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Search results 301 to 400 out of 878 for Sf1

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Type Details Score
Publication
10706291 | J:60621
First Author: Birk OS
Year: 2000
Journal: Nature
Title: The LIM homeobox gene Lhx9 is essential for mouse gonad formation.
Volume: 403
Issue: 6772
Pages: 909-13
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Publication
19457926 | J:150743
First Author: Buaas FW
Year: 2009
Journal: Hum Mol Genet
Title: The transcription co-factor CITED2 functions during sex determination and early gonad development.
Volume: 18
Issue: 16
Pages: 2989-3001
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Publication
11574675 | J:72113
First Author: Zhou D
Year: 2001
Journal: Nucleic Acids Res
Title: PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif.
Volume: 29
Issue: 19
Pages: 3939-48
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Publication
18588901 | J:168878
First Author: Manceau V
Year: 2008
Journal: J Mol Biol
Title: Different requirements of the kinase and UHM domains of KIS for its nuclear localization and binding to splicing factors.
Volume: 381
Issue: 3
Pages: 748-62
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Publication
33974562 | J:322269
 
First Author: Kaneko K
Year: 2021
Journal: JCI Insight
Title: Rap1 in the VMH regulates glucose homeostasis.
Volume: 6
Issue: 11
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Publication
16840539 | J:114716
First Author: Ellsworth BS
Year: 2006
Journal: Mol Endocrinol
Title: FOXL2 in the pituitary: molecular, genetic, and developmental analysis.
Volume: 20
Issue: 11
Pages: 2796-805
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Publication
16469766 | J:110059
First Author: McNay DE
Year: 2006
Journal: Mol Endocrinol
Title: Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells.
Volume: 20
Issue: 7
Pages: 1623-32
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Publication
24130552 | J:261765
 
First Author: Knoll JG
Year: 2013
Journal: Front Endocrinol (Lausanne)
Title: Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain.
Volume: 4
Pages: 140
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Publication
22294746 | J:183814
First Author: Ludbrook LM
Year: 2012
Journal: Endocrinology
Title: Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9).
Volume: 153
Issue: 4
Pages: 1948-58
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Publication
23843232 | J:203711
First Author: Wainwright EN
Year: 2013
Journal: Biol Reprod
Title: SOX9 regulates microRNA miR-202-5p/3p expression during mouse testis differentiation.
Volume: 89
Issue: 2
Pages: 34
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Publication
37129912 | J:337744
First Author: Mohan DR
Year: 2023
Journal: Cancer Res
Title: β-Catenin-Driven Differentiation Is a Tissue-Specific Epigenetic Vulnerability in Adrenal Cancer.
Volume: 83
Issue: 13
Pages: 2123-2141
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Publication
30260703 | J:283715
First Author: Haraguchi H
Year: 2019
Journal: FASEB J
Title: Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality.
Volume: 33
Issue: 2
Pages: 2610-2620
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Publication
21074524 | J:168022
First Author: Pelling M
Year: 2011
Journal: Dev Biol
Title: Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus.
Volume: 349
Issue: 2
Pages: 406-16
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Publication
21757499 | J:178424
First Author: Kashimada K
Year: 2011
Journal: FASEB J
Title: Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice.
Volume: 25
Issue: 10
Pages: 3561-9
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Publication
26671183 | J:233849
First Author: Berger A
Year: 2016
Journal: Endocrinology
Title: Gsα Deficiency in the Ventromedial Hypothalamus Enhances Leptin Sensitivity and Improves Glucose Homeostasis in Mice on a High-Fat Diet.
Volume: 157
Issue: 2
Pages: 600-10
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Publication
34905510 | J:320691
 
First Author: Yadav VK
Year: 2022
Journal: J Clin Invest
Title: Embryonic osteocalcin signaling determines lifelong adrenal steroidogenesis and homeostasis in the mouse.
Volume: 132
Issue: 4
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Publication
32719118 | J:293935
First Author: Fagan MP
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balance.
Volume: 117
Issue: 32
Pages: 19566-19577
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Publication
11124111 | J:66593
First Author: Zhao L
Year: 2001
Journal: Development
Title: Steroidogenic factor 1 (SF1) is essential for pituitary gonadotrope function.
Volume: 128
Issue: 2
Pages: 147-54
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Publication
18037398 | J:130185
First Author: Ellsworth BS
Year: 2008
Journal: Dev Biol
Title: Mechanisms underlying pituitary hypoplasia and failed cell specification in Lhx3-deficient mice.
Volume: 313
Issue: 1
Pages: 118-29
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Publication
37735247 | J:340815
First Author: Liu W
Year: 2023
Journal: Sci Rep
Title: A novel monoclonal antibody against 6-sulfo sialyl Lewis x glycans attenuates murine allergic rhinitis by suppressing Th2 immune responses.
Volume: 13
Issue: 1
Pages: 15740
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Publication
32839348 | J:300713
First Author: Quenneville S
Year: 2020
Journal: Diabetes
Title: Hypoglycemia-Sensing Neurons of the Ventromedial Hypothalamus Require AMPK-Induced Txn2 Expression but Are Dispensable for Physiological Counterregulation.
Volume: 69
Issue: 11
Pages: 2253-2266
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Publication
36007872 | J:330546
 
First Author: Brix LM
Year: 2022
Journal: Mol Metab
Title: Contribution of the co-chaperone FKBP51 in the ventromedial hypothalamus to metabolic homeostasis in male and female mice.
Volume: 65
Pages: 101579
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Publication
12651892 | J:82562
First Author: Pulichino AM
Year: 2003
Journal: Genes Dev
Title: Tpit determines alternate fates during pituitary cell differentiation.
Volume: 17
Issue: 6
Pages: 738-47
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Publication
25029241 | J:216230
First Author: Walczak EM
Year: 2014
Journal: Mol Endocrinol
Title: Wnt signaling inhibits adrenal steroidogenesis by cell-autonomous and non-cell-autonomous mechanisms.
Volume: 28
Issue: 9
Pages: 1471-86
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Publication
22987798 | J:193956
First Author: Cheung CC
Year: 2013
Journal: J Comp Neurol
Title: Genetic labeling of steroidogenic factor-1 (SF-1) neurons in mice reveals ventromedial nucleus of the hypothalamus (VMH) circuitry beginning at neurogenesis and development of a separate non-SF-1 neuronal cluster in the ventrolateral VMH.
Volume: 521
Issue: 6
Pages: 1268-88
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Publication
31366244 | J:298582
First Author: Furigo IC
Year: 2019
Journal: FASEB J
Title: Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons.
Volume: 33
Issue: 11
Pages: 11909-11924
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Publication
27422385 | J:247100
First Author: Steinbusch LK
Year: 2016
Journal: Diabetes
Title: Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase.
Volume: 65
Issue: 10
Pages: 2920-31
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Publication
32337532 | J:292651
 
First Author: Felsted JA
Year: 2020
Journal: Endocrinology
Title: Sex-specific Effects of α2δ-1 in the Ventromedial Hypothalamus of Female Mice Controlling Glucose and Lipid Balance.
Volume: 161
Issue: 7
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Publication
33069692 | J:309894
 
First Author: Pedroso JAB
Year: 2021
Journal: Peptides
Title: Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise.
Volume: 135
Pages: 170426
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Publication
12151099 | J:78371
First Author: Du X
Year: 2002
Journal: Biochim Biophys Acta
Title: The LIM-only coactivator FHL2 modulates WT1 transcriptional activity during gonadal differentiation.
Volume: 1577
Issue: 1
Pages: 93-101
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Publication
11602358 | J:72593
First Author: Whitworth DJ
Year: 2001
Journal: Gene
Title: Characterization of steroidogenic factor 1 during sexual differentiation in a marsupial.
Volume: 277
Issue: 1-2
Pages: 209-19
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Publication
10675033 | J:59930
First Author: Western PS
Year: 2000
Journal: Gene
Title: Temperature-dependent sex determination in the American alligator: expression of SF1, WT1 and DAX1 during gonadogenesis.
Volume: 241
Issue: 2
Pages: 223-32
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Publication
9154138 | J:40866
First Author: Lahbib-Mansais Y
Year: 1997
Journal: Cytogenet Cell Genet
Title: Mapping in pig of genes involved in sexual differentiation: AMH, WT1, FTZF1, SOX2, SOX9, AHC, and placental and embryonic CYP19.
Volume: 76
Issue: 1-2
Pages: 109-14
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Publication
9783910 | J:49864
First Author: Wood WM
Year: 1998
Journal: Mol Cell Endocrinol
Title: Functional interactions of an upstream enhancer of the mouse glycoprotein hormone alpha-subunit gene with proximal promoter sequences.
Volume: 142
Issue: 1-2
Pages: 141-52
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Publication
9879712 | J:57530
First Author: Toyooka Y
Year: 1998
Journal: Int J Dev Biol
Title: Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY.
Volume: 42
Issue: 8
Pages: 1143-51
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Publication
10336677 | J:55825
First Author: Pieri I
Year: 1999
Journal: Eur J Neurosci
Title: Regulation of the murine NMDA-receptor-subunit NR2C promoter by Sp1 and fushi tarazu factor1 (FTZ-F1) homologues.
Volume: 11
Issue: 6
Pages: 2083-92
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Publication
19147497 | J:148612
First Author: Jin Z
Year: 2009
Journal: J Biol Chem
Title: Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development.
Volume: 284
Issue: 12
Pages: 8160-73
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Publication
20962249 | J:170160
First Author: Gao L
Year: 2011
Journal: Biol Reprod
Title: Two regions within the proximal steroidogenic factor 1 promoter drive somatic cell-specific activity in developing gonads of the female mouse.
Volume: 84
Issue: 3
Pages: 422-34
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Publication
23874228 | J:199294
First Author: Munger SC
Year: 2013
Journal: PLoS Genet
Title: Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination.
Volume: 9
Issue: 7
Pages: e1003630
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Publication
30939050 | J:276000
First Author: Choi H
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Krüppel-like factor 4 plays a role in the luteal transition in steroidogenesis by downregulating Cyp19A1 expression.
Volume: 316
Issue: 6
Pages: E1071-E1080
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Protein
Q8C776
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
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Publication
2045359 | -
First Author: Toone WM
Year: 1991
Journal: J Bacteriol
Title: deaD, a new Escherichia coli gene encoding a presumed ATP-dependent RNA helicase, can suppress a mutation in rpsB, the gene encoding ribosomal protein S2.
Volume: 173
Issue: 11
Pages: 3291-302
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Publication
15148362 | -
First Author: Charollais J
Year: 2004
Journal: Nucleic Acids Res
Title: CsdA, a cold-shock RNA helicase from Escherichia coli, is involved in the biogenesis of 50S ribosomal subunit.
Volume: 32
Issue: 9
Pages: 2751-9
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Publication
18083833 | -
First Author: Jain C
Year: 2008
Journal: RNA
Title: The E. coli RhlE RNA helicase regulates the function of related RNA helicases during ribosome assembly.
Volume: 14
Issue: 2
Pages: 381-9
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Publication
23175611 | -
First Author: Zhang Y
Year: 2013
Journal: Nucleic Acids Res
Title: Structure, phosphorylation and U2AF65 binding of the N-terminal domain of splicing factor 1 during 3'-splice site recognition.
Volume: 41
Issue: 2
Pages: 1343-54
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Publication
17589525 | -
First Author: Corsini L
Year: 2007
Journal: Nat Struct Mol Biol
Title: U2AF-homology motif interactions are required for alternative splicing regulation by SPF45.
Volume: 14
Issue: 7
Pages: 620-9
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Publication
20236180 | -
First Author: Horikoshi N
Year: 2010
Journal: Genes Cells
Title: Holliday junction-binding activity of human SPF45.
Volume: 15
Issue: 4
Pages: 373-83
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Publication
17154718 | -
First Author: Chaouki AS
Year: 2006
Journal: PLoS Genet
Title: Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair.
Volume: 2
Issue: 12
Pages: e178
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Protein Domain
IPR045055 | DNA2/NAM7-like
Type: Family
Description: This entry represents a group of helicases, including DNA2 and Nam7. Proteins in this family contain a conserved domain with s a P-loop motif that is characteristic of the AAA superfamily. They are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA [, , ].Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [, ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway [].
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Protein Domain
IPR028618 | DEAD_helicase_DeaD
Type: Family
Description: RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). The RNA helicase DeaD is ATP-dependent []and is induced by low temperatures []. In addition to its role in unwinding double stranded RNA, it is involved in ribosomal subunit biogenesis [].
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Protein Domain
IPR028622 | DEAD_helicase_RhlE
Type: Family
Description: RNA helicases from the DEAD-box family are found in almost all organisms andhave important roles in RNA metabolism, such as splicing, RNA transport,ribosome biogenesis, translation and RNA decay. They are enzymes that unwinddouble-stranded RNA molecules in an energy dependent fashion through thehydrolysis of NTP. DEAD-box RNA helicases belong to superfamily 2 (SF2) ofhelicases. As other SF1 and SF2 members they contain seven conserved motifswhich are characteristic of these two superfamilies [].DEAD-box is named after the amino acids of motif II or Walker B (Mg2+-bindingaspartic acid). RhlE is a DEAD-box RNA helicase that is involved in ribosome assembly. It may play a role in the interconversion of ribosomal RNA-folding intermediates that are further processed by DeaD or SrmB during ribosome maturation [].
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Protein Domain
IPR041679 | DNA2/NAM7-like_C
Type: Domain
Description: This domain contains a P-loop motif that is characteristic of the AAA superfamily. Proteins containing this domain are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA [, , ].Proteins containing this domain include helicases, such as Dna2 an Nam7. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities [, ]. Nam7 (also known as Upf1) is an ATP-dependent RNA helicase involved in the nonsense-mediated mRNA decay (NMD) pathway []. This domain can also be found in some virus polyproteins. This domain is also known as HelicC.
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Protein Domain
IPR034653 | SPF45_RRM
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of SPF45. SPF45, also termed RNA-binding motif protein 17 (RBM17), is an RNA-binding protein consisting of an unstructured N-terminal region, followed by a G-patch motif and a C-terminal U2AF (U2 auxiliary factor) homology motifs (UHM) that harbours a RNA recognition motif (RRM) and an Arg-Xaa-Phe sequence motif. SPF45 is a bifunctional protein that functions in splicing and DNA repair. It is involved in regulating alternative splicing of the apoptosis regulatory gene FAS (also called CD95). Its UHM binds UHM-ligand motifs (ULMs) present in the 3' splice site-recognizing factors U2AF65, SF1 and SF3b155 []. It binds to the Holliday junction, which is a key DNA intermediate in the homologous-recombination pathway [, ].
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Protein Domain
IPR044348 | NSP10_1B_Av
Type: Domain
Description: Nidoviruses (Coronaviridae, Arteriviridae, and Roniviridae) feature the most complex genetic organization among plus-strand RNA viruses. Their replicase genes encode an exceptionally large replicase polyprotein 1a/ab which is then proteolytically processed to release different nonstructural proteins (NSPs) that mediate the key functions required for replication and transcription. One of these NSPs, called NSP10 in arteriviruses (Av) and NSP13 in coronaviruses (CoV) functions as a helicase [, ]. It is a multidomain protein consisting of a N-terminal Cys/His rich zinc-binding domain (ZBD) and a helicase core that belongs to the superfamily SF1 of helicases. The helicase core contains two RecA1 and RecA2 domains and a 1B domain [].This entry represents the 1B domain, which has a regulatory role modulating the nucleic acid substrate binding. Based on the structures from the Equine arteritis virus (EAV) NSP10, 1B domain undergoes large conformational change upon substrate binding, and forms a channel together with 1A and 2A domains that accommodates the single stranded nucleic acids [, ].
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Protein Domain
IPR032570 | SF1-HH
Type: Domain
Description: This helix-hairpin domain can be found in N-terminal region of mammalian splicing factor 1 (SF1) and fungal branchpoint binding proteins (BBP) []. These proteins are required for pre-spliceosome formation, which is the first step of pre-mRNA splicing [, ]. SF1 forms a complex with U2AF65 through the interaction between this domain and the C-terminal U2AF homology motif domain (UHM) of U2AF65. This domain forms a secondary, hydrophobic interface with U2AF65(UHM) to lock the orientation of the two subunits, which is essential for cooperative formation of the ternary SF1-U2AF65-RNA complex []. This domain contains a highly conserved SPSP motif at its C terminus; the phophorylation of the SPSP motif induces a disorder-to-order transition within a novel SF1/U2AF65 interface [].
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Protein Domain
IPR001650 | Helicase_C
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). For the two largest groups, commonly referred to as SF1 and SF2, a total of seven characteristic motifs has been identified []. These two superfamilies encompass a large number of DNA and RNA helicases from archaea, eubacteria, eukaryotes and viruses.This entry represents the C-terminal domain found in proteins belonging to the helicase superfamilies 1 and 2. Included in this group is the eukaryotic translation initiation factor 4A (eIF4A), a member of the DEA(D/H)-box RNA helicase family. The structure of the carboxyl-terminal domain of eIF4A has been determined; it has a parallel α-β topology that superimposes, with minor variations, on the structures and conserved motifs of the equivalent domain in other, distantly related helicases [].
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Publication
16935882 | -
First Author: Fuller-Pace FV
Year: 2006
Journal: Nucleic Acids Res
Title: DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
Volume: 34
Issue: 15
Pages: 4206-15
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Publication
10322435 | -
First Author: de la Cruz J
Year: 1999
Journal: Trends Biochem Sci
Title: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.
Volume: 24
Issue: 5
Pages: 192-8
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Publication
1531961 | -
First Author: Koonin EV
Year: 1992
Journal: FEBS Lett
Title: Autogenous translation regulation by Escherichia coli ATPase SecA may be mediated by an intrinsic RNA helicase activity of this protein.
Volume: 298
Issue: 1
Pages: 6-8
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Publication
22496664 | J:183829
First Author: Correa SM
Year: 2012
Journal: PLoS Genet
Title: Sex reversal in C57BL/6J XY mice caused by increased expression of ovarian genes and insufficient activation of the testis determining pathway.
Volume: 8
Issue: 4
Pages: e1002569
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Publication
21906594 | J:178372
First Author: Büdefeld T
Year: 2011
Journal: Exp Neurol
Title: Altered position of cell bodies and fibers in the ventromedial region in SF-1 knockout mice.
Volume: 232
Issue: 2
Pages: 176-84
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Publication
11738790 | J:73634
First Author: Achermann JC
Year: 2001
Journal: Mol Cell Endocrinol
Title: Phenotypic spectrum of mutations in DAX-1 and SF-1.
Volume: 185
Issue: 1-2
Pages: 17-25
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Publication
25271967 | J:223482
First Author: Baldo B
Year: 2014
Journal: PLoS One
Title: Effects of deletion of mutant huntingtin in steroidogenic factor 1 neurons on the psychiatric and metabolic phenotype in the BACHD mouse model of Huntington disease.
Volume: 9
Issue: 10
Pages: e107691
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Publication
35192609 | J:322528
First Author: Agrimson KS
Year: 2022
Journal: PLoS Genet
Title: Lrh1 can help reprogram sexual cell fate and is required for Sertoli cell development and spermatogenesis in the mouse testis.
Volume: 18
Issue: 2
Pages: e1010088
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Publication
37507231 | J:355559
First Author: Meng A
Year: 2023
Journal: J Neurosci
Title: mGluR5 in Astrocytes in the Ventromedial Hypothalamus Regulates Pituitary Adenylate Cyclase-Activating Polypeptide Neurons and Glucose Homeostasis.
Volume: 43
Issue: 33
Pages: 5918-5935
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Publication
9178747 | J:40616
First Author: Cammas FM
Year: 1997
Journal: Mol Endocrinol
Title: The mouse adrenocorticotropin receptor gene: cloning and characterization of its promoter and evidence for a role for the orphan nuclear receptor steroidogenic factor 1.
Volume: 11
Issue: 7
Pages: 867-76
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Publication
11087862 | -
First Author: Caruthers JM
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase.
Volume: 97
Issue: 24
Pages: 13080-5
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Publication
11839499 | -
First Author: Caruthers JM
Year: 2002
Journal: Curr Opin Struct Biol
Title: Helicase structure and mechanism.
Volume: 12
Issue: 1
Pages: 123-33
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Publication
11545728 | -
First Author: Tanner NK
Year: 2001
Journal: Mol Cell
Title: DExD/H box RNA helicases: from generic motors to specific dissociation functions.
Volume: 8
Issue: 2
Pages: 251-62
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Publication
8385320 | -
First Author: Koonin EV
Year: 1993
Journal: Nucleic Acids Res
Title: Escherichia coli dinG gene encodes a putative DNA helicase related to a group of eukaryotic helicases including Rad3 protein.
Volume: 21
Issue: 6
Pages: 1497
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Protein
Q5F0J9
Organism: Mus musculus/domesticus
Length: 34  
Fragment?: true
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Publication
2546125 | -
First Author: Gorbalenya AE
Year: 1989
Journal: Nucleic Acids Res
Title: Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes.
Volume: 17
Issue: 12
Pages: 4713-30
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Protein Domain
IPR014001 | Helicase_ATP-bd
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). All of the proteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. For the two largest groups, commonlyreferred to as SF1 and SF2, a total of seven characteristic motifs has beenidentified []. These two superfamilies encompass a large number of DNA andRNA helicases from archaea, eubacteria, eukaryotes and viruses that seem to beactive as monomers or dimers. RNA and DNA helicases are considered to beenzymes that catalyze the separation of double-stranded nucleic acids in anenergy-dependent manner [].The various structures of SF1 and SF2 helicases present a common core with twoα-β RecA-like domains [, ]. Thestructural homology with the RecA recombination protein covers the fivecontiguous parallel beta strands and the tandem alpha helices. ATP binds tothe amino proximal α-β domain, where the Walker A (motif I) and WalkerB (motif II) are found. The N-terminal domain also contains motif III (S-A-T)which was proposed to participate in linking ATPase and helicase activities.The carboxy-terminal α-β domain is structurally very similar to theproximal one even though it is bereft of an ATP-binding site, suggesting thatit may have originally arisen through gene duplication of the first one.Some members of helicase superfamilies 1 and 2 are listed below:DEAD-box RNA helicases. The prototype of DEAD-boxproteins is the translation initiation factor eIF4A. The eIF4A protein isan RNA-dependent ATPase which functions together with eIF4B as an RNAhelicase [].DEAH-box RNA helicases. Mainly pre-mRNA-splicing factorATP-dependent RNA helicases [].Eukaryotic DNA repair helicase RAD3/ERCC-2, an ATP-dependent 5'-3' DNAhelicase involved in nucleotide excision repair of UV-damaged DNA.Eukaryotic TFIIH basal transcription factor complex helicase XPB subunit.An ATP-dependent 3'-5' DNA helicase which is a component of the core-TFIIHbasal transcription factor, involved in nucleotide excision repair (NER) ofDNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.It acts by opening DNA either around the RNA transcription start site orthe DNA.Eukaryotic ATP-dependent DNA helicase Q. A DNA helicase that may play arole in the repair of DNA that is damaged by ultraviolet light or othermutagens.Bacterial and eukaryotic antiviral SKI2-like helicase. SKI2 has a role inthe 3'-mRNA degradation pathway, repressing dsRNA virus propagation byspecifically blocking translation of viral mRNAs, perhaps recognizing theabsence of CAP or poly(A).Bacterial DNA-damage-inducible protein G (DinG). A probable helicaseinvolved in DNA repair and perhaps also replication [].Bacterial primosomal protein N' (PriA). PriA protein is one of sevenproteins that make up the restart primosome, an apparatus that promotesassembly of replisomes at recombination intermediates and stalledreplication forks.Bacterial ATP-dependent DNA helicase recG. It has a critical role inrecombination and DNA repair, helping process Holliday junctionintermediates to mature products by catalyzing branch migration. It has aDNA unwinding activity characteristic of helicases with a 3' to 5'polarity.A variety of DNA and RNA virus helicases and transcription factorsThis entry represents the DNA-binding domain of classical SF1 and SF2 helicases. It does not recognize bacterial DinG and eukaryotic Rad3 which differ from other SF1-SF2 helicases by the presence of a large insert after the Walker A (see ).
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Protein Domain
IPR014013 | Helic_SF1/SF2_ATP-bd_DinG/Rad3
Type: Domain
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). All of the proteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. For the two largest groups, commonlyreferred to as SF1 and SF2, a total of seven characteristic motifs has beenidentified []. These two superfamilies encompass a large number of DNA andRNA helicases from archaea, eubacteria, eukaryotes and viruses that seem to beactive as monomers or dimers. RNA and DNA helicases are considered to beenzymes that catalyze the separation of double-stranded nucleic acids in anenergy-dependent manner [].The various structures of SF1 and SF2 helicases present a common core with twoα-β RecA-like domains [, ]. Thestructural homology with the RecA recombination protein covers the fivecontiguous parallel beta strands and the tandem alpha helices. ATP binds tothe amino proximal α-β domain, where the Walker A (motif I) and WalkerB (motif II) are found. The N-terminal domain also contains motif III (S-A-T)which was proposed to participate in linking ATPase and helicase activities.The carboxy-terminal α-β domain is structurally very similar to theproximal one even though it is bereft of an ATP-binding site, suggesting thatit may have originally arisen through gene duplication of the first one.Some members of helicase superfamilies 1 and 2 are listed below:DEAD-box RNA helicases. The prototype ofDEAD-boxproteins is the translation initiation factor eIF4A. The eIF4A protein isan RNA-dependent ATPase which functions together with eIF4B as an RNAhelicase [].DEAH-box RNA helicases. Mainly pre-mRNA-splicing factorATP-dependent RNA helicases [].Eukaryotic DNA repair helicase RAD3/ERCC-2, an ATP-dependent 5'-3' DNAhelicase involved in nucleotide excision repair of UV-damaged DNA.Eukaryotic TFIIH basal transcription factor complex helicase XPB subunit.An ATP-dependent 3'-5' DNA helicase which is a component of the core-TFIIHbasal transcription factor, involved in nucleotide excision repair (NER) ofDNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.It acts by opening DNA either around the RNA transcription start site orthe DNA.Eukaryotic ATP-dependent DNA helicase Q. A DNA helicase that may play arole in the repair of DNA that is damaged by ultraviolet light or othermutagens.Bacterial and eukaryotic antiviral SKI2-like helicase. SKI2 has a role inthe 3'-mRNA degradation pathway, repressing dsRNA virus propagation byspecifically blocking translation of viral mRNAs, perhaps recognizing theabsence of CAP or poly(A).Bacterial DNA-damage-inducible protein G (DinG). A probable helicaseinvolved in DNA repair and perhaps also replication [].Bacterial primosomal protein N' (PriA). PriA protein is one of sevenproteins that make up the restart primosome, an apparatus that promotesassembly of replisomes at recombination intermediates and stalledreplication forks.Bacterial ATP-dependent DNA helicase recG. It has a critical role inrecombination and DNA repair, helping process Holliday junctionintermediates to mature products by catalyzing branch migration. It has aDNA unwinding activity characteristic of helicases with a 3' to 5'polarity.A variety of DNA and RNA virus helicases and transcription factorsThis entry represents the ATP-binding domain found within bacterial DinG and eukaryotic Rad3 proteins, differing from other SF1 and SF2 helicases by the presence of a large insert after the Walker A motif [].
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Protein Domain
IPR045028 | DinG/Rad3-like
Type: Family
Description: Helicases have been classified in 5 superfamilies (SF1-SF5). All of the proteins bind ATP and, consequently, all of them carry the classical Walker A(phosphate-binding loop or P-loop) and Walker B(Mg2+-binding aspartic acid) motifs. For the two largest groups, commonlyreferred to as SF1 and SF2, a total of seven characteristic motifs has beenidentified []. These two superfamilies encompass a large number of DNA andRNA helicases from archaea, eubacteria, eukaryotes and viruses that seem to beactive as monomers or dimers. RNA and DNA helicases are considered to beenzymes that catalyze the separation of double-stranded nucleic acids in anenergy-dependent manner [].The various structures of SF1 and SF2 helicases present a common core with twoα-β RecA-like domains [, ]. Thestructural homology with the RecA recombination protein covers the fivecontiguous parallel beta strands and the tandem alpha helices. ATP binds tothe amino proximal α-β domain, where the Walker A (motif I) and WalkerB (motif II) are found. The N-terminal domain also contains motif III (S-A-T)which was proposed to participate in linking ATPase and helicase activities.The carboxy-terminal α-β domain is structurally very similar to theproximal one even though it is bereft of an ATP-binding site, suggesting thatit may have originally arisen through gene duplication of the first one.Some members of helicase superfamilies 1 and 2 are listed below:DEAD-box RNA helicases. The prototype of DEAD-boxproteins is the translation initiation factor eIF4A. The eIF4A protein isan RNA-dependent ATPase which functions together with eIF4B as an RNAhelicase [].DEAH-box RNA helicases. Mainly pre-mRNA-splicing factorATP-dependent RNA helicases [].Eukaryotic DNA repair helicase RAD3/ERCC-2, an ATP-dependent 5'-3' DNAhelicase involved in nucleotide excision repair of UV-damaged DNA.Eukaryotic TFIIH basal transcription factor complex helicase XPB subunit.An ATP-dependent 3'-5' DNA helicase which is a component of the core-TFIIHbasal transcription factor, involved in nucleotide excision repair (NER) ofDNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.It acts by opening DNA either around the RNA transcription start site orthe DNA.Eukaryotic ATP-dependent DNA helicase Q. A DNA helicase that may play arole in the repair of DNA that is damaged by ultraviolet light or othermutagens.Bacterial and eukaryotic antiviral SKI2-like helicase. SKI2 has a role inthe 3'-mRNA degradation pathway, repressing dsRNA virus propagation byspecifically blocking translation of viral mRNAs, perhaps recognizing theabsence of CAP or poly(A).Bacterial DNA-damage-inducible protein G (DinG). A probable helicaseinvolved in DNA repair and perhaps also replication [].Bacterial primosomal protein N' (PriA). PriA protein is one of sevenproteins that make up the restart primosome, an apparatus that promotesassembly of replisomes at recombination intermediates and stalledreplication forks.Bacterial ATP-dependent DNA helicase recG. It has a critical role inrecombination and DNA repair, helping process Holliday junctionintermediates to mature products by catalyzing branch migration. It has aDNA unwinding activity characteristic of helicases with a 3' to 5'polarity.A variety of DNA and RNA virus helicases and transcription factorsThis entry includes bacterial DinG and eukaryotic Rad3 proteins, differing from other SF1 and SF2 helicases by the presence of a large insert after the Walker A motif [].
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Protein
Q8C1K4
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
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Protein
Q8K2R9
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: false
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Publication
29236296 | -
 
First Author: M Plank TD
Year: 2018
Journal: Bioessays
Title: RNA Decay Factor UPF1 Promotes Protein Decay: A Hidden Talent.
Volume: 40
Issue: 1
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Publication
16181749 | J:102608
 
First Author: Zhou D
Year: 2005
Journal: Gene
Title: Transcriptional regulation of the mouse PNRC2 promoter by the nuclear factor Y (NFY) and E2F1.
Volume: 361
Pages: 89-100
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Protein
Q6P9R1
Organism: Mus musculus/domesticus
Length: 639  
Fragment?: false
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Protein
Q6PFE3
Organism: Mus musculus/domesticus
Length: 886  
Fragment?: false
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Protein
P70270
Organism: Mus musculus/domesticus
Length: 747  
Fragment?: false
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Protein
Q9DBV3
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
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Protein
Q2VPA6
Organism: Mus musculus/domesticus
Length: 1069  
Fragment?: false
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Protein
Q8BHK9
Organism: Mus musculus/domesticus
Length: 1240  
Fragment?: false
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Protein
F8VPZ5
Organism: Mus musculus/domesticus
Length: 1481  
Fragment?: false
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Protein
Q9CZU3
Organism: Mus musculus/domesticus
Length: 1040  
Fragment?: false
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Protein
D3YTV3
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
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Protein
Q3U8I0
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
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Protein
F7DCU7
Organism: Mus musculus/domesticus
Length: 972  
Fragment?: true
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Protein
Q3TVD8
Organism: Mus musculus/domesticus
Length: 505  
Fragment?: true
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Protein
G3X9F7
Organism: Mus musculus/domesticus
Length: 1710  
Fragment?: false
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Protein
Q66JM5
Organism: Mus musculus/domesticus
Length: 1145  
Fragment?: false
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Protein
Q3UZ56
Organism: Mus musculus/domesticus
Length: 229  
Fragment?: true
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Protein
Q8BVI7
Organism: Mus musculus/domesticus
Length: 616  
Fragment?: true
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Protein
Q3TEK1
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
A0A0A6YWV8
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: true
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Protein
E9Q561
Organism: Mus musculus/domesticus
Length: 312  
Fragment?: false
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Protein
Q8BY42
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
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Protein
E9PZQ1
Organism: Mus musculus/domesticus
Length: 1711  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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