
Carninci P |
Year: |
2005 |
Journal: |
Science |
Title: |
The transcriptional landscape of the mammalian genome. |
Volume: |
309 |
Issue: |
5740 |
Pages: |
1559-63 |
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•
•
•
•
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Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
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•
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Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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•
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Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
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•
•
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•
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Publication |
First Author: |
UniProt-GOA |
Year: |
2012 |
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Title: |
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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•
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•
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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•
•
•
•
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Liu Y |
Year: |
2004 |
Journal: |
J Neurosci |
Title: |
Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. |
Volume: |
24 |
Issue: |
2 |
Pages: |
310-8 |
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•
•
•
•
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Publication |
First Author: |
Berndt JD |
Year: |
2006 |
Journal: |
Development |
Title: |
Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain. |
Volume: |
133 |
Issue: |
20 |
Pages: |
3983-92 |
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Protein Domain |
Type: |
Domain |
Description: |
Semaphorin-3D (Sema3D) is a secreted semaphorin expressed during the development of the nervous system []. In zebrafish, Sema3D is expressed in the ventral tectum []. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract []. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer [, ]. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module. |
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Allele |
Name: |
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; targeted mutation 2.1, Jonthan Epstein |
Allele Type: |
Targeted |
Attribute String: |
Recombinase |
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Strain |
Attribute String: |
mutant stock |
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Genotype |
Symbol: |
Sema3d/Sema3d |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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Genotype |
Symbol: |
Sema3d/Sema3d<+> |
Background: |
involves: 129S6/SvEvTac * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
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•
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Publication |
First Author: |
Potiron V |
Year: |
2005 |
Journal: |
Sci STKE |
Title: |
Class 3 semaphorin signaling: the end of a dogma. |
Volume: |
2005 |
Issue: |
285 |
Pages: |
pe24 |
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•
•
•
•
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Publication |
First Author: |
Gaur P |
Year: |
2009 |
Journal: |
Clin Cancer Res |
Title: |
Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. |
Volume: |
15 |
Issue: |
22 |
Pages: |
6763-70 |
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HT Experiment |
Series Id: |
E-GEOD-22034 |
Experiment Type: |
transcription profiling by array |
Study Type: |
Baseline |
Source: |
GEO |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
660
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Jurisic G |
Year: |
2012 |
Journal: |
Circ Res |
Title: |
An unexpected role of semaphorin3a-neuropilin-1 signaling in lymphatic vessel maturation and valve formation. |
Volume: |
111 |
Issue: |
4 |
Pages: |
426-36 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
777
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
777
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Jurcak NR |
Year: |
2019 |
Journal: |
Gastroenterology |
Title: |
Axon Guidance Molecules Promote Perineural Invasion and Metastasis of Orthotopic Pancreatic Tumors in Mice. |
Volume: |
157 |
Issue: |
3 |
Pages: |
838-850.e6 |
|
•
•
•
•
•
|